Neurobiology of Aging最新文献_第10页

Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline 认知储备代用指标与年龄相关的认知能力下降有关，而与年龄相关的步速下降无关。

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-27 DOI: 10.1016/j.neurobiolaging.2024.05.012

Helena M. Blumen , Oshadi Jayakody , Emmeline Ayers , Nir Barzilai , Christian Habeck , Sofiya Milman , Yaakov Stern , Erica F. Weiss , Joe Verghese

{"title":"Cognitive reserve proxies are associated with age-related cognitive decline – Not age-related gait speed decline","authors":"Helena M. Blumen , Oshadi Jayakody , Emmeline Ayers , Nir Barzilai , Christian Habeck , Sofiya Milman , Yaakov Stern , Erica F. Weiss , Joe Verghese","doi":"10.1016/j.neurobiolaging.2024.05.012","DOIUrl":"10.1016/j.neurobiolaging.2024.05.012","url":null,"abstract":"<div><p>Cognition and gait share brain substrates in aging and dementia. Cognitive reserve (CR) allows individuals to cope with brain pathology and delay cognitive impairment and dementia. Yet, evidence for that CR is associated with age-related cognitive decline is mixed, and evidence for that CR is associated with age-related gait decline is limited. In 1,079 older (<em>M</em> Age = 75.4 years; 56.0% women) LonGenity study participants without dementia at baseline and up to 12 years of annual follow-up (<em>M</em> follow-up = 3.9 years, <em>SD</em> = 2.5 years), high CR inferred from cognitive (education years), physical (number of blocks walked per day; weekly physical activity days), and social (volunteering/working; living with someone) proxies were associated with slower rates of age-related decline in global cognition – not gait speed decline. Thus, cognitive, physical, and social CR proxies are associated with cognitive decline in older adults without dementia. The multifactorial etiology and earlier decline in gait than cognition may render it less modifiable by CR proxies later in life.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 46-54"},"PeriodicalIF":4.2,"publicationDate":"2024-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141184480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of dorsal premotor cortex differentially influences visuomotor adaptation in young and older adults 对背侧前运动皮层的调节会对年轻人和老年人的视觉运动适应性产生不同影响

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-25 DOI: 10.1016/j.neurobiolaging.2024.05.011

Wei-Yeh Liao , George M. Opie , Ulf Ziemann , John G. Semmler

{"title":"Modulation of dorsal premotor cortex differentially influences visuomotor adaptation in young and older adults","authors":"Wei-Yeh Liao , George M. Opie , Ulf Ziemann , John G. Semmler","doi":"10.1016/j.neurobiolaging.2024.05.011","DOIUrl":"10.1016/j.neurobiolaging.2024.05.011","url":null,"abstract":"<div><p>The communication between dorsal premotor cortex (PMd) and primary motor cortex (M1) is important for visuomotor adaptation, but it is unclear how this relationship changes with advancing age. The present study recruited 21 young and 23 older participants for two experimental sessions during which intermittent theta burst stimulation (iTBS) or sham was applied over PMd. We assessed the effects of PMd iTBS on M1 excitability using motor evoked potentials (MEP) recorded from right first dorsal interosseous when single-pulse transcranial magnetic stimulation (TMS) was applied with posterior-anterior (PA) or anterior-posterior (AP) currents; and adaptation by quantifying error recorded during a visuomotor adaptation task (VAT). PMd iTBS potentiated PA (<em>P</em> < 0.0001) and AP (<em>P</em> < 0.0001) MEP amplitude in both young and older adults. PMd iTBS increased error in young adults during adaptation (<em>P</em> = 0.026), but had no effect in older adults (<em>P</em> = 0.388). Although PMd iTBS potentiated M1 excitability in both young and older adults, the intervention attenuated visuomotor adaptation specifically in young adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 34-45"},"PeriodicalIF":4.2,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001027/pdfft?md5=7d8d8de6f838000edaceaa3b11cce308&pid=1-s2.0-S0197458024001027-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141098513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging 测试结构断裂假说：髓鞘含量与健康老年人的记忆力有关

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-23 DOI: 10.1016/j.neurobiolaging.2024.05.013

Andrea Mendez Colmenares , Michael L. Thomas , Charles Anderson , David B. Arciniegas , Vince Calhoun , In-Young Choi , Arthur F. Kramer , Kaigang Li , Jongho Lee , Phil Lee , Agnieszka Z. Burzynska

