Neurobiology of Aging最新文献_第10页

Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer’s disease: A putative biomarker of amyloid-induced vascular damage 血管内皮生长因子受体-1 （FLT1）与淀粉样蛋白- β在阿尔茨海默病中的相互作用：淀粉样蛋白诱导的血管损伤的推定生物标志物。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-25 DOI: 10.1016/j.neurobiolaging.2024.12.010

Rebecca L. Winfree , Emma Nolan , Kaj Blennow , Henrik Zetterberg , Katherine A. Gifford , Kimberly R. Pechman , Julie Schneider , David A. Bennett , Vladislav A. Petyuk , Angela L. Jefferson , Timothy J. Hohman

{"title":"Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer’s disease: A putative biomarker of amyloid-induced vascular damage","authors":"Rebecca L. Winfree , Emma Nolan , Kaj Blennow , Henrik Zetterberg , Katherine A. Gifford , Kimberly R. Pechman , Julie Schneider , David A. Bennett , Vladislav A. Petyuk , Angela L. Jefferson , Timothy J. Hohman","doi":"10.1016/j.neurobiolaging.2024.12.010","DOIUrl":"10.1016/j.neurobiolaging.2024.12.010","url":null,"abstract":"<div><div>We have identified FLT1 as a protein that changes during Alzheimer’s disease (AD) whereby higher brain protein levels are associated with more amyloid, more tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis and immune activation, we hypothesized that FLT1 is upregulated in response to amyloid pathology, driving a vascular-immune cascade resulting in neurodegeneration and cognitive decline. We sought to determine (1) if <em>in vivo</em> FLT1 levels (CSF and plasma) associate with biomarkers of AD neuropathology or differ between diagnostic staging in an aged cohort enriched for early disease, and (2) whether FLT1 expression interacts with amyloid on downstream outcomes, such as phosphorylated tau levels and cognitive performance. Additionally, we sought to replicate FLT1 interactions in the brain. The results showed that higher levels of FLT1 in CSF and <em>post-mortem</em> brain tissue related to increased tau, particularly among amyloid positive individuals. These analyses help clarify the potential utility of FLT1 as a biomarker among individuals with evidence of brain amyloidosis.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 141-149"},"PeriodicalIF":3.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to “Modulation of lipopolysaccharide-induced memory insult, g-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase” [Neurobiol. Aging 35 (2014) 1024–1031 ] “用5-脂氧合酶调节脂多糖诱导的记忆损伤、g-分泌酶和三重转基因小鼠的神经炎症”[神经生物学]的更正。老龄化35(2014)1024-1031]。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-24 DOI: 10.1016/j.neurobiolaging.2024.12.004

Yash B. Joshi, Phillip F. Giannopoulos, Jin Chu, Domenico Praticò

引用次数: 0

Effector-dependent decline in strength and subcortical motor excitability with aging 随着年龄增长，强度和皮层下运动兴奋性的效应依赖性下降。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-24 DOI: 10.1016/j.neurobiolaging.2024.12.008

Ronan A. Mooney , Pablo A. Celnik

{"title":"Effector-dependent decline in strength and subcortical motor excitability with aging","authors":"Ronan A. Mooney , Pablo A. Celnik","doi":"10.1016/j.neurobiolaging.2024.12.008","DOIUrl":"10.1016/j.neurobiolaging.2024.12.008","url":null,"abstract":"<div><div>A decline in upper limb strength is common with normal aging. However, whether age-related strength decline is paralleled by reduced excitability of descending motor pathways is unclear. The reticulospinal tract is a key subcortical pathway involved in gross motor output and exhibits increased excitability following resistance training. Here, we sought to determine age-related effects on strength and reticulospinal excitability in flexors and extensors of the upper limb in humans. In 15 younger and 14 older adults, we quantified upper limb strength using dynamometry, and reticulospinal excitability by using transcranial magnetic stimulation to elicit ipsilateral motor evoked potentials. We observed a decline in flexion, but not extension strength, in older compared with younger adults. This behavioral pattern was paralleled by an age-related reduction in ipsilateral motor evoked potential presence specific to flexor muscles. Our findings indicate that reduced excitability of the reticulospinal tract, which exhibits strong innervation of flexor muscles, may be a key contributor to upper limb strength decline commonly observed in older adults.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 98-104"},"PeriodicalIF":3.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice 具有治疗阿尔茨海默病潜力的新型低剂量姜黄素衍生物：来自小鼠体内和体外研究的结果。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-21 DOI: 10.1016/j.neurobiolaging.2024.12.005

Beatriz Rodrigues , Eduarda Ventura , Patrícia Moreira , Rosa Resende , Joana Bicker , Armanda E. Santos , Cláudia Fragão Pereira , Maria Teresa Cruz , Maria Paula Robalo , Ana Silva , Sónia Silva

