Neurobiology of Aging最新文献_第3页

Brain activation in older adults during odor identification is related to ApoE, t-tau/Aβ1–42, and hippocampal volume

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-12 DOI: 10.1016/j.neurobiolaging.2025.02.001

Abigail Albertazzi , Claire Murphy

{"title":"Brain activation in older adults during odor identification is related to ApoE, t-tau/Aβ1–42, and hippocampal volume","authors":"Abigail Albertazzi , Claire Murphy","doi":"10.1016/j.neurobiolaging.2025.02.001","DOIUrl":"10.1016/j.neurobiolaging.2025.02.001","url":null,"abstract":"<div><div>Despite altered odor identification preceding and predicting Alzheimer’s disease (AD) cognitive decline, an inadequate understanding of how AD pathology affects odor memory functions limits its use as a preclinical biomarker. Multivariate linear regression was applied to whole-brain blood-oxygen-level-dependent (BOLD) activations during odor identification task (OID) responses in older adults without dementia (<em>N</em> = 36, 44.4 % ε4 carriers, <em>M</em><sub>Age</sub>= 76.61). Apolipoprotein-E ε4 allele status, cerebrospinal fluid levels of total-tau to Amyloid-β<sub>1–42</sub>, and MRI-derived hippocampal volume measures were used as predictors. The predictors described significant BOLD variation in regions that are associated with necessary OID functions and affected by AD neurodegeneration during OID responses; moreover, all predictors were associated with significant (<em>P</em> < .001) negative BOLD effects in essential task regions during at least one response condition. This evidence suggests significant pathological effects of AD biomarkers on OID-response neural activity in older adults without dementia and should motivate future combined-biomarker investigations of OID functions in preclinical populations.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"149 ","pages":"Pages 44-53"},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-12 DOI: 10.1016/j.neurobiolaging.2025.02.002

Charles M. Higgins , Sri Harsha Vishwanath , Fiona M. McCarthy , Michelle L. Gordon , Beate Peter , Julie E. Miller

{"title":"Normative aging results in degradation of gene networks in a zebra finch basal ganglia nucleus dedicated to vocal behavior","authors":"Charles M. Higgins , Sri Harsha Vishwanath , Fiona M. McCarthy , Michelle L. Gordon , Beate Peter , Julie E. Miller","doi":"10.1016/j.neurobiolaging.2025.02.002","DOIUrl":"10.1016/j.neurobiolaging.2025.02.002","url":null,"abstract":"<div><div>Aging increases brain susceptibility to neurodegenerative diseases, but the mechanisms are not clear. Vocal behavior provides an accessible, reliable, and sensitive biomarker to address this because voice changes in middle age can be early indicators of neurodegenerative diseases. The adult male zebra finch is an excellent model organism for these studies due to well-characterized vocal brain circuitry and strong homology to human brain centers. We performed RNA sequencing of song-dedicated basal ganglia nucleus Area X followed by weighted gene co-expression network analyses to examine changes in gene patterns across younger adult, middle, and older ages. Song-correlated gene networks degrade with age, with modules losing their coherence and migrating to different sets of genes, and changes in connection strength particularly for hub genes including those associated with human speech, Parkinson’s, and Alzheimer’s diseases. Gene pathway enrichment analyses reveal a lack of ongoing metabolic and biogenic processes in older finches. Our findings provide a robust platform for targeting network hubs in the treatment of neurologically driven human vocal disorders.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"149 ","pages":"Pages 19-33"},"PeriodicalIF":3.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143444308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-07 DOI: 10.1016/j.neurobiolaging.2025.01.011

Aurélie Bussy , Raihaan Patel , Olivier Parent , Alyssa Salaciak , Saashi A. Bedford , Sarah Farzin , Stephanie Tullo , Cynthia Picard , Sylvia Villeneuve , Judes Poirier , John CS Breitner , Gabriel A. Devenyi , PREVENT-AD Research Group, Christine L. Tardif , M. Mallar Chakravarty

