Neurological Sciences最新文献

{"title":"The impact of Down syndrome on patients' caregivers: a survey of an Italian paediatric cohort.","authors":"Rossana Gnasso, Ayda Tavakkolifar, Giuseppe Esposito, Angela Palomba, Stefano Palermi, Antonio Picone, Carlo Ruosi","doi":"10.1007/s10072-025-08266-9","DOIUrl":"10.1007/s10072-025-08266-9","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5105-5109"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144333602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to Editor concerning \"rapidly progressive dementia in tacrolimus neurotoxicity: rare but reversible\".","authors":"Vincenzina Lo Re, Giuseppe Mamone, Alessandro Mattina","doi":"10.1007/s10072-025-08378-2","DOIUrl":"10.1007/s10072-025-08378-2","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5477-5478"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144708260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Temporal white matter lesion originating periodic spike-wave discharges or polypleds.","authors":"José L Fernández-Torre, Marta Drake-Pérez, Enrique Marco de Lucas","doi":"10.1007/s10072-025-08356-8","DOIUrl":"10.1007/s10072-025-08356-8","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5579-5580"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144591807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-GABAB receptor encephalitis combined with autoimmune polyendocrine gland syndrome.","authors":"Yi He, Fahang Yi, Ping Tang, Kaiqiang Xiao, Liang Wang","doi":"10.1007/s10072-025-08433-y","DOIUrl":"10.1007/s10072-025-08433-y","url":null,"abstract":"<p><p>Anti-GABAB receptor encephalitis coexistence with autoimmune polyendocrine syndrome (APS) has not been reported. We present the first case of anti-GABAB receptor encephalitis coexisting with APS type III. A 64-year-old male presented with recurrent convulsions with loss of consciousness. Diagnostic evaluation revealed positive anti-GABAB receptor antibodies, elevated HbA1cand fasting blood glucose, and glutamic aciddecarboxylase antibodies (GAD-Ab), hypothyroidism with positive thyroglobulin and peroxidase antibody. The patient demonstrated complete diagnostic criteria for both anti-GABAB receptor encephalitis and APS type III. A Combination therapy with pulse corticosteroids, intravenous immunoglobulin, levothyroxine, and insulin achieved significant clinical improvement. The findings expand the spectrum of autoimmune overlap syndromes and highlight diagnostic challenges in patients presenting with concurrent neurological and endocrine dysfunction.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5273-5277"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Don't miss the prodrome: neurogenic orthostatic hypotension as a window into multiple sclerosis.","authors":"Katarina Tešija, Mašan Sredanović, Magdalena Krbot Skorić, Mario Habek","doi":"10.1007/s10072-025-08438-7","DOIUrl":"10.1007/s10072-025-08438-7","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5517-5519"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144874301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dystonia-predominant VPS35-related parkinson's disease: diagnostic challenges and the role of Levodopa response in unmasking genetic etiology.","authors":"Changhong Tan, Jiali Yang, Qian Yang, Xiaopeng Feng","doi":"10.1007/s10072-025-08437-8","DOIUrl":"10.1007/s10072-025-08437-8","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5479-5480"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144962863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of transcranial direct current stimulation on brain network connectivity and topology in post-stroke cognitive impairment patients: a resting-state fMRI study.","authors":"Jiali Zhong, Xiaoshan Jing, Ying Liang, Pan Hao, Ruchen Peng, Ruiqiang Xin","doi":"10.1007/s10072-025-08348-8","DOIUrl":"10.1007/s10072-025-08348-8","url":null,"abstract":"<p><strong>Background: </strong>Post-stroke cognitive impairment (PSCI) is a common and severe consequence of ischemic stroke (IS) that significantly affects patient outcomes. Transcranial direct current stimulation (tDCS) has shown promise in enhancing cognitive function in IS patients, but its underlying mechanisms are not fully understood. This study investigates the effects of tDCS on brain functional connectivity and network topology using resting-state functional magnetic resonance imaging (rs-fMRI).</p><p><strong>Methods: </strong>In this double-blind study, sixty-five IS patients with PSCI were randomly assigned to either the tDCS or control group. Rs-fMRI data were acquired before and after the intervention. We analyzed functional connectivity (FC) and graph theory-based topological properties. Cognitive performance was assessed using the Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA). RESULTS AFTER: treatment, both groups showed improvements in MMSE and MoCA scores, with the tDCS group demonstrating significantly greater improvements (p < 0.05). In the tDCS group, FC significantly increased between four pairs of brain regions (p < 0.05, FDR-corrected). Additionally, Global Efficiency (E_g) significantly improved (p < 0.05, FDR-corrected), and this improvement positively correlated with enhancements in MMSE scores (r = 0.403, p = 0.037).</p><p><strong>Conclusion: </strong>These findings suggest that tDCS improves cognitive function in PSCI by altering brain network connectivity and topological organization, providing neuroimaging evidence to support its therapeutic mechanisms.