Neurological Sciences最新文献

{"title":"Presence of cortical lesions in older persons with multiple sclerosis and association with cognitive function.","authors":"Jimmy S Lee, Mark E Wagshul, Siddharth Nayak, Roee Holtzer","doi":"10.1007/s10072-025-08141-7","DOIUrl":"https://doi.org/10.1007/s10072-025-08141-7","url":null,"abstract":"<p><strong>Background: </strong>Cortical lesions (CL) have been reported and characterized in multiple sclerosis (MS), but their presence and association with cognitive function in older adults with MS (OAMS) have not been evaluated.</p><p><strong>Objective: </strong>To quantify the presence of CL in OAMS and healthy controls. We hypothesized that compared to controls, OAMS would have more CL, and CL would be associated with worse cognition.</p><p><strong>Methods: </strong>OAMS (n = 95, mean age 64.5 ± 4.2) and controls (n = 106, mean age 68.3 ± 7.3) underwent MRI and cognitive assessments. Cognitive function was assessed through Symbol-Digit-Modalities-Test (SDMT).</p><p><strong>Results: </strong>CL were identified in 43/95 (45%) of OAMS, and 2/106 (1.9%) of controls. OAMS were further stratified by CL burden (0, 1-2, and ≥ 3 CL). Linear regressions showed that compared to participants with no CL, those with ≥ 3 CL, but not 1-2 CL demonstrated worse SDMT performance in unadjusted (p = 0.005) and adjusted (p = 0.034) analyses. Stratification of results by age of onset into typical (TOMS) and late (LOMS) onset MS, show that among LOMS white matter lesion load (WMLL), but not CL burden, is associated with worse SDMT (p < 0.001). In contrast, CL burden in TOMS was associated with lower SDMT performance (p = 0.021), independent of WMLL.</p><p><strong>Conclusion: </strong>CL are present in OAMS and are significantly greater than in controls. Among OAMS, higher CL burden was associated with worse speed of processing and working memory performance. Age of MS onset modified the effect CL burden has on SDMT performance, which suggests that there may be different disease processes between LOMS and TOMS that affect cognitive performance.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional network hubs in vestibular migraine: a neuroimaging perspective.","authors":"Wei Liu, Zhihui Fu, Chen Guo, Yichao Wang, Bing Yao, Zhengxin Ni","doi":"10.1007/s10072-025-08106-w","DOIUrl":"https://doi.org/10.1007/s10072-025-08106-w","url":null,"abstract":"<p><strong>Objective: </strong>This study utilizes resting-state functional magnetic resonance imaging (rs-fMRI) and graph theory analysis to identify key brain regions in vestibular migraine (VM), explore their associations with clinical symptoms, and examine the role of these functional network hubs in the pathophysiology of VM, offering novel insights and a theoretical basis for understanding its neural mechanisms and improving its clinical diagnosis and treatment.</p><p><strong>Methods: </strong>We enrolled patients diagnosed with VM, individuals with Migraine without Aura (MwoA), and healthy control subjects, collecting both clinical and sociodemographic data alongside MRI data. Employing graph theory analysis, we focused on identifying critical hub nodes and networks within VM patients, using metrics like degree, betweenness centrality, and eigenvector centrality for our analysis.</p><p><strong>Results: </strong>The study included 30 VM patients, 28 MwoA subjects, and 31 healthy controls. Analysis of rich-club coefficients across different levels of network sparsity indicated significantly lower normalized rich-club coefficients for VM and MwoA groups compared to healthy controls at a 65% sparsity threshold, particularly within a node degree range of 91 to 94. Notably, the temporal lobes, limbic system, and frontal lobes were predominant regions for rich-club nodes in the VM group, with significant increases in centrality metrics observed in the right posterior parahippocampal gyrus. These metrics in the hippocampus and parahippocampal gyrus showed a positive correlation with the intensity, duration, and progression of headache episodes in VM patients.</p><p><strong>Conclusions: </strong>In vestibular migraine patients, critical hub nodes such as the hippocampus and parahippocampal gyrus are identified, potentially associated with emotional regulation, pain perception, and the memory of pain.