{"title":"New low-dose curcumin derivative with therapeutic potential in Alzheimer’s disease: Results from an in vitro and in vivo study in mice","authors":"Beatriz Rodrigues , Eduarda Ventura , Patrícia Moreira , Rosa Resende , Joana Bicker , Armanda E. Santos , Cláudia Fragão Pereira , Maria Teresa Cruz , Maria Paula Robalo , Ana Silva , Sónia Silva","doi":"10.1016/j.neurobiolaging.2024.12.005","DOIUrl":"10.1016/j.neurobiolaging.2024.12.005","url":null,"abstract":"<div><div>Curcumin has been proposed as a potential treatment for Alzheimer’s disease (AD) due to its ability to inhibit amyloid-β (Aβ) peptide aggregates and to destabilise pre-formed ones. Derivative 27 was synthesized to improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant and anti-amyloidogenic activities were evaluated <em>in chemico</em>, <em>in vitro</em> using AD and neuroinflammation cell models, and <em>in vivo</em> using the double-transgenic APP/PS1 mice. <em>In vitro,</em> this curcumin derivative significantly reduced nitric oxide (NO) production and levels of pro-inflammatory proteins, inducible NO synthase, pro-interleukin-1β (Pro-IL-1β) and cyclooxygenase-2. Furthermore, Derivative 27 activated nuclear factor erythroid 2-related factor 2 transcription factor (Nrf2) and significantly increased Nrf2 and heme-oxygenase-1 protein levels in the nucleus and in the cytoplasm, respectively. In one-year-old APP/PS1 mice, orally administered-Derivative 27 (50 mg/Kg/day) for 28 days improved spatial short-term memory and significantly decreased hippocampal Pro-IL-1β and amyloid precursor protein levels, as well as Aβ levels in the hippocampus and plasma. This study supports developing new chemical approaches to alter curcumin molecule, enabling lower doses, while increasing the effectiveness in AD treatment.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 105-123"},"PeriodicalIF":3.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model 在P301S牛头病小鼠模型中，Tau与突触线粒体的关联与能量功能障碍和兴奋性突触丧失相吻合。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-20 DOI: 10.1016/j.neurobiolaging.2024.12.006

L. Daniel Estrella, Andrew J. Trease, Lexi Sheldon, Nashanthea J. Roland, Howard S. Fox, Kelly L. Stauch

{"title":"Tau association with synaptic mitochondria coincides with energetic dysfunction and excitatory synapse loss in the P301S tauopathy mouse model","authors":"L. Daniel Estrella, Andrew J. Trease, Lexi Sheldon, Nashanthea J. Roland, Howard S. Fox, Kelly L. Stauch","doi":"10.1016/j.neurobiolaging.2024.12.006","DOIUrl":"10.1016/j.neurobiolaging.2024.12.006","url":null,"abstract":"<div><div>Neurodegenerative Tauopathies are a part of several neurological disorders and aging-related diseases including, but not limited to, Alzheimer’s Disease, Frontotemporal Dementia with Parkinsonism, and Chronic Traumatic Encephalopathy. The major hallmarks present in these conditions include Tau pathology (composed of hyperphosphorylated Tau tangles) and synaptic loss. <em>in vivo</em> studies linking Tau pathology and mitochondrial alterations at the synapse, an avenue that could lead to synaptic loss, remain predominantly scarce. For this reason, using 3-month-old wild-type and human mutant Tau P301S transgenic mice, we investigated the association of Tau with mitochondria, synaptosome bioenergetics, and characterized excitatory synaptic loss across hippocampal regions (<em>Dentate Gyrus</em>, perisomatic CA3, and perisomatic CA1) and in the parietal cortex. We found a significant loss of excitatory synapses in the parietal cortex and hippocampal <em>Dentate Gyrus</em> (DG) of Tau P301S mice. Furthermore, we found that Tau (total and disease-relevant phosphorylated Tau) associates with both the non-synaptic and synaptic mitochondria of Tau P301S mice and this coincided with synaptic mitochondrial dysfunction. The findings presented here suggest that Tau associates with mitochondria at the synapse, leading to synaptic mitochondrial dysfunction, and likely contributing to synaptic loss.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 163-175"},"PeriodicalIF":3.7,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142952271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice 一种新的14聚体肽T14与雌性小鼠的年龄依赖性行为有关。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-15 DOI: 10.1016/j.neurobiolaging.2024.12.003

Sibah Hasan , Adam Mohammed Khan , Sara Garcia-Ratés , Robin A. Murphy , Susan A. Greenfield