{"title":"Testing the structural disconnection hypothesis: Myelin content correlates with memory in healthy aging","authors":"Andrea Mendez Colmenares , Michael L. Thomas , Charles Anderson , David B. Arciniegas , Vince Calhoun , In-Young Choi , Arthur F. Kramer , Kaigang Li , Jongho Lee , Phil Lee , Agnieszka Z. Burzynska","doi":"10.1016/j.neurobiolaging.2024.05.013","DOIUrl":"10.1016/j.neurobiolaging.2024.05.013","url":null,"abstract":"<div><h3>Introduction</h3><p>The \"structural disconnection\" hypothesis of cognitive aging suggests that deterioration of white matter (WM), especially myelin, results in cognitive decline, yet in vivo evidence is inconclusive.</p></div><div><h3>Methods</h3><p>We examined age differences in WM microstructure using Myelin Water Imaging and Diffusion Tensor Imaging in 141 healthy participants (age 20–79). We used the Virginia Cognitive Aging Project and the NIH Toolbox® to generate composites for memory, processing speed, and executive function.</p></div><div><h3>Results</h3><p>Voxel-wise analyses showed that lower myelin water fraction (MWF), predominantly in prefrontal WM, genu of the corpus callosum, and posterior limb of the internal capsule was associated with reduced memory performance after controlling for age, sex, and education. In structural equation modeling, MWF in the prefrontal white matter and genu of the corpus callosum significantly mediated the effect of age on memory, whereas fractional anisotropy (FA) did not.</p></div><div><h3>Discussion</h3><p>Our findings support the disconnection hypothesis, showing that myelin decline contributes to age-related memory loss and opens avenues for interventions targeting myelin health.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 21-33"},"PeriodicalIF":4.2,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001039/pdfft?md5=7963c6090dbb9f64129e736b2f2616d8&pid=1-s2.0-S0197458024001039-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141131422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences 健康人血糖控制、心脏变异性和大脑自律神经功能之间的关联：年龄和性别差异

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-05-23 DOI: 10.1016/j.neurobiolaging.2024.05.007

{"title":"The associations among glycemic control, heart variability, and autonomic brain function in healthy individuals: Age- and sex-related differences","authors":"","doi":"10.1016/j.neurobiolaging.2024.05.007","DOIUrl":"10.1016/j.neurobiolaging.2024.05.007","url":null,"abstract":"<div><h3>Introduction</h3><p>The purpose of this study was to clarify the relationships between glycemia and function of the autonomic nervous system (ANS), assessed via resting-state functional connectivity (FC) and heart-rate variability (HRV).</p></div><div><h3>Methods</h3><p>Data for this study were extracted from the Leipzig Study for Mind-Body-Emotion Interactions, including 146 healthy adults (114 young, 32 older). Variables of interest were glycated hemoglobin (HbA1c), resting-state FC in the salience aspect of the central-autonomic (S-CAN) and salience network (SN) and HRV (RMSSD and high-frequency HRV (HF-HRV)).</p></div><div><h3>Results</h3><p>HbA1c was inversely correlated with FC in the S-CAN but not SN. HbA1c was inversely correlated with HRV. Both RMSSD and log(HF-HRV) were correlated with FC in the S-CAN and SN. Age- (not sex-related) differences were observed in the Hb1Ac-FC associations (stronger in older adults) while sex- (not age-related) differences were observed in the HRV-FC (stronger in females).</p></div><div><h3>Conclusions</h3><p>These findings extend the diabetes literature to healthy adults in relating glycemia and brain function. The age- and sex-related differences in these relationships highlight the need to account for the potential effects of age and sex in future investigations.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 41-51"},"PeriodicalIF":3.7,"publicationDate":"2024-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141145636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: “Pinocembrin improves cognition and protects the neurovascular unit in Alzheimer related deficits” [Neurobiol. Aging 35 (2014) 1275–1285] 更正："Pinocembrin 改善认知能力并保护阿尔茨海默氏症相关缺陷的神经血管单元》[Neurobiol. Aging 35 (2014) 1275-1285]。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-05-22 DOI: 10.1016/j.neurobiolaging.2024.05.010

引用次数: 0

Interstitial fluid flow decreases with age, especially after 50 years 随着年龄的增长，尤其是 50 岁以后，细胞间质的流动会减少

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-19 DOI: 10.1016/j.neurobiolaging.2024.05.006

Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi

{"title":"Interstitial fluid flow decreases with age, especially after 50 years","authors":"Yuji Suzuki, Yukimi Nakamura, Hironaka Igarashi","doi":"10.1016/j.neurobiolaging.2024.05.006","DOIUrl":"10.1016/j.neurobiolaging.2024.05.006","url":null,"abstract":"<div><p>Physiological age-related alterations in the interstitial flow in the brain, which plays an important role in waste product removal, remain unclear. Using [<sup>15</sup>O]H<sub>2</sub>O positron emission tomography (PET), water dynamics were evaluated in 63 healthy adult participants aged between 20 and 80 years. Interstitial flow was assessed by influx ratio (IR) and drain rate (DR), using time-activity concentration data. Participants were divided into four age groups with 15-year ranges, to evaluate age-related functional alterations. At least one of the indices declined significantly with age across all groups. A significant linear negative correlation between age and both indicators was found in the scatter plots (IR: R<sup>2</sup> = 0.54, DR: R<sup>2</sup> = 0.44); both indicators were predominantly lower after age 50 years. These results suggest interstitial flow decreases with age, especially after 50 years. These important findings can contribute to devising therapeutic interventions for neurological diseases characterized by abnormal accumulation of waste products, and suggest the need for taking measures to maintain interstitial flow starting around the age of 50 years.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 14-20"},"PeriodicalIF":4.2,"publicationDate":"2024-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024000976/pdfft?md5=b298965dd91a81f6061a51f5fa49222e&pid=1-s2.0-S0197458024000976-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients 老年手术患者皮质脑萎缩、谵妄和长期认知能力下降之间的关系

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-18 DOI: 10.1016/j.neurobiolaging.2024.05.008

Michele Cavallari , Alexandra Touroutoglou , Yuta Katsumi , Tamara G. Fong , Eva Schmitt , Thomas G. Travison , Mouhsin M. Shafi , Towia A. Libermann , Edward R. Marcantonio , David C. Alsop , Richard N. Jones , Sharon K. Inouye , Bradford C. Dickerson , for the SAGES study group

{"title":"Relationship between cortical brain atrophy, delirium, and long-term cognitive decline in older surgical patients","authors":"Michele Cavallari , Alexandra Touroutoglou , Yuta Katsumi , Tamara G. Fong , Eva Schmitt , Thomas G. Travison , Mouhsin M. Shafi , Towia A. Libermann , Edward R. Marcantonio , David C. Alsop , Richard N. Jones , Sharon K. Inouye , Bradford C. Dickerson , for the SAGES study group","doi":"10.1016/j.neurobiolaging.2024.05.008","DOIUrl":"10.1016/j.neurobiolaging.2024.05.008","url":null,"abstract":"<div><p>In older patients, delirium after surgery is associated with long-term cognitive decline (LTCD). The neural substrates of this association are unclear. Neurodegenerative changes associated with dementia are possible contributors. We investigated the relationship between brain atrophy rates in Alzheimer’s disease (AD) and cognitive aging signature regions from magnetic resonance imaging before and one year after surgery, LTCD assessed by the general cognitive performance (GCP) score over 6 years post-operatively, and delirium in 117 elective surgery patients without dementia (mean age = 76). The annual change in cortical thickness was 0.2(1.7) % (AD-signature p = 0.09) and 0.4(1.7) % (aging-signature p = 0.01). Greater atrophy was associated with LTCD (AD-signature: beta(CI) = 0.24(0.06–0.42) points of GCP/mm of cortical thickness; p < 0.01, aging-signature: beta(CI) = 0.55(0.07–1.03); p = 0.03). Atrophy rates were not significantly different between participants with and without delirium. We found an interaction with delirium severity in the association between atrophy and LTCD (AD-signature: beta(CI) = 0.04(0.00–0.08), p = 0.04; aging-signature: beta(CI) = 0.08(0.03–0.12), p < 0.01). The rate of cortical atrophy and severity of delirium are independent, synergistic factors determining postoperative cognitive decline in the elderly.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"140 ","pages":"Pages 130-139"},"PeriodicalIF":4.2,"publicationDate":"2024-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140961593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain reserve in midlife is associated with executive function changes across 12 years 中年时期的大脑储备与 12 年间的执行功能变化有关

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-16 DOI: 10.1016/j.neurobiolaging.2024.05.001

Daniel E. Gustavson , Jeremy A. Elman , Chandra A. Reynolds , Lisa T. Eyler , Christine Fennema-Notestine , Olivia K. Puckett , Matthew S. Panizzon , Nathan A. Gillespie , Michael C. Neale , Michael J. Lyons , Carol E. Franz , William S. Kremen

{"title":"Brain reserve in midlife is associated with executive function changes across 12 years","authors":"Daniel E. Gustavson , Jeremy A. Elman , Chandra A. Reynolds , Lisa T. Eyler , Christine Fennema-Notestine , Olivia K. Puckett , Matthew S. Panizzon , Nathan A. Gillespie , Michael C. Neale , Michael J. Lyons , Carol E. Franz , William S. Kremen","doi":"10.1016/j.neurobiolaging.2024.05.001","DOIUrl":"10.1016/j.neurobiolaging.2024.05.001","url":null,"abstract":"<div><p>We examined how brain reserve in midlife, measured by brain-predicted age difference scores (Brain-PADs), predicted executive function concurrently and longitudinally into early old age, and whether these associations were moderated by young adult cognitive reserve or <em>APOE</em> genotype. 508 men in the Vietnam Era Twin Study of Aging (VETSA) completed neuroimaging assessments at mean age 56 and six executive function tasks at mean ages 56, 62, and 68 years. Results indicated that greater brain reserve at age 56 was associated with better concurrent executive function (<em>r</em>=.10, <em>p</em>=.040) and less decline in executive function over 12 years (<em>r</em>=.34, <em>p</em>=.001). These associations were not moderated by cognitive reserve or <em>APOE</em> genotype. Twin analysis suggested associations with executive function slopes were driven by genetic influences. Our findings suggest that greater brain reserve allowed for better cognitive maintenance from middle- to old age, driven by a genetic association. The results are consistent with differential preservation of executive function based on brain reserve that is independent of young adult cognitive reserve or <em>APOE</em> genotype.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 113-120"},"PeriodicalIF":4.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141023952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain 长期限制卡路里摄入可减少少突胶质细胞的 DNA 氧化损伤并促进老龄猴脑中的小胶质细胞自律性

