Neurological Sciences最新文献_第3页

Consequences of age and education correction of cognitive screening tests - A simulation study of the MoCA test in Italy. 认知筛查测试的年龄和教育修正后果--意大利 MoCA 测试模拟研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI: 10.1007/s10072-024-07691-6

Hans-Aloys Wischmann, Giancarlo Logroscino, Tobias Kurth, Marco Piccininni

{"title":"Consequences of age and education correction of cognitive screening tests - A simulation study of the MoCA test in Italy.","authors":"Hans-Aloys Wischmann, Giancarlo Logroscino, Tobias Kurth, Marco Piccininni","doi":"10.1007/s10072-024-07691-6","DOIUrl":"10.1007/s10072-024-07691-6","url":null,"abstract":"Background: Cognitive screening tools are widely used in clinical practice to screen for age-related cognitive impairment and dementia. These tools' test scores are known to be influenced by age and education, leading to routine correction of raw scores for these factors. Despite these corrections being common practice, there is evidence suggesting that corrected scores may perform worse in terms of discrimination than raw scores.Objective: To address the ongoing debate in the field of dementia research, we assessed the impact of the corrections on discrimination, specificity, and sensitivity of the Montreal Cognitive Assessment test in Italy, both for the overall population and across age and education strata.Methodology: We created a realistic model of the resident population in Italy in terms of age, education, cognitive impairment and test scores, and performed a simulation study.Results: We confirmed that the discrimination performance was higher for raw scores than for corrected scores in discriminating patients with cognitive impairment from individuals without (areas under the curve of 0.947 and 0.923 respectively). With thresholds determined on the overall population, raw scores showed higher sensitivities for higher-risk age-education groups and higher specificities for lower-risk groups. Conversely, corrected scores showed uniform sensitivity and specificity across demographic strata, and thus better performance for certain age-education groups.Conclusion: Raw and corrected scores show different performances due to the underlying causal relationships between the variables. Each approach has advantages and disadvantages, the optimal choice between raw and corrected scores depends on the aims and preferences of practitioners and policymakers.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5697-5706"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prognostic communication in amyotrophic lateral sclerosis: findings from a Nationwide Italian survey. 肌萎缩性脊髓侧索硬化症的预后沟通：意大利全国调查的结果。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1007/s10072-024-07702-6

Cristina Moglia, Francesca Palumbo, Rossana Botto, Barbara Iazzolino, Nicola Ticozzi, Andrea Calvo, Paolo Leombruni

{"title":"Prognostic communication in amyotrophic lateral sclerosis: findings from a Nationwide Italian survey.","authors":"Cristina Moglia, Francesca Palumbo, Rossana Botto, Barbara Iazzolino, Nicola Ticozzi, Andrea Calvo, Paolo Leombruni","doi":"10.1007/s10072-024-07702-6","DOIUrl":"10.1007/s10072-024-07702-6","url":null,"abstract":"Background: Amyotrophic Lateral Sclerosis (ALS) is a fatal motor neuron disease with a highly variable prognosis. Among the proposed prognostic models, the European Network for the cure of ALS (ENCALS) survival model has demonstrated good predictive performance. However, few studies have examined prognostic communication and the diffusion of prognostic algorithms in ALS care.Objective: To investigate neurologists' attitudes toward prognostic communication and their knowledge and utilization of the ENCALS survival model in clinical practice.Methods: A web-based survey was administered between May 2021 and March 2022 to the 40 Italian ALS Centers members of the Motor Neuron Disease Study Group of the Italian Society of Neurology.Results: Twenty-two out of 40 (55.0%) Italian ALS Centers responded to the survey, totaling 37 responses. The model was known by 27 (73.0%) respondents. However, it was predominantly utilized for research (81.1%) rather than for clinical prognostic communication (7.4%). Major obstacles to prognostic communication included the unpredictability of disease course, fear of a negative impact on patients or caregivers, dysfunctional reaction to diagnosis, and cognitive impairment. Nonetheless, the model was viewed as potentially useful for improving clinical management, increasing disease awareness, and facilitating care planning, especially end-of-life planning.Conclusions: Despite the widespread recognition and positive perceptions of the ENCALS survival model among Italian neurologists with expertise in ALS, its implementation in clinical practice remains limited. Addressing this disparity may require systematic investigations and targeted training to integrate tailored prognostic communication into ALS care protocols, aligning with the growing availability of prognostic tools for ALS.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5787-5794"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141788684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of intravenous thrombolysis before endovascular therapy on outcomes in acute ischemic stroke with large core: a systematic review and meta-analysis. 大核心急性缺血性脑卒中患者在血管内治疗前静脉溶栓对预后的影响：系统综述和荟萃分析。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-05 DOI: 10.1007/s10072-024-07682-7