{"title":"Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors","authors":"Aurélie Bussy , Raihaan Patel , Olivier Parent , Alyssa Salaciak , Saashi A. Bedford , Sarah Farzin , Stephanie Tullo , Cynthia Picard , Sylvia Villeneuve , Judes Poirier , John CS Breitner , Gabriel A. Devenyi , PREVENT-AD Research Group, Christine L. Tardif , M. Mallar Chakravarty","doi":"10.1016/j.neurobiolaging.2025.01.011","DOIUrl":"10.1016/j.neurobiolaging.2025.01.011","url":null,"abstract":"<div><div>Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and quantitative MRI (qMRI) measures of myelin and iron in a unique dataset of 158 participants across the AD spectrum, including those without cognitive impairment, at familial risk for AD, with mild cognitive impairment, and with AD dementia. Our results revealed a brain pattern with decreased cortical thickness, indicating increased neuronal death, and compromised hippocampal integrity due to reduced myelin content. This pattern was associated with lifestyle factors such as smoking, high blood pressure, high cholesterol, and anxiety, as well as older age, AD progression, and APOE-ɛ4 carrier status. These findings underscore the value of qMRI metrics as a non-invasive tool, offering sensitivity to lifestyle-related modifiable risk factors and medical history, even in preclinical stages of AD.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"149 ","pages":"Pages 1-18"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-07 DOI: 10.1016/j.neurobiolaging.2025.01.010

David J. Horovitz , Laura A. Askins , Grace M. Regnier, Joseph A. McQuail

{"title":"Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions","authors":"David J. Horovitz , Laura A. Askins , Grace M. Regnier, Joseph A. McQuail","doi":"10.1016/j.neurobiolaging.2025.01.010","DOIUrl":"10.1016/j.neurobiolaging.2025.01.010","url":null,"abstract":"<div><div>Age-related cognitive decline varies widely among individuals, with some showing resilience despite older age. This study examines synaptic markers of glutamatergic and GABAergic neurotransmission in the hippocampus and cortex of older rats with differing cognitive abilities, aiming to uncover mechanisms that contribute to cognitive resilience. We observed significant age-related reductions in vesicular glutamate transporter VGluT1, particularly in the stratum oriens (SO), radiatum (SR), and lacunosum-moleculare (SLM) of the dorsal CA3 and SLM of the dorsal CA1. Furthermore, loss of VGluT1 in the dorsal CA3-SLM correlated with severity of memory impairment. Higher levels of the vesicular GABA transporter (VGAT) were associated with better spatial learning in older rats, across several synaptic zones of the dorsal hippocampus, including the outer molecular layer of the dentate gyrus (DG), and the SO, SR, SLM, and pyramidal cell layers of both CA3 and CA1. This suggests that enhanced inhibitory neurotransmission specific to the dorsal aspect of the hippocampus may protect against age-related cognitive decline. While the dorsal hippocampus showed consistent age- and memory-related changes, markers in the ventral hippocampus remained largely intact. In the perirhinal cortex, VGluT1 declined with no changes in VGAT, while both markers remained unchanged in other cortical regions, including the lateral entorhinal, retrosplenial, and posterior parietal cortices. These findings highlight region-specific patterns of synaptic aging as potential markers of brain and cognitive reserve.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 80-97"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-05 DOI: 10.1016/j.neurobiolaging.2024.12.013

Lucile Meunier-Duperray , Céline Souchay , Lucie Angel , Eric Salmon , Christine Bastin

