Neurobiology of Aging最新文献_第9页

Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study 小鼠概率学习中与年龄有关的非线性差异：五臂强盗任务研究

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-26 DOI: 10.1016/j.neurobiolaging.2024.06.004

Hiroyuki Ohta , Takashi Nozawa , Takashi Nakano , Yuji Morimoto , Toshiaki Ishizuka

{"title":"Nonlinear age-related differences in probabilistic learning in mice: A 5-armed bandit task study","authors":"Hiroyuki Ohta , Takashi Nozawa , Takashi Nakano , Yuji Morimoto , Toshiaki Ishizuka","doi":"10.1016/j.neurobiolaging.2024.06.004","DOIUrl":"10.1016/j.neurobiolaging.2024.06.004","url":null,"abstract":"<div><p>This study explores the impact of aging on reinforcement learning in mice, focusing on changes in learning rates and behavioral strategies. A 5-armed bandit task (5-ABT) and a computational Q-learning model were used to evaluate the positive and negative learning rates and the inverse temperature across three age groups (3, 12, and 18 months). Results showed a significant decline in the negative learning rate of 18-month-old mice, which was not observed for the positive learning rate. This suggests that older mice maintain the ability to learn from successful experiences while decreasing the ability to learn from negative outcomes. We also observed a significant age-dependent variation in inverse temperature, reflecting a shift in action selection policy. Middle-aged mice (12 months) exhibited higher inverse temperature, indicating a higher reliance on previous rewarding experiences and reduced exploratory behaviors, when compared to both younger and older mice. This study provides new insights into aging research by demonstrating that there are age-related differences in specific components of reinforcement learning, which exhibit a non-linear pattern.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 8-16"},"PeriodicalIF":3.7,"publicationDate":"2024-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141727584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set 脑血管疾病和阿尔茨海默病病理变化与认知能力下降的关系：国家阿尔茨海默氏症协调中心统一数据集分析

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-21 DOI: 10.1016/j.neurobiolaging.2024.06.002

Ankita Chatterjee , Shannon Lee , Valentina Diaz , Rowan Saloner , Mark Sanderson-Cimino , Charles deCarli , Pauline Maillard , Jason Hinman , Keith Vossel , Kaitlin B. Casaletto , Adam M. Staffaroni , Emily W. Paolillo , Joel H. Kramer

{"title":"Associations of cerebrovascular disease and Alzheimer’s disease pathology with cognitive decline: Analysis of the National Alzheimer’s Coordinating Center Uniform Data Set","authors":"Ankita Chatterjee , Shannon Lee , Valentina Diaz , Rowan Saloner , Mark Sanderson-Cimino , Charles deCarli , Pauline Maillard , Jason Hinman , Keith Vossel , Kaitlin B. Casaletto , Adam M. Staffaroni , Emily W. Paolillo , Joel H. Kramer","doi":"10.1016/j.neurobiolaging.2024.06.002","DOIUrl":"10.1016/j.neurobiolaging.2024.06.002","url":null,"abstract":"<div><p>Cerebrovascular disease (CVD) and Alzheimer’s disease (AD) often co-occur and may impact specific cognitive domains. This study’s goal was to determine effects of CVD and AD burden on cross-sectional and longitudinal executive function (EF) and memory in older adults.</p><p>Longitudinally followed participants from the National Alzheimer Coordinating Center database (n = 3342) were included. Cognitive outcomes were EF and memory composite scores. Baseline CVD presence was defined by moderate-to-severe white matter hyperintensities or lacunar infarct on MRI. Baseline AD pathology was defined by amyloid positivity via PET or CSF. Linear mixed models examined effects of CVD, AD, and time on cognitive outcomes, controlling for sex, education, baseline age, MoCA score, and total number of study visits.</p><p>At baseline, CVD associated with lower EF (p < 0.001), while AD associated with lower EF and memory (ps < 0.001). Longitudinally only AD associated with faster declines in memory and EF (ps < 0.001).</p><p>These results extend our understanding of CVD and AD pathology, highlighting that CVD does not necessarily indicate accelerated decline.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 1-7"},"PeriodicalIF":3.7,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001209/pdfft?md5=8720dbfa497c4bc9ebf648ef72b4054b&pid=1-s2.0-S0197458024001209-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638563","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with 11C-PiB beta-amyloid PET and 7T magnetic resonance spectroscopy 利用 11C-PiB beta-amyloid PET 和 7T 磁共振波谱对轻度认知障碍和晚年抑郁症的神经病理学和神经代谢物进行多模式研究。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-20 DOI: 10.1016/j.neurobiolaging.2024.06.003

