Neurological Sciences最新文献_第8页

Case series of functional non epileptic seizures (PNES) in patients with brain tumors. 脑肿瘤患者功能性非癫痫性发作（PNES）的病例系列分析。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-31 DOI: 10.1007/s10072-025-08255-y

Roni Loebenstein, Shany Guly Gofrit, Mailam Eltity, Erez Magiel, Uriel Fennig, Keren Altman, Ory Haisraely, Noga Atar, Elisheva Jan, Naum Margolin, Marina Boxer, Nicola Maggio, Alisa Taliansky

{"title":"Case series of functional non epileptic seizures (PNES) in patients with brain tumors.","authors":"Roni Loebenstein, Shany Guly Gofrit, Mailam Eltity, Erez Magiel, Uriel Fennig, Keren Altman, Ory Haisraely, Noga Atar, Elisheva Jan, Naum Margolin, Marina Boxer, Nicola Maggio, Alisa Taliansky","doi":"10.1007/s10072-025-08255-y","DOIUrl":"https://doi.org/10.1007/s10072-025-08255-y","url":null,"abstract":"Purpose: Functional (Psychogenic) non epileptic seizures (PNES) are events which mimic epileptic seizures without ictal electrical findings on the EEG recording during the events. Diagnosis of PNES is made by correlating the clinical presentation with the lack of ictal activity as diagnosed by video EEG (VEEG) and is crucial for proper decision-making regarding management. Patients with brain tumors have a high prevalence of epileptic seizures. However, clinician's awareness of PNES in those patients is often insufficient.Patients and methods: We collected data regarding 6 patients with brain tumors which were followed-up in the neuro-oncology unit in Sheba medical center and were diagnosed with epilepsy, along with PNES according to VEEG.Results: We describe data regarding 6 patients aged 20-68, four of them females, with different brain tumors and in various stages of the disease. PNES were mostly focal, and a clear trigger was identified in four patients. Improvement in PNES frequency alongside a reduction in anti-seizure medicaions followed diagnosis of PNES in 5 out of the 6 patients.Conclusions: In our case series, PNES were usually focal, and patients did not have all the risk factors associated with PNES in the general population. PNES frequency was unrelated to oncological status. Diagnosis of PNES with open discussion reduced PNES frequency and dosages of anti-seizure medications in our patients.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144187443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postmortem neuropathologies are associated with retrospective tensor-based morphometry findings in Alzheimer's dementia continuum. 死后神经病理与阿尔茨海默氏痴呆症连续体的回顾性张量形态测量结果相关。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-31 DOI: 10.1007/s10072-025-08268-7

Amirmohammad Azizzadeh, Mahla Najafi, Zahra Nafar, Shahed Salehzehi, Sahba Azadikhah Jahromi, Hamed Fallah, Hamed Ghoshouni

