Neurological Sciences最新文献_第2页

Pediatric nummular headache: review of the literature and a case series with nosographic considerations. 小儿麻木性头痛：回顾文献和病例系列与医院的考虑。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-10 DOI: 10.1007/s10072-025-08494-z

Sofia D'Agostino, Antonella Morea, Carola Meo, Martina Tarantini, Giuditta Gambino, Umberto Quartetti, Maria Rosita Ruta, Edvige Correnti, Daniela D'Agnano, Giuseppe Santangelo, Giuseppe Giglia, Vittorio Sciruicchio, Vincenzo Raieli

{"title":"Pediatric nummular headache: review of the literature and a case series with nosographic considerations.","authors":"Sofia D'Agostino, Antonella Morea, Carola Meo, Martina Tarantini, Giuditta Gambino, Umberto Quartetti, Maria Rosita Ruta, Edvige Correnti, Daniela D'Agnano, Giuseppe Santangelo, Giuseppe Giglia, Vittorio Sciruicchio, Vincenzo Raieli","doi":"10.1007/s10072-025-08494-z","DOIUrl":"https://doi.org/10.1007/s10072-025-08494-z","url":null,"abstract":"Background: Nummular headache (NH) is a rare, often underdiagnosed form of primary headache, characterized by pain localized to a well-circumscribed area of the scalp. Although well documented in adults, its presentation in pediatric age is still poorly understood and rarely described.Methods: The narrative review synthesizes the few pediatric NH cases reported in the literature. Further we describe our small case series of six pediatric patients (age 9-17 years) diagnosed with NH. For each case, the following were evaluated: clinical features, age of onset, localization and form of pain, associated symptoms, family history, response to treatments and neuroradiological findings. Diagnoses were compared with ICHD-3 criteria and with data present in the literature.Results: Five patients presented with episodic NH, one with a continuous form. The painful area ranged from 1 to 4 cm in diameter, with round, oval and rectangular shapes. Four reported migraine-like symptoms. In one case NH was secondary to Langerhans cell histiocytosis. In two patients, a rectangular-shaped area of pain was observed, suggesting the need to review the diagnostic criteria.Conclusions: This case series highlights the clinical heterogeneity of NH in pediatric age, with episodic and continuous forms, morphological variability and migraine-like symptoms. The rectangular shape found in some cases calls into question the current nosographic limits and suggests the need for a broader pathophysiological understanding. Here we also propose possible new criteria for the diagnosis of Nummular Headache.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145275366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Instrumental evaluation of the effect of oral medium-chain triglycerides oil on paroxysmal exercise-induced dyskinesia in GLUT1 deficiency syndrome. 口服中链甘油三酯油对GLUT1缺乏症患者阵发性运动障碍影响的仪器评价。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-10 DOI: 10.1007/s10072-025-08551-7

Zeno Bercini, Francesco Cavallieri, Isabella Campanini, Lorenzo Cavazzuti, Sara Scaltriti, Benedetta Damiano, Annalisa Gessani, Jessica Rossi, Sara Montepietra, Franco Valzania, Andrea Merlo

引用次数: 0

Ultrasound-guided acupotomy in stroke limb rehabilitation: efficacy insights and unaddressed methodological concerns. 超声引导针刀在中风肢体康复：疗效见解和未解决的方法学问题。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-09 DOI: 10.1007/s10072-025-08555-3

Yijun Li, Qing Li

引用次数: 0

Risk of dementia in patients treated with anticholinergics for overactive bladder syndrome: a systematic review and meta-analysis. 抗胆碱能药物治疗膀胱过度活动综合征患者痴呆的风险：一项系统回顾和荟萃分析

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-09 DOI: 10.1007/s10072-025-08546-4

Martin Kotochinsky, Laura Mora, Diogo Carrazzoni Godoi, Fátima Maria Thaiz da Fonte Gomes da Silva, Karolina Guedes Amorim, Wellgner Fernandes Oliveira Amador, Douglas Barroso, Thales Pardini Fagundes