Christopher W. Davies-Jenkins , Clifford I. Workman , Kathleen E. Hupfeld , Helge J. Zöllner , Jeannie-Marie Leoutsakos , Michael A. Kraut , Peter B. Barker , Gwenn S. Smith , Georg Oeltzschner

{"title":"Multimodal investigation of neuropathology and neurometabolites in mild cognitive impairment and late-life depression with 11C-PiB beta-amyloid PET and 7T magnetic resonance spectroscopy","authors":"Christopher W. Davies-Jenkins , Clifford I. Workman , Kathleen E. Hupfeld , Helge J. Zöllner , Jeannie-Marie Leoutsakos , Michael A. Kraut , Peter B. Barker , Gwenn S. Smith , Georg Oeltzschner","doi":"10.1016/j.neurobiolaging.2024.06.003","DOIUrl":"10.1016/j.neurobiolaging.2024.06.003","url":null,"abstract":"<div><p>Positron emission tomography (PET) and magnetic resonance spectroscopy (<sup>1</sup>H-MRS) are complementary techniques that can be applied to study how proteinopathy and neurometabolism relate to cognitive deficits in preclinical stages of Alzheimer’s disease (AD)—mild cognitive impairment (MCI) and late-life depression (LLD). We acquired beta-amyloid (Aβ) PET and 7 T <sup>1</sup>H-MRS measures of GABA, glutamate, glutathione, N-acetylaspartate, N-acetylaspartylglutamate, myo-inositol, choline, and lactate in the anterior and posterior cingulate cortices (ACC, PCC) in 13 MCI and 9 LLD patients, and 13 controls. We used linear regression to examine associations between metabolites, Aβ, and cognitive scores, and whether metabolites and Aβ explained cognitive scores better than Aβ alone. In the ACC, higher Aβ was associated with lower GABA in controls but not MCI or LLD patients, but results depended upon MRS data quality control criteria. Greater variance in California Verbal Learning Test scores was better explained by a model that combined ACC glutamate and Aβ deposition than by models that only included one of these variables. These findings identify preliminary associations between Aβ, neurometabolites, and cognition.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 27-40"},"PeriodicalIF":3.7,"publicationDate":"2024-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141902477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer’s disease and a history of traumatic brain injury 阿尔茨海默病患者的脑脊液生物标志物和认知轨迹以及脑外伤史

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-14 DOI: 10.1016/j.neurobiolaging.2024.06.001

Suzan van Amerongen , Shreyasee Das , Suzie Kamps , Julie Goossens , Bram Bongers , Yolande A.L. Pijnenburg , Eugeen Vanmechelen , Everard G.B. Vijverberg , Charlotte E. Teunissen , Inge M.W. Verberk