{"title":"Postmortem neuropathologies are associated with retrospective tensor-based morphometry findings in Alzheimer's dementia continuum.","authors":"Amirmohammad Azizzadeh, Mahla Najafi, Zahra Nafar, Shahed Salehzehi, Sahba Azadikhah Jahromi, Hamed Fallah, Hamed Ghoshouni","doi":"10.1007/s10072-025-08268-7","DOIUrl":"https://doi.org/10.1007/s10072-025-08268-7","url":null,"abstract":"Background: Understanding the relationship between postmortem neuropathological findings and in vivo imaging biomarkers is crucial for advancing the early diagnosis and treatment of Alzheimer's disease (AD). This study investigates the association between postmortem neuropathologies and retrospective Tensor-Based Morphometry (TBM) findings across the Alzheimer's dementia continuum.Methods: This study utilized tensor-based morphometry (TBM) to investigate structural brain changes associated with AD neuropathology. Data from the Alzheimer's Disease Neuroimaging Initiative (ADNI) were analyzed, including MRI scans and neuropathological findings from 98 participants. Logistic regression was used to explore the relationship between TBM indices and neuropathological outcomes. The diagnostic performance of TBM was evaluated using accuracy analysis.Results: Significant differences in TBM indices (StatROI and TempROI) were observed between the dementia and non-dementia groups. Logistic regression indicated that higher StatROI and TempROI indices were associated with lower odds of AD pathology, such as amyloid plaques (OR = 0.939 and 0.927), neurofibrillary tangles (OR = 0.961 and 0.931), and neuritic plaques (OR = 0.943 and 0.916). Accuracy analysis demonstrated good discriminatory power of TBM indices in differentiating pathologically confirmed AD from non-AD dementia (sensitivity up to 61.29, specificity up to 93.33%) and cognitively normal individual (sensitivity up to 82.26, specificity up to 75%).Conclusion: TBM is a promising tool for predicting the underlying neuropathology of AD and distinguishing between different causes of dementia. Integrating TBM into clinical assessments can enhance the accuracy of AD diagnosis and improve patient management.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermittent theta burst stimulation improves spasticity, pain and cognitive functions in progressive multiple sclerosis: a pilot study. 间歇性θ波爆发刺激改善进行性多发性硬化症的痉挛、疼痛和认知功能：一项初步研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-30 DOI: 10.1007/s10072-025-08270-z

Rezzan Yildiz, Mehmet Ilker Yon, Tahir Kurtulus Yoldas, Evren Yasar, Elif Yalcin Topcuoglu, Funda Eren

引用次数: 0

From clinic to stage: Jean-Martin Charcot's influence on the performing arts (Cinema, Theatre, Dance, and Opera). 从诊所到舞台：让·马丁·夏科对表演艺术（电影、戏剧、舞蹈和歌剧）的影响。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-30 DOI: 10.1007/s10072-025-08271-y

Francesco Brigo

引用次数: 0

Association of biological age acceleration with poor outcome after endovascular thrombectomy. 生物年龄加速与血管内血栓切除术后不良预后的关系。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-29 DOI: 10.1007/s10072-025-08261-0

Mingyue Qian, Wei Wang, Shuaiyu Chen, Yan E, Bin Wei, Lulu Liu, Jiayu Chen, Hao Wu

{"title":"Association of biological age acceleration with poor outcome after endovascular thrombectomy.","authors":"Mingyue Qian, Wei Wang, Shuaiyu Chen, Yan E, Bin Wei, Lulu Liu, Jiayu Chen, Hao Wu","doi":"10.1007/s10072-025-08261-0","DOIUrl":"https://doi.org/10.1007/s10072-025-08261-0","url":null,"abstract":"Background: Accelerated aging is recognized as a risk factor for various chronic diseases and mortality. This study aimed to utilize phenotypic age to evaluate the role of biological age in clinical outcomes in ischemic stroke patients after endovascular thrombectomy (EVT).Methods: We retrospectively enrolled patients from the prospectively maintained stroke registry admitted at 2 stroke centers in China. We employed the widely recognized PhenoAge algorithms to calculate accelerated biological age. Poor outcome was defined by a modified Rankin Scale score > 2 at 90 days post-treatment. Multivariable logistic regression models were utilized to evaluate the independent impact of phenotypic age on poor outcome. The association pattern between phenotypic age and poor outcome were analyzed using restricted cubic splines.Results: A total of 745 patients were included with 61.5% male, a mean age of 70.1 ± 12.2 years, and a mean phenotypic age of 78.5 ± 15.1 years. In the multivariable logistic regression analysis, phenotypic age was significantly associated with 90-day poor outcome after EVT (per 1-year increase: odds ratio [OR], 1.067; 95% confidence interval [CI], 1.042-1.092; P < 0.001; fourth vs first quartile: OR, 8.295; 95% CI, 3.742-18.394; P < 0.001). Additionally, the multiple-adjusted spline regression model further confirmed the dose-response association between phenotypic age and poor outcome (P = 0.527 for nonlinearity; P = 0.001 for linearity).Conclusion: This study demonstrated that phenotypic age was associated with poor outcomes in large vessel occlusive stroke patients treated with EVT. Further research is required to validate our findings in different populations.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Misdiagnosis of autoimmune glial fibrillary acidic protein astrocytopathy as infectious meningitis: a case report. 自身免疫胶质原纤维酸性蛋白星形细胞病误诊为感染性脑膜炎1例。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-29 DOI: 10.1007/s10072-025-08258-9

