Neurobiology of Aging最新文献

{"title":"The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study","authors":"Lars Michels ,&nbsp;Ruth O’Gorman-Tuura ,&nbsp;Dario Bachmann ,&nbsp;Susanne Müller ,&nbsp;Sandro Studer ,&nbsp;Antje Saake ,&nbsp;Esmeralda Gruber ,&nbsp;Katrin Rauen ,&nbsp;Andreas Buchmann ,&nbsp;Isabelle Zuber ,&nbsp;Christoph Hock ,&nbsp;Anton Gietl ,&nbsp;Valerie Treyer","doi":"10.1016/j.neurobiolaging.2024.08.010","DOIUrl":"10.1016/j.neurobiolaging.2024.08.010","url":null,"abstract":"<div><p>Glutathione (GSH) is a brain marker for oxidative stress and has previously been associated with cerebral amyloid deposition and memory decline. However, to date, no study has examined the links among GSH, sex, age, amyloid, and Apolipoprotein E (APOE) genotype in a large non-clinical cohort of older adults. We performed APOE genotyping, magnetic resonance spectroscopy (MRS) as well as simultaneous positron emission tomography with the radiotracer Flutemetamol (Amyloid-PET), in a group of older adults. The final analysis set comprised 140 healthy older adults (mean age: 64.7 years) and 49 participants with mild cognitive impairment (mean age: 71.4 years). We recorded metabolites in the posterior cingulate cortex (PCC) by a GSH-edited MEGAPRESS sequence. Structural equation modeling revealed that higher GSH levels were associated with female sex, but neither APOE- epsilon 4 carrier status nor age showed significant associations with GSH. Conversely, older age and the presence of an APOE4 allele, but not sex, are linked to higher global amyloid load. Our results suggest that the PCC shows sex-specific GSH alterations in older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 19-29"},"PeriodicalIF":3.7,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers","authors":"Agnès Pérez-Millan ,&nbsp;Bertrand Thirion ,&nbsp;Neus Falgàs ,&nbsp;Sergi Borrego-Écija ,&nbsp;Beatriz Bosch ,&nbsp;Jordi Juncà-Parella ,&nbsp;Adrià Tort-Merino ,&nbsp;Jordi Sarto ,&nbsp;Josep Maria Augé ,&nbsp;Anna Antonell ,&nbsp;Nuria Bargalló ,&nbsp;Mircea Balasa ,&nbsp;Albert Lladó ,&nbsp;Raquel Sánchez-Valle ,&nbsp;Roser Sala-Llonch","doi":"10.1016/j.neurobiolaging.2024.08.008","DOIUrl":"10.1016/j.neurobiolaging.2024.08.008","url":null,"abstract":"<div><p>Neuroimaging and fluid biomarkers are used to differentiate frontotemporal dementia (FTD) from Alzheimer’s disease (AD). We implemented a machine learning algorithm that provides individual probabilistic scores based on magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data. We investigated whether combining MRI and CSF levels could improve the diagnosis confidence. 215 AD patients, 103 FTD patients, and 173 healthy controls (CTR) were studied. With MRI data, we obtained an accuracy of 82 % for AD vs. FTD. A total of 74 % of FTD and 73 % of AD participants have a high probability of accurate diagnosis. Adding CSF-NfL and 14–3–3 levels improved the accuracy and the number of patients in the confidence group for differentiating FTD from AD. We obtain individual diagnostic probabilities with high precision to address the problem of confidence in the diagnosis. We suggest when MRI, CSF, or the combination are necessary to improve the FTD and AD diagnosis. This algorithm holds promise towards clinical applications as support to clinical findings or in settings with limited access to expert diagnoses.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 1-11"},"PeriodicalIF":3.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001453/pdfft?md5=27ed6918da1a31097d24f8f77b77fe57&pid=1-s2.0-S0197458024001453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(24)00140-4","DOIUrl":"10.1016/S0197-4580(24)00140-4","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Page IFC"},"PeriodicalIF":3.7,"publicationDate":"2024-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001404/pdfft?md5=a3bf977b52fd136a927f0b7d11a974e3&pid=1-s2.0-S0197458024001404-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142094772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults","authors":"Michelle You ,&nbsp;Cutter A. Lindbergh ,&nbsp;Renaud La Joie ,&nbsp;Emily W. Paolillo ,&nbsp;Rowan Saloner ,&nbsp;Valentina Diaz ,&nbsp;Devyn L. Cotter ,&nbsp;Samantha Walters ,&nbsp;Marie Altendahl ,&nbsp;Adam M. Staffaroni ,&nbsp;Joel H. Kramer ,&nbsp;Leslie S. Gaynor ,&nbsp;Kaitlin B. Casaletto","doi":"10.1016/j.neurobiolaging.2024.08.006","DOIUrl":"10.1016/j.neurobiolaging.2024.08.006","url":null,"abstract":"<div><p>Subjective cognitive concerns (SCC) are common even in cognitively normal older adults who lack objectively-detectable deficits on standard neuropsychological evaluation. The clinical relevance of these concerns, particularly considering the nature of concerns (e.g., memory versus non-memory), remains unclear. Thus, we examined whether baseline memory and non-memory SCC relate to longitudinal change in brain volume and neuropsychological test performance in 476 functionally-intact, objectively unimpaired older adults (<em>M</em>_<em>age</em> = 72y, 56 % female, follow-up time = 1 – 9 years). Mixed-effects models revealed that both higher baseline memory and non-memory SCC predicted greater atrophy in total gray matter and dorsolateral prefrontal cortex atrophy over time, while only memory SCC predicted steeper medial temporal lobe atrophy. Regarding neuropsychological performance, higher non-memory SCC predicted decline in processing speed performance, while memory SCC did not predict neuropsychological trajectories. SCC are a risk factor for more adverse brain and cognitive aging trajectories, even in functionally-intact, seemingly cognitively normal older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA","authors":"Virginia Quaresima ,&nbsp;Andrea Pilotto ,&nbsp;Chiara Trasciatti ,&nbsp;Chiara Tolassi ,&nbsp;Marta Parigi ,&nbsp;Diego Bertoli ,&nbsp;Cristina Mordenti ,&nbsp;Alice Galli ,&nbsp;Andrea Rizzardi ,&nbsp;Salvatore Caratozzolo ,&nbsp;Alberto Benussi ,&nbsp;Nicholas J. Ashton ,&nbsp;Kaj Blennow ,&nbsp;Henrik Zetterberg ,&nbsp;Silvia Giliani ,&nbsp;Duilio Brugnoni ,&nbsp;Alessandro Padovani","doi":"10.1016/j.neurobiolaging.2024.08.007","DOIUrl":"10.1016/j.neurobiolaging.2024.08.007","url":null,"abstract":"<div><p>Aim of the project was to evaluate the technical and clinical validity of plasma Lumipulse p-tau, Aβ42 and Aβ40 species and their correlation with CSF core Alzheimer’s Disease (AD) markers; a method comparison with SIMOA was also performed. One-hundred-thirthy-three participants, namely 55 A+T+N+ AD, 28 Neurodegenerative disorders (NDD) and 50 controls were enrolled for the study. Lumipulse technical validity showed high stability for p-tau181, Aβ42, and Aβ40, with higher stability of p-tau to repeated freezing thaw cycles. p-tau181 levels detected by both techniques were higher in AD compared to both NDD/controls and exhibited a similar correlation with CSF p-tau levels, whereas Aβ42 levels were slightly lower in AD with both methods. In the comparison between SIMOA and Lumipulse plasma markers, both techniques exhibited similar diagnostic accuracy for AD for p-tau181 (0.87; 95 %CI 0.81–0.94, vs 0.85; 95 %CI 0.78–0.93), whereas the best performance was reached by p-tau181/ Aβ42 Lumipulse ratio (ROC AUC 0.915, 95 %CI 0.86–0.97). The study thus confirmed the construct validity of both Lumipulse and SIMOA techniques for the identification of CSF AD pattern in clinical settings.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 30-40"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001374/pdfft?md5=a1f0f456d843a0edb19575e002f8adad&pid=1-s2.0-S0197458024001374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting association pattern of plasma low-density lipoprotein with white matter integrity in APOE4 carriers versus non-carriers","authors":"Zhenyao Ye ,&nbsp;Yezhi Pan ,&nbsp;Rozalina G. McCoy ,&nbsp;Chuan Bi ,&nbsp;Chen Mo ,&nbsp;Li Feng ,&nbsp;Jiaao Yu ,&nbsp;Tong Lu ,&nbsp;Song Liu ,&nbsp;J. Carson Smith ,&nbsp;Minxi Duan ,&nbsp;Si Gao ,&nbsp;Yizhou Ma ,&nbsp;Chixiang Chen ,&nbsp;Braxton D. Mitchell ,&nbsp;Paul M. Thompson ,&nbsp;L. Elliot Hong ,&nbsp;Peter Kochunov ,&nbsp;Tianzhou Ma ,&nbsp;Shuo Chen","doi":"10.1016/j.neurobiolaging.2024.08.005","DOIUrl":"10.1016/j.neurobiolaging.2024.08.005","url":null,"abstract":"<div><p>Apolipoprotein