Neurological Sciences最新文献

{"title":"Extensive lower limb neuropathies following coronary artery bypass surgery.","authors":"Berkay Yalçınkaya, Ahmet Furkan Çolak, Hilmi Berkan Abacıoğlu, Alp Çetin","doi":"10.1007/s10072-025-08534-8","DOIUrl":"https://doi.org/10.1007/s10072-025-08534-8","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A review of MRI signal changes of cerebellar disorders in adults.","authors":"Dimitri Renard, Manon Rival, Anne Le Floch, Jean Sebastien Guillamo, Giovanni Castelnovo","doi":"10.1007/s10072-025-08557-1","DOIUrl":"https://doi.org/10.1007/s10072-025-08557-1","url":null,"abstract":"<p><strong>Background: </strong>MRI signal changes in the cerebellum are observed in multiple disorders including vascular diseases, neoplastic lesions, degenerative diseases, inflammatory disorders, metabolic diseases, infections, and trauma. In some diseases, cerebellar involvement is typical and sometimes isolated, while in other diseases cerebellar lesions are only observed occasionally in the presence of other typical extra-cerebellar abnormalities.</p><p><strong>Methods: </strong>In this review, we will discuss the MRI characteristics of cerebellar lesions in adults observed in disorders with typical or frequent cerebellar involvement.</p><p><strong>Results: </strong>Interpreting these cerebellar signal changes on MRI is essential to determine the underlying disorder. Assessing the lesion on MRI forms an essential part of diagnosis and follow-up, alongside patient's history, clinical state and other radiological and non-radiological examinations.</p><p><strong>Conclusion: </strong>The interpretation of cerebellar lesions on MRI depends on their exact localisation inside the cerebellum (e.g. uni- or bilateral lesions, involvement of the cerebellar peduncles, subcortical or cortical regions, or the deep cerebellar nuclei), signal changes on different MRI sequences, change of abnormalities over time, and the presence and characteristics of associated MRI lesions outside the cerebellum.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the neuroprotective effect of GLP-1 receptor agonists in parkinson's disease: a systematic review and meta-analysis of randomized controlled trials.","authors":"Yago Marcos Pessoa-Gonçalves, Victor Hugo Palhares Flávio-Reis, Chamberttan Souza Desidério, Marlos Aureliano Dias-Sousa, Carlo José Freire Oliveira, Rubens Gisbert Cury, Wellington Francisco Rodrigues","doi":"10.1007/s10072-025-08568-y","DOIUrl":"https://doi.org/10.1007/s10072-025-08568-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain connectivity changes associated with acute sleep deprivation: a systematic review.","authors":"Stephanie Hosang, Karen Wong, Daniella Mlinarevic, Brian Krivoruk, Hiruthika Ravi, Darren Hamilton, Loretta Norton, Bobby Stojanoski, Saptharishi Lalgudi Ganesan","doi":"10.1007/s10072-025-08517-9","DOIUrl":"https://doi.org/10.1007/s10072-025-08517-9","url":null,"abstract":"<p><strong>Study objectives: </strong>Sleep deprivation related changes in brain connectivity have been poorly characterized but have important implications for delirium patients and shift workers. This study aimed to describe the functional and effective brain connectivity changes after acute sleep deprivation (ASD).</p><p><strong>Methods: </strong>A systematic search of OvidSP Embase, PubMed, and Web of Science databases was conducted for studies published between January 1, 1947, to September 11, 2024. Selected studies examined brain connectivity strength or topology, estimated by electroencephalography, functional magnetic resonance imaging, functional near-infrared spectroscopy, magnetoencephalography, or positron emission tomography, after ASD. Data extracted from eligible studies included primary outcomes: functional neuroimaging modality, type of brain connectivity analyses and results of brain connectivity analyses. Studies were grouped for synthesis based on functional neuroimaging modality and connectivity measures.</p><p><strong>Results: </strong>The search produced 1015 articles. 357 duplicates were removed, and 658 articles were screened. Of these, 250 underwent full-text review and 141 were excluded. This produced 109 articles for review. Results demonstrated that the methodology and analyses employed to study functional and effective connectivity after ASD were heterogeneous. However, despite this heterogeneity, studies demonstrated that ASD leads to robust and consistent alterations in the functional/effective connectivity of multiple brain networks, particularly the default mode network.