Chengji Wu, Xuefei Han, Fen Yang, Guangyun Zhang, Cong Zhao

{"title":"Misdiagnosis of autoimmune glial fibrillary acidic protein astrocytopathy as infectious meningitis: a case report.","authors":"Chengji Wu, Xuefei Han, Fen Yang, Guangyun Zhang, Cong Zhao","doi":"10.1007/s10072-025-08258-9","DOIUrl":"https://doi.org/10.1007/s10072-025-08258-9","url":null,"abstract":"Background: Autoimmune glial fibrillary acidic protein astrocytopathy (A-GFAP-A) is a rare autoimmune central nervous system disorder associated with anti-GFAP IgG, presenting with meningoencephalitis or myelitis. Differential diagnosis from infectious causes, such as tuberculous meningitis (TBM), is challenging due to overlapping clinical and radiological features.Case presentation: A 24-year-old Chinese female presented with acute headache, fever, and vomiting. The cerebrospinal fluid (CSF) analysis showed lymphocytic pleocytosis, elevated protein and decreased glucose level. Brain magnetic resonance imaging (MRI) showed diffuse leptomeningeal enhancement. She was initially diagnosed with infectious meningitis and emperically treated with antibiotics and anti-tuberculosis therapy. However, her symptoms progressed with seizures, urinary retention, and tremor. Subsequent MRI revealed the involvement of the whole spinal cord. CSF analysis identified anti-GFAP IgG (titer 1:32). Bacterial, viral and tuberculous infection were excluded through bacterial culturing, metagenomic next-generation sequencing and Xpert MTB/RIF assay. The patient responded well to intravenous immunoglobulin and corticosteroids, achieving full remission. Finally, the diagnosis of A-GFAP-A was confirmed.Conclusion: A-GFAP-A mimics infectious meningitis such as TBM due to similar CSF abnormalities and neuroimaging findings. This case underscores the importance of GFAP-IgG testing in differential diagnosis of patients with meningitis who have negative microbiological studies and atypical symptoms such as urinary retention and tremor.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dopa-responsive dystonia and phenotypes associated with TH gene variants: a systematic review and Mexican case series. 多巴反应性肌张力障碍和与TH基因变异相关的表型：系统回顾和墨西哥病例系列。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-29 DOI: 10.1007/s10072-025-08246-z

Carlos Ulises Lopez-Urias, Nancy Monroy-Jaramillo, Renee Barreda Fierro, Miguel Ángel Ramírez-García