E ε4 (<em>APOE4</em>) is a strong genetic risk factor of Alzheimer’s disease and metabolic dysfunction. However, whether <em>APOE4</em> and markers of metabolic dysfunction synergistically impact the deterioration of white matter (WM) integrity in older adults remains unknown. In the UK Biobank data, we conducted a multivariate analysis to investigate the interactions between <em>APOE4</em> and 249 plasma metabolites (measured using nuclear magnetic resonance spectroscopy) with whole-brain WM integrity (measured by diffusion-weighted magnetic resonance imaging) in a cohort of 1917 older adults (aged 65.0–81.0 years; 52.4 % female). Although no main association was observed between either <em>APOE4</em> or metabolites with WM integrity (adjusted <em>P</em> &gt; 0.05), significant interactions between <em>APOE4</em> and metabolites with WM integrity were identified. Among the examined metabolites, higher concentrations of low-density lipoprotein and very low-density lipoprotein were associated with a lower level of WM integrity (b=<span><math><mrow><mo>−</mo><mn>0.12</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.14</mn><mo>,</mo><mo>−</mo><mn>0.10</mn></mrow></mfenced></mrow></math></span>) among <em>APOE4</em> carriers. Conversely, among non-carriers, they were associated with a higher level of WM integrity (b=0.05, CI=<span><math><mrow><mfenced><mrow><mn>0.04,0.07</mn></mrow></mfenced></mrow></math></span>), demonstrating a significant moderation role of <em>APOE4</em> (b =<span><math><mrow><mo>−</mo><mn>0.18</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.20</mn><mo>,</mo><mo>−</mo><mn>0.15</mn></mrow></mfenced></mrow></math></span>, P&lt;0.00001).</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 41-52"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between brain structure and dual decline in gait and cognition","authors":"Sadhani Karunarathna ,&nbsp;Monique Breslin ,&nbsp;Jane Alty ,&nbsp;Richard Beare ,&nbsp;Taya A. Collyer ,&nbsp;Velandai K. Srikanth ,&nbsp;James Scott McDonald ,&nbsp;Michele L. Callisaya","doi":"10.1016/j.neurobiolaging.2024.08.004","DOIUrl":"10.1016/j.neurobiolaging.2024.08.004","url":null,"abstract":"<div><p>Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations of baseline brain structure with dual decliners using three serial gait speed and cognitive assessments in memory, processing speed-attention, and verbal fluency. Participants (n=267) were categorized based on annual decline in gait speed and cognitive measures. Lower gray and white matter volume and higher white matter hyperintensity volume increased the risk of being a dual decliner in gait and both the memory and processing speed-attention groups (all p &lt; 0.05). Lower hippocampal volume (p = 0.047) was only associated with dual decline in gait and memory group. No brain structures were correlated with dual decline in gait and verbal fluency. These results suggest that neurodegenerative pathology and white matter hyperintensities are involved in dual decline in gait and both memory and processing speed-attention. Smaller hippocampal volume may only contribute to dual decline in gait and memory.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 10-18"},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001386/pdfft?md5=3f3ee4f11a8de446b5c1252b938496ce&pid=1-s2.0-S0197458024001386-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults do not show enhanced benefits from multisensory information on speeded perceptual discrimination tasks","authors":"Christopher Atkin ,&nbsp;Jemaine E. Stacey ,&nbsp;Harriet A. Allen ,&nbsp;Helen Henshaw ,&nbsp;Katherine L. Roberts ,&nbsp;Stephen P. Badham","doi":"10.1016/j.neurobiolaging.2024.08.003","DOIUrl":"10.1016/j.neurobiolaging.2024.08.003","url":null,"abstract":"<div><p>Some research has shown that older adults benefit more from multisensory information than do young adults. However, more recent evidence has shown that the multisensory age benefit varies considerably across tasks. In the current study, older (65 – 80) and young (18 – 30) adults (<em>N</em> = 191) completed a speeded perceptual discrimination task either