Neurobiology of Aging最新文献

{"title":"Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis","authors":"Avinash Chandra ,&nbsp;Benjamin A. Levett ,&nbsp;Sheena Waters ,&nbsp;Petroula Proitsi ,&nbsp;Yue Liu ,&nbsp;Chris J.D. Hardy ,&nbsp;Jason D. Warren ,&nbsp;Charles R. Marshall","doi":"10.1016/j.neurobiolaging.2025.07.003","DOIUrl":"10.1016/j.neurobiolaging.2025.07.003","url":null,"abstract":"<div><div>Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not clear. In this systematic review and meta-analysis, we evaluated associations between hearing loss and Alzheimer’s disease (AD) neuropathology, specifically β-amyloid (Aβ) and tau burden. Databases including PubMed, MEDLINE via Ovid, Web of Science, and EMBASE were searched to identify cohort and cross-sectional studies that examined the relationship between hearing loss and Aβ and/or tau neuropathology in humans. Meta-analyses were conducted using random-effects models and examined associations between hearing loss, either peripheral, central, or subjective, and <em>in vivo</em> AD neuropathology measured through PET or CSF. Estimates were converted to correlation coefficients prior to quantitative analysis. 6224 records were screened, of which 22 studies were included in the review. Significant associations between hearing loss and both Aβ (r, 0.09; 95 % CI, 0.02–0.16) and tau burden (r,0.16; 95 % CI, 0.08–0.23), were found across cross-sectional <em>in vivo</em> studies. However, in subgroup analyses, associations between Aβ burden and hearing loss were only significant for studies using central hearing measures or PET. Findings from studies in the systematic review, including post-mortem and longitudinal ones, were mixed. This study provides evidence for an association between hearing loss and AD neuropathology. The pattern of stronger meta-analytic findings localised to central hearing, PET, and tau studies suggests that higher levels of neuropathological burden may be linked to dysfunction in central auditory processing. The causality underpinning this relationship should be investigated in future studies.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 92-102"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of age on the strategic control of recollected content as reflected by modulation of neural correlates of scene retrieval","authors":"Marianne de Chastelaine ,&nbsp;Sabina Srokova ,&nbsp;Sarah Monier ,&nbsp;Joshua M. Olivier ,&nbsp;Michael D. Rugg","doi":"10.1016/j.neurobiolaging.2025.06.005","DOIUrl":"10.1016/j.neurobiolaging.2025.06.005","url":null,"abstract":"<div><div>A previous study employing fMRI measures of retrieval-related neural selectivity reported that young, but not older, adults employ ‘retrieval gating’ to attenuate aspects of an episodic memory that are irrelevant to the retrieval goal. We examined whether the weak memories of the older adults in that study rendered goal-irrelevant memories insufficiently intrusive to motivate retrieval gating. Young and older participants studied words superimposed on rural or urban scenes, or on scrambled backgrounds. To strengthen memory for background information, word-image pairs were studied twice, initially centrally, and then in one of three locations. During scanning, one retrieval test probed memory for the test words’ studied backgrounds and another test assessed memory for their location. Background memory performance was markedly higher than in the prior study. Retrieval gating was examined in two scene-selective regions of interest, the parahippocampal place area (PPA) and the medial place area (MPA). In the background task, robust scene-specific retrieval effects were identified in both age groups in both ROIs. These effects were attenuated (‘gated’) in the location task in the young age group only, replicating the prior finding. The results did not differ when the two groups were sub-sampled to match strength of scene-specific retrieval effects when scene information was goal relevant. The findings indicate that older adults’ failure to gate goal-irrelevant scene information does not reflect age differences in memory strength and may instead reflect an age-related decline in top-down inhibitory control.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 1-15"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Elevation of cytoskeletal protein breakdown in aged Wistar rat brain” [Neurobiol. Aging 27 (2006) 624–632]","authors":"Eric Bernath ,&nbsp;Nancy Kupina ,&nbsp;Ming Cheng Liu ,&nbsp;Ronald L. Hayes ,&nbsp;Colleen Meegan ,&nbsp;Kevin K.W. Wang","doi":"10.1016/j.neurobiolaging.2025.04.004","DOIUrl":"10.1016/j.neurobiolaging.2025.04.004","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Page 103"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explaining tip-of-the-tongue experiences in older adults: The role of brain-based and cardiorespiratory fitness factors","authors":"Foyzul Rahman ,&nbsp;Kamen A. Tsvetanov ,&nbsp;Jack Feron ,&nbsp;Karen Mullinger ,&nbsp;Kelsey Joyce ,&nbsp;Ahmed Gilani ,&nbsp;Eunice G. Fernandes ,&nbsp;Allison Wetterlin ,&nbsp;Linda Wheeldon ,&nbsp;Samuel J.E. Lucas ,&nbsp;Katrien Segaert","doi":"10.1016/j.neurobiolaging.2025.06.008","DOIUrl":"10.1016/j.neurobiolaging.2025.06.008","url":null,"abstract":"<div><div>Cognitive