Neurobiology of Aging最新文献

{"title":"Exploring morphological and microstructural signatures across the Alzheimer's spectrum and risk factors","authors":"Aurélie Bussy ,&nbsp;Raihaan Patel ,&nbsp;Olivier Parent ,&nbsp;Alyssa Salaciak ,&nbsp;Saashi A. Bedford ,&nbsp;Sarah Farzin ,&nbsp;Stephanie Tullo ,&nbsp;Cynthia Picard ,&nbsp;Sylvia Villeneuve ,&nbsp;Judes Poirier ,&nbsp;John CS Breitner ,&nbsp;Gabriel A. Devenyi ,&nbsp;PREVENT-AD Research Group,&nbsp;Christine L. Tardif ,&nbsp;M. Mallar Chakravarty","doi":"10.1016/j.neurobiolaging.2025.01.011","DOIUrl":"10.1016/j.neurobiolaging.2025.01.011","url":null,"abstract":"<div><div>Neural alterations, including myelin degeneration and inflammation-related iron burden, may accompany early Alzheimer's disease (AD) pathophysiology. This study aims to identify multi-modal signatures associated with MRI-derived atrophy and quantitative MRI (qMRI) measures of myelin and iron in a unique dataset of 158 participants across the AD spectrum, including those without cognitive impairment, at familial risk for AD, with mild cognitive impairment, and with AD dementia. Our results revealed a brain pattern with decreased cortical thickness, indicating increased neuronal death, and compromised hippocampal integrity due to reduced myelin content. This pattern was associated with lifestyle factors such as smoking, high blood pressure, high cholesterol, and anxiety, as well as older age, AD progression, and APOE-ɛ4 carrier status. These findings underscore the value of qMRI metrics as a non-invasive tool, offering sensitivity to lifestyle-related modifiable risk factors and medical history, even in preclinical stages of AD.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"149 ","pages":"Pages 1-18"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related synaptic signatures of brain and cognitive reserve in the rat hippocampus and parahippocampal regions","authors":"David J. Horovitz ,&nbsp;Laura A. Askins ,&nbsp;Grace M. Regnier,&nbsp;Joseph A. McQuail","doi":"10.1016/j.neurobiolaging.2025.01.010","DOIUrl":"10.1016/j.neurobiolaging.2025.01.010","url":null,"abstract":"<div><div>Age-related cognitive decline varies widely among individuals, with some showing resilience despite older age. This study examines synaptic markers of glutamatergic and GABAergic neurotransmission in the hippocampus and cortex of older rats with differing cognitive abilities, aiming to uncover mechanisms that contribute to cognitive resilience. We observed significant age-related reductions in vesicular glutamate transporter VGluT1, particularly in the stratum oriens (SO), radiatum (SR), and lacunosum-moleculare (SLM) of the dorsal CA3 and SLM of the dorsal CA1. Furthermore, loss of VGluT1 in the dorsal CA3-SLM correlated with severity of memory impairment. Higher levels of the vesicular GABA transporter (VGAT) were associated with better spatial learning in older rats, across several synaptic zones of the dorsal hippocampus, including the outer molecular layer of the dentate gyrus (DG), and the SO, SR, SLM, and pyramidal cell layers of both CA3 and CA1. This suggests that enhanced inhibitory neurotransmission specific to the dorsal aspect of the hippocampus may protect against age-related cognitive decline. While the dorsal hippocampus showed consistent age- and memory-related changes, markers in the ventral hippocampus remained largely intact. In the perirhinal cortex, VGluT1 declined with no changes in VGAT, while both markers remained unchanged in other cortical regions, including the lateral entorhinal, retrosplenial, and posterior parietal cortices. These findings highlight region-specific patterns of synaptic aging as potential markers of brain and cognitive reserve.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 80-97"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143419194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the domain specificity and the neural correlates of memory unawareness in Alzheimer's disease","authors":"Lucile Meunier-Duperray ,&nbsp;Céline Souchay ,&nbsp;Lucie Angel ,&nbsp;Eric Salmon ,&nbsp;Christine Bastin","doi":"10.1016/j.neurobiolaging.2024.12.013","DOIUrl":"10.1016/j.neurobiolaging.2024.12.013","url":null,"abstract":"<div><div>Patients with Alzheimer’s disease (AD) are less accurate than controls to predict their episodic performance, but they are as accurate as controls to predict their semantic performance. However, the dissociation between episodic and semantic metamemory had never been tested directly in the same patients. This study aimed to explore the dissociation between episodic and semantic metamemory in AD using the feeling-of-knowing paradigm. In addition, we investigated the link between memory