Neurological Sciences最新文献

{"title":"Eponymous of migraine spectra of fortification: Vauban or Sanmicheli?","authors":"Federico Mainardi, Ferdinando Maggioni, Giorgio Zanchin","doi":"10.1007/s10072-025-08130-w","DOIUrl":"10.1007/s10072-025-08130-w","url":null,"abstract":"<p><p>The most frequent type of aura preceding the migraine headache is the visual one. The visual perception of the migraineur can be variegated, the most common being a zig-zag pattern of luminous lines, the complete denomination of this phenomenon being \"fortification spectra of Vauban\". We investigated on original sources about the origin of this complex denomination and more in detail about the eponym and the priority on the construction of the Reinassance fortification. This kind of visual aura was compared to Reinassance fortifications by John Fothergill. (1712-1780). In 1870 Hubert Airy, reporting on his own attack of migraine with aura, compared the visual disturbance to a fortified town with its bastions of a colourful appearance. Moreover, realising the illusory nature of these images, he called them \"fortification spectra\". Later on, William Gowers (1845-1915), with reference to \".its projecting and reintrant angles bearing resemblance to the plan which the French engineer Vauban first described as the most effective for the defence of a fortress.\", introduced the term \"fortification of Vauban\", that since then has been largely used. Historically, these kinds of fortifications were first developed in early sixteen century in Italy by Michele Sanmicheli (1484-1559), a Venetian military engineer, when medieval tall courtains and circular towers were substituted with low and thicker walls and polygonal bastions, to face the destroying power of the new mobile siege guns. Only later Sébastien Le Prestre De Vauban (1633-1707), at the service of Louis XIV, the Sun King, greatly contributed to the development of this branch of military engineering. With reference to the visual aura, the eponym \"fortifications spectra of Vauban\" should be substituted for that \"of Sanmicheli\".</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3307-3311"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurology, epilepsy, peace and Africa: narrative report of a lasting partnership.","authors":"Massimo Leone, Pierre Somsè, Alessandro Padovani, Giuseppe Lauria Pinter, Giovanni Guidotti","doi":"10.1007/s10072-025-08056-3","DOIUrl":"10.1007/s10072-025-08056-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3335-3337"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143441552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DVA-associated intracranial venous varix.","authors":"Marialuisa Zedde, Rosario Pascarella","doi":"10.1007/s10072-025-08068-z","DOIUrl":"10.1007/s10072-025-08068-z","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3345-3347"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143523653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The interrelationship between intestinal immune cells and enteric α-synuclein in the progression of Parkinson's disease.","authors":"Yuan-Kai Cheng, Hao-Sen Chiang","doi":"10.1007/s10072-025-08114-w","DOIUrl":"10.1007/s10072-025-08114-w","url":null,"abstract":"<p><p>Parkinson's disease (PD) is a neurodegenerative disorder primarily characterized by motor impairment, resulting from the accumulation of α-synuclein and neuronal cell death in the substantia nigra of the midbrain. Emerging evidence suggests that α-synuclein aggregation may originate in the enteric nervous system (ENS) and subsequently propagate to the brain via the vagus nerve. Clinical observations, such as prodromal gastrointestinal dysfunction in PD patients and the increased incidence of PD among individuals with inflammatory bowel disease, support the hypothesis that abnormal intestinal inflammation may contribute to the onset of motor dysfunction and neuropathology in PD. This review examines recent findings on the interplay between intestinal immune cells and α-synuclein aggregation within the framework of gut-originated PD pathogenesis. It begins by discussing evidence linking dysbiosis and intestinal inflammation to α-synuclein aggregation in the ENS. Additionally, it explores the potential role of intestinal immune cells in influencing enteric neurons and α-synuclein aggregation, furthering the understanding of PD development.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"2965-2977"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute onset anti-MAG neuropathy and paradoxical worsening to rituximab: a challenging case.","authors":"Emanuele Cassano, Rosa Iodice, Isabella Di Sarno, Roberta Bencivenga, Fiore Manganelli, Stefano Tozza","doi":"10.1007/s10072-025-08087-w","DOIUrl":"10.1007/s10072-025-08087-w","url":null,"abstract":"<p><strong>Background and aim: </strong>Anti-myelin-associated glycoprotein (anti-MAG) neuropathy is typically a chronic, progressive, predominantly sensory distal and demyelinating neuropathy, with ataxia and postural tremor METHODS AND RESULTS: Herein we describe an atypical case of anti-MAG neuropathy, characterized by acute lower limb weakness and severe ataxia with difficulty in stance and walking, resembling a Guillain-Barrè Syndrome. The presence of disproportionate distal nerve conduction slowing, and an IgM k monoclonal component have arisen the suspect of anti-MAG neuropathy, confirmed by high titer anti-MAG antibody. Rituximab treatment was started, and patient experienced a dramatic clinical worsening which was rescued by Plasma Exchange.