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-16 DOI: 10.1016/j.neurobiolaging.2024.05.005

Ana T. Vitantonio , Christina Dimovasili , Farzad Mortazavi , Kelli L. Vaughan , Julie A. Mattison , Douglas L. Rosene

{"title":"Long-term calorie restriction reduces oxidative DNA damage to oligodendroglia and promotes homeostatic microglia in the aging monkey brain","authors":"Ana T. Vitantonio , Christina Dimovasili , Farzad Mortazavi , Kelli L. Vaughan , Julie A. Mattison , Douglas L. Rosene","doi":"10.1016/j.neurobiolaging.2024.05.005","DOIUrl":"10.1016/j.neurobiolaging.2024.05.005","url":null,"abstract":"<div><p>Calorie restriction (CR) is a robust intervention that can slow biological aging and extend lifespan. In the brain, terminally differentiated neurons and glia accumulate oxidative damage with age, reducing their optimal function. We investigated if CR could reduce oxidative DNA damage to white matter oligodendrocytes and microglia. This study utilized post-mortem brain tissue from rhesus monkeys that died after decades on a 30 % reduced calorie diet. We found that CR subjects had significantly fewer cells with oxidative damage within the corpus callosum and the cingulum bundle. Oligodendrocytes specifically showed the greatest response to CR with a robust reduction in DNA damage. Additionally, we observed alterations in microglia morphology with CR subjects having a higher proportion of ramified, homeostatic microglia and fewer pro-inflammatory, hypertrophic microglia relative to controls. Furthermore, we determined that the observed attenuation in damaged DNA occurs primarily within mitochondria. Overall, these data suggest that long-term CR can reduce oxidative DNA damage and offer a neuroprotective effect in a cell-type-specific manner in the aging monkey brain.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 1-13"},"PeriodicalIF":4.2,"publicationDate":"2024-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141033409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease 神经元抑制 AMPK 催化亚基对阿尔茨海默病小鼠模型中 LTD 损伤的同工酶特异性影响

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-15 DOI: 10.1016/j.neurobiolaging.2024.05.009

Qian Yang , Xueyan Zhou , Tao Ma

{"title":"Isoform-specific effects of neuronal inhibition of AMPK catalytic subunit on LTD impairments in a mouse model of Alzheimer’s disease","authors":"Qian Yang , Xueyan Zhou , Tao Ma","doi":"10.1016/j.neurobiolaging.2024.05.009","DOIUrl":"10.1016/j.neurobiolaging.2024.05.009","url":null,"abstract":"<div><p>Synaptic dysfunction is highly correlated with cognitive impairments in Alzheimer’s disease (AD), the most common dementia syndrome in the elderly. Long-term potentiation (LTP) and long-term depression (LTD) are two primary forms of synaptic plasticity with opposite direction of synaptic efficiency change. Both LTD and LTD are considered to mediate the cellular process of learning and memory. Substantial studies demonstrate AD-associated deficiency of both LTP and LTD. Meanwhile, the molecular signaling mechanisms underlying impairment of synaptic plasticity, particularly LTD, are poorly understood. By taking advantage of the novel transgenic mouse models recently developed in our lab, here we aimed to investigate the roles of AMP-activated protein kinase (AMPK), a central molecular senor that plays a critical role in maintaining cellular energy homeostasis, in regulation of LTD phenotypes in AD. We found that brain-specific suppression of the AMPKα1 isoform (but not AMPKα2 isoform) was able to alleviate mGluR-LTD deficits in APP/PS1 AD mouse model. Moreover, suppression of either AMPKα isoform failed to alleviate AD-related NMDAR-dependent LTD deficits. Taken together with our recent studies on roles of AMPK signaling in AD pathophysiology, the data indicate isoform-specific roles of AMPK in mediating AD-associated synaptic and cognitive impairments.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"140 ","pages":"Pages 116-121"},"PeriodicalIF":4.2,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141065886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0