Neurobiology of Aging最新文献_第9页

Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood 与整个成年期脑铁积累有关的生活方式、生物和遗传因素

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-10 DOI: 10.1016/j.neurobiolaging.2024.09.004

Jonatan Gustavsson , Zuzana Ištvánfyová , Goran Papenberg , Farshad Falahati , Erika J. Laukka , Jenni Lehtisalo , Francesca Mangialasche , Grégoria Kalpouzos

{"title":"Lifestyle, biological, and genetic factors related to brain iron accumulation across adulthood","authors":"Jonatan Gustavsson , Zuzana Ištvánfyová , Goran Papenberg , Farshad Falahati , Erika J. Laukka , Jenni Lehtisalo , Francesca Mangialasche , Grégoria Kalpouzos","doi":"10.1016/j.neurobiolaging.2024.09.004","DOIUrl":"10.1016/j.neurobiolaging.2024.09.004","url":null,"abstract":"<div><p>Iron is necessary for many neurobiological mechanisms, but its overaccumulation can be harmful. Factors triggering age-related brain iron accumulation remain largely unknown and longitudinal data are insufficient. We examined associations between brain iron load and accumulation and, blood markers of iron metabolism, cardiovascular health, lifestyle factors (smoking, alcohol use, physical activity, diet), and <em>ApoE</em> status using longitudinal data from the IronAge study (n = 208, age = 20–79, mean follow-up time = 2.75 years). Iron in cortex and basal ganglia was estimated with magnetic resonance imaging using quantitative susceptibility mapping (QSM). Our results showed that (1) higher peripheral iron levels (i.e., composite score of blood iron markers) were related to greater iron load in the basal ganglia; (2) healthier diet was related to higher iron levels in the cortex and basal ganglia, although for the latter the association was significant only in younger adults (age = 20–39); (3) worsening cardiovascular health was related to increased iron accumulation; (4) younger <em>ApoE ε4</em> carriers accumulated more iron in basal ganglia than younger non-carriers. Our results demonstrate that modifiable factors, including lifestyle, cardiovascular, and physiological ones, are linked to age-related brain iron content and accumulation, contributing novel information on potential targets for interventions in preventing brain iron-overload.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 56-67"},"PeriodicalIF":3.7,"publicationDate":"2024-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001593/pdfft?md5=b36547ea1432e1ca96649c5939730069&pid=1-s2.0-S0197458024001593-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142232116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-07 DOI: 10.1016/S0197-4580(24)00150-7

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Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice 小鼠慢性系统性炎症后，cofilin1通路（LIMK1/SSH1）的年龄依赖性性别差异及其与AD生物标志物的关系

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-07 DOI: 10.1016/j.neurobiolaging.2024.09.003

Amsha S. Alsegiani, Zahoor A. Shah

{"title":"Age-dependent sex differences in cofilin1 pathway (LIMK1/SSH1) and its association with AD biomarkers after chronic systemic inflammation in mice","authors":"Amsha S. Alsegiani, Zahoor A. Shah","doi":"10.1016/j.neurobiolaging.2024.09.003","DOIUrl":"10.1016/j.neurobiolaging.2024.09.003","url":null,"abstract":"<div><p>Chronic systemic inflammation (CSI) results in neuroinflammation and neurodegeneration. Cofilin1 is a stress protein that activates microglia and induces neuroinflammation, but its role in CSI at different aging stages remains unidentified. Therefore, the study aims to identify cofilin1 and its upstream regulators LIMK1 and SSH1 after CSI in young-, middle-, and advanced-aged mice. CSI was induced by injecting the male and female mice with a sub-lethal dose of Lipopolysaccharide weekly for six weeks. The results showed that normal male mice did not show cofilin pathway dysregulation, but a significant dysregulation was observed in CSI advanced-aged mice. In females, cofilin1 dysregulation was observed in healthy and CSI advanced-aged mice, while significant cofilin1 dysregulation was observed in middle-aged mice during CSI. Furthermore, cofilin1 pathway dysregulations correlated with Alzheimer's disease (AD) biomarkers in the brain and saliva, astrocyte activation, synaptic degeneration, neurobehavioral impairments, gut-microbiota abnormalities, and circulatory inflammation. These results provide new insights into cofilin1 sex and age-dependent mechanistic differences that might help identify targets for modulating neuroinflammation and early onset of AD.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 43-55"},"PeriodicalIF":3.7,"publicationDate":"2024-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease 补充母体胆碱可挽救唐氏综合征和阿尔茨海默病 Ts65Dn 小鼠模型中基底前脑胆碱能神经元的早期内质体病理变化