Jiali Liu, Jialiang Wang, Yujie Wang

{"title":"Effect of intravenous thrombolysis before endovascular therapy on outcomes in acute ischemic stroke with large core: a systematic review and meta-analysis.","authors":"Jiali Liu, Jialiang Wang, Yujie Wang","doi":"10.1007/s10072-024-07682-7","DOIUrl":"10.1007/s10072-024-07682-7","url":null,"abstract":"Objective: To investigate the effect of intravenous thrombolysis (IVT) before endovascular therapy (EVT) on outcomes in acute ischemic stroke of large core.Methods: The studies comparing functional outcomes after EVT with and without IVT were systematically searched up to October 10th, 2023. Odds ratio (OR) was pooled using random effects model. Subgroup analysis was performed stratified by study design, country or region, study date, imaging methods and time window.Results: Thirteen studies were included, enrolling 1717 patients. The pooled rate of functional independence in patients receiving IVT + EVT was 26% (95% CI 20% - 33%), significantly higher than 18% (95% CI 15% - 20%) in those receiving EVT alone (OR 1.55, 95% CI 1.13-2.12, P = 0.006; I²= 23.9%). In subgroup analysis, prior IVT increased the probability of functional independence in retrospective studies (OR 1.97, 95% 1.47-2.63, P < 0.00001; I2 = 0). Non-Asian patients benefit from IVT before EVT for functional independence (OR 2.04, 95% 1.48-2.81, P < 0.0001; I2 = 0), but Asian patients did not (OR 1.45, 95% 0.90-2.35, p = 0.13; I2 = 0). The pooled rate of symptomatic intracranial hemorrhage in patients receiving IVT + EVT was 16% (95% CI 12% - 20%), inclining to be higher than 11% (95% CI 6% - 15%) in those receiving EVT alone without significant difference (OR 1.42, 0.83-2.41, P = 0.20; I²= 12%).Conclusions: IVT before EVT might increase the probability of functional independence in non-Asian patients with large ischemic core. The results provided clinicians with additional information on selecting eligible patients for EVT.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5617-5625"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534925","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ischemic stroke despite direct oral anticoagulation: what is hidden? 直接口服抗凝药后仍发生缺血性中风：隐藏着什么？

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-10-28 DOI: 10.1007/s10072-024-07799-9

A De Martino, V Andreone, I Mormile, F W Rossi, Giorgia Teresa Maniscalco

引用次数: 0

Tibial nerve stimulation in the management of primary sexual dysfunction in patients with multiple sclerosis: a pilot randomized control trial. 胫神经刺激治疗多发性硬化症患者的原发性性功能障碍：随机对照试验。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-16 DOI: 10.1007/s10072-024-07687-2

Vasileios Giannopapas, Vassiliki Smyrni, Dimitrios K Kitsos, Athanasios K Chasiotis, Konstantina Stavrogianni, Georgia Papagiannopoulou, Georgios Tsivgoulis, Konstantinos Voumvourakis, Sotirios Giannopoulos, Daphne Bakalidou