awareness and resting-state cerebral glucose metabolism and gray matter density, in episodic and semantic tasks independently. Data from 50 patients with AD were compared to data from 30 healthy controls. Results showed that patients with AD had more difficulties to predict their recognition in the episodic task than in the semantic task, while this difference was smaller in controls. However, this dissociation was only shown with a measure of absolute accuracy, but not with a measure of relative accuracy. Lack of awareness in the episodic task was associated with hypometabolism in right frontoparietal areas in patients with AD, while semantic metamemory was associated with gray matter integrity in the left angular gyrus. The consequence of metacognitive bias and memory status on metamemory judgments are discussed.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 61-70"},"PeriodicalIF":3.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143379358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains” [Neurobiol. Aging 36 (2015) 1994–2003]","authors":"Caihong Zhu ,&nbsp;Uli S. Herrmann ,&nbsp;Bei Li ,&nbsp;Irina Abakumova ,&nbsp;Rita Moos ,&nbsp;Petra Schwarz ,&nbsp;Elisabeth J. Rushing ,&nbsp;Marco Colonna ,&nbsp;Adriano Aguzzi","doi":"10.1016/j.neurobiolaging.2024.09.008","DOIUrl":"10.1016/j.neurobiolaging.2024.09.008","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"146 ","pages":"Pages 77-78"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142292085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to: Homozygous alpha-synuclein p.A53V in familial Parkinson’s disease","authors":"Kenya Nishioka","doi":"10.1016/j.neurobiolaging.2024.09.001","DOIUrl":"10.1016/j.neurobiolaging.2024.09.001","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"146 ","pages":"Pages 74-76"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142257306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(24)00206-9","DOIUrl":"10.1016/S0197-4580(24)00206-9","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"146 ","pages":"Page IFC"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143141964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823–10 G>T at the intron 9/exon 10 of the MAPT gene","authors":"Diana A. Olszewska ,&nbsp;Conor Fearon ,&nbsp;Christopher McGuigan ,&nbsp;Terri P. McVeigh ,&nbsp;Henry Houlden ,&nbsp;James M. Polke ,&nbsp;Brian Lawlor ,&nbsp;Robert Coen ,&nbsp;Michael Hutchinson ,&nbsp;Michael Hutton ,&nbsp;Alan Beausang ,&nbsp;Isabelle Delon ,&nbsp;Francesca Brett ,&nbsp;Ioanna Sevastou ,&nbsp;Nuria Seto-Salvia ,&nbsp;Rohan de Silva ,&nbsp;Tim Lynch","doi":"10.1016/j.neurobiolaging.2024.09.011","DOIUrl":"10.1016/j.neurobiolaging.2024.09.011","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"146 ","pages":"Page 79"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142350677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stability of locus coeruleus cell counts despite volume loss in cognitively impaired aged rhesus macaques","authors":"Kelsey E. McDermott ,&nbsp;Carol A. Barnes","doi":"10.1016/j.neurobiolaging.2025.01.007","DOIUrl":"10.1016/j.neurobiolaging.2025.01.007","url":null,"abstract":"<div><div>The locus coeruleus (LC) is a brainstem nucleus that provides the primary source of noradrenaline (NA) in the nervous system and optimizes behavioral performance in mammals. In humans, the LC shows Alzheimer’s disease (AD)-like pathology at its earliest stages, but little is known about LC integrity in normative, non-pathological aging. The present research addresses these gaps by investigating neuron numbers, densities of glia and vasculature, and volume of the LC itself in cognitively assessed adult and aged rhesus macaques. These primates do not spontaneously exhibit AD, and thus are an excellent model for normative human aging. Immunohistochemical methods were used to quantify noradrenaline-producing cells, total cells, and vascular and glial density in the LC, and use a recently developed alignment protocol to incorporate Nissl- and immunohistochemically stained tissue with previously collected magnetic resonance images to generate precise volumes of the LC and its’ subcompartments. The medial LC subcompartment alone (not the lateral or compact regions) in aged animals showed significantly smaller volume than did the adult monkeys, however, there was no difference in NA-containing cell numbers, vascular or glial densities observed in any compartment between age groups. Additionally, volumes and cell counts were not significantly associated with performance on memory tasks, indicating that cell populations within the locus coeruleus nucleus itself are highly resistant to age-related change.