Prevalence of neurological manifestation in familial mediterranean fever patients: systematic review & meta-analysis.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-10-01 Epub Date: 2025-07-11 DOI:10.1007/s10072-025-08351-z

Mohammad Hamad, Tala Mohammad, Mira Bishtawi, Randa Shahwan, Jaber H Jaradat, Wafa' A Hazaymeh, Omar F Jbarah, Ethar Hazaimeh

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引用次数: 0

Abstract

Background: Familial Mediterranean Fever (FMF) is the most common autoinflammatory disease worldwide, characterized by recurrent attacks of fever and polyserositis. Several studies have reported FMF cases with neurological conditions. As well as multiple neurological diseases have been reported in multiple studies in patients with FMF.

Aims: to summarize the frequency of neurologic manifestations reported among FMF patients.

Methods: PubMed, Web of Science, and SCOPUS were searched for studies that reported any neurological manifestation in FMF patients. Studies were screened first by abstract and then by full text, any conflict was resolved by a discussion. The JBI tool was used for assessing the risk of bias in studies. A meta-analysis of the proportions was performed for neurological manifestations in patients with FMF. A random effects model was indicated when I² was greater than 50%, and a fixed model was used otherwise. R version 4.3.2 for performing the analysis.

Results: Out of 787 citations, 36 studies (14 case reports, 22 others) were included with a total of 906 FMF patients (14 case reports, 892 others) with neurological manifestations. For case-report studies, the common manifestation was headache (42.9%) followed by Muscle weakness, diplopia (35.7%), Sensory disorders (35.7%) and facial nerve palsy (14.3%), The most common comorbid neurological condition was Multiple sclerosis (28.6%). Regarding Other study types, the Pooled prevalence of the most common manifestation was Neuropathy (0.45 [0.00; 0.99]), then Myalgia (0.27, 95%CI: [0.11; 0.47]), Headache (0.23, 95%CI: [0.12; 0.36]), and visual disorders (0.13 [0.01; 0.37]). The most common comorbid was ADHD (0.31, 95%CI: [0.25; 0.37]). Most studies were evaluated at a low risk of bias.

Conclusion: Nearly half of the patients in our review had Neuropathy in this review. ADHD was co-comorbid in 31% of patients. These findings underscore the importance of increased awareness and surveillance for these manifestations in patients with FMF. Further research is needed to better understand the pathogenesis of this manifestation.

查看原文本刊更多论文

家族性地中海热患者神经系统表现的患病率：系统回顾和荟萃分析。

背景：家族性地中海热（FMF）是世界上最常见的自身炎症性疾病，其特征是反复发作的发烧和多浆液炎。一些研究报告了伴有神经系统疾病的FMF病例。此外，在FMF患者的多项研究中也报道了多种神经系统疾病。目的：总结FMF患者神经系统表现的频率。方法：检索PubMed、Web of Science和SCOPUS中报道FMF患者神经学表现的研究。研究首先通过摘要筛选，然后通过全文筛选，任何冲突都通过讨论解决。JBI工具用于评估研究中的偏倚风险。对FMF患者神经系统表现的比例进行了荟萃分析。当I2大于50%时采用随机效应模型，否则采用固定模型。R版本4.3.2来执行分析。结果：在787篇引用中，36篇研究（14例报告，22例其他）被纳入，共有906例FMF患者（14例报告，892例其他）出现神经系统症状。在病例报告研究中，最常见的表现为头痛（42.9%），其次是肌肉无力、复视（35.7%）、感觉障碍（35.7%）和面神经麻痹（14.3%），最常见的神经系统合并症为多发性硬化症（28.6%）。在其他研究类型中，最常见的表现为神经病变(0.45 [0.00；0.99])，其次是肌痛(0.27,95%CI: [0.11；0.47])，头痛(0.23,95%CI: [0.12；0.36])，视力障碍(0.13 [0.01；0.37])。最常见的合并症是ADHD (0.31, 95%CI: [0.25；0.37])。大多数研究被评价为低偏倚风险。结论：本综述中近一半的患者有神经病变。31%的患者伴有ADHD。这些发现强调了提高对FMF患者这些表现的认识和监测的重要性。需要进一步的研究来更好地了解这种表现的发病机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.