</p><p><strong>Conclusions: </strong>This review summarizes the key functional and effective connectivity changes associated with ASD. This work will serve as a reference and resource for researchers and clinicians focused on delirium and related conditions, in addition to those interested in ASD and shift work.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145280775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"European neurologists need to be aware of chikungunya (CHIKV) and dengue (DENV) viruses.","authors":"Guglielmo Lucchese, Angela Stufano","doi":"10.1007/s10072-025-08538-4","DOIUrl":"https://doi.org/10.1007/s10072-025-08538-4","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of branded vs generic lacosamide in epilepsy: a retrospective real-world study.","authors":"Giuseppe Salafica, Diana Tilenni, Attilio Vinaccia, Giovanni Tripepi, Chiara Martellino, Salvatore Maria Lima, Giorgia Atanasio, Fabio Lamanna, Orazio Pardeo, Mariangela Panebianco, Angelina Laganà, Angelo Labate","doi":"10.1007/s10072-025-08563-3","DOIUrl":"https://doi.org/10.1007/s10072-025-08563-3","url":null,"abstract":"<p><strong>Purpose: </strong>Lacosamide (LCS) is a third-generation antiseizure medication (ASM) approved for focal-onset seizures and generalized epilepsy. Although the branded formulation, Vimpat^®, has shown efficacy and safety, the introduction of generic versions, such as Stutan^®, raises concerns about clinical equivalence, especially considering the potential for therapeutic fluctuations that could result in breakthrough seizures or adverse events. This study aimed to compare the real-world efficacy, safety and tolerability of branded lacosamide (Vimpat^®) versus its generic counterpart (Stutan^®) in patients with focal or generalized epilepsy.</p><p><strong>Methods: </strong>A multicenter, retrospective, observational study was conducted at two epilepsy centers in Southern Italy. Sixty adult patients were included and divided into two groups: Group A (n = 30) received branded LCS and Group B (n = 30) received the generic formulation. Data were collected at treatment initiation (T0) and the first follow-up (T1), including seizure frequency, adverse events and dose adjustments. The primary outcome was the responder rate (≥ 50% reduction in seizure frequency), with secondary outcomes including seizure freedom, adverse events and dose changes.</p><p><strong>Results: </strong>Baseline characteristics were similar between groups. The average daily LCS dose was significantly higher in the Vimpat^® group (275 ± 121 mg) compared to the Stutan^® group (168 ± 89 mg, p < 0.001). Despite this, efficacy outcomes were comparable, with 60.0% of patients in Group A and 43.3% in Group B achieving a ≥ 50% seizure reduction (p = 0.08). Adverse events were mild or moderate.</p><p><strong>Conclusions: </strong>In this real-world setting, generic LCS (Stutan^®) demonstrated comparable efficacy, safety and tolerability to Vimpat^®, supporting its clinical use as a valid alternative in epilepsy management.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemichorea as a primary manifestation of varicella-zoster virus neuroinfection in a child - a case report and review of literature.","authors":"Mateusz Tomkiewicz, Dominik Gosławski, Zuzanna Krasula, Agata Klawikowska, Marta Zawadzka, Jakub Szymarek, Maria Mazurkiewicz-Bełdzińska","doi":"10.1007/s10072-025-08550-8","DOIUrl":"https://doi.org/10.1007/s10072-025-08550-8","url":null,"abstract":"<p><strong>Background: </strong>Varicella is a common childhood infection caused by the varicella-zoster virus. Reactivation of latent virus within somatosensory ganglia can lead to numerous complications, including cerebral vasculitis. Inflammatory processes can alter vascular structure and lead to ischemic stroke in both the pediatric and adult population. Chorea is a rare extrapyramidal symptom which might be a result of vascular insult in the course of cerebrovascular events.