Neurobiology of Aging最新文献

{"title":"Contrasting association pattern of plasma low-density lipoprotein with white matter integrity in APOE4 carriers versus non-carriers","authors":"Zhenyao Ye ,&nbsp;Yezhi Pan ,&nbsp;Rozalina G. McCoy ,&nbsp;Chuan Bi ,&nbsp;Chen Mo ,&nbsp;Li Feng ,&nbsp;Jiaao Yu ,&nbsp;Tong Lu ,&nbsp;Song Liu ,&nbsp;J. Carson Smith ,&nbsp;Minxi Duan ,&nbsp;Si Gao ,&nbsp;Yizhou Ma ,&nbsp;Chixiang Chen ,&nbsp;Braxton D. Mitchell ,&nbsp;Paul M. Thompson ,&nbsp;L. Elliot Hong ,&nbsp;Peter Kochunov ,&nbsp;Tianzhou Ma ,&nbsp;Shuo Chen","doi":"10.1016/j.neurobiolaging.2024.08.005","DOIUrl":"10.1016/j.neurobiolaging.2024.08.005","url":null,"abstract":"<div><p>Apolipoprotein E ε4 (<em>APOE4</em>) is a strong genetic risk factor of Alzheimer’s disease and metabolic dysfunction. However, whether <em>APOE4</em> and markers of metabolic dysfunction synergistically impact the deterioration of white matter (WM) integrity in older adults remains unknown. In the UK Biobank data, we conducted a multivariate analysis to investigate the interactions between <em>APOE4</em> and 249 plasma metabolites (measured using nuclear magnetic resonance spectroscopy) with whole-brain WM integrity (measured by diffusion-weighted magnetic resonance imaging) in a cohort of 1917 older adults (aged 65.0–81.0 years; 52.4 % female). Although no main association was observed between either <em>APOE4</em> or metabolites with WM integrity (adjusted <em>P</em> &gt; 0.05), significant interactions between <em>APOE4</em> and metabolites with WM integrity were identified. Among the examined metabolites, higher concentrations of low-density lipoprotein and very low-density lipoprotein were associated with a lower level of WM integrity (b=<span><math><mrow><mo>−</mo><mn>0.12</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.14</mn><mo>,</mo><mo>−</mo><mn>0.10</mn></mrow></mfenced></mrow></math></span>) among <em>APOE4</em> carriers. Conversely, among non-carriers, they were associated with a higher level of WM integrity (b=0.05, CI=<span><math><mrow><mfenced><mrow><mn>0.04,0.07</mn></mrow></mfenced></mrow></math></span>), demonstrating a significant moderation role of <em>APOE4</em> (b =<span><math><mrow><mo>−</mo><mn>0.18</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.20</mn><mo>,</mo><mo>−</mo><mn>0.15</mn></mrow></mfenced></mrow></math></span>, P&lt;0.00001).</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 41-52"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between brain structure and dual decline in gait and cognition","authors":"Sadhani Karunarathna ,&nbsp;Monique Breslin ,&nbsp;Jane Alty ,&nbsp;Richard Beare ,&nbsp;Taya A. Collyer ,&nbsp;Velandai K. Srikanth ,&nbsp;James Scott McDonald ,&nbsp;Michele L. Callisaya","doi":"10.1016/j.neurobiolaging.2024.08.004","DOIUrl":"10.1016/j.neurobiolaging.2024.08.004","url":null,"abstract":"<div><p>Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations of baseline brain structure with dual decliners using three serial gait speed and cognitive assessments in memory, processing speed-attention, and verbal fluency. Participants (n=267) were categorized based on annual decline in gait speed and cognitive measures. Lower gray and white matter volume and higher white matter hyperintensity volume increased the risk of being a dual decliner in gait and both the memory and processing speed-attention groups (all p &lt; 0.05). Lower hippocampal volume (p = 0.047) was only associated with dual decline in gait and memory group. No brain structures were correlated with dual decline in gait and verbal fluency. These results suggest that neurodegenerative pathology and white matter hyperintensities are involved in dual decline in gait and both memory and processing speed-attention. Smaller hippocampal volume may only contribute to dual decline in gait and memory.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 10-18"},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001386/pdfft?md5=3f3ee4f11a8de446b5c1252b938496ce&pid=1-s2.0-S0197458024001386-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults do not show enhanced benefits from multisensory information on speeded perceptual discrimination tasks","authors":"Christopher Atkin ,&nbsp;Jemaine E. Stacey ,&nbsp;Harriet A. Allen ,&nbsp;Helen Henshaw ,&nbsp;Katherine L. Roberts ,&nbsp;Stephen P. Badham","doi":"10.1016/j.neurobiolaging.2024.08.003","DOIUrl":"10.1016/j.neurobiolaging.2024.08.003","url":null,"abstract":"<div><p>Some research has shown that older adults benefit more from multisensory information than do young adults. However, more recent evidence has shown that the multisensory age benefit varies considerably across tasks. In the current study, older (65 – 80) and young (18 – 30) adults (<em>N</em> = 191) completed a speeded perceptual discrimination task either online or face-to-face to assess task response speed. We examined whether presenting stimuli in multiple sensory modalities (audio-visual) instead of one (audio-only or visual-only) benefits older adults more than young adults. Across all three experiments, a consistent speeding of response was found in the multisensory condition compared to the unisensory conditions for both young and older adults. Furthermore, race model analysis showed a significant multisensory benefit across a broad temporal interval. Critically, there were no significant differences between young and older adults. Taken together, these findings provide strong evidence in favour of a multisensory benefit that does not differ across age groups, contrasting with prior research.