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 41-49"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Circulating non-esterified fatty acids, risk of dementia and cognitive decline: The cardiovascular health study and multi-ethnic study of atherosclerosis","authors":"Kristine F. Moseholm ,&nbsp;Majken K. Jensen ,&nbsp;Petra Buzkova ,&nbsp;Sarah A. Aroner ,&nbsp;Annette L. Fitzpatrick ,&nbsp;W.T. Longstreth Jr ,&nbsp;Oscar Lopez ,&nbsp;David S. Siscovick ,&nbsp;Jorge R. Kizer ,&nbsp;Joachim H. Ix ,&nbsp;Timothy M. Hughes ,&nbsp;Kathleen M. Hayden ,&nbsp;Sarah Nomura ,&nbsp;Michael Y. Tsai ,&nbsp;Robyn McClelland ,&nbsp;Luc Djoussé ,&nbsp;Kenneth J. Mukamal","doi":"10.1016/j.neurobiolaging.2025.01.009","DOIUrl":"10.1016/j.neurobiolaging.2025.01.009","url":null,"abstract":"<div><div>Circulating non-esterified fatty acids (NEFAs) have toxic effects on a variety of organs central to cardiometabolic disease and can cross the blood-brain barrier. Whether NEFAs associate with cognitive decline or dementia remains unknown. Circulating total NEFA levels were measured in 3242 participants without dementia among older adults of the Cardiovascular Health Study (CHS) and related to adjudicated dementia over 6 years (n = 456 cases) and annually assessed cognitive decline. For confirmation, we related circulating NEFAs to cognition assessed 10 years later among 4361 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). In CHS participants, each SD higher NEFA levels were associated with a hazard ratio (HR) for all-cause dementia of 1.11 (95 % CI: 1.01; 1.22). Baseline NEFA levels were also associated with more rapid decline in cognition over 6 years of follow-up. In MESA, circulating NEFA measurements were associated with lower cognitive scores measured 10 years later.’</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 71-79"},"PeriodicalIF":3.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143394636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differences in cholinergic terminal density in adults with Down syndrome compared to neurotypical controls measured by [18F]-fluoroethoxybenzovesamicol positron emission tomography imaging","authors":"Jason K. Russell ,&nbsp;Alexander C. Conley ,&nbsp;Brian D. Boyd ,&nbsp;J. Patrick Begnoche ,&nbsp;Rachel Schlossberg ,&nbsp;Allison Stranick ,&nbsp;Adam J. Rosenberg ,&nbsp;Lealani Mae Y. Acosta ,&nbsp;Dann Martin ,&nbsp;Yasmeen Neal ,&nbsp;Prabesh Kanel ,&nbsp;Roger L. Albin ,&nbsp;Michael S. Rafii ,&nbsp;Julie Dumas ,&nbsp;Paul A. Newhouse","doi":"10.1016/j.neurobiolaging.2025.01.008","DOIUrl":"10.1016/j.neurobiolaging.2025.01.008","url":null,"abstract":"<div><div>Adults with Down syndrome are genetically predisposed to developing Alzheimer’s disease after the age of 40. The cholinergic system, which is critical for cognitive functioning, is known to decline in Alzheimer’s disease and although first investigated in individuals with Down syndrome 40 years ago, remains relatively understudied. Existing studies suggest individuals with Down syndrome have an intact cholinergic system at birth that declines through adulthood alongside the development of Alzheimer’s disease pathology. The present study provides the first description of cholinergic terminals in vivo in non-demented adults with Down syndrome utilizing [¹⁸F]-fluoroethoxybenzovesamicol PET imaging. In addition, we investigated age-associated decline in cholinergic terminal density. Sixteen (16) non-demented adults with Down syndrome (mean age 35.5, 8 females) and 20 neurotypically developed individuals (mean age 35.5, 10 females) were studied, comparing radiotracer uptake groupwise and associations with age utilizing a voxel-based approach. Adults with Down syndrome displayed significantly increased [¹⁸F]-fluoroethoxybenzovesamicol uptake in the cerebellum, brainstem, thalamus, and numerous cortical regions compared to age-matched controls following an unpaired t-test thresholded at p &lt; 0.001 and minimum cluster size 50. Cholinergic terminal density in numerous cortical regions showed a steeper decline associated with older age in adults with Down syndrome than observed in neurotypically developed adults in the age range tested following a generalized linear model testing the interaction between age and group, thresholded at p &lt; 0.005 and minimum cluster size 50. These data suggest higher cholinergic terminal density in early adulthood in individuals with Down syndrome, with a greater age-related difference than is observed in neurotypically developed individuals.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"148 ","pages":"Pages 50-60"},"PeriodicalIF":3.7,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143169114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}