Serum sirtuin 3 levels and multimodal abnormalities in brain structure and function in Parkinson's disease patients with depression.

IF 2.4 4区医学 Q2 CLINICAL NEUROLOGY

Neurological Sciences Pub Date : 2025-08-01 Epub Date: 2025-04-21 DOI:10.1007/s10072-025-08170-2

Zonghan She, Xuelin Qi, Xiaoxue Shi, Haoran Peng, Jinhua Zheng, Jianjun Ma, Yunfei Sun, Mengyan Zhang, Yingyun Wang, Qing Xu, Qi Gu, Siyuan Chen, Xue Li

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引用次数: 0

Abstract

Background: Depression is a common nonmotor symptom in patients with Parkinson's disease (PD). Currently, few studies have investigated the relationships between serum markers and neuroimaging changes associated with depression in PD patients.

Objective: To explore the correlations among depression, serum SIRT3 levels, and brain structural and functional alterations in PD patients.

Methods: The Hamilton Depression Scale-17 (HAMD-17) was used to assess depression. Serum SIRT3 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Voxel-based morphometry (VBM) and resting-state functional magnetic resonance imaging (rs-fMRI) were used to examine structural and functional alterations.

Results: Compared to healthy individuals, serum SIRT3 levels were lower in PD patients, especially in those with depression. PD patients with depression had lower total gray matter volume/total intracranial volume (GMV/TIV) ratio, and GMVs of the right amygdala, lower fractional amplitude of low-frequency fluctuations (fALFF) values of the left middle frontal gyrus (MidFG.L) and left superior parietal lobule (SPL.L), and altered functional connectivity(FC) primarily involving the Salience Network (SN) and the default Mode Network (DMN) compared to those without depression. Serum SIRT3 levels, total GMV/TIV ratios, and fALFF values of the MidFG.L and SPL.L have diagnostic value for PD patients with depression, and their combination can improve predictive accuracy.

Conclusions: Depression in PD patients is associated with lower serum SIRT3 levels, right amygdala atrophy, decreased spontaneous activity in MidFG.L and SPL.L, and altered FC in the DMN and SN.

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帕金森病伴抑郁患者血清sirtuin 3水平与脑结构和功能多模态异常

背景：抑郁是帕金森病（PD）患者常见的非运动症状。目前，很少有研究调查PD患者抑郁相关的血清标志物与神经影像学变化之间的关系。目的：探讨PD患者抑郁、血清SIRT3水平与脑结构和功能改变的相关性。方法：采用汉密尔顿抑郁量表-17 （HAMD-17）进行抑郁评定。采用酶联免疫吸附试验(ELISA)测定血清SIRT3水平。使用基于体素的形态测量（VBM）和静息状态功能磁共振成像（rs-fMRI）检查结构和功能改变。结果：与健康个体相比，PD患者血清SIRT3水平较低，尤其是抑郁症患者。PD患者伴抑郁的总灰质体积/总颅内体积（GMV/TIV）比和右侧杏仁核GMV较低，左侧额叶中回（MidFG.L）和左侧顶叶上小叶（spll）低频波动幅度分数（fALFF）值较低，主要涉及显著性网络（SN）和默认模式网络（DMN）的功能连接（FC）改变。血清SIRT3水平，总GMV/TIV比值，以及MidFG的fALFF值。L和SPL。L对PD患者合并抑郁症有诊断价值，两者联合使用可提高预测准确率。结论：PD患者抑郁与血清SIRT3水平降低、右杏仁核萎缩、MidFG自发活性降低有关。L和SPL。L， DMN和SN的FC改变。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurological Sciences 医学-临床神经学

CiteScore

6.10

自引率

3.00%

发文量

743

审稿时长

4 months

期刊介绍： Neurological Sciences is intended to provide a medium for the communication of results and ideas in the field of neuroscience. The journal welcomes contributions in both the basic and clinical aspects of the neurosciences. The official language of the journal is English. Reports are published in the form of original articles, short communications, editorials, reviews and letters to the editor. Original articles present the results of experimental or clinical studies in the neurosciences, while short communications are succinct reports permitting the rapid publication of novel results. Original contributions may be submitted for the special sections History of Neurology, Health Care and Neurological Digressions - a forum for cultural topics related to the neurosciences. The journal also publishes correspondence book reviews, meeting reports and announcements.