{"title":"Risk of dementia in patients treated with anticholinergics for overactive bladder syndrome: a systematic review and meta-analysis.","authors":"Martin Kotochinsky, Laura Mora, Diogo Carrazzoni Godoi, Fátima Maria Thaiz da Fonte Gomes da Silva, Karolina Guedes Amorim, Wellgner Fernandes Oliveira Amador, Douglas Barroso, Thales Pardini Fagundes","doi":"10.1007/s10072-025-08546-4","DOIUrl":"https://doi.org/10.1007/s10072-025-08546-4","url":null,"abstract":"Background: Urinary anticholinergic (AC) medications are commonly prescribed for Overactive Bladder (OAB) syndrome. Although recent studies suggest a potential link between their use and an increased risk of dementia, this association remains debated.Methods: We conducted a systematic review and meta-analysis to evaluate the risk of dementia in patients receiving AC treatment for OAB syndrome. A comprehensive search of PubMed, Embase, and Cochrane databases was performed. Outcomes of interest included dementia risk and its association with age, sex distribution, treatment duration, and follow-up length. Two subgroup analyses were assessed: (1) AC vs. no drug therapy and (2) AC vs. mirabegron, a beta-3 agonist and current standard of care for OAB syndrome. Relative risk (RR) with p-value < 0.05 was considered statistically significant.Results: Eight studies were included, comprising a total of 3,656,686 patients diagnosed with OAB syndrome, of whom 44.7% were exposed to urinary AC. The comparison between AC and no drug therapy showed a statistically significant higher risk of dementia in the exposed group (RR 1.2, 95% CI [1.09-1.32], I²=96%, p < 0.01). When the AC group was compared to patients who received Mirabegron, the AC use also presented a statistically significant increase in dementia risk (RR 1.28; 95% CI [1.03-1.58], I²=98%, p = 0.02).Conclusions: Patients who received urinary AC therapy for OAB syndrome were associated with an increased risk of dementia compared to both no drug therapy and medical therapy with mirabegron. These findings suggest that, for the long-term treatment of adult patients with OAB syndrome, alternative therapeutic options to AC should be considered, with Mirabegron emerging as a valid choice in clinical decision-making.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A possible atypical presentation of Tolosa-Hunt syndrome, a case report. 托罗萨-亨特综合征的一种可能的非典型表现。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-09 DOI: 10.1007/s10072-025-08541-9

Marco Bolchini, Giulia Campana, Matteo Cortinovis, Paola Zavarise, Giorgio Dalla Volta

引用次数: 0

Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children. 儿童可逆性脾损害综合征的新病因及临床特点。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-09 DOI: 10.1007/s10072-025-08554-4

Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han

{"title":"Some novel causes and clinical characteristics of reversible splenial lesion syndrome- found in children.","authors":"Xinpeng Wang, Xiaoyu Li, Min Cheng, Xiujuan Li, Siqi Hong, Li Jiang, Wei Han","doi":"10.1007/s10072-025-08554-4","DOIUrl":"https://doi.org/10.1007/s10072-025-08554-4","url":null,"abstract":"Objective: To describe causes, clinical manifestations, imaging features and prognosis of reversible splenial lesion syndrome (RESLES) in children.Methods: A total of 36 patients with RESLES hospitalized in Children's Hospital of Chongqing Medical University between January 1, 2017 and Mar 31, 2024 were included. The clinical features including the causes, clinical manifestations and prognosis were statistically analyzed.Results: The patients' ages ranged from 16 to 170 months with a median age of 49 months. Of the 36 patients, 24 patients were RESLES type-1 (the lesions were limited to SCC) and 12 patients were RESLES type-2(the lesions spread to other parts of the corpus callosum, extensive brain white matter, or both). The participating causes included infection, chemotherapy, immunoglobulin A vasculitis, autoimmune glial fibrillary acidic protein astrocytopathy, hypertension and hypoparathyroidism. The common neurological symptoms were seizures(n = 27), headache(n = 10), dizziness(n = 6), altered consciousness(n = 8), and psychologico-behavioral abnormalities(n = 14). Most patients had a good prognosis except 1 patient remained in a state of minimal consciousness during the follow-up.Conclusion: This research demonstrates some possible causes of RESLES. Patients with RESLES present with a variety of nonspecific symptoms and most of them had a good prognosis.Significance: These findings are groundbreaking to a deeper understanding of RESLES.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Global temporal trends and projections of epilepsy in women of childbearing age: insights from the global burden of disease study 2021. 育龄妇女癫痫的全球时间趋势和预测：来自2021年全球疾病负担研究的见解

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-09 DOI: 10.1007/s10072-025-08540-w

Siyuan Yang, Xiaoyu Ji, Dejing Cheng, Chengyuan Ji

{"title":"Global temporal trends and projections of epilepsy in women of childbearing age: insights from the global burden of disease study 2021.","authors":"Siyuan Yang, Xiaoyu Ji, Dejing Cheng, Chengyuan Ji","doi":"10.1007/s10072-025-08540-w","DOIUrl":"https://doi.org/10.1007/s10072-025-08540-w","url":null,"abstract":"Background: This study aimed at delineating the temporal trends of epilepsy among women of childbearing age (WCBA), offering essential insights for prevention and management approaches in specific population.Methods: Data from the Global Burden of Disease (GBD) 2021 were used to measure the burden of epilepsy among WCBA by region, country, age, and sociodemographic index (SDI). Age-period-cohort model, joinpoint regression analysis and the Auto Regressive Integrated Moving Average (ARIMA) model were carried out.Results: The global prevalence, years-lived with disability (YLDs) rates of idiopathic epilepsy among WCBA show a decrease in 2021 compared with 1992, while the global prevalence and YLDs rates of secondary epilepsy increased; notably, the absolute number of cases has continued to rise. Low, low-middle and middle SDI regions face a growing epilepsy burden compared with higher SDI regions while high-SDI regions also showed higher idiopathic epilepsy prevalence among WCBA. The age effect revealed a general decline in idiopathic and total epilepsy prevalence with increasing age across global and SDI regions, in contrast to a progressive rise in secondary epilepsy prevalence. Unfavorable period effects of idiopathic and secondary epilepsy among WCBA were mostly exhibited in low, low-middle, middle and high SDI region. Favorable birth cohort effects were always seen in high-middle SDI region.Conclusions: This study elucidates the complex epidemiological landscape of epilepsy among WCBA, noting a increase in disease burden. Strengthening epilepsy health education, optimizing WCBA epilepsy diagnosis and treatment and emphasizing WCBA epilepsy prevention can effectively reduce new cases of epilepsy and related disabilities.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145252010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of levodopa on motor and cerebellar network connectivity in Parkinson's disease. 左旋多巴对帕金森病运动和小脑网络连通性的影响。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-08 DOI: 10.1007/s10072-025-08565-1

