Intrathecal treatment of Anti-N-Methyl-D-Aspartate receptor encephalitis: a promising approach for refractory cases.

IF 2.7 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-03-25 DOI:10.1007/s10072-025-08134-6

Xiaobo Yang

引用次数: 0

Abstract

Background: Anti-N-methyl-D-aspartate receptor encephalitis is a severe neurological disorder. While standard treatments work for many patients, up to 25% are resistant to these treatments. In such challenging cases, there is growing interest in using intrathecal approaches.

Methods: A narrative review of relevant papers was conducted.

Results: Case reports and case series have demonstrated the successful use of intrathecal methotrexate, either alone or in combination with steroids, particularly in pediatric patients. Additionally, intrathecal rituximab has shown promise in select cases.

Conclusions: Although outcomes vary, this approach appears to be safe and has the potential to rescue refractory cases.

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鞘内治疗抗n -甲基- d -天冬氨酸受体脑炎：一种治疗难治性病例的有希望的方法。

背景：抗n -甲基- d -天冬氨酸受体脑炎是一种严重的神经系统疾病。虽然标准治疗对许多患者有效，但高达25%的患者对这些治疗有抗药性。在这些具有挑战性的病例中，越来越多的人对使用鞘内入路感兴趣。方法：对相关文献进行综述。结果：病例报告和病例系列已经证明鞘内甲氨蝶呤的成功使用，无论是单独使用还是与类固醇联合使用，特别是在儿科患者中。此外，鞘内利妥昔单抗在某些病例中显示出前景。结论：尽管结果不同，但这种方法似乎是安全的，并有可能挽救难治性病例。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.