Cerebrospinal-fluid Orexin-A levels in different neurocognitive disorders: a comparison study.

IF 2.7 4区 医学 Q2 CLINICAL NEUROLOGY
Susana Lozano-Tovar, Riccardo Cremascoli, Marzia Nuccetelli, Giuseppe Sancesario, Stefania Cattaldo, Elisa Prina, Federico Verde, Simone Cappelli, Sergio Bernardini, Nicola Biagio Mercuri, Claudio Liguori
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Abstract

In the present study, we investigated the differences in cerebrospinal fluid (CSF) orexin-A levels among patients with different neurocognitive disorders, such as mild or moderate to severe Alzheimer's disease (AD; mAD, msAD, respectively), behavioral variants of frontotemporal dementia (bv-FTD), non-fluent primary aphasia (NFPA), and idiopathic normal pressure hydrocephalus (iNPH). A total of 214 participants were evaluated (mAD, 45; msAD, 31; bv-FTD, 12; NFPA, 22; iNPH, 13; non-demented elderly controls, 91). The highest CSF orexin-A levels were found in iNPH patients (263.31 ± 56.89 pg/mL). Patients affected by NFPA (210.86 ± 61.99 pg/mL), iNPH, and msAD (173.04 ± 19.76 pg/mL) showed higher CSF orexin-A concentrations than controls (145.18 ± 27.01pg/mL) (p < 0.001). Bv-FTD (190.12 ± 100.84 pg/mL) and mAD (130.76 ± 21.70 pg/mL) patients showed no significant differences in CSF orexin-A levels compared with controls. mAD patients showed also lower CSF orexin-A concentrations than all other patient groups.In conclusion, orexin-A presents different CSF levels among neurocognitive disorders. The mechanisms underlying this difference vary and may include sleep-wake cycle impairment, behavioral disturbances, and CSF dynamics. The development of drugs that antagonize the orexin system could open a new frontier of research linking orexin neurotransmission to neurocognitive disorders.

不同神经认知障碍患者脑脊液食欲素a水平的比较研究
在本研究中,我们研究了不同神经认知障碍患者脑脊液(CSF) orexin-A水平的差异,如轻度或中重度阿尔茨海默病(AD);分别为mAD、msAD)、额颞叶痴呆(bv-FTD)、非流畅性原发性失语(NFPA)和特发性常压脑积水(iNPH)的行为变异。共有214名参与者被评估(mAD, 45;msAD, 31日;bv-FTD 12;美国22;iNPH 13;非痴呆老年人对照组,91岁)。脑脊液促食欲素- a水平在iNPH患者中最高(263.31±56.89 pg/mL)。NFPA组(210.86±61.99 pg/mL)、iNPH组(173.04±19.76 pg/mL)、msAD组(173.04±19.76 pg/mL)患者脑脊液食欲素- a浓度高于对照组(145.18±27.01pg/mL) (p
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来源期刊
Neurological Sciences
Neurological Sciences 医学-临床神经学
CiteScore
6.10
自引率
3.00%
发文量
743
审稿时长
4 months
期刊介绍: Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.
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