Neurobiology of Aging最新文献

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Corrigendum to "Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains" [Neurobiol. Aging 36 (2015) 1994-2003]. 髓系细胞-2上表达的触发受体参与了朊病毒诱导的小胶质细胞活化,但对小鼠大脑中的朊病毒发病机制没有贡献》[Neurobiol. Aging 36 (2015) 1994-2003]的更正。
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-18 DOI: 10.1016/j.neurobiolaging.2024.09.008
Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi
{"title":"Corrigendum to \"Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains\" [Neurobiol. Aging 36 (2015) 1994-2003].","authors":"Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi","doi":"10.1016/j.neurobiolaging.2024.09.008","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.09.008","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erratum to: Homozygous alpha-synuclein p.A53V in familial Parkinson's disease. 勘误:家族性帕金森病中的α-突触核蛋白p.A53V。
IF 4.2 3区 医学
Neurobiology of Aging Pub Date : 2024-09-17 DOI: 10.1016/j.neurobiolaging.2024.09.001
Kenya Nishioka
{"title":"Erratum to: Homozygous alpha-synuclein p.A53V in familial Parkinson's disease.","authors":"Kenya Nishioka","doi":"10.1016/j.neurobiolaging.2024.09.001","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.09.001","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"1 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study 健康老年人持续注意力的大脑结构相关性:LEISURE 研究的横断面发现
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-17 DOI: 10.1016/j.neurobiolaging.2024.09.010
Ciara Treacy , Alicia J. Campbell , Toomas Erik Anijärv , Jim Lagopoulos , Daniel F. Hermens , Sophie C. Andrews , Jacob M. Levenstein
{"title":"Structural brain correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study","authors":"Ciara Treacy ,&nbsp;Alicia J. Campbell ,&nbsp;Toomas Erik Anijärv ,&nbsp;Jim Lagopoulos ,&nbsp;Daniel F. Hermens ,&nbsp;Sophie C. Andrews ,&nbsp;Jacob M. Levenstein","doi":"10.1016/j.neurobiolaging.2024.09.010","DOIUrl":"10.1016/j.neurobiolaging.2024.09.010","url":null,"abstract":"<div><p>Sustained attention is important for maintaining cognitive function and autonomy during ageing, yet older people often show reductions in this domain. The role of the underlying neurobiology is not yet well understood, with most neuroimaging studies primarily focused on fMRI. Here, we utilise sMRI to investigate the relationships between age, structural brain volumes and sustained attention performance. Eighty-nine healthy older adults (50–84 years, M<sub>age</sub> 65.5 (SD=8.4) years, 74 f) underwent MRI brain scanning and completed two sustained attention tasks: a rapid visual information processing (RVP) task and sustained attention to response task (SART). Independent hierarchical linear regressions demonstrated that greater volumes of white matter hyperintensities (WMH) were associated with worse RVP_<em>A’</em> performance, whereas greater grey matter volumes were associated with better RVP_<em>A’</em> performance. Further, greater cerebral white matter volumes were associated with better SART_<em>d’</em> performance. Importantly, mediation analyses revealed that both grey and white matter volumes completely mediated the relationship between ageing and sustained attention. These results explain disparate attentional findings in older adults, highlighting the intervening role of brain structure.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 93-103"},"PeriodicalIF":3.7,"publicationDate":"2024-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001647/pdfft?md5=27124f82c52029ee94875f7192601613&pid=1-s2.0-S0197458024001647-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study 主观认知能力下降的静息态功能连接异常:7T 磁共振成像研究
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-14 DOI: 10.1016/j.neurobiolaging.2024.09.007
M. Pievani , F. Ribaldi , K. Toussas , S. Da Costa , J. Jorge , O. Reynaud , C. Chicherio , J.L. Blouin , M. Scheffler , V. Garibotto , J. Jovicich , I.O. Jelescu , G.B. Frisoni