{"title":"A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice","authors":"Sibah Hasan , Adam Mohammed Khan , Sara Garcia-Ratés , Robin A. Murphy , Susan A. Greenfield","doi":"10.1016/j.neurobiolaging.2024.12.003","DOIUrl":"10.1016/j.neurobiolaging.2024.12.003","url":null,"abstract":"<div><div>Age-related cognitive decline presents a healthcare challenge. While age-related mechanisms are mainly studied in humans, animal models provide key insights. Despite evidence of sex-specific differences in aging and cognition, the impact of age on female rodent behaviour is underexplored. This study investigated age-related behavioural changes in female C57BL/6 mice over 8 months, alongside neurochemical markers amyloid, Tau, and T14, a novel peptide from acetylcholinesterase (AChE) that promotes cell growth/renewal. Behavioural assessments showed an age-dependent decline in nest-building ability and familiar odour discrimination from 10 months. Spatial learning declined at 10 and 13 months, while object recognition memory remained intact from 5 to 13 months of age. Neurochemical analyses revealed a decline in T14 and its receptor α7-AChR during postnatal development and adulthood. However, there was a disparity between AChE expression and its enzymatic activity. T14 levels correlated with phosphorylated tau, but not amyloid, and negatively with nest-building scores, suggesting a role of T14 in age-related behavioural changes. This study highlights early behavioural and molecular indicators of cognitive decline in middle-aged female mice.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 88-97"},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling functional loss in Alzheimer’s Disease through cognitive reserve and cognitive state: A panel data longitudinal study 通过认知储备和认知状态模拟阿尔茨海默病的功能丧失：一项面板数据纵向研究。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-13 DOI: 10.1016/j.neurobiolaging.2024.12.002

Laura Veronelli , Giorgia Tosi , Daniele Romano , for the Alzheimer’s Disease Neuroimaging Initiative

{"title":"Modeling functional loss in Alzheimer’s Disease through cognitive reserve and cognitive state: A panel data longitudinal study","authors":"Laura Veronelli , Giorgia Tosi , Daniele Romano , for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2024.12.002","DOIUrl":"10.1016/j.neurobiolaging.2024.12.002","url":null,"abstract":"<div><div>Cognitive Reserve (CR) refers to the brain's ability, supported by active and modifiable forms of lifestyle compensation, to cope with neural changes due to age or disease, delaying the onset of cognitive deficits. In CR studies, neuropsychological performances and functional autonomy are considered alternative outcomes. While decreased functional independence gains importance in dementia diagnosis and monitoring, cognitive functioning may play a role in staging its severity. The main aim of the present study was to test a longitudinal model of Alzheimer’s Disease (AD), in which CR (years of education) and current cognitive status (Mini-Mental State Examination, MMSE, score) would predict clinical progression in terms of loss of functional independence at a later time. From the ADNI database, we considered 308 AD participants, and for 180 of them, we could extract CSF Aβ1–42 baseline levels as an index of amyloid burden. Functional decline (one-year delta score at the Functional Activities of Daily Living Questionnaire) was explained by the CR and MMSE score interaction net of age; a trend was found also when controlling for amyloid burden. Functional decline at one year was increased for patients with high CR levels and low MMSE and with low CR and high cognitive state, compared to the opposite. The present investigation demonstrated the mutual role of past acquired CR and current cognitive status in predicting functional progression in AD. The study suggests a way to predictively interpret available demographic and clinical data, defining differential longitudinal trajectories that might be useful for clinical management.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 60-67"},"PeriodicalIF":3.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer’s disease pathology α5-GABA-A受体阳性变构调节在阿尔茨海默病病理小鼠β-淀粉样蛋白沉积模型中的认知和神经营养益处

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-10 DOI: 10.1016/j.neurobiolaging.2024.12.001

Ashley M. Bernardo , Michael Marcotte , Kayla Wong , Dishary Sharmin , Kamal P. Pandey , James M. Cook , Etienne L. Sibille , Thomas D. Prevot