decline associated with healthy ageing is multifactorial: brain-based and lifestyle factors uniquely and jointly contribute to distinct neurocognitive trajectories of ageing. To evaluate existing models of neurocognitive ageing such as compensation, maintenance, or reserve, we explore how various known brain-based and cardiorespiratory fitness factors intersect to better understand cognitive decline. In a pre-registered study (<span><span>https://osf.io/6fqg7</span><svg><path></path></svg></span>), we tested 73 healthy older adults aged 60—81 (<em>M</em> = 65.51, <em>SD</em> = 4.94) and collected neuroimaging (functional, structural, and perfusion MRI), cardiorespiratory fitness, and cognitive data to investigate a prominent challenge for older adults: word-finding failures. fMRI signal was recorded while participants responded to a definition-based tip-of-the-tongue task, T1-weighted imaging estimated grey matter volume, and cerebral blood flow was indexed using multi-delay pseudo-continuous arterial spin labelling. Commonality analyses were used to analyse these multi-domain data (neuroimaging, cardiorespiratory fitness, language skills, demographic characteristics) and uncover associations between predictors in explaining age-related tip-of-the-tongue rates. Commonality analyses revealed that functional activation of language networks associated with tip-of-the-tongue states is in part linked with age and, interestingly, cardiorespiratory fitness: the combination of higher cardiorespiratory fitness and functional recruitment in some older adults offsets part of the age-related variance in tip-of-the-tongues. Moreover, age-associated atrophy and perfusion in regions other than those showing functional differences accounted for variance in tip-of-the-tongues. Our findings can be interpreted in the context of the classic models of neurocognitive ageing, suggesting compensation. Brain health indices in concordance with cardiorespiratory fitness can provide a more holistic explanation of individual differences in age-related cognitive decline.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 25-36"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two-year changes in hippocampal subfield volumes are age-dependent across the lifespan","authors":"Roya Homayouni ,&nbsp;Samaah Saifullah ,&nbsp;Alexis N. Chargo ,&nbsp;Kelsey L. Canada ,&nbsp;Naftali Raz ,&nbsp;Noa Ofen ,&nbsp;Ana M. Daugherty","doi":"10.1016/j.neurobiolaging.2025.06.011","DOIUrl":"10.1016/j.neurobiolaging.2025.06.011","url":null,"abstract":"<div><div>The hippocampus (Hc), which is crucial for memory across the lifespan, is comprised of distinct subfields: dentate gyrus (DG), Cornu Ammonis (CA) sectors 1–3, and subiculum. Cross-sectional studies show that Hc subfield volumes exhibit a differential association with age across the lifespan. However, the evidence of age-related changes and individual variability in developmental trajectories is sparse. We examined changes in Hc subfield volumes in a large normative lifespan sample (<em>N</em> = 474 at baseline, <em>n</em> = 189 at follow-up; mean interval = 2.5 years) while comparing patterns of change in children (ages 5–10.9 years), adolescents (ages 11–18.9 years), young (ages 19–35.9 years), middle-aged (ages 36–55.9 years), and older adults (ages 56–73.9 years). In a pooled lifespan sample, we observed no mean change in Hc subfield volumes. Nonetheless, there were significant individual differences in change for all subfields that depended on the baseline age. A general tendency for volume gain in young individuals attenuated in adulthood and shifted toward loss in late lifespan segments. Across age groups, CA1–2 volume increased into young adulthood, whereas DG-CA3 and subiculum volumes remained stable and declined significantly after age of 55 years. Thus, our results reveal age-related differences in Hc subfield volume changes over nearly the entire human lifespan. Our findings have significant implications for models of neural development and aging and for understanding lifespan trajectories of memory.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 62-70"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144549281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in the impact of background noise on neural speech tracking","authors":"Björn Herrmann","doi":"10.1016/j.neurobiolaging.2025.06.001","DOIUrl":"10.1016/j.neurobiolaging.2025.06.001","url":null,"abstract":"<div><div>Tracking the envelope of speech in the brain is important for speech comprehension. Recent research suggests that acoustic background noise can enhance neural speech tracking, enabling the auditory system to robustly encode speech even under unfavorable conditions. Aging and hearing loss are associated with internal, neural noise in the auditory system, raising the question whether additional acoustic background noise enhances neural speech tracking in older adults. In the current electroencephalography study, younger (∼25.5 years) and older adults (∼68.5 years) listened to spoken stories in quiet (clear) or in the presence of background noise at a wide range of different signal-to-noise ratios. In younger adults, early neural speech