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Dihydroartemisinin suppresses glioma proliferation and invasion via inhibition of the ADAM17 pathway.","authors":"Junyan Chen, Xiangrong Chen, Fan Wang, Hongzhi Gao, Weipeng Hu","doi":"10.1007/s10072-025-08131-9","DOIUrl":"https://doi.org/10.1007/s10072-025-08131-9","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"AChR-blocking antibodies and complement system dynamics: evaluating their interplay and clinical implications in myasthenia gravis.","authors":"Florencia Aguirre, Mariano E Justo, Lucía Cialdella, Mariela L Paz","doi":"10.1007/s10072-025-08137-3","DOIUrl":"https://doi.org/10.1007/s10072-025-08137-3","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does kinesio taping affect balance in individuals with multiple sclerosis?","authors":"Fatma Erdeo, Ali Ulvi Uca, Musa Çankaya, Neslihan Altuntaş Yılmaz","doi":"10.1007/s10072-025-08115-9","DOIUrl":"https://doi.org/10.1007/s10072-025-08115-9","url":null,"abstract":"<p><strong>Background: </strong>Balance disorders are common in individuals with multiple sclerosis (MS) due to the combined effects of lack of adequate postural control, muscle weakness, ataxia, and lack of sensory information. The aim of this study was to assess the effect of Kinesio taping (KT) on balance among subjects with MS.</p><p><strong>Method: </strong>This was a non-controlled observational study. A consecutive convenience sample of 30 individuals with MS was assessed. KT was applied directly to the skin under the foot. Clinical assessments were performed at baseline, immediately before and after application of the tape. Balance was evaluated with both eyes open and closed. The effects of sense of balance, spasticity, and muscle strength were evaluated.</p><p><strong>Results: </strong>A significant difference was observed before and after banding in the dominant and non-dominant extremities (p_before = .001, p_after = .002). There was a significant difference between vibration and two-point discrimination and balance (p > 0.05). There was no significant relationship between light touch sense and balance (p > 0.05). Further, except for tibialis anterior muscle strength, there was no significant difference between balance and other lower extremity muscles (p > 0.05). In addition, except for muscle spasticity in the quadriceps, there was a significant difference between balance and other lower extremity muscles (p < 0.05).</p><p><strong>Conclusions: </strong>KT appears to be a useful tool in reducing the fall rate and improving balance skills in patients with MS. These preliminary results suggest that the use of Kinesio foot taping may be useful in immediately stabilising body posture.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intrathecal treatment of Anti-N-Methyl-D-Aspartate receptor encephalitis: a promising approach for refractory cases.","authors":"Xiaobo Yang","doi":"10.1007/s10072-025-08134-6","DOIUrl":"https://doi.org/10.1007/s10072-025-08134-6","url":null,"abstract":"<p><strong>Background: </strong>Anti-N-methyl-D-aspartate receptor encephalitis is a severe neurological disorder. While standard treatments work for many patients, up to 25% are resistant to these treatments. In such challenging cases, there is growing interest in using intrathecal approaches.</p><p><strong>Methods: </strong>A narrative review of relevant papers was conducted.</p><p><strong>Results: </strong>Case reports and case series have demonstrated the successful use of intrathecal methotrexate, either alone or in combination with steroids, particularly in pediatric patients. Additionally, intrathecal rituximab has shown promise in select cases.</p><p><strong>Conclusions: </strong>Although outcomes vary, this approach appears to be safe and has the potential to rescue refractory cases.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral optic neuropathy as first neurological sign of Central Nervous System (CNS) involvement in indolent chronic lymphocytic leukemia.","authors":"Paola Ciasca, Sebastiano Crisafulli, Ludovica Gargiulo, Stefania Bianchi Marzoli, Massimo Magagnoli, Marco Moscatelli, Elena Anghileri","doi":"10.1007/s10072-025-08118-6","DOIUrl":"https://doi.org/10.1007/s10072-025-08118-6","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143710841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efgartigimod improves non-AChR generalized Myasthenia Gravis: a real world experience.","authors":"Carlo Antozzi, Rita Frangiamore, Elena Rinaldi, Fiammetta Vanoli, Francesca Andreetta, Eleonora Giacopuzzi Grigoli, Emilio Ciusani, Silvia Bonanno, Lorenzo Maggi, Renato Mantegazza","doi":"10.1007/s10072-025-08096-9","DOIUrl":"https://doi.org/10.1007/s10072-025-08096-9","url":null,"abstract":"<p><strong>Introduction: </strong>The neonatal Fc receptor (FcRn) inhibitor Efgartigimod (EFG) has been approved for treatment of generalized Myasthenia Gravis (gMG) with anti-AChR antibodies. Information on the effect of EFG in non-AChR MG is limited. We investigated the efficacy of EFG in non-AChR gMG along a clinical follow-up of 2 years.