{"title":"Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer’s disease and a history of traumatic brain injury","authors":"Suzan van Amerongen , Shreyasee Das , Suzie Kamps , Julie Goossens , Bram Bongers , Yolande A.L. Pijnenburg , Eugeen Vanmechelen , Everard G.B. Vijverberg , Charlotte E. Teunissen , Inge M.W. Verberk","doi":"10.1016/j.neurobiolaging.2024.06.001","DOIUrl":"10.1016/j.neurobiolaging.2024.06.001","url":null,"abstract":"<div><p>Traumatic brain injury (TBI) and Alzheimer’s disease (AD) have overlapping mechanisms but it remains unknown if pathophysiological characteristics and cognitive trajectories in AD patients are influenced by TBI history. Here, we studied AD patients (stage MCI or dementia) with TBI history (AD<sup>TBI+,</sup> n=110), or without (AD<sup>TBI-</sup>, n=110) and compared baseline CSF concentrations of amyloid beta 1–42 (Aβ42), phosphorylated tau181 (pTau181), total tau, neurofilament light chain (NfL), synaptosomal associated protein-25kDa (SNAP25), neurogranin (Ng), neuronal pentraxin-2 (NPTX2) and glutamate receptor-4 (GluR4), as well as differences in cognitive trajectories using linear mixed models. Explorative, analyses were repeated within stratified TBI groups by TBI characteristics (timing, severity, number). We found no differences in baseline CSF biomarker concentrations nor in cognitive trajectories between AD<sup>TBI+</sup> and AD<sup>TBI-</sup> patients. TBI >5 years ago was associated with higher NPTX2 and a tendency for higher SNAP25 concentrations compared to TBI ≤ 5 years ago, suggesting that TBI may be associated with long-term synaptic dysfunction only when occurring before onset or in a pre-clinical disease stage of AD.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 121-128"},"PeriodicalIF":3.7,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001192/pdfft?md5=0928a431c4d50a9745ff24f2e3b90e2f&pid=1-s2.0-S0197458024001192-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141391569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Editorial Advisory Board 编辑顾问委员会

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-06-08 DOI: 10.1016/S0197-4580(24)00110-6

引用次数: 0

Menopause status- and sex-related differences in age associations with spatial context memory and white matter microstructure at midlife 更年期状态与中年空间情境记忆和白质微结构年龄相关性和性别相关性的差异

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-08 DOI: 10.1016/j.neurobiolaging.2024.05.017

Rikki Lissaman , Sricharana Rajagopal , Julia Kearley , Stamatoula Pasvanis , Maria Natasha Rajah

{"title":"Menopause status- and sex-related differences in age associations with spatial context memory and white matter microstructure at midlife","authors":"Rikki Lissaman , Sricharana Rajagopal , Julia Kearley , Stamatoula Pasvanis , Maria Natasha Rajah","doi":"10.1016/j.neurobiolaging.2024.05.017","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.05.017","url":null,"abstract":"<div><p>Decline in spatial context memory emerges in midlife, the time when most females transition from pre- to post-menopause. Recent evidence suggests that, among post-menopausal females, advanced age is associated with functional brain alterations and lower spatial context memory. However, it is unknown whether similar effects are evident for white matter (WM) and, moreover, whether such effects contribute to sex differences at midlife. To address this, we conducted a study on 96 cognitively unimpaired middle-aged adults (30 males, 32 pre-menopausal females, 34 post-menopausal females). Spatial context memory was assessed using a face-location memory paradigm, while WM microstructure was assessed using diffusion tensor imaging. Behaviorally, advanced age was associated with lower spatial context memory in post-menopausal females but not pre-menopausal females or males. Additionally, advanced age was associated with microstructural variability in predominantly frontal WM (e.g., anterior corona radiata, genu of corpus callosum), which was related to lower spatial context memory among post-menopausal females. Our findings suggest that post-menopausal status enhances vulnerability to age effects on the brain’s WM and episodic memory.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 151-159"},"PeriodicalIF":3.7,"publicationDate":"2024-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001155/pdfft?md5=ba0dbd9649fcb4efd3bf480369ec6cc7&pid=1-s2.0-S0197458024001155-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141482567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans 下丘脑 MRI 衍生微结构与人类神经认知衰老有关

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-06-03 DOI: 10.1016/j.neurobiolaging.2024.05.018