tracking responses (&lt;0.15 s) were enhanced by minimal background noise, indicating response facilitation through noise. In contrast, older adults, compared to younger adults, showed enhanced neural speech tracking for clear speech and speech masked by minimal background noise, but the acoustic noise led to little enhancement of the early neural tracking response in older people. The data demonstrate different sensitivity of the auditory cortex to speech masked by noise between younger and older adults. The results are consistent with the idea that the auditory cortex of older people exhibits more internal, neural noise that enhances neural speech tracking but that additional acoustic noise does not further support speech encoding. The work points to a highly non-linear auditory system that differs between younger and older adults.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"153 ","pages":"Pages 10-20"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biological age acceleration in Alzheimer’s disease modulates relative cortical to medial temporal lobe neurodegeneration","authors":"Lasya P. Sreepada ,&nbsp;Christopher A. Brown ,&nbsp;Sandhitsu R. Das ,&nbsp;Paul A. Yushkevich ,&nbsp;David A. Wolk ,&nbsp;Corey T. McMillan ,&nbsp;on behalf of the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2025.06.003","DOIUrl":"10.1016/j.neurobiolaging.2025.06.003","url":null,"abstract":"<div><div>Alzheimer’s disease (AD) is highly associated with aging, typically presenting with amnestic, multi-domain cognitive impairment and greater medial temporal lobe (MTL) atrophy relative to cortex. However, approximately 15 % of AD cases present atypically, often at younger ages and with greater cortical involvement relative to MTL. This association between age and AD presentation is imperfect: some younger-onset cases are typical, amnestic presentations while some older-onset cases present less typically. We hypothesize that this discordance may be partially modulated by discordance between chronological age and biological age, defined epigenetically. Participants from the Alzheimer’s Disease Neuroimaging Initiative with MRI and known amyloid status were selected (<em>n</em> = 1011, 44.4 % female, 75.33 ± 7.28 years) and classified as amyloid-negative, cognitively unimpaired (<em>n</em> = 329) or amyloid-positive, symptomatic individuals with mild cognitive impairment or dementia (<em>n</em> = 682). Biological age was estimated in individuals with DNA methylation (<em>n</em> = 448) using established epigenetic clocks. Biological age gap (BAG) was calculated to categorize individuals into “accelerated” (biological age &gt; chronological age) or “decelerated” (biological age &lt; chronological age) groups. We define the Cortico-Medial Temporal index (CoMeT), derived from MRI, to quantify age-adjusted relative differences between cortical and MTL structures. Lower CoMeT scores indicate relatively greater cortical involvement. BAG and CoMeT were significantly correlated (Pearson <em>R</em>=0.13, <em>p</em> = 0.023). Symptomatic individuals with decelerated BAG exhibited significantly lower CoMeT scores than individuals with accelerated BAG, with a large effect size, reflecting greater cortical involvement relative to MTL (Wilcoxon <em>p</em> = 0.023, rank-biserial correlation=−0.98). We conclude that biological aging modulates AD presentation beyond chronological age, providing novel insights into mechanisms underlying AD heterogeneity.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"153 ","pages":"Pages 21-29"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144254247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in GABAergic synapses across the central inferior colliculus in the Fischer Brown Norway rat","authors":"Alexa Wawrzyniak ,&nbsp;Justine Busby ,&nbsp;Alice Dalo ,&nbsp;Syllissa Duncan ,&nbsp;Laila S. Almassri ,&nbsp;Dakota Z. Smallridge ,&nbsp;Andrew P. Ohl ,&nbsp;Amir M. Mafi ,&nbsp;Nick J. Tokar ,&nbsp;Jesse W. Young ,&nbsp;Jeffrey G. Mellott","doi":"10.1016/j.neurobiolaging.2025.06.002","DOIUrl":"10.1016/j.neurobiolaging.2025.06.002","url":null,"abstract":"<div><div>Presbycusis, one of the most widespread disorders, is in part associated with the loss of temporal precision within the central auditory system. A contributor to the dysfunctional temporal precision during aging is the substantial downregulation of GABA in the central inferior colliculus (ICc), the hub of ascending and descending inputs of the auditory midbrain. However, how GABAergic inputs across the tonotopic axis of the ICc change with age has not been well explored. We sought to determine age-related changes to GABAergic synapses in the lemniscal ICc, and if changes are uniform across the ICc axis. Using immuno-electron microscopy across four age groups of Fisher Brown Norway rats, a model that acquires low frequency presbycusis, our results demonstrate several nonuniform ultrastructural changes to GABAergic synapses in the ICc. There was a significant (∼29–33 %) downregulation of GABAergic synapses in the high and middle frequency regions of old rats, but a loss (∼22 %) in the old low frequency region was not as robust and did not reach statistical significance. Interestingly, in the high and middle frequency regions, GABAergic presynaptic area increased with age, while there was an ultimately decline in the old low frequency region. Also unique to the high and middle frequencies was the increasing proportion of GABAergic synapses onto larger GABAergic dendrites. These changes demonstrate that aging differentially affects the GABAergic ultrastructure of the ICc tonotopic axis.