Li-Chuan Huang, Li-Guo Chen, Sheng-Huang Lin, Sheng-Tzung Tsai, Ping-An Wu, Shin-Yuan Chen

{"title":"Effects of levodopa on motor and cerebellar network connectivity in Parkinson's disease.","authors":"Li-Chuan Huang, Li-Guo Chen, Sheng-Huang Lin, Sheng-Tzung Tsai, Ping-An Wu, Shin-Yuan Chen","doi":"10.1007/s10072-025-08565-1","DOIUrl":"https://doi.org/10.1007/s10072-025-08565-1","url":null,"abstract":"Background: Levodopa is the most effective treatment for motor symptoms in Parkinson's disease (PD), but its therapeutic mechanisms and effects on resting-state functional connectivity (FC) remain incompletely understood. This study aims to investigate the acute impact of levodopa on FC within motor-related networks in PD.Methods: Twenty-seven patients with PD underwent resting-state functional magnetic resonance imaging on 2 consecutive days under OFF and ON dopaminergic therapy conditions. Ten age-matched healthy controls were included for comparison. FC analyses targeted 57 regions of interest (ROIs) across the basal ganglia, motor cortex, and cerebellum, assessed using ROI-to-ROI connectivity and graph theory.Results: Levodopa altered FC in motor circuits, with six connections increasing and seven decreasing. Key changes involved enhanced FC between the right globus pallidus externa and left pre-supplementary motor area, and reduced FC between the right cerebellum 10 and bilateral primary motor cortex. These changes were correlated with improvements in UPDRS-III scores. Graph metrics revealed increased clustering in the right cerebellar Crus I and reduced global efficiency in the left primary motor cortex.Conclusions: Levodopa modulates FC in motor-related networks in PD, enhancing cerebellar and PPN connectivity while reducing cortical coupling. These changes, reflected in graph-theoretical metrics, suggest a shift from global integration toward a more modular and locally segregated organization. This reconfiguration may underlie levodopa's therapeutic effects on motor symptoms.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bioelectric; Neuromodulation; Epilepsy; DBS; High-frequency stimulation; Low frequency stimulation. 生物;神经调节;癫痫;星展银行;高频刺激;低频刺激。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-08 DOI: 10.1007/s10072-025-08552-6

Faeze Sadat Ahmadi Tabatabaei, Sam Zarbakhsh, Mohammad Taghi Joghataei, Samaneh Dehghan, Marzieh Khodadai, Nooshin Ahmadirad

{"title":"Bioelectric; Neuromodulation; Epilepsy; DBS; High-frequency stimulation; Low frequency stimulation.","authors":"Faeze Sadat Ahmadi Tabatabaei, Sam Zarbakhsh, Mohammad Taghi Joghataei, Samaneh Dehghan, Marzieh Khodadai, Nooshin Ahmadirad","doi":"10.1007/s10072-025-08552-6","DOIUrl":"https://doi.org/10.1007/s10072-025-08552-6","url":null,"abstract":"Drug-resistant epilepsy affects a significant portion of epileptic patients, necessitating alternative treatment strategies beyond pharmacological interventions. Bioelectric medicine, employing techniques like vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation, has emerged as a promising approach. This review comparatively analyzes the mechanisms and clinical outcomes of high-frequency stimulation and low-frequency stimulation in the context of epilepsy treatment. We delve into the synaptic plasticity, neuronal network modulation, and neurochemical alterations induced by these stimulation paradigms, highlighting their potential to disrupt pathological synchronization and reduce seizure frequency. Furthermore, we discuss the rationale for selecting specific stimulation frequencies and target brain regions, considering the heterogeneity of epilepsy syndromes. By synthesizing existing literature, this review aims to provide a comprehensive overview of bioelectric approaches in epilepsy, informing future research and clinical applications.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.4,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145244616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction to: Lower risk of seizure recurrence with levetiracetam and oxcarbazepine after withdrawal in pediatric epilepsy: a pilot study. 更正：小儿癫痫停药后左乙拉西坦和奥卡西平降低癫痫复发风险：一项试点研究。

IF 2.4 4区医学

Neurological Sciences Pub Date : 2025-10-08 DOI: 10.1007/s10072-025-08573-1

Dilek Cebeci, Ebru Arhan, Ercan Demir, Tugba Hirfanoglu, Kivilcim Gucuyener, Esra Serdaroglu, Kursad Aydin, Ayse Serdaroglu

引用次数: 0