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-06 DOI: 10.1016/j.neurobiolaging.2024.09.002

Megan K. Gautier , Christy M. Kelley , Sang Han Lee , Elliott J. Mufson , Stephen D. Ginsberg

{"title":"Maternal choline supplementation rescues early endosome pathology in basal forebrain cholinergic neurons in the Ts65Dn mouse model of Down syndrome and Alzheimer’s disease","authors":"Megan K. Gautier , Christy M. Kelley , Sang Han Lee , Elliott J. Mufson , Stephen D. Ginsberg","doi":"10.1016/j.neurobiolaging.2024.09.002","DOIUrl":"10.1016/j.neurobiolaging.2024.09.002","url":null,"abstract":"<div><p>Individuals with DS develop Alzheimer’s disease (AD) neuropathology, including endosomal-lysosomal system abnormalities and degeneration of basal forebrain cholinergic neurons (BFCNs). We investigated whether maternal choline supplementation (MCS) affects early endosome pathology within BFCNs using the Ts65Dn mouse model of DS/AD. Ts65Dn and disomic (2N) offspring from dams administered MCS were analyzed for endosomal pathology at 3–4 months or 10–12 months. Morphometric analysis of early endosome phenotype was performed on individual BFCNs using Imaris. The effects of MCS on the endosomal interactome were interrogated by relative co-expression (RCE) analysis. MCS effectively reduced age- and genotype-associated increases in early endosome number in Ts65Dn and 2N offspring, and prevented increases in early endosome size in Ts65Dn offspring. RCE revealed a loss of interactome cooperativity among endosome genes in Ts65Dn offspring that was restored by MCS. These findings demonstrate MCS rescues early endosome pathology, a driver of septohippocampal circuit dysfunction. The genotype-independent benefits of MCS on endosomal phenotype indicate translational applicability as an early-life therapy for DS as well as other neurodevelopmental/neurodegenerative disorders involving endosomal pathology.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 30-42"},"PeriodicalIF":3.7,"publicationDate":"2024-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001556/pdfft?md5=76623227f0464d1bb041c9a20ba3aa70&pid=1-s2.0-S0197458024001556-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults 淀粉样β42/38比值是认知功能未受损的老年人早期记忆缺陷的血浆生物标志物。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-03 DOI: 10.1016/j.neurobiolaging.2024.08.009

Alison R. Bamford , Jenna N. Adams , Soyun Kim , Liv C. McMillan , Rond Malhas , Mark Mapstone , Brian D. Hitt , Michael A. Yassa , Elizabeth A. Thomas

{"title":"The amyloid beta 42/38 ratio as a plasma biomarker of early memory deficits in cognitively unimpaired older adults","authors":"Alison R. Bamford , Jenna N. Adams , Soyun Kim , Liv C. McMillan , Rond Malhas , Mark Mapstone , Brian D. Hitt , Michael A. Yassa , Elizabeth A. Thomas","doi":"10.1016/j.neurobiolaging.2024.08.009","DOIUrl":"10.1016/j.neurobiolaging.2024.08.009","url":null,"abstract":"<div><p>The amyloid beta (Aβ) 42/40 ratio has been widely studied as a biomarker in Alzheimer’s disease (AD); however, other Aβ peptides could also represent relevant biomarkers. We measured levels of Aβ38/40/42 in plasma samples from cognitively-unimpaired older adults and determined the relationships between Aβ levels and amyloid positron-emission-tomography (PET) and performance on a learning and memory task. We found that all Aβ peptides individually and the Aβ42/40 ratio, but not the Aβ42/38 ratio, were significantly correlated with brain amyloid (Aβ-PET). Multiple linear modeling, adjusting for age, sex, education, <em>APOE4</em> and Aβ-PET showed significant associations between the Aβ42/38 ratio and memory. Further, associations between the Aβ42/38 ratio and learning scores were stronger in males and in Aβ-PET-negative individuals. In contrast, no significant associations were detected between the Aβ42/40 ratio and any learning measure. These studies implicate the Aβ42/38 ratio as a biomarker to assess early memory deficits and underscore the utility of the Aβ38 fragment as an important biomarker in the AD field.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 12-18"},"PeriodicalIF":3.7,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001465/pdfft?md5=8c0c03c060a0f5e56ad007395fbc003b&pid=1-s2.0-S0197458024001465-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142146029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study 年龄、性别和谷胱甘肽之间的联系：一项横断面磁共振光谱研究

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-08-31 DOI: 10.1016/j.neurobiolaging.2024.08.010

Lars Michels , Ruth O’Gorman-Tuura , Dario Bachmann , Susanne Müller , Sandro Studer , Antje Saake , Esmeralda Gruber , Katrin Rauen , Andreas Buchmann , Isabelle Zuber , Christoph Hock , Anton Gietl , Valerie Treyer