online or face-to-face to assess task response speed. We examined whether presenting stimuli in multiple sensory modalities (audio-visual) instead of one (audio-only or visual-only) benefits older adults more than young adults. Across all three experiments, a consistent speeding of response was found in the multisensory condition compared to the unisensory conditions for both young and older adults. Furthermore, race model analysis showed a significant multisensory benefit across a broad temporal interval. Critically, there were no significant differences between young and older adults. Taken together, these findings provide strong evidence in favour of a multisensory benefit that does not differ across age groups, contrasting with prior research.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 65-72"},"PeriodicalIF":3.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001349/pdfft?md5=562261707f77496910d9ed7e9e43b249&pid=1-s2.0-S0197458024001349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks","authors":"George M. Opie ,&nbsp;James M. Hughes ,&nbsp;Rohan Puri","doi":"10.1016/j.neurobiolaging.2024.08.001","DOIUrl":"10.1016/j.neurobiolaging.2024.08.001","url":null,"abstract":"<div><p>While the <em>shape</em> of cortical oscillations is increasingly recognised to be physiologically and functionally informative, its relevance to the aging motor system has not been established. We therefore examined the shape of alpha and beta band oscillations recorded at rest, as well as during performance of simple and go/no-go reaction time tasks, in 33 young (23.3 ± 2.9 years, 27 females) and 27 older (60.0 ± 5.2 years, 23 females) adults. The shape of individual oscillatory cycles was characterised using a recently developed pipeline involving empirical mode decomposition, before being decomposed into waveform motifs using principal component analysis. This revealed four principal components that were uniquely influenced by task and/or age. These described specific dimensions of shape and tended to be modulated during the reaction phase of each task. Our results suggest that although oscillation shape is task-dependent, the nature of this effect is altered by advancing age, possibly reflecting alterations in cortical activity. These outcomes demonstrate the utility of this approach for understanding the neurophysiological effects of ageing.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 52-64"},"PeriodicalIF":3.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001325/pdfft?md5=70b87d1e5a245772f9470cc43494761b&pid=1-s2.0-S0197458024001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden","authors":"Simone Beer ,&nbsp;David Elmenhorst ,&nbsp;Gerard N. Bischof ,&nbsp;Alfredo Ramirez ,&nbsp;Andreas Bauer ,&nbsp;Alexander Drzezga ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2024.08.002","DOIUrl":"10.1016/j.neurobiolaging.2024.08.002","url":null,"abstract":"<div><p>Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome in Alzheimer’s disease as well as sleep measures. We examined whether a risk score calculated from several AQP4 single-nucleotide polymorphisms (SNPs) is related to Aβ neuropathology in older cognitively unimpaired white individuals. We used a machine learning approach and explainable artificial intelligence to extract information on synergistic effects of AQP4 SNPs on brain amyloid burden from the ADNI cohort. From this information, we formulated a sex-specific AQP4 SNP-based risk score and evaluated it using data from the screening process of the A4 study. We found in both cohorts significant associations of the risk score with brain amyloid burden. The results support the hypothesis of an involvement of the glymphatic system, and particularly AQP4, in brain amyloid aggregation pathology. They suggest also that different AQP4 SNPs exert a synergistic effect on the build-up of brain amyloid burden.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 19-29"},"PeriodicalIF":3.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001337/pdfft?md5=c5699bac2cc221af526e85186f349a58&pid=1-s2.0-S0197458024001337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}