Sandra Aleksic , Roman Fleysher , Erica F. Weiss , Noa Tal , Timothy Darby , Helena M. Blumen , Juan Vazquez , Kenny Q. Ye , Tina Gao , Shira M. Siegel , Nir Barzilai , Michael L. Lipton , Sofiya Milman

{"title":"Hypothalamic MRI-derived microstructure is associated with neurocognitive aging in humans","authors":"Sandra Aleksic , Roman Fleysher , Erica F. Weiss , Noa Tal , Timothy Darby , Helena M. Blumen , Juan Vazquez , Kenny Q. Ye , Tina Gao , Shira M. Siegel , Nir Barzilai , Michael L. Lipton , Sofiya Milman","doi":"10.1016/j.neurobiolaging.2024.05.018","DOIUrl":"10.1016/j.neurobiolaging.2024.05.018","url":null,"abstract":"<div><p>The hypothalamus regulates homeostasis across the lifespan and is emerging as a regulator of aging. In murine models, aging-related changes in the hypothalamus, including microinflammation and gliosis, promote accelerated neurocognitive decline. We investigated relationships between hypothalamic microstructure and features of neurocognitive aging, including cortical thickness and cognition, in a cohort of community-dwelling older adults (age range 65–97 years, n=124). Hypothalamic microstructure was evaluated with two magnetic resonance imaging diffusion metrics: mean diffusivity (MD) and fractional anisotropy (FA), using a novel image processing pipeline. Hypothalamic MD was cross-sectionally positively associated with age and it was negatively associated with cortical thickness. Hypothalamic FA, independent of cortical thickness, was cross-sectionally positively associated with neurocognitive scores. An exploratory analysis of longitudinal neurocognitive performance suggested that lower hypothalamic FA may predict cognitive decline. No associations between hypothalamic MD, age, and cortical thickness were identified in a younger control cohort (age range 18–63 years, n=99). To our knowledge, this is the first study to demonstrate that hypothalamic microstructure is associated with features of neurocognitive aging in humans.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 102-112"},"PeriodicalIF":4.2,"publicationDate":"2024-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141274954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease 端粒长度与阿尔茨海默氏症高危人群认知功能之间的关系。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-06-01 DOI: 10.1016/j.neurobiolaging.2024.05.015

Blanca Rodríguez-Fernández , Gonzalo Sánchez-Benavides , Patricia Genius , Carolina Minguillon , Karine Fauria , Immaculata De Vivo , Arcadi Navarro , Jose Luis Molinuevo , Juan Domingo Gispert , Aleix Sala-Vila , Natalia Vilor-Tejedor , Marta Crous-Bou , for the ALFA study

{"title":"Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer’s disease","authors":"Blanca Rodríguez-Fernández , Gonzalo Sánchez-Benavides , Patricia Genius , Carolina Minguillon , Karine Fauria , Immaculata De Vivo , Arcadi Navarro , Jose Luis Molinuevo , Juan Domingo Gispert , Aleix Sala-Vila , Natalia Vilor-Tejedor , Marta Crous-Bou , for the ALFA study","doi":"10.1016/j.neurobiolaging.2024.05.015","DOIUrl":"10.1016/j.neurobiolaging.2024.05.015","url":null,"abstract":"<div><h3>Introduction</h3><p>Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.</p></div><div><h3>Methods</h3><p>A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.</p></div><div><h3>Results</h3><p>Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.</p></div><div><h3>Discussion</h3><p>Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 140-150"},"PeriodicalIF":3.7,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001088/pdfft?md5=e4233d2783bef079b1bb7248ca2acd9c&pid=1-s2.0-S0197458024001088-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141233040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between cortical thickness and white matter hyperintensities in mid to late life 中晚年皮质厚度与白质高密度之间的关系

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-05-29 DOI: 10.1016/j.neurobiolaging.2024.05.014