{"title":"The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study","authors":"Lars Michels , Ruth O’Gorman-Tuura , Dario Bachmann , Susanne Müller , Sandro Studer , Antje Saake , Esmeralda Gruber , Katrin Rauen , Andreas Buchmann , Isabelle Zuber , Christoph Hock , Anton Gietl , Valerie Treyer","doi":"10.1016/j.neurobiolaging.2024.08.010","DOIUrl":"10.1016/j.neurobiolaging.2024.08.010","url":null,"abstract":"<div><p>Glutathione (GSH) is a brain marker for oxidative stress and has previously been associated with cerebral amyloid deposition and memory decline. However, to date, no study has examined the links among GSH, sex, age, amyloid, and Apolipoprotein E (APOE) genotype in a large non-clinical cohort of older adults. We performed APOE genotyping, magnetic resonance spectroscopy (MRS) as well as simultaneous positron emission tomography with the radiotracer Flutemetamol (Amyloid-PET), in a group of older adults. The final analysis set comprised 140 healthy older adults (mean age: 64.7 years) and 49 participants with mild cognitive impairment (mean age: 71.4 years). We recorded metabolites in the posterior cingulate cortex (PCC) by a GSH-edited MEGAPRESS sequence. Structural equation modeling revealed that higher GSH levels were associated with female sex, but neither APOE- epsilon 4 carrier status nor age showed significant associations with GSH. Conversely, older age and the presence of an APOE4 allele, but not sex, are linked to higher global amyloid load. Our results suggest that the PCC shows sex-specific GSH alterations in older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 19-29"},"PeriodicalIF":3.7,"publicationDate":"2024-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142163402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers 超越群体分类：利用核磁共振成像和脑脊液生物标记物对额颞叶痴呆症和阿尔茨海默病进行概率鉴别诊断

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-08-30 DOI: 10.1016/j.neurobiolaging.2024.08.008

Agnès Pérez-Millan , Bertrand Thirion , Neus Falgàs , Sergi Borrego-Écija , Beatriz Bosch , Jordi Juncà-Parella , Adrià Tort-Merino , Jordi Sarto , Josep Maria Augé , Anna Antonell , Nuria Bargalló , Mircea Balasa , Albert Lladó , Raquel Sánchez-Valle , Roser Sala-Llonch

{"title":"Beyond group classification: Probabilistic differential diagnosis of frontotemporal dementia and Alzheimer’s disease with MRI and CSF biomarkers","authors":"Agnès Pérez-Millan , Bertrand Thirion , Neus Falgàs , Sergi Borrego-Écija , Beatriz Bosch , Jordi Juncà-Parella , Adrià Tort-Merino , Jordi Sarto , Josep Maria Augé , Anna Antonell , Nuria Bargalló , Mircea Balasa , Albert Lladó , Raquel Sánchez-Valle , Roser Sala-Llonch","doi":"10.1016/j.neurobiolaging.2024.08.008","DOIUrl":"10.1016/j.neurobiolaging.2024.08.008","url":null,"abstract":"<div><p>Neuroimaging and fluid biomarkers are used to differentiate frontotemporal dementia (FTD) from Alzheimer’s disease (AD). We implemented a machine learning algorithm that provides individual probabilistic scores based on magnetic resonance imaging (MRI) and cerebrospinal fluid (CSF) data. We investigated whether combining MRI and CSF levels could improve the diagnosis confidence. 215 AD patients, 103 FTD patients, and 173 healthy controls (CTR) were studied. With MRI data, we obtained an accuracy of 82 % for AD vs. FTD. A total of 74 % of FTD and 73 % of AD participants have a high probability of accurate diagnosis. Adding CSF-NfL and 14–3–3 levels improved the accuracy and the number of patients in the confidence group for differentiating FTD from AD. We obtain individual diagnostic probabilities with high precision to address the problem of confidence in the diagnosis. We suggest when MRI, CSF, or the combination are necessary to improve the FTD and AD diagnosis. This algorithm holds promise towards clinical applications as support to clinical findings or in settings with limited access to expert diagnoses.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 1-11"},"PeriodicalIF":3.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001453/pdfft?md5=27ed6918da1a31097d24f8f77b77fe57&pid=1-s2.0-S0197458024001453-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Neurobiology of Aging Pub Date : 2024-08-29 DOI: 10.1016/S0197-4580(24)00140-4

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Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults 用认知正常老年人的基线主观认知问题预测脑萎缩和认知老化轨迹

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-08-23 DOI: 10.1016/j.neurobiolaging.2024.08.006