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 65-72"},"PeriodicalIF":3.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001349/pdfft?md5=562261707f77496910d9ed7e9e43b249&pid=1-s2.0-S0197458024001349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks","authors":"George M. Opie ,&nbsp;James M. Hughes ,&nbsp;Rohan Puri","doi":"10.1016/j.neurobiolaging.2024.08.001","DOIUrl":"10.1016/j.neurobiolaging.2024.08.001","url":null,"abstract":"<div><p>While the <em>shape</em> of cortical oscillations is increasingly recognised to be physiologically and functionally informative, its relevance to the aging motor system has not been established. We therefore examined the shape of alpha and beta band oscillations recorded at rest, as well as during performance of simple and go/no-go reaction time tasks, in 33 young (23.3 ± 2.9 years, 27 females) and 27 older (60.0 ± 5.2 years, 23 females) adults. The shape of individual oscillatory cycles was characterised using a recently developed pipeline involving empirical mode decomposition, before being decomposed into waveform motifs using principal component analysis. This revealed four principal components that were uniquely influenced by task and/or age. These described specific dimensions of shape and tended to be modulated during the reaction phase of each task. Our results suggest that although oscillation shape is task-dependent, the nature of this effect is altered by advancing age, possibly reflecting alterations in cortical activity. These outcomes demonstrate the utility of this approach for understanding the neurophysiological effects of ageing.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 52-64"},"PeriodicalIF":3.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001325/pdfft?md5=70b87d1e5a245772f9470cc43494761b&pid=1-s2.0-S0197458024001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden","authors":"Simone Beer ,&nbsp;David Elmenhorst ,&nbsp;Gerard N. Bischof ,&nbsp;Alfredo Ramirez ,&nbsp;Andreas Bauer ,&nbsp;Alexander Drzezga ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2024.08.002","DOIUrl":"10.1016/j.neurobiolaging.2024.08.002","url":null,"abstract":"<div><p>Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome in Alzheimer’s disease as well as sleep measures. We examined whether a risk score calculated from several AQP4 single-nucleotide polymorphisms (SNPs) is related to Aβ neuropathology in older cognitively unimpaired white individuals. We used a machine learning approach and explainable artificial intelligence to extract information on synergistic effects of AQP4 SNPs on brain amyloid burden from the ADNI cohort. From this information, we formulated a sex-specific AQP4 SNP-based risk score and evaluated it using data from the screening process of the A4 study. We found in both cohorts significant associations of the risk score with brain amyloid burden. The results support the hypothesis of an involvement of the glymphatic system, and particularly AQP4, in brain amyloid aggregation pathology. They suggest also that different AQP4 SNPs exert a synergistic effect on the build-up of brain amyloid burden.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 19-29"},"PeriodicalIF":3.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001337/pdfft?md5=c5699bac2cc221af526e85186f349a58&pid=1-s2.0-S0197458024001337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(24)00127-1","DOIUrl":"10.1016/S0197-4580(24)00127-1","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Page IFC"},"PeriodicalIF":3.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001271/pdfft?md5=ee9c6407e2fa85942cf08dcabd62ec8c&pid=1-s2.0-S0197458024001271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifespan differences in hippocampal subregion connectivity patterns during movie watching","authors":"Can Fenerci ,&nbsp;Roni Setton ,&nbsp;Giulia Baracchini ,&nbsp;Jamie Snytte ,&nbsp;R. Nathan Spreng ,&nbsp;Cam CAN ,&nbsp;Signy Sheldon","doi":"10.1016/j.neurobiolaging.2024.06.006","DOIUrl":"10.1016/j.neurobiolaging.2024.06.006","url":null,"abstract":"<div><p>Age-related episodic memory decline is attributed to functional alternations in the hippocampus. Less clear is how aging affects the functional connections of the hippocampus to the rest of the brain during episodic memory processing. We examined fMRI data from the CamCAN dataset, in which a large cohort of participants watched a movie (N = 643; 18–88 years), a proxy for naturalistic episodic memory encoding. We examined connectivity profiles across the lifespan both within the hippocampus (anterior, posterior), and between the hippocampal subregions and cortical networks. Aging was associated with reductions in contralateral (left, right) but not ipsilateral (anterior, posterior) hippocampal subregion connectivity. Aging was primarily associated with increased coupling between the anterior hippocampus and regions affiliated with Control, Dorsal Attention and Default Mode networks, yet decreased coupling between the posterior hippocampus and a selection of these regions. Differences in age-related hippocampal-cortical, but not within-hippocampus circuitry selectively predicted worse memory performance. Our findings comprehensively characterize hippocampal functional topography in relation to cognition in older age, suggesting that shifts in cortico-hippocampal connectivity may be sensitive markers of age-related episodic memory decline.