{"title":"Tibial nerve stimulation in the management of primary sexual dysfunction in patients with multiple sclerosis: a pilot randomized control trial.","authors":"Vasileios Giannopapas, Vassiliki Smyrni, Dimitrios K Kitsos, Athanasios K Chasiotis, Konstantina Stavrogianni, Georgia Papagiannopoulou, Georgios Tsivgoulis, Konstantinos Voumvourakis, Sotirios Giannopoulos, Daphne Bakalidou","doi":"10.1007/s10072-024-07687-2","DOIUrl":"10.1007/s10072-024-07687-2","url":null,"abstract":"Introduction: Sexual dysfunction (SD) is a common symptom that affects 40-90% of patients with multiple sclerosis (MS). Previous studies have highlighted the negative impact of sexual dysfunction in the mental health status and overall quality of life in patients with MS.Methods: The aim of this study was to examine the effects of transcutaneous tibial nerve stimulation (TTNS) in the primary SD symptoms in patients with MS. A total of 40 participants were randomized (1:1 ratio) to either TTNS or Sham group and received three 20 min sessions over the course of two months. Pre and post intervention SD was evaluated using the Multiple Sclerosis Intimacy Questionnaire (MISQ-15).Results: Statistically significant improvements in the aspects of primary sexual dysfunction were observed in the TTNS group pre-post intervention (specifically erectile function (for males)/vaginal lubrication (for females) (p < .001), orgasm quality and satisfaction for both male and female patients (p < .001), sexual desire (p < .05) and bladder related symptomatology (p < .005). In the sham group pre-post intervention, the only observed improvement was in the sexual desire aspect (p < .05). Post intervention the groups significantly differed erectile function/vaginal lubrication and orgasm quality and satisfaction (p < .05).Conclusions: Our findings underline the efficacy of TTNS in improving primary SD symptoms as well as bladder problems in both male and female patients with MS. TTNS demonstrated significant improvement in the following domains: erectile function, vaginal lubrication, orgasm quality, satisfaction, bladder-related symptoms, and sexual desire.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5849-5858"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141620506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Local immunosuppression in ofatumumab: a series of three cases with bacterial infections near the injection sites. 奥妥木单抗的局部免疫抑制：三例注射部位附近细菌感染的系列病例。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-29 DOI: 10.1007/s10072-024-07714-2

Rok Bernik, Alenka Horvat Ledinek, Gregor Brecl Jakob

引用次数: 0

Clinical effectiveness of dimethyl fumarate in multiple sclerosis patients from Argentina. 富马酸二甲酯对阿根廷多发性硬化症患者的临床疗效。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-31 DOI: 10.1007/s10072-024-07712-4

Edgar Carnero Contentti, Ricardo Alonso, Berenice Silva, Marcos Burgos, Darío Tavolini, Pablo Lopez, Edgardo Cristiano, Liliana Patrucco, Verónica Tkachuk, Carolina Mainella, Gisella Zanga, Felisa Leguizamón, Geraldine Luetic, Emanuel Silva, Santiago Tizio, Marina Alonso Serena, Juan Ignacio Rojas