Michelle You , Cutter A. Lindbergh , Renaud La Joie , Emily W. Paolillo , Rowan Saloner , Valentina Diaz , Devyn L. Cotter , Samantha Walters , Marie Altendahl , Adam M. Staffaroni , Joel H. Kramer , Leslie S. Gaynor , Kaitlin B. Casaletto

{"title":"Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults","authors":"Michelle You , Cutter A. Lindbergh , Renaud La Joie , Emily W. Paolillo , Rowan Saloner , Valentina Diaz , Devyn L. Cotter , Samantha Walters , Marie Altendahl , Adam M. Staffaroni , Joel H. Kramer , Leslie S. Gaynor , Kaitlin B. Casaletto","doi":"10.1016/j.neurobiolaging.2024.08.006","DOIUrl":"10.1016/j.neurobiolaging.2024.08.006","url":null,"abstract":"<div><p>Subjective cognitive concerns (SCC) are common even in cognitively normal older adults who lack objectively-detectable deficits on standard neuropsychological evaluation. The clinical relevance of these concerns, particularly considering the nature of concerns (e.g., memory versus non-memory), remains unclear. Thus, we examined whether baseline memory and non-memory SCC relate to longitudinal change in brain volume and neuropsychological test performance in 476 functionally-intact, objectively unimpaired older adults (<em>M</em><sub><em>age</em></sub> = 72y, 56 % female, follow-up time = 1 – 9 years). Mixed-effects models revealed that both higher baseline memory and non-memory SCC predicted greater atrophy in total gray matter and dorsolateral prefrontal cortex atrophy over time, while only memory SCC predicted steeper medial temporal lobe atrophy. Regarding neuropsychological performance, higher non-memory SCC predicted decline in processing speed performance, while memory SCC did not predict neuropsychological trajectories. SCC are a risk factor for more adverse brain and cognitive aging trajectories, even in functionally-intact, seemingly cognitively normal older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA 阿尔茨海默病的血浆 p-tau181 和淀粉样蛋白标记物：Lumipulse 和 SIMOA 的比较

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-08-22 DOI: 10.1016/j.neurobiolaging.2024.08.007

Virginia Quaresima , Andrea Pilotto , Chiara Trasciatti , Chiara Tolassi , Marta Parigi , Diego Bertoli , Cristina Mordenti , Alice Galli , Andrea Rizzardi , Salvatore Caratozzolo , Alberto Benussi , Nicholas J. Ashton , Kaj Blennow , Henrik Zetterberg , Silvia Giliani , Duilio Brugnoni , Alessandro Padovani

{"title":"Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA","authors":"Virginia Quaresima , Andrea Pilotto , Chiara Trasciatti , Chiara Tolassi , Marta Parigi , Diego Bertoli , Cristina Mordenti , Alice Galli , Andrea Rizzardi , Salvatore Caratozzolo , Alberto Benussi , Nicholas J. Ashton , Kaj Blennow , Henrik Zetterberg , Silvia Giliani , Duilio Brugnoni , Alessandro Padovani","doi":"10.1016/j.neurobiolaging.2024.08.007","DOIUrl":"10.1016/j.neurobiolaging.2024.08.007","url":null,"abstract":"<div><p>Aim of the project was to evaluate the technical and clinical validity of plasma Lumipulse p-tau, Aβ42 and Aβ40 species and their correlation with CSF core Alzheimer’s Disease (AD) markers; a method comparison with SIMOA was also performed. One-hundred-thirthy-three participants, namely 55 A+T+N+ AD, 28 Neurodegenerative disorders (NDD) and 50 controls were enrolled for the study. Lumipulse technical validity showed high stability for p-tau181, Aβ42, and Aβ40, with higher stability of p-tau to repeated freezing thaw cycles. p-tau181 levels detected by both techniques were higher in AD compared to both NDD/controls and exhibited a similar correlation with CSF p-tau levels, whereas Aβ42 levels were slightly lower in AD with both methods. In the comparison between SIMOA and Lumipulse plasma markers, both techniques exhibited similar diagnostic accuracy for AD for p-tau181 (0.87; 95 %CI 0.81–0.94, vs 0.85; 95 %CI 0.78–0.93), whereas the best performance was reached by p-tau181/ Aβ42 Lumipulse ratio (ROC AUC 0.915, 95 %CI 0.86–0.97). The study thus confirmed the construct validity of both Lumipulse and SIMOA techniques for the identification of CSF AD pattern in clinical settings.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 30-40"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001374/pdfft?md5=a1f0f456d843a0edb19575e002f8adad&pid=1-s2.0-S0197458024001374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0