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5211-5219"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488762/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Large artery atherosclerotic versus cardioembolism subtypes of large hemispheric infarction in the middle cerebral artery.","authors":"Han Xiao, Zi-Yan He, Xue-Ming Li, Jing Mao, Yun Zhou","doi":"10.1007/s10072-025-08347-9","DOIUrl":"10.1007/s10072-025-08347-9","url":null,"abstract":"<p><strong>Background: </strong>Large hemispheric infarction (LHI) of the middle cerebral artery (MCA) is linked to high mortality and morbidity. This study aims to investigate the characteristics of large artery atherosclerosis (LAA) and cardioembolism subtypes of LHI in MCA.</p><p><strong>Methods: </strong>This retrospective cohort study included 70 patients with LHI hospitalized at the Second Affiliated Hospital of Anhui Medical University from May 2019 to May 2021. Patients were classified according to the TOAST classification into LAA and cardioembolism subtypes.</p><p><strong>Results: </strong>Among the 70 patients, 44 were identified with the LAA subtype (aged 76.00 years, 50% were male) and 26 with cardioembolism (aged 71.50 years, 57.1% were male). The LAA group exhibited significantly higher rates of hyperhomocysteinemia (18.2% vs. 0%, P = 0.022) and diabetes (38.6% vs. 15.4%, P = 0.042). In contrast, atrial fibrillation prevalence was higher in the cardioembolism group (84.6% vs. 20.5%, P < 0.001), as was the rate of decompressive craniectomy (15.4% vs. 2.3%, P = 0.041), while, hypertension prevalence, thrombectomy, and rehabilitation scores, showed no significant differences (all P > 0.05). Additionally, multivariable linear regression analysis showed that, after adjusted the confounders, LAA (vs. CE) subtype was independently associated with higher mRS scores (β = 0.86, 95%CI: 0.61-1.22), higher NIHSS (β = 4.85, 95%CI: 0.19-9.89), higher Visual Analog Scale (VAS) (β = 0.86, 95%CI: 0.66-1.12), and higher GCS (β = 0.62, 95%CI: 0.09-4.00) (all P < 0.05).</p><p><strong>Conclusions: </strong>Patients with the LAA subtype of LHI in MCA are more likely to have hyperhomocysteinemia and diabetes, while atrial fibrillation and the need for decompressive craniectomy are more prevalent in the cardioembolism subtype. LHI subtypes may significantly impact patient rehabilitation outcomes.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5173-5181"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12488826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144619408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unreported collateral pathways in internal carotid artery agenesis.","authors":"Monique Boukobza, Jean-Pierre Laissy","doi":"10.1007/s10072-025-08336-y","DOIUrl":"10.1007/s10072-025-08336-y","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"5493-5495"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144512202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of neurological manifestation in familial mediterranean fever patients: systematic review & meta-analysis.","authors":"Mohammad Hamad, Tala Mohammad, Mira Bishtawi, Randa Shahwan, Jaber H Jaradat, Wafa' A Hazaymeh, Omar F Jbarah, Ethar Hazaimeh","doi":"10.1007/s10072-025-08351-z","DOIUrl":"10.1007/s10072-025-08351-z","url":null,"abstract":"<p><strong>Background: </strong>Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease worldwide, characterized by recurrent attacks of fever and polyserositis. Several studies have reported FMF cases with neurological conditions. As well as multiple neurological diseases have been reported in multiple studies in patients with FMF.</p><p><strong>Aims: </strong>to summarize the frequency of neurologic manifestations reported among FMF patients.</p><p><strong>Methods: </strong>PubMed, Web of Science, and SCOPUS were searched for studies that reported any neurological manifestation in FMF patients. Studies were screened first by abstract and then by full text, any conflict was resolved by a discussion. The JBI tool was used for assessing the risk of bias in studies. A meta-analysis of the proportions was performed for neurological manifestations in patients with FMF. A random effects model was indicated when I² was greater than 50%, and a fixed model was used otherwise. R version 4.3.2 for performing the analysis.</p><p><strong>Results: </strong>Out of 787 citations, 36 studies (14 case reports, 22 others) were included with a total of 906 FMF patients (14 case reports, 892 others) with neurological manifestations. For case-report studies, the common manifestation was headache (42.9%) followed by Muscle weakness, diplopia (35.7%), Sensory disorders (35.7%) and facial nerve palsy (14.3%), The most common comorbid neurological condition was Multiple sclerosis (28.6%). Regarding Other study types, the Pooled prevalence of the most common manifestation was Neuropathy (0.45 [0.00; 0.99]), then Myalgia (0.27, 95%CI: [0.11; 0.47]), Headache (0.23, 95%CI: [0.12; 0.36]), and visual disorders (0.13 [0.01; 0.37]). The most common comorbid was ADHD (0.31, 95%CI: [0.25; 0.37]). Most studies were evaluated at a low risk of bias.</p><p><strong>Conclusion: </strong>Nearly half of the patients in our review had Neuropathy in this review. ADHD was co-comorbid in 31% of patients. These findings underscore the importance of increased awareness and surveillance for these manifestations in patients with FMF. Further research is needed to better understand the pathogenesis of this manifestation.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":"4943-4953"},"PeriodicalIF":2.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144608928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}