{"title":"Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer’s disease pathology","authors":"Ashley M. Bernardo , Michael Marcotte , Kayla Wong , Dishary Sharmin , Kamal P. Pandey , James M. Cook , Etienne L. Sibille , Thomas D. Prevot","doi":"10.1016/j.neurobiolaging.2024.12.001","DOIUrl":"10.1016/j.neurobiolaging.2024.12.001","url":null,"abstract":"<div><div>Reduced somatostatin (SST) and SST-expressing GABAergic neurons are well-replicated findings in Alzheimer’s disease (AD) and are associated with cognitive deficits. SST cells inhibit pyramidal cell dendrites through α5-GABA-A receptors (α5-GABAA-R). α5-GABAAR positive allosteric modulation (α5-PAM) has procognitive and neurotrophic effects in stress and aging models. We tested whether α5-PAM (GL-II-73) could prevent cognitive deficits and neuronal spine loss in early stages, and reverse them in late stages of β-amyloid deposition in the 5xFAD model (N = 48/study; 50 % female). Acute administration of GL-II-73 prevented spatial working memory deficits in 5xFAD mice at 2 months of age, while chronic administration reversed the deficits at 5 months of age. Chronic GL-II-73 treatment prevented 5xFAD-induced loss of spine density, spine count and dendritic length at both time points, despite β-amyloid accumulation. These results demonstrate procognitive and neurotrophic effects of GL-II-73 in early and late stages of Alzheimer-related β-amyloid deposition. This suggests α5-PAM as a novel β-amyloid-independent symptomatic therapeutic approach.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 49-59"},"PeriodicalIF":3.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging 脑老化中的变异：对衰老中功能网络的个性化研究方法的回顾和展望。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-07 DOI: 10.1016/j.neurobiolaging.2024.11.010

Diana C. Perez , Joanna J. Hernandez , Gretchen Wulfekuhle , Caterina Gratton

{"title":"Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging","authors":"Diana C. Perez , Joanna J. Hernandez , Gretchen Wulfekuhle , Caterina Gratton","doi":"10.1016/j.neurobiolaging.2024.11.010","DOIUrl":"10.1016/j.neurobiolaging.2024.11.010","url":null,"abstract":"<div><div>Healthy aging is associated with cognitive decline across multiple domains, including executive function, memory, and attention. These cognitive changes can often influence an individual’s ability to function and quality of life. However, the degree to which individuals experience cognitive decline, as well as the trajectory of these changes, exhibits wide variability across people. These cognitive abilities are thought to depend on the coordinated activity of large-scale networks. Like behavioral effects, large variation can be seen in brain structure and function with aging, including in large-scale functional networks. However, tracking this variation requires methods that reliably measure individual brain networks and their changes over time. Here, we review the literature on age-related cognitive decline and on age-related differences in brain structure and function. We focus particularly on functional networks and the individual variation that exists in these measures. We propose that novel individual-centered fMRI approaches can shed new light on patterns of inter- and intra-individual variability in aging. These approaches may be instrumental in understanding the neural bases of cognitive decline.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 68-87"},"PeriodicalIF":3.7,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults 中老年人海马微结构介导了睡眠和体力活动与认知的独立关联。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-05 DOI: 10.1016/j.neurobiolaging.2024.11.011

Daniel D. Callow , Adam P. Spira , Vadim Zipunnikov , Corinne Pettigrew , Andreia Faria , Sarah K. Wanigatunga , Marilyn Albert , Arnold Bakker , Anja Soldan , the BIOCARD Research Team

{"title":"Independent associations of sleep and physical activity with cognition are mediated by hippocampal microstructure in middle-aged and older adults","authors":"Daniel D. Callow , Adam P. Spira , Vadim Zipunnikov , Corinne Pettigrew , Andreia Faria , Sarah K. Wanigatunga , Marilyn Albert , Arnold Bakker , Anja Soldan , the BIOCARD Research Team","doi":"10.1016/j.neurobiolaging.2024.11.011","DOIUrl":"10.1016/j.neurobiolaging.2024.11.011","url":null,"abstract":"<div><div>Sleep and physical activity levels are both associated with cognitive performance among older adults; however, the brain mechanisms underlying these beneficial relationships remain poorly understood. This study investigated cross-sectional associations of actigraphic estimates of physical activity and sleep with cognition and diffusion imaging-based measures of medial temporal lobe (MTL) gray matter microstructural integrity in adults free of dementia. Participants were 132 older adults from the Biomarkers of Cognitive Decline Among Normal Individuals (BIOCARD) cohort study (119 cognitively unimpaired and 13 with mild cognitive impairment; mean age=70.8 years). Multiple linear regression analyses assessed the relationships between total volume of physical activity (TVPA), total sleep time (TST), and sleep efficiency (SE) with cognitive performance and MTL microstructural integrity. Results indicated that greater TVPA and SE were both independently associated with higher hippocampal and parahippocampal microstructure integrity (indicated by lower mean diffusivity) and better visuospatial processing abilities, independent of the volume of these structures and of amyloid burden, measured by positron emission tomography. Additionally, higher hippocampal microstructure statistically mediated the independent associations of physical activity and sleep with visuospatial abilities, independent of MTL volume and Aβ load. These findings suggest that physical activity and sleep are independently associated with cognitive performance, and that hippocampal microstructural integrity may be an underlying mechanism supporting these associations.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"Pages 22-31"},"PeriodicalIF":3.7,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0