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 182-193"},"PeriodicalIF":3.7,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes","authors":"Camila de Ávila ,&nbsp;Crystal Suazo ,&nbsp;Jennifer Nolz ,&nbsp;J. Nicholas Cochran ,&nbsp;Qi Wang ,&nbsp;Ramon Velazquez ,&nbsp;Eric Dammer ,&nbsp;Benjamin Readhead ,&nbsp;Diego Mastroeni","doi":"10.1016/j.neurobiolaging.2024.06.007","DOIUrl":"10.1016/j.neurobiolaging.2024.06.007","url":null,"abstract":"<div><p>Women have a higher incidence of Alzheimer’s disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify genes that underpin sex-associated risk of AD. PIN1 is a key regulator of the tau phosphorylation signaling pathway; however, potential differences in PIN1 expression, in males and females, are still unknown. We analyzed brain transcriptomic datasets focusing on sex differences in PIN1 mRNA levels in an aging and AD cohort, which revealed reduced PIN1 levels primarily within females. We validated this observation in an independent dataset (ROS/MAP), which also revealed that PIN1 is negatively correlated with multiregional neurofibrillary tangle density and global cognitive function in females only. Additional analysis revealed a decrease in PIN1 in subjects with mild cognitive impairment (MCI) compared with aged individuals, again driven predominantly by female subjects. Histochemical analysis of PIN1 in AD and control male and female neocortex revealed an overall decrease in axonal PIN1 protein levels in females. These findings emphasize the importance of considering sex differences in AD research.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 160-170"},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001258/pdfft?md5=c32858ca61f61acfd6886574acd18ff8&pid=1-s2.0-S0197458024001258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in retinal function and structure in C57BL/6J and Thy1-YFPh mice","authors":"Pei Ying Lee,&nbsp;Bang V. Bui","doi":"10.1016/j.neurobiolaging.2024.06.005","DOIUrl":"10.1016/j.neurobiolaging.2024.06.005","url":null,"abstract":"<div><p>Age-related neuronal adaptations are known to help maintain function. This study aims to examine gross age-related <em>in vivo</em> retinal functional adaptations (using electroretinography) in young and middle aged C57BL/6J and Thy1-YFPh mice and to relate this to <em>in vivo</em> retinal structure (using optical coherence tomography). Electroretinography responses were generally larger in Thy1-YFPh mice than in C57BL/6J mice, with similar <em>in vivo</em> retinal layer thicknesses except for longer inner/outer photoreceptor segment in Thy1-YFPh mice. Relative to 3-month-old mice, 12-month-old mice showed reduced photoreceptor (C57BL/6J 84.0±2.5 %; Thy1-YFPh 80.2±5.2 %) and bipolar cell (C57BL/6J 75.6±2.3 %; Thy1-YFPh 68.1±5.5 %) function. There was relative preservation of ganglion cell function (C57BL/6J 79.7±3.7 %; Thy1-YFPh 91.7±5.0 %) with age, which was associated with increased b-wave (bipolar cell) sensitivities to light. Ganglion cell function was correlated with both b-wave amplitude and sensitivity. This study shows that there are normal age-related adaptations to preserve functional output. Different mouse strains may have varied age-related adaptation capacity and should be taken into consideration when examining age-related susceptibility to injury.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 171-181"},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001234/pdfft?md5=02b1a963332ac9bdba26abf96e92e507&pid=1-s2.0-S0197458024001234-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study","authors":"Hiroyuki Ohta ,&nbsp;Takashi Nozawa ,&nbsp;Takashi Nakano ,&nbsp;Yuji Morimoto ,&nbsp;Toshiaki Ishizuka","doi":"10.1016/j.neurobiolaging.2024.06.004","DOIUrl":"10.1016/j.neurobiolaging.2024.06.004","url":null,"abstract":"<div><p>This study explores the impact of aging on reinforcement learning in mice, focusing on changes in learning rates and behavioral strategies. A 5-armed bandit task (5-ABT) and a computational Q-learning model were used to evaluate the positive and negative learning rates and the inverse temperature across three age groups (3, 12, and 18 months). Results showed a significant decline in the negative learning rate of 18-month-old mice, which was not observed for the positive learning rate. This suggests that older mice maintain the ability to learn from successful experiences while decreasing the ability to learn from negative outcomes. We also observed a significant age-dependent variation in inverse temperature, reflecting a shift in action selection policy. Middle-aged mice (12 months) exhibited higher inverse temperature, indicating a higher reliance on previous rewarding experiences and reduced exploratory behaviors, when compared to both younger and older mice. This study provides new insights into aging research by demonstrating that there are age-related differences in specific components of reinforcement learning, which exhibit a non-linear pattern.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 8-16"},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}