</p><p><strong>Interpretation: </strong>We described an atypical case of anti-MAG neuropathy that was challenging in diagnosis and therapeutic management.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3291-3294"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143573535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the beats: a systematic review of the underlying inflammatory pathways between atrial fibrillation and cognitive decline.","authors":"Ana Mónica Machado, Ana Sofia Ferraz, M Graça Pereira, Fernanda Leite","doi":"10.1007/s10072-025-08040-x","DOIUrl":"10.1007/s10072-025-08040-x","url":null,"abstract":"<p><p>Atrial fibrillation (AF) and cognitive decline represent significant health challenges with increasing prevalence and significant socioeconomic implications. Emerging evidence suggests a potential link between AF and cognitive decline, including dementia and Alzheimer's disease, although the underlying mechanisms remain incompletely understood. Inflammation has emerged as a key mediator in cardiovascular and neurological diseases, encouraging an investigation into its role in the atrial fibrillation-cognition association. A systematic search of PubMed, Web of Science, and PsycInfo was conducted to identify relevant studies investigating possible inflammatory mechanisms bridging AF and cognitive decline. Studies were assessed for quality and relevance, and data were synthesized using a narrative approach. Five papers were included, with only two longitudinal studies. Inflammatory biomarkers emerged as significant factors associated with both AF and cognitive decline. Three studies revealed a correlation between high-sensitivity CRP (HS-CRP) levels and cognitive decline in patients with AF, AF patients with cerebral infarction, and elderly individuals with AF. However, conflicting results were observed, as one study did not identify any associations between cognitive decline and HS-CRP levels. The scientific literature on this topic is scarce, and the results of existing studies often lack consistency in their findings, highlighting the need for further research to better understand and prevent this significant health burden in patients with AF. So, the results of this study are expected to inform future research directions and cognitive decline risk stratification, guiding the development of targeted interventions aimed at preserving cognitive function and improving outcomes in patients with AF.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"2951-2963"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143458616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosing migraine in children and adolescence using ID migraine: results of an Italian multicenter validation.","authors":"Ilaria Frattale, Vittorio Sciruicchio, Daniela D'Agnano, Vincenzo Raieli, Salvatore Lo Cascio, Giuseppe Santangelo, Edvige Correnti, Fabiana Ursitti, Giorgia Sforza, Gabriele Monte, Luigi Mazzone, Massimiliano Valeriani, Laura Papetti","doi":"10.1007/s10072-025-08076-z","DOIUrl":"10.1007/s10072-025-08076-z","url":null,"abstract":"<p><strong>Background: </strong>Since migraine is the most frequent neurological condition, an early diagnosis is important to limit the impact of the disease on the quality of life. Although migraine diagnosis is based on the International Classification of Headache Disorders 3rd edition (ICHD3) criteria, other briefer questionnaires have been developed, especially for screening purpose. While the three-item ID Migraine has proved useful for migraine diagnosis in adulthood, no validated tools are available for children and adolescents. The aim of this study is to validate ID Migraine also in pediatric patients.</p><p><strong>Results: </strong>The Italian ID Migraine for adulthood was completed by 289 pediatric patients (mean age 12.14 ± 3.15, range 6-17) who attended three third-level pediatric headache centers. Clinical and neurological examinations were performed, and the final diagnosis was reached according to the ICHD3 criteria. The migraine group consisted of 230 patients, and the control group consisted of 59 patients who received headache diagnoses different from migraine. We considered the ID migraine positive whether 2 out of 3 responses were 'yes'. ID migraine for diagnosis of pediatric migraine showed a sensitivity of 0.86 (86%), a specificity of 0.95 (95%), a positive predictive value (PPV) of 0.98 (98%) and a negative predictive value (NPV) 0.64 (64%).</p><p><strong>Conclusion: </strong>ID Migraine can be considered a valid tool for migraine diagnosis also in pediatric age, starting from the age of 6 years.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3213-3220"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143720860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer's disease-related primary progressive aphasia.","authors":"Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Ai Kawamura, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Minoru Matsuda, Shigenori Kanno, Kyoko Suzuki","doi":"10.1007/s10072-025-08100-2","DOIUrl":"10.1007/s10072-025-08100-2","url":null,"abstract":"<p><p>Alzheimer's disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal heterogeneity of linguistic and neuroimaging features in this population. This study aimed to investigate cerebral hypoperfusion patterns and elucidate their correlation with diverse linguistic features in patients with AD-related PPA using a data-driven approach. Eleven patients with AD-related PPA and 34 with non-AD-related PPA were categorized based on cerebrospinal fluid biomarkers, and their single-photon emission computed tomography (SPECT) data were analyzed. Cerebral hypoperfusion was assessed