{"title":"Resting-state functional connectivity abnormalities in subjective cognitive decline: A 7T MRI study","authors":"M. Pievani ,&nbsp;F. Ribaldi ,&nbsp;K. Toussas ,&nbsp;S. Da Costa ,&nbsp;J. Jorge ,&nbsp;O. Reynaud ,&nbsp;C. Chicherio ,&nbsp;J.L. Blouin ,&nbsp;M. Scheffler ,&nbsp;V. Garibotto ,&nbsp;J. Jovicich ,&nbsp;I.O. Jelescu ,&nbsp;G.B. Frisoni","doi":"10.1016/j.neurobiolaging.2024.09.007","DOIUrl":"10.1016/j.neurobiolaging.2024.09.007","url":null,"abstract":"<div><p>Resting-state functional connectivity (FC) MRI is sensitive to brain changes in Alzheimer’s disease in preclinical stages, however studies in persons with subjective cognitive decline (SCD) have reported conflicting findings, and no study is available at 7T MRI. In this study, we investigated FC alterations in sixty-six participants recruited at the Geneva Memory Center (24 controls, 14 SCD, 28 cognitively impaired [CI]). Participants were classified as SCD if they reported cognitive complaints without objective cognitive deficits, and underwent 7T fMRI to assess FC in canonical brain networks and their association with cognitive/clinical features. SCD showed normal cognition, a trend for higher depressive symptoms, and normal AD biomarkers. Compared to the other two groups, SCD showed higher FC in frontal default mode network (DMN) and insular and superior temporal nodes of ventral attention network (VAN). Higher FC in the DMN and VAN was associated with worse cognition but not depression, suggesting that hyper-connectivity in these networks may be a signature of age-related cognitive decline in SCD at low risk of developing AD.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 104-113"},"PeriodicalIF":3.7,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142272617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals 痴呆症的心血管风险与认知健康的中年人大脑行为变化有关
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-13 DOI: 10.1016/j.neurobiolaging.2024.09.006
Feng Deng , Maria-Eleni Dounavi , Emanuele R.G. Plini , Karen Ritchie , Graciela Muniz-Terrera , Siobhan Hutchinson , Paresh Malhotra , Craig W. Ritchie , Brian Lawlor , Lorina Naci
{"title":"Cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals","authors":"Feng Deng ,&nbsp;Maria-Eleni Dounavi ,&nbsp;Emanuele R.G. Plini ,&nbsp;Karen Ritchie ,&nbsp;Graciela Muniz-Terrera ,&nbsp;Siobhan Hutchinson ,&nbsp;Paresh Malhotra ,&nbsp;Craig W. Ritchie ,&nbsp;Brian Lawlor ,&nbsp;Lorina Naci","doi":"10.1016/j.neurobiolaging.2024.09.006","DOIUrl":"10.1016/j.neurobiolaging.2024.09.006","url":null,"abstract":"<div><p>Alzheimer’s Disease (AD) neuropathology start decades before clinical manifestations, but whether risk factors are associated with early cognitive and brain changes in midlife remains poorly understood. We examined whether AD risk factors were associated with cognition and functional connectivity (FC) between the Locus Coeruleus (LC) and hippocampus – two key brain structures in AD neuropathology – cross-sectionally and longitudinally in cognitively healthy midlife individuals. Neuropsychological assessments and functional Magnetic Resonance Imaging were obtained at baseline (N=210), and two-years follow-up (N=188). Associations of cognition and FC with apolipoprotein ε4 (APOE ε4) genotype, family history of dementia, and the Cardiovascular Risk Factors, Aging, and Incidence of Dementia (CAIDE) score were investigated. Cross-sectionally, higher CAIDE scores were associated with worse cognition. Menopausal status interacted with the CAIDE risk on cognition. Furthermore, the CAIDE score significantly moderated the relationship between cognition and LC–Hippocampus FC. Longitudinally, the LC–Hippocampus FC decreased significantly over 2 years. These results suggest that cardiovascular risk of dementia is associated with brain–behaviour changes in cognitively healthy, middle-aged individuals.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 78-92"},"PeriodicalIF":3.7,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142243698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study 健康老年人持续注意力的静息态脑电图相关性:LEISURE 研究的横断面发现
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-12 DOI: 10.1016/j.neurobiolaging.2024.09.005
Alicia J. Campbell , Toomas Erik Anijärv , Thomas Pace , Ciara Treacy , Jim Lagopoulos , Daniel F. Hermens , Jacob M. Levenstein , Sophie C. Andrews