</p><p><strong>Case presentation: </strong>An 8-year old boy with a recent history of varicella presented with acute-onset choreiform movements of the right extremities. A lumbar puncture revealed the presence of varicella-zoster virus genetic material in the cerebrospinal fluid. Brain magnetic resonance imaging showed ischemic lesions affecting basal ganglia, while vascular imaging was unremarkable. A diagnosis of arterial ischemic stroke secondary to varicella-zoster vasculitis was suspected, which was later supported by exclusion of other potential causes of cerebrovascular events. After a course of acyclovir and prednisone, as well as the initiation of a long-term antiplatelet therapy, marked clinical recovery was achieved. A follow-up visit 6 months later confirmed our patient's return to his pre-stroke level of functioning.</p><p><strong>Conclusions: </strong>Varicella remains a major cerebrovascular risk factor, particularly in the unvaccinated pediatric population. Patients with varicella-zoster vasculitis might present with various neurological deficits, including hemichorea, even when vascular imaging reveals no abnormalities. Early initiation of antiviral, steroid and antiplatelet treatment might positively impact the clinical recovery time of affected individuals, although a need for large-cohort studies assessing treatment efficacy is evident.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Establishment of molecular subtypes and prognostic models for glioblastoma based on non-apoptotic regulatory cell death genes.","authors":"Wentao Dong, Haidong Zhang, Yangyang Wei","doi":"10.1007/s10072-025-08556-2","DOIUrl":"https://doi.org/10.1007/s10072-025-08556-2","url":null,"abstract":"<p><strong>Background: </strong>Non-apoptotic regulatory cell death (NARCD) encompasses a range of cell death mechanisms beyond apoptosis. It plays a crucial role in the development and progression of brain gliomas; however, the specific regulatory mechanisms involved remain insufficiently explored. This study aims to construct a prognostic model to predict disease progression based on the potential mechanisms of NARCD-related genes in brain gliomas.</p><p><strong>Methods: </strong>mRNA expression profiles and clinical data of brain glioma patients were downloaded from The Cancer Genome Atlas (TCGA) database. Control gene expression profiles were obtained from the Genotype-Tissue Expression (GTEx) project. The external validation set was sourced from the Chinese Glioma Genome Atlas (CGGA). Molecular subtyping was performed using unsupervised clustering, and functional analysis was conducted on the differentially expressed genes among the subtypes. A NARCD-related prognostic model was developed using univariate Cox, LASSO, and multivariate Cox regression analysis. Subsequently, patients were stratified into high- and low-risk groups, and comprehensive validations were performed to evaluate the prognostic value of the model. Additionally, the associations between the prognostic model, immune infiltration, and drug sensitivity were explored. Quantitative PCR (q-PCR) experiments were conducted to validate the expression of nine key genes.</p><p><strong>Results: </strong>This study categorized brain glioma patients into three subtypes based on key NARCD genes. A prognostic risk model was established using nine differential genes among the three subtypes. Patients with high-risk scores exhibited poorer overall prognosis. Furthermore, in the high-risk population, we observed reduced immune cell infiltration, suppressed immune function, and elevated tumor mutation burden (TMB). Patients in the low-risk group were more sensitive to drugs than those in the high-risk group. The q-PCR results for the characteristic genes were in agreement with the outcomes of the model analysis.</p><p><strong>Conclusion: </strong>The NARCD-related prognostic model established in this study serves as a reliable biomarker for predicting clinical outcomes in brain glioma patients, assessing immune infiltration status, and forecasting drug sensitivity.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: letter to the editor regarding \"beyond memory: leveraging CSF biomarkers in all MCI patients ahead of anti-amyloid therapies\".","authors":"M Poli, C G Bonomi, M G Di Donna, C Motta, Alessandro Martorana","doi":"10.1007/s10072-025-08530-y","DOIUrl":"https://doi.org/10.1007/s10072-025-08530-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145258602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Charcot on screen: portrayals and preconceptions of a medical icon.","authors":"Francesco Brigo","doi":"10.1007/s10072-025-08564-2","DOIUrl":"https://doi.org/10.1007/s10072-025-08564-2","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}