</p><p><strong>Methods: </strong>We treated 13 patients with gMG without anti-AChR antibodies: 5 MuSK+, 2 LRP4 + and 6 triple-negative (confirmed by live CBA). EFG was administered according to the GENERATIVE protocol (consisting of a Fixed period of 2 treatment cycles of 4 infusions at weekly intervals, followed by a Flexible period during which EFG was given in case of initial worsening) starting from November 2021. Outcomes were evaluated by means of the MG-ADL, QMG, MGC and MGQoL15r scales.</p><p><strong>Results: </strong>The mean follow-up was 21 ± 5.3 months. Meaningful improvement was observed with the clinical scores adopted. The number of cycles/year was 3.92 ± 0.9. The interval between cycles was 10.1 ± 3.6 weeks. MG-ADL improvement of at least 5 points was recorded in 58% of cycles. 46% of patients required hospitalization during the two years before treament with EFG and 70% plasmaexchange/IVIG; during EFG none of the patients was hospitalized or required immunomodulation. No major side effects or infusion related reactions occurred.</p><p><strong>Conclusion: </strong>EFG was effective in non-AChR gMG and modified significantly the course of the disease. Our experience strengthens the role of FcRn inhibition as a new therapeutic tool for MG without anti-AChR antibodies.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Neurology and physician-assisted suicide: position of the Italian society of neurology.","authors":"Eugenio Pucci, Nicola Ticozzi, Giancarlo Comi, Gianluigi Mancardi, Leandro Provinciali, Alessandro Padovani, Alessandra Solari","doi":"10.1007/s10072-025-08122-w","DOIUrl":"10.1007/s10072-025-08122-w","url":null,"abstract":"","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinct cerebral perfusion patterns and linguistic profiles in Alzheimer's disease-related primary progressive aphasia.","authors":"Kazuto Katsuse, Kazuo Kakinuma, Nobuko Kawakami, Shoko Ota, Nanayo Ogawa, Ai Kawamura, Chifumi Iseki, Masashi Hamada, Tatsushi Toda, Minoru Matsuda, Shigenori Kanno, Kyoko Suzuki","doi":"10.1007/s10072-025-08100-2","DOIUrl":"https://doi.org/10.1007/s10072-025-08100-2","url":null,"abstract":"<p><p>Alzheimer's disease (AD)-related primary progressive aphasia (PPA) exhibits considerable heterogeneity in clinical presentation and neuroimaging patterns. No studies have quantitatively assessed cerebral perfusion patterns or systematically evaluated the internal heterogeneity of linguistic and neuroimaging features in this population. This study aimed to investigate cerebral hypoperfusion patterns and elucidate their correlation with diverse linguistic features in patients with AD-related PPA using a data-driven approach. Eleven patients with AD-related PPA and 34 with non-AD-related PPA were categorized based on cerebrospinal fluid biomarkers, and their single-photon emission computed tomography (SPECT) data were analyzed. Cerebral hypoperfusion was assessed across 56 regions of interest (ROIs) covering the entire cerebral hemisphere. Sparse principal component (sPC) analysis was performed on the AD-related PPA group to identify distinct patterns of cerebral perfusion reduction and correlate these components with clinical assessments of linguistic abilities. AD-derived sPCs were identified, reflecting hypoperfusion patterns in the left temporoparietal, frontal, and temporal pole regions, corresponding to regions typically associated with logopenic, nonfluent, and semantic variants. In both AD-PPA and non-AD-PPA, the sPC corresponding to the anterior temporal region was associated with semantic comprehension deficits, whereas that corresponding to the frontal region was linked to nonfluent speech and Kana writing impairment. sPC-based hierarchical clustering revealed clusters corresponding to logopenic, nonfluent, and semantic variants, with the anomic subtype distinguished from logopenic PPA. AD-positive cases were distributed across these clusters, emphasizing AD-PPA heterogeneity. These findings suggested that AD-related PPA heterogeneity is reflected in distinct cerebral perfusion patterns, which correlate with varying linguistic deficits.</p>","PeriodicalId":19191,"journal":{"name":"Neurological Sciences","volume":" ","pages":""},"PeriodicalIF":2.7,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143701192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}