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"153 ","pages":"Pages 30-48"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144263129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute corticospinal and reticulospinal responses to strength training in ageing","authors":"Ummatul Siddique ,&nbsp;Ashlyn K. Frazer ,&nbsp;Jamie Tallent ,&nbsp;Oliver Hayman ,&nbsp;Justin Andrushko ,&nbsp;Juha P. Ahtiainen ,&nbsp;Janne Avela ,&nbsp;Yonas Akalu ,&nbsp;Mohamad Rostami ,&nbsp;Sergio Uribe ,&nbsp;Simon Walker ,&nbsp;Dawson J. Kidgell","doi":"10.1016/j.neurobiolaging.2025.06.007","DOIUrl":"10.1016/j.neurobiolaging.2025.06.007","url":null,"abstract":"<div><div>Ageing is associated with declines in neuromuscular function, yet the neural mechanisms underlying strength adaptations in older adults remain unclear. While the corticospinal tract (CST) is the primary pathway for voluntary movement, the reticulospinal tract (RST) may play a compensatory role with age. This study investigated CST and RST responses following a single session of high-intensity metronome-paced strength training (MPST) in young and older adults. Thirty-five participants (17 young, 18 older) performed unilateral biceps curls at 70–75 % of their one-repetition maximum (1-RM). Cortical and subcortical excitability were assessed pre- and post-exercise using transcranial magnetic stimulation (TMS) and the StartReact paradigm. Young adults showed significant increases in corticospinal excitability (CSE; p &lt; 0.05) and early-phase motor evoked potentials (MEPs) following exercise, whereas no changes were observed in older adults. Both groups exhibited reductions in silent period duration (SP; p &lt; 0.01) and short-interval intracortical inhibition (SICI; p &lt; 0.05), suggesting a general release of inhibition. However, no significant changes in reaction time or evidence of enhanced RST drive were observed in either group. These findings highlight age-related differences in the modulation of descending pathways, with older adults showing reduced CSE plasticity following acute MPST, possibly reflecting delayed potentiation due to ageing. Although MPST effectively reduced inhibition, it may be insufficient to engage the RST in older adults. Future research should explore alternative training modalities that more directly target subcortical circuits to optimise functional outcomes in ageing populations.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"153 ","pages":"Pages 49-62"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144492005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Processivity and BDNF-dependent modulation of signalling endosome axonal transport are impaired in mice with advanced age","authors":"David Villarroel-Campos ,&nbsp;Elena R. Rhymes ,&nbsp;Andrew P. Tosolini ,&nbsp;Bilal Malik ,&nbsp;Alessio Vagnoni ,&nbsp;Giampietro Schiavo ,&nbsp;James N. Sleigh","doi":"10.1016/j.neurobiolaging.2025.05.002","DOIUrl":"10.1016/j.neurobiolaging.2025.05.002","url":null,"abstract":"<div><div>A healthy nervous system is reliant upon an efficient transport network to deliver essential cargoes throughout the extensive and polarised architecture of neurons. The trafficking of cargoes, such as organelles and proteins, is particularly challenging within the long projections of neurons, which, in the case of axons, can be more than four orders of magnitude longer than cell bodies. It is therefore unsurprising that disruptions in axonal transport have been reported across neurological diseases. A decline in this essential process has also been identified in many aging models, perhaps compounding age-related neurodegeneration. Via intravital imaging, we recently determined that, despite a reduction in overall motility, the run speed and displacement of anterograde mitochondrial transport were unexpectedly enhanced in 19–22 month-old mouse peripheral nerves. Here, to determine how aging impacts a different axonal cargo, we evaluated <em>in vivo</em> trafficking of signalling endosomes in motor axons of mouse sciatic nerves from 3 to 22 months. Contrasting with mitochondria, we did not detect alterations in signalling endosome speed, but found a consistent rise in pausing that manifested after 18 months. We then treated muscles with brain-derived neurotrophic factor (BDNF), which regulates axonal transport of signalling endosomes in motor neurons; however, we observed no change in the processivity defect at 22 months, consistent with downregulation of the BDNF receptor TrkB at the neuromuscular junction. Together, these findings indicate that aging negatively impacts signalling endosome trafficking in motor axons, likely through dampened BDNF signalling at the motor neuron-muscle interface.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"153 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}