{"title":"Clinical effectiveness of dimethyl fumarate in multiple sclerosis patients from Argentina.","authors":"Edgar Carnero Contentti, Ricardo Alonso, Berenice Silva, Marcos Burgos, Darío Tavolini, Pablo Lopez, Edgardo Cristiano, Liliana Patrucco, Verónica Tkachuk, Carolina Mainella, Gisella Zanga, Felisa Leguizamón, Geraldine Luetic, Emanuel Silva, Santiago Tizio, Marina Alonso Serena, Juan Ignacio Rojas","doi":"10.1007/s10072-024-07712-4","DOIUrl":"10.1007/s10072-024-07712-4","url":null,"abstract":"Background: We assessed the effectiveness, safety and patient-reported outcomes (PROs) of dimethyl fumarate (DMF) in real-world clinical practice in patients with multiple sclerosis (PwMS) from Argentina.Methods: We conducted a multicenter ambispective cohort study in Argentina between September 2020 and March 2023. Changes in annualized relapse rate (ARR), Expanded Disability Status Scale (EDSS) score, magnetic resonance imaging (MRI), no evidence of disease activity (NEDA), PROs (depression, anxiety, fatigue, burden of treatment and quality of life), and safety data were collected at clinical visits performed every 6 months for at least 24 months.Results: We included 161 PwMS (64% female). DMF treatment was associated with a significant reduction in ARR from baseline after 24 months of treatment (from 0.87 to 0.23, p < 0.001). Disability progression was observed in 27.9% vs. 9.3% pre- and post-DMF, and disability improvement was found in 13% of patients from baseline to month 24. MRI activity was significantly reduced compared with baseline. Fatigue, depression, and quality of life scores were significantly improved from baseline to 24 months. Flushing was the most frequent adverse event reported in 19.2%. No significant reduction was observed in the hospitalization rate pre- and post-DMF (19.8% vs. 5.6%, p = 0.32). During follow-up, 135 (83%) patients were relapse-free, 110 (68.3%) were MRI free activity (Gad + lesion) and 108 (67%) reached NEDA.Conclusions: DMF significantly reduced disease activity in PwMS from Argentina with a good safety profile in real-world settings. A significant impact on the quality of life during follow-up was found.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5833-5840"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141856124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of various exercise interventions on motor function in cerebral palsy patients: a systematic review and network meta-analysis. 各种运动干预对脑瘫患者运动功能的影响：系统综述和网络荟萃分析。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-08-27 DOI: 10.1007/s10072-024-07741-z

Bingjie Wang, Hailiang Huang

{"title":"Effects of various exercise interventions on motor function in cerebral palsy patients: a systematic review and network meta-analysis.","authors":"Bingjie Wang, Hailiang Huang","doi":"10.1007/s10072-024-07741-z","DOIUrl":"10.1007/s10072-024-07741-z","url":null,"abstract":"Purpose: A network meta-analysis was utilized to compare the rehabilitative effectiveness of different exercise interventions on motor function in cerebral palsy(CP) patients.Methods: Computer searches were conducted across 9 databases, including PubMed, Cochrane Library, Scopus, Web of Science, Embase, and others, to identify randomized controlled trials focusing on different exercise interventions aimed at enhancing motor function in CP patients. The search spanned from the inception of the databases to January 31, 2024.Results: 20 articles, encompassing 570 patients and evaluating three types of exercise interventions, were included in the analysis. Results showed that aerobic training, resistance training, and mixed training exhibited superior outcomes compared to the control group, as evidenced by improvements in Gross Motor Function Measure scores, muscle strength, gait speed, and 10-Meter Walk Test scores (P < 0.05). Furthermore, the network meta-analysis revealed that resistance training ranked highest in enhancing gross motor function and gait speed among CP patients, while mixed training was deemed most effective in improving muscle strength and 10-Meter Walk Test scores.Conclusion: Exercise interventions have been shown to significantly improve motor function in CP patients. Among these, resistance training and mixed training stand out for their effectiveness in enhancing walking capabilities. Resistance training is specifically aimed at improving gross motor function, while mixed training focuses on increasing muscle strength.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5915-5927"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142073442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy of pain management strategies in adults with Amyotrophic Lateral Sclerosis (ALS): A Systematic Review. 肌肉萎缩性侧索硬化症（ALS）成人患者疼痛管理策略的疗效：系统综述。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-05 DOI: 10.1007/s10072-024-07643-0

Juan Camilo Rojas-López, Pablo Isaac Estrada-Gualdron, Sofía Ramírez-Guerrero, Maria J Velásquez-Cárdenas, Jesús Redondo-Escobar, Sofía Vargas-Arenas, Leonardo Palacios-Sánchez, Ximena Palacios-Espinosa