{"title":"Dopa-responsive dystonia and phenotypes associated with TH gene variants: a systematic review and Mexican case series.","authors":"Carlos Ulises Lopez-Urias, Nancy Monroy-Jaramillo, Renee Barreda Fierro, Miguel Ángel Ramírez-García","doi":"10.1007/s10072-025-08246-z","DOIUrl":"https://doi.org/10.1007/s10072-025-08246-z","url":null,"abstract":"Introduction: Dopa-responsive dystonia (DRD) has a broad, clinical, and genetically heterogeneous spectrum; its manifestations include parkinsonism, dystonia, tremor, and other movement disorders. The severity of DRD ranges from mild to fatal encephalopathy. DRD is caused by recessive mutations in the TH gene.Methods: This article is a systematic review (SR) of all reports of patients with DRD, including the first Mexican cases and other phenotypes associated with variants in the gene encoding tyrosine hydroxylase (TH), from its first description to the first quarter of 2024. The SR followed the PRISMA guidelines in five databases (Scopus, MEDLINE, PubMed Central, LILACS, and Scielo).Results: Sixty-two publications were selected. They included 179 patients with TH deficiency, but only 143 included clinical descriptions. The age of onset was infantile regardless of phenotype, and there was a delay in age at diagnosis (t = -7.139, P < 0.001). Encephalopathy was the earliest presentation, and psychomotor retardation was common in all forms of TH deficiency. Multiple motor manifestations may be present, including dystonia, parkinsonism, gait disturbances, and others. Response to dopaminergic replacement therapy (DRT) has been reported in 143 patients (good in 64.3%, moderate in 23.7%, and poor in 12%). The compound heterozygous genotype was the most common (61.45%) for the biallelic variants of the TH gene. In addition, data from 6 cases with heterozygous variants are described.Conclusions: This is the most comprehensive review of TH deficiency cases and shows that these phenotypes are rare, have a wide neurological phenotypic variability, are often infantile-onset, and respond well to DRT.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144174280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Letter to the editor concerning "Plasma levels of glial fibrillary acidic protein and neurofilament light chain in patients with chronic migraine: a multicenter case-control study". 致编辑关于“慢性偏头痛患者血浆胶质纤维酸性蛋白和神经丝轻链水平：一项多中心病例对照研究”的信。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-29 DOI: 10.1007/s10072-025-08179-7

Ali Abasi, Majid Mohseni, Hossein Zare

引用次数: 0

Artery of percheron infarction presented as encephalitis-like manifestations. 动脉梗死表现为脑炎样。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-28 DOI: 10.1007/s10072-025-08263-y

Chen Ye, Youjie Wang, Biqiu Tang, Ruosu Pan, Bo Wu

引用次数: 0

Seizure prediction in cerebral venous thrombosis- a retrospective single-centre observational study. 脑静脉血栓的发作预测-一项回顾性单中心观察性研究。

IF 2.7 4区医学

Neurological Sciences Pub Date : 2025-05-28 DOI: 10.1007/s10072-025-08256-x

Patrícia Faustino, Diana Melancia

{"title":"Seizure prediction in cerebral venous thrombosis- a retrospective single-centre observational study.","authors":"Patrícia Faustino, Diana Melancia","doi":"10.1007/s10072-025-08256-x","DOIUrl":"https://doi.org/10.1007/s10072-025-08256-x","url":null,"abstract":"Cerebral venous thrombosis (CVT) accounts for 0.5-1% of all strokes and 24-50% of these patients develop acute symptomatic seizures (AS). Clinical and radiological characteristics have been associated with an increased risk of AS in CVT. We aimed to identify clinical and imaging predictors associated with a higher risk of AS in CVT patients.We conducted a single-centre, retrospective cohort study and included all patients with CVT admitted to our stroke unit between January/2011-December/2022. Our primary outcome was AS occurence. Clinical and radiological characteristics were compared through a logistic binary regression, followed by a multivariable analysis.We included 156 patients, 80.8% female and a mean age of 41.5 ± 15.2 years. Fifty-two patients (33.3%) had a seizure during follow-up, the majority as AS (30.1%). We found an increased risk of AS in patients with focal signs at presentation (OR 5.35), superior longitudinal sinus (SLS) or cortical vein involvement (OR 5.03; OR 3.94), hemorrhagic lesions or oedema (OR 3.88; OR 4.17) and lesions located in the frontal or the parietal lobe (OR 4.61; OR 4.61). A multivariable analysis was also conducted and only SLS involvement (OR 6.06), cortical vein involvement (OR 2.76) and hemorrhagic lesion (OR 3.47) remained statistically significant.Seizures occurred in about a third of our CVT patients, the majority as AS. Haemorrhagic lesions, SLS and cortical vein involvement had a stronger association with AS that may raise our awareness for the risk of seizures in this population during the acute phase.","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144160606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0