Increased expression of proinflammatory cytokines in the cerebrospinal fluid of patients with a history of electrical status epilepticus in sleep.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-05-05 DOI:10.1007/s10072-025-08217-4

Xing-Guang Ye, Shi-Wei Dong, Ben-Ze Wu, Zhi-Gang Liu

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引用次数: 0

Abstract

Objective: This study was to investigate the cytokine expression profiles in the cerebrospinal fluid (CSF) of Self-limited epilepsy with centrotemporal spikes (SeLECTS) patients with electrical status epilepticus during sleep (ESES) and compare these to other neurological diseases to identify the cytokines that correlate with ESES.

Methods: Seven SeLECTS patients with ESES and nine non-ESES controls were included in this study. CSF was centrifuged within one hour and stored at -80 °C; subsequently, High mobility group box 1 (HMGB1), Caspase-1, interleukin (IL)-1β, IL-1α, IL-6, IL-8, IL-10 and tumour necrosis factor-α (TNF-α) were measured with enzyme-linked immunosorbent assay.

Results: CSF levels of IL-1β, TNF-α, IL-1α, and Caspase-1 in ESES group were significantly elevated compared with those non-ESES controls. Moreover, IL-1β CSF levels were positively correlated with Caspase-1 and TNF-α whereas it moderately correlated with IL-1α.

Conclusions: The present study indicates a close relationship between neuroinflammation and ESES pathogenesis in patients with SeLECTS.

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有睡眠中癫痫持续状态病史的患者脑脊液中促炎细胞因子的表达增加

目的：本研究旨在研究伴有睡眠期间癫痫持续电状态（ESES）的自限性癫痫伴中央颞叶尖峰（SeLECTS）患者脑脊液（CSF）中细胞因子的表达谱，并将其与其他神经系统疾病进行比较，以确定与ESES相关的细胞因子。方法：选取7例伴有ESES的select患者和9例非ESES对照。1小时内离心CSF， -80℃保存；随后，采用酶联免疫吸附法测定高迁移率组1 （HMGB1）、Caspase-1、白细胞介素(IL)-1β、IL-1α、IL-6、IL-8、IL-10和肿瘤坏死因子-α (TNF-α)的含量。结果：ESES组脑脊液中IL-1β、TNF-α、IL-1α、Caspase-1水平明显高于非ESES组。IL-1β CSF水平与Caspase-1、TNF-α呈正相关，与IL-1α呈正相关。结论：本研究提示select患者的神经炎症与ESES发病密切相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.