{"title":"Resting-state EEG correlates of sustained attention in healthy ageing: Cross-sectional findings from the LEISURE study","authors":"Alicia J. Campbell ,&nbsp;Toomas Erik Anijärv ,&nbsp;Thomas Pace ,&nbsp;Ciara Treacy ,&nbsp;Jim Lagopoulos ,&nbsp;Daniel F. Hermens ,&nbsp;Jacob M. Levenstein ,&nbsp;Sophie C. Andrews","doi":"10.1016/j.neurobiolaging.2024.09.005","DOIUrl":"10.1016/j.neurobiolaging.2024.09.005","url":null,"abstract":"<div><p>While structural and biochemical brain changes are well-documented in ageing, functional neuronal network differences, as indicated by electrophysiological markers, are less clear. Moreover, age-related changes in sustained attention and their associated electrophysiological correlates are still poorly understood. To address this, we analysed cross-sectional baseline electroencephalography (EEG) and cognitive data from the Lifestyle Intervention Study for Dementia Risk Reduction (LEISURE). Participants were 96 healthy older adults, aged 50–84. We examined resting-state EEG periodic (individual alpha frequency [IAF], aperiodic-adjusted individual alpha power [aIAP]) and aperiodic (exponent and offset) activity, and their associations with age and sustained attention. Results showed associations between older age and slower IAF, but not aIAP or global aperiodic exponent and offset. Additionally, hierarchical linear regression revealed that after controlling for demographic variables, faster IAF was associated with better Sustained Attention to Response Task performance, and mediation analysis confirmed IAF as a mediator between age and sustained attention performance. These findings indicate that IAF may be an important marker of ageing, and a slower IAF may signal diminished cognitive processing capacity for sustained attention in older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 68-77"},"PeriodicalIF":3.7,"publicationDate":"2024-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S019745802400160X/pdfft?md5=d9bfc6247646460e3a2740c6fe703e42&pid=1-s2.0-S019745802400160X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142233771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood 与整个成年期脑铁积累有关的生活方式、生物和遗传因素
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-10 DOI: 10.1016/j.neurobiolaging.2024.09.004
Jonatan Gustavsson , Zuzana Ištvánfyová , Goran Papenberg , Farshad Falahati , Erika J. Laukka , Jenni Lehtisalo , Francesca Mangialasche , Grégoria Kalpouzos
{"title":"Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood","authors":"Jonatan Gustavsson ,&nbsp;Zuzana Ištvánfyová ,&nbsp;Goran Papenberg ,&nbsp;Farshad Falahati ,&nbsp;Erika J. Laukka ,&nbsp;Jenni Lehtisalo ,&nbsp;Francesca Mangialasche ,&nbsp;Grégoria Kalpouzos","doi":"10.1016/j.neurobiolaging.2024.09.004","DOIUrl":"10.1016/j.neurobiolaging.2024.09.004","url":null,"abstract":"<div><p>Iron is necessary for many neurobiological mechanisms, but its overaccumulation can be harmful. Factors triggering age-related brain iron accumulation remain largely unknown and longitudinal data are insufficient. We examined associations between brain iron load and accumulation and, blood markers of iron metabolism, cardiovascular health, lifestyle factors (smoking, alcohol use, physical activity, diet), and <em>ApoE</em> status using longitudinal data from the IronAge study (n = 208, age = 20–79, mean follow-up time = 2.75 years). Iron in cortex and basal ganglia was estimated with magnetic resonance imaging using quantitative susceptibility mapping (QSM). Our results showed that (1) higher peripheral iron levels (i.e., composite score of blood iron markers) were related to greater iron load in the basal ganglia; (2) healthier diet was related to higher iron levels in the cortex and basal ganglia, although for the latter the association was significant only in younger adults (age = 20–39); (3) worsening cardiovascular health was related to increased iron accumulation; (4) younger <em>ApoE ε4</em> carriers accumulated more iron in basal ganglia than younger non-carriers. Our results demonstrate that modifiable factors, including lifestyle, cardiovascular, and physiological ones, are linked to age-related brain iron content and accumulation, contributing novel information on potential targets for interventions in preventing brain iron-overload.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 56-67"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001593/pdfft?md5=b36547ea1432e1ca96649c5939730069&pid=1-s2.0-S0197458024001593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Advisory Board 编辑顾问委员会
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-07 DOI: 10.1016/S0197-4580(24)00150-7