{"title":"Efficacy of pain management strategies in adults with Amyotrophic Lateral Sclerosis (ALS): A Systematic Review.","authors":"Juan Camilo Rojas-López, Pablo Isaac Estrada-Gualdron, Sofía Ramírez-Guerrero, Maria J Velásquez-Cárdenas, Jesús Redondo-Escobar, Sofía Vargas-Arenas, Leonardo Palacios-Sánchez, Ximena Palacios-Espinosa","doi":"10.1007/s10072-024-07643-0","DOIUrl":"10.1007/s10072-024-07643-0","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by progressive muscle weakness. Presence of pain in ALS patients is heterogeneously reported in studies, and mostly underrepresented in symptom scales. The aim of this study is to evaluate the efficacy of pharmacological and non-pharmacological therapeutic modalities for pain management in patients with ALS. A systematic review was conducted in four databases; PubMed, Scopus, Clinicaltrials.gov, and Cochrane-Ovid. Five randomized controlled clinical trials were included regarding pharmacological and non-pharmacological pain management interventions in adult patients with confirmed diagnosis of ALS in whom pain was objectively evaluated. Risk of bias assessment was evaluated using the RoB2.0 tool. Eligible studies were reported as a descriptive analysis. This systematic review was registered with PROSPERO ID: CRD42024495009. Five clinical trials regarding pain management strategies in ALS were eligible for analysis. Two out of five were non-pharmacological approaches whilst the remaining three provided pharmacological therapies. Of these, Mexiletine was efficient in terms of pain relief, particularly between 600 and 900 mg per day, whereas Mecasin showed no pain relief at both, high and low doses. Non-pharmacological therapies, such as exercise and osteopathic manual treatment also lacked efficacy in regard to pain management. Clinical trials focusing on pain management strategies for ALS patients are limited. Medical professionals, understandably focused on immediate life-threatening aspects, may inadvertently sideline the nuanced and intricate dimension of pain experienced by patients with ALS.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5591-5604"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554732/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical and multimodal imaging features of adult-onset neuronal intranuclear inclusion disease. 成人神经元核内包涵体病的临床和多模态成像特征。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2024-12-01 Epub Date: 2024-07-18 DOI: 10.1007/s10072-024-07699-y

Rui Zhu, Junyu Qu, Guihua Xu, Yongsheng Wu, Jiaxiang Xin, Dawei Wang

{"title":"Clinical and multimodal imaging features of adult-onset neuronal intranuclear inclusion disease.","authors":"Rui Zhu, Junyu Qu, Guihua Xu, Yongsheng Wu, Jiaxiang Xin, Dawei Wang","doi":"10.1007/s10072-024-07699-y","DOIUrl":"10.1007/s10072-024-07699-y","url":null,"abstract":"Objectives: This study aimed to analyze the clinical and multimodal imaging manifestations of adult-onset neuronal intranuclear inclusion disease (NIID) patients and to investigate NIID-specific neuroimaging biomarkers.Methods: Forty patients were retrospectively enrolled from the Qilu Hospital of Shandong University. We analyzed the clinical and imaging characteristics of 40 adult-onset NIID patients and investigated the correlation between these characteristics and genetic markers and neuropsychological scores. We further explored NIID-specific alterations using multimodal imaging indices, including diffusion tensor imaging (DTI), magnetic resonance spectroscopy (MRS), and brain age estimation. In addition, we summarized the dynamic evolution pattern of NIID by examining the changes in diffusion weighted imaging (DWI) signals over time.Results: The NIID patients' ages ranged from 31 to 77 years. Cognitive impairment was the most common symptom (30/40, 75.0%), while some patients (18/40, 45.0%) initially presented with episodic symptoms such as headache (10/40, 25.0%). Patients with cognitive impairment symptoms had more cerebral white matter damage (χ2 = 11.475, P = 0.009). The most prevalent imaging manifestation was a high signal on DWI in the corticomedullary junction area, which was observed in 80.0% (32/40) of patients. In addition, the DWI dynamic evolution patterns could be classified into four main patterns. Diffusion tensor imaging (DTI) revealed extensive thinning of cerebral white matter fibers. The estimated brain age surpassed the patient's chronological age, signifying advanced brain aging in NIID patients.Conclusions: The clinical manifestations of NIID exhibit significant variability, usually leading to misdiagnosis. Our results provided new imaging perspectives for accurately diagnosing and exploring this disease's neuropathological mechanisms.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5795-5805"},"PeriodicalIF":2.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554744/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141634069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0