across 56 regions of interest (ROIs) covering the entire cerebral hemisphere. Sparse principal component (sPC) analysis was performed on the AD-related PPA group to identify distinct patterns of cerebral perfusion reduction and correlate these components with clinical assessments of linguistic abilities. AD-derived sPCs were identified, reflecting hypoperfusion patterns in the left temporoparietal, frontal, and temporal pole regions, corresponding to regions typically associated with logopenic, nonfluent, and semantic variants. In both AD-PPA and non-AD-PPA, the sPC corresponding to the anterior temporal region was associated with semantic comprehension deficits, whereas that corresponding to the frontal region was linked to nonfluent speech and Kana writing impairment. sPC-based hierarchical clustering revealed clusters corresponding to logopenic, nonfluent, and semantic variants, with the anomic subtype distinguished from logopenic PPA. AD-positive cases were distributed across these clusters, emphasizing AD-PPA heterogeneity. These findings suggested that AD-related PPA heterogeneity is reflected in distinct cerebral perfusion patterns, which correlate with varying linguistic deficits.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3071-3083"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How far are we from bringing intensive care bundle for intracerebral hemorrhage into the real-world setting? A 5-year population based-study.","authors":"Paola Colantuono, Lucio D'Anna, Matteo Foschi, Michela Adipietro, Stefania Lancia, Leondino Mammarella, Simona Sacco, Raffaele Ornello","doi":"10.1007/s10072-025-08113-x","DOIUrl":"10.1007/s10072-025-08113-x","url":null,"abstract":"<p><strong>Introduction: </strong>Comprehensive care bundles including rapid blood pressure management, anticoagulation reversal, neurosurgical consultation, control of blood glucose and body temperature, can improve short- and medium-term outcomes in patients with intracerebral hemorrhage (ICH). This study assessed how the acute management of ICH practices evolved in a real-world setting over five years characterized by global changes in ICH care.</p><p><strong>Methods: </strong>This study analysed ICH cases from a population-based stroke registry between 2018 and 2022. We collected demographic and clinical data, focusing on key parameters of ICH management, such as systolic blood pressure, anticoagulation reversal, neurosurgical referrals, blood glucose, and body temperature. We also examined yearly trends in control of parameters over time.</p><p><strong>Results: </strong>We included 460 patients with ICH (55.4% male, median age 79 years, interquartile range 69-85). At onset, 266 patients (57.8%) had high SBP (SBP ≥ 140 mmHg), 286 (70.3%) hyperglycemia (blood glucose ≥ 108 mg/dL), and 63 (17.3%) hyperpyrexia (body temperature ≥ 37.0*C). Anticoagulation was reversed in 21.4% of anticoagulated patients within 24 h. Neurosurgical referrals were made for 84.6% of patients while only 12.4% underwent surgery. From 2018 to 2022, anticoagulation reversal rates increased from 0 to 88.9% (p < 0.001), while neurosurgical referrals not followed by surgery decreased from 79.5 to 55.7% (p < 0.001).</p><p><strong>Conclusions: </strong>This real-world study demonstrates suboptimal management of key factors associated with ICH prognosis; nevertheless, it highlights improvement over time. There is a need for structured interventions to improve the timely and consistent application of simple yet effective measures yielding the potential to improve patients' outcomes.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"3147-3155"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12152059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143753584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenging the impostor: a scoping review of the pharmacological management of Capgras syndrome in Parkinson's disease and Lewy bodies dementia.","authors":"Antonina Luca, Maria Luca, Raffaele Ferri, Alessandro Serretti","doi":"10.1007/s10072-025-08078-x","DOIUrl":"10.1007/s10072-025-08078-x","url":null,"abstract":"<p><strong>Introduction: </strong>Capgras syndrome (CS) is a delusional misidentification phenomenon increasingly reported in patients with Parkinson's disease (PD) and Lewy Body Dementia (LBD). Aim of the present scoping review was to provide an overview on current evidence on the pharmacological treatment of CS in PD and LBD, identifying knowledge gaps in the literature.</p><p><strong>Methods: </strong>The following databases were consulted: PubMed, Google Scholar, the Cochrane Database and Web of Science.</p><p><strong>Results: </strong>The search query covered a time period from 1976 until 2022. Fourteen studies on PD (11 single case reports, 3 case series) and five on LBD (all single case reports) met the inclusion criteria. Most PD patients with CS had cognitive decline and visual hallucinations, and were managed by reducing dopaminergic therapy and prescribing neuroleptics (quetiapine, clozapine or pimavanserin), which often resulted in improvement. Neuroleptics have also been used in LBD, but with variable efficacy.</p><p><strong>Conclusion: </strong>Although neuroleptics and dopaminergic dose adjustments appear to be beneficial for CS in PD and LBD, robust evidence is lacking. Future prospective studies are essential to establish evidence-based guidelines for this challenging syndrome.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"2979-2984"},"PeriodicalIF":2.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143567769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}