{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(24)00150-7","DOIUrl":"10.1016/S0197-4580(24)00150-7","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Page IFC"},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001507/pdfft?md5=102e739daa84821e01f280329fa77082&pid=1-s2.0-S0197458024001507-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142149441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice 小鼠慢性系统性炎症后,cofilin1通路(LIMK1/SSH1)的年龄依赖性性别差异及其与AD生物标志物的关系
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-07 DOI: 10.1016/j.neurobiolaging.2024.09.003
Amsha S. Alsegiani, Zahoor A. Shah
{"title":"Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice","authors":"Amsha S. Alsegiani,&nbsp;Zahoor A. Shah","doi":"10.1016/j.neurobiolaging.2024.09.003","DOIUrl":"10.1016/j.neurobiolaging.2024.09.003","url":null,"abstract":"<div><p>Chronic systemic inflammation (CSI) results in neuroinflammation and neurodegeneration. Cofilin1 is a stress protein that activates microglia and induces neuroinflammation, but its role in CSI at different aging stages remains unidentified. Therefore, the study aims to identify cofilin1 and its upstream regulators LIMK1 and SSH1 after CSI in young-, middle-, and advanced-aged mice. CSI was induced by injecting the male and female mice with a sub-lethal dose of Lipopolysaccharide weekly for six weeks. The results showed that normal male mice did not show cofilin pathway dysregulation, but a significant dysregulation was observed in CSI advanced-aged mice. In females, cofilin1 dysregulation was observed in healthy and CSI advanced-aged mice, while significant cofilin1 dysregulation was observed in middle-aged mice during CSI. Furthermore, cofilin1 pathway dysregulations correlated with Alzheimer's disease (AD) biomarkers in the brain and saliva, astrocyte activation, synaptic degeneration, neurobehavioral impairments, gut-microbiota abnormalities, and circulatory inflammation. These results provide new insights into cofilin1 sex and age-dependent mechanistic differences that might help identify targets for modulating neuroinflammation and early onset of AD.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 43-55"},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease 补充母体胆碱可挽救唐氏综合征和阿尔茨海默病 Ts65Dn 小鼠模型中基底前脑胆碱能神经元的早期内质体病理变化
IF 3.7 3区 医学
Neurobiology of Aging Pub Date : 2024-09-06 DOI: 10.1016/j.neurobiolaging.2024.09.002
Megan K. Gautier , Christy M. Kelley , Sang Han Lee , Elliott J. Mufson , Stephen D. Ginsberg
{"title":"Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease","authors":"Megan K. Gautier ,&nbsp;Christy M. Kelley ,&nbsp;Sang Han Lee ,&nbsp;Elliott J. Mufson ,&nbsp;Stephen D. Ginsberg","doi":"10.1016/j.neurobiolaging.2024.09.002","DOIUrl":"10.1016/j.neurobiolaging.2024.09.002","url":null,"abstract":"<div><p>Individuals with DS develop Alzheimer’s disease (AD) neuropathology, including endosomal-lysosomal system abnormalities and degeneration of basal forebrain cholinergic neurons (BFCNs). We investigated whether maternal choline supplementation (MCS) affects early endosome pathology within BFCNs using the Ts65Dn mouse model of DS/AD. Ts65Dn and disomic (2N) offspring from dams administered MCS were analyzed for endosomal pathology at 3–4 months or 10–12 months. Morphometric analysis of early endosome phenotype was performed on individual BFCNs using Imaris. The effects of MCS on the endosomal interactome were interrogated by relative co-expression (RCE) analysis. MCS effectively reduced age- and genotype-associated increases in early endosome number in Ts65Dn and 2N offspring, and prevented increases in early endosome size in Ts65Dn offspring. RCE revealed a loss of interactome cooperativity among endosome genes in Ts65Dn offspring that was restored by MCS. These findings demonstrate MCS rescues early endosome pathology, a driver of septohippocampal circuit dysfunction. The genotype-independent benefits of MCS on endosomal phenotype indicate translational applicability as an early-life therapy for DS as well as other neurodevelopmental/neurodegenerative disorders involving endosomal pathology.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 30-42"},"PeriodicalIF":3.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001556/pdfft?md5=76623227f0464d1bb041c9a20ba3aa70&pid=1-s2.0-S0197458024001556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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