{"title":"Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease","authors":"Lucile Meunier-Duperray , Céline Souchay , Lucie Angel , Eric Salmon , Christine Bastin","doi":"10.1016/j.neurobiolaging.2024.12.013","DOIUrl":"10.1016/j.neurobiolaging.2024.12.013","url":null,"abstract":"<div><div>Patients with Alzheimer’s disease (AD) are less accurate than controls to predict their episodic performance, but they are as accurate as controls to predict their semantic performance. However, the dissociation between episodic and semantic metamemory had never been tested directly in the same patients. This study aimed to explore the dissociation between episodic and semantic metamemory in AD using the feeling-of-knowing paradigm. In addition, we investigated the link between memory awareness and resting-state cerebral glucose metabolism and gray matter density, in episodic and semantic tasks independently. Data from 50 patients with AD were compared to data from 30 healthy controls. Results showed that patients with AD had more difficulties to predict their recognition in the episodic task than in the semantic task, while this difference was smaller in controls. However, this dissociation was only shown with a measure of absolute accuracy, but not with a measure of relative accuracy. Lack of awareness in the episodic task was associated with hypometabolism in right frontoparietal areas in patients with AD, while semantic metamemory was associated with gray matter integrity in the left angular gyrus. The consequence of metacognitive bias and memory status on metamemory judgments are discussed.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 61-70"},"PeriodicalIF":3.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains” [Neurobiol. Aging 36 (2015) 1994–2003] 髓系细胞-2上表达的触发受体参与了朊病毒诱导的小胶质细胞活化，但对小鼠大脑中的朊病毒发病机制没有贡献》[Neurobiol. Aging 36 (2015) 1994-2003]的更正。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 DOI: 10.1016/j.neurobiolaging.2024.09.008

Caihong Zhu , Uli S. Herrmann , Bei Li , Irina Abakumova , Rita Moos , Petra Schwarz , Elisabeth J. Rushing , Marco Colonna , Adriano Aguzzi

引用次数: 0

Erratum to: Homozygous alpha-synuclein p.A53V in familial Parkinson’s disease 勘误：家族性帕金森病中的α-突触核蛋白p.A53V。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 DOI: 10.1016/j.neurobiolaging.2024.09.001

Kenya Nishioka

引用次数: 0

Editorial Advisory Board

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 DOI: 10.1016/S0197-4580(24)00206-9

引用次数: 0

Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823–10 G>T at the intron 9/exon 10 of the MAPT gene 更正：一个患有 MAPT 基因内含子 9/ 外显子 10 的杂合剪接变异 c.823-10 G>T 的 FTDP-17 家族的临床、分子遗传学和病理学研究。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 DOI: 10.1016/j.neurobiolaging.2024.09.011

Diana A. Olszewska , Conor Fearon , Christopher McGuigan , Terri P. McVeigh , Henry Houlden , James M. Polke , Brian Lawlor , Robert Coen , Michael Hutchinson , Michael Hutton , Alan Beausang , Isabelle Delon , Francesca Brett , Ioanna Sevastou , Nuria Seto-Salvia , Rohan de Silva , Tim Lynch

引用次数: 0

Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 DOI: 10.1016/j.neurobiolaging.2025.01.007

Kelsey E. McDermott , Carol A. Barnes

{"title":"Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques","authors":"Kelsey E. McDermott , Carol A. Barnes","doi":"10.1016/j.neurobiolaging.2025.01.007","DOIUrl":"10.1016/j.neurobiolaging.2025.01.007","url":null,"abstract":"<div><div>The locus coeruleus (LC) is a brainstem nucleus that provides the primary source of noradrenaline (NA) in the nervous system and optimizes behavioral performance in mammals. In humans, the LC shows Alzheimer’s disease (AD)-like pathology at its earliest stages, but little is known about LC integrity in normative, non-pathological aging. The present research addresses these gaps by investigating neuron numbers, densities of glia and vasculature, and volume of the LC itself in cognitively assessed adult and aged rhesus macaques. These primates do not spontaneously exhibit AD, and thus are an excellent model for normative human aging. Immunohistochemical methods were used to quantify noradrenaline-producing cells, total cells, and vascular and glial density in the LC, and use a recently developed alignment protocol to incorporate Nissl- and immunohistochemically stained tissue with previously collected magnetic resonance images to generate precise volumes of the LC and its’ subcompartments. The medial LC subcompartment alone (not the lateral or compact regions) in aged animals showed significantly smaller volume than did the adult monkeys, however, there was no difference in NA-containing cell numbers, vascular or glial densities observed in any compartment between age groups. Additionally, volumes and cell counts were not significantly associated with performance on memory tasks, indicating that cell populations within the locus coeruleus nucleus itself are highly resistant to age-related change.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 41-49"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0