Joan Jiménez-Balado , Christian Habeck , Yaakov Stern , Teal Eich

{"title":"The relationship between cortical thickness and white matter hyperintensities in mid to late life","authors":"Joan Jiménez-Balado , Christian Habeck , Yaakov Stern , Teal Eich","doi":"10.1016/j.neurobiolaging.2024.05.014","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.05.014","url":null,"abstract":"<div><p>White matter hyperintensities (WMH) are associated with cortical thinning. Although they are primarily detected in older participants, these lesions can appear in younger and midlife individuals. Here, we tested whether WMH are associated with cortical thinning in relatively younger (26–50 years) and relatively older (58–84) participants who were free of dementia, and how these associations are moderated by WMH localization. WMH were automatically quantified and categorized according to the localization of three classes of white matter tracts: association, commissural and projection fibers. Mediation analyses were used to infer whether differences in cortical thickness between younger and older participants were explained by WMH. Our results revealed that total WMH explained between 20.6 % and 65.5 % of the effect of age on cortical thickness in AD-signature regions including the lateral temporal lobes and supramarginal gyrus, among others. This mediation was slightly stronger for projection WMH, although it was still significant for association and commissural WMH. These results suggest that there is an interplay between vascular and AD causes of cognitive impairment that starts at younger ages.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 129-139"},"PeriodicalIF":3.7,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141438179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s disease 年龄调整后的脑脊液 t-tau 和 NfL 不能提高阿尔茨海默病前兆的诊断准确性

IF 4.2 3区医学

Neurobiology of Aging Pub Date : 2024-05-29 DOI: 10.1016/j.neurobiolaging.2024.05.016

Stephanie Lindgård Knudtzon , Kaja Nordengen , Gøril Rolfseng Grøntvedt , Jonas Jarholm , Ingvild Vøllo Eliassen , Per Selnes , Lene Pålhaugen , Jacob Espenes , Berglind Gísladóttir , Knut Waterloo , Tormod Fladby , Bjørn-Eivind Kirsebom

{"title":"Age-adjusted CSF t-tau and NfL do not improve diagnostic accuracy for prodromal Alzheimer’s disease","authors":"Stephanie Lindgård Knudtzon , Kaja Nordengen , Gøril Rolfseng Grøntvedt , Jonas Jarholm , Ingvild Vøllo Eliassen , Per Selnes , Lene Pålhaugen , Jacob Espenes , Berglind Gísladóttir , Knut Waterloo , Tormod Fladby , Bjørn-Eivind Kirsebom","doi":"10.1016/j.neurobiolaging.2024.05.016","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.05.016","url":null,"abstract":"<div><p>Cerebrospinal fluid total-tau (t-tau) and neurofilament light chain (NfL) are biomarkers of neurodegeneration and are increased in Alzheimer’s disease (AD). In order to adjust for age-related increases in t-tau and NfL, cross-sectional age-adjusted norms were developed based on amyloid negative cognitively normal (CN) adults aged 41–78 years (CN, n = 137). The age-adjusted norms for t-tau and NfL did not improve receiver operating curve based diagnostic accuracies in individuals with mild cognitive impairment (MCI) due to AD (AD-MCI, n = 144). Furthermore, while NfL was correlated with higher age in AD-MCI, no significant correlation was found for t-tau. The cox proportional hazard models, applied in 429 participants with baseline t-tau and NfL, showed higher hazard ratio of progression to MCI or dementia without age-adjustments (HR = 3.39 for t-tau and HR = 3.17 for NfL), as compared to using our norms (HR = 2.29 for t-tau and HR = 1.89 for NfL). Our results indicate that utilizing normative reference data could obscure significant age-related increases in these markers associated with neurodegeneration and AD leading to a potential loss of overall diagnostic accuracy.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 74-84"},"PeriodicalIF":4.2,"publicationDate":"2024-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001076/pdfft?md5=1be7dd54d842fe2d83c9e6dc8b226de6&pid=1-s2.0-S0197458024001076-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141250518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0