Neurobiology of Aging最新文献

Corrigendum to "Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains" [Neurobiol. Aging 36 (2015) 1994-2003]. 髓系细胞-2上表达的触发受体参与了朊病毒诱导的小胶质细胞活化，但对小鼠大脑中的朊病毒发病机制没有贡献》[Neurobiol. Aging 36 (2015) 1994-2003]的更正。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 Epub Date: 2024-09-18 DOI: 10.1016/j.neurobiolaging.2024.09.008

Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzzi

引用次数: 0

Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823-10 G>T at the intron 9/exon 10 of the MAPT gene. 更正：一个患有 MAPT 基因内含子 9/ 外显子 10 的杂合剪接变异 c.823-10 G>T 的 FTDP-17 家族的临床、分子遗传学和病理学研究。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2025-02-01 Epub Date: 2024-09-23 DOI: 10.1016/j.neurobiolaging.2024.09.011

Diana A Olszewska, Conor Fearon, Christopher McGuigan, Terri P McVeigh, Henry Houlden, James M Polke, Brian Lawlor, Robert Coen, Michael Hutchinson, Michael Hutton, Alan Beausang, Isabelle Delon, Francesca Brett, Ioanna Sevastou, Nuria Seto-Salvia, Rohan de Silva, Tim Lynch

引用次数: 0

Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-26 DOI: 10.1016/j.neurobiolaging.2024.12.009

Elettra Capogna, Øystein Sørensen, Leiv Otto Watne, James Roe, Marie Strømstad, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Piñeiro

{"title":"Subtypes of brain change in aging and their associations with cognition and Alzheimer's disease biomarkers.","authors":"Elettra Capogna, Øystein Sørensen, Leiv Otto Watne, James Roe, Marie Strømstad, Ane Victoria Idland, Nathalie Bodd Halaas, Kaj Blennow, Henrik Zetterberg, Kristine Beate Walhovd, Anders Martin Fjell, Didac Vidal-Piñeiro","doi":"10.1016/j.neurobiolaging.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.009","url":null,"abstract":"Structural brain changes underlie cognitive changes and interindividual variability in cognition in older age. By using structural MRI data-driven clustering, we aimed to identify subgroups of cognitively unimpaired older adults based on brain change patterns and assess how changes in cortical thickness, surface area, and subcortical volume relate to cognitive change. We tested (1) which brain structural changes predict cognitive change (2) whether these are associated with core cerebrospinal fluid (CSF) Alzheimer's disease biomarkers, and (3) the degree of overlap between clusters derived from different structural modalities in 1899 cognitively healthy older adults followed up to 16 years. We identified four groups for each brain feature, based on the degree of a main longitudinal component of decline. The minimal overlap between features suggested that each contributed uniquely and independently to structural brain changes in aging. Cognitive change and baseline cognition were associated with cortical area change, whereas higher baseline levels of phosphorylated tau and amyloid-β related to changes in subcortical volume. These results may contribute to a better understanding of different aging trajectories.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"124-140"},"PeriodicalIF":3.7,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142910076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-25 DOI: 10.1016/j.neurobiolaging.2024.12.010

Rebecca L Winfree, Emma Nolan, Kaj Blennow, Henrik Zetterberg, Katherine A Gifford, Kimberly R Pechman, Julie Schneider, David A Bennett, Vladislav A Petyuk, Angela L Jefferson, Timothy J Hohman

{"title":"Vascular endothelial growth factor receptor-1 (FLT1) interactions with amyloid-beta in Alzheimer's disease: A putative biomarker of amyloid-induced vascular damage.","authors":"Rebecca L Winfree, Emma Nolan, Kaj Blennow, Henrik Zetterberg, Katherine A Gifford, Kimberly R Pechman, Julie Schneider, David A Bennett, Vladislav A Petyuk, Angela L Jefferson, Timothy J Hohman","doi":"10.1016/j.neurobiolaging.2024.12.010","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.010","url":null,"abstract":"We have identified FLT1 as a protein that changes during Alzheimer's disease (AD) whereby higher brain protein levels are associated with more amyloid, more tau, and faster longitudinal cognitive decline. Given FLT1's role in angiogenesis and immune activation, we hypothesized that FLT1 is upregulated in response to amyloid pathology, driving a vascular-immune cascade resulting in neurodegeneration and cognitive decline. We sought to determine (1) if in vivo FLT1 levels (CSF and plasma) associate with biomarkers of AD neuropathology or differ between diagnostic staging in an aged cohort enriched for early disease, and (2) whether FLT1 expression interacts with amyloid on downstream outcomes, such as phosphorylated tau levels and cognitive performance. Additionally, we sought to replicate FLT1 interactions in the brain. The results showed that higher levels of FLT1 in CSF and post-mortem brain tissue related to increased tau, particularly among amyloid positive individuals. These analyses help clarify the potential utility of FLT1 as a biomarker among individuals with evidence of brain amyloidosis.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"141-149"},"PeriodicalIF":3.7,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142927681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to "Modulation of lipopolysaccharide-induced memory insult, g-secretase, and neuroinflammation in triple transgenic mice by 5-lipoxygenase" [Neurobiol. Aging 35 (2014) 1024-1031 ].

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-24 DOI: 10.1016/j.neurobiolaging.2024.12.004

Yash B Joshi, Phillip F Giannopoulos, Jin Chu, Domenico Praticò

引用次数: 0

Effector-dependent decline in strength and subcortical motor excitability with aging.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-24 DOI: 10.1016/j.neurobiolaging.2024.12.008

Ronan A Mooney, Pablo A Celnik

{"title":"Effector-dependent decline in strength and subcortical motor excitability with aging.","authors":"Ronan A Mooney, Pablo A Celnik","doi":"10.1016/j.neurobiolaging.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.008","url":null,"abstract":"A decline in upper limb strength is common with normal aging. However, whether age-related strength decline is paralleled by reduced excitability of descending motor pathways is unclear. The reticulospinal tract is a key subcortical pathway involved in gross motor output and exhibits increased excitability following resistance training. Here, we sought to determine age-related effects on strength and reticulospinal excitability in flexors and extensors of the upper limb in humans. In 15 younger and 14 older adults, we quantified upper limb strength using dynamometry, and reticulospinal excitability by using transcranial magnetic stimulation to elicit ipsilateral motor evoked potentials. We observed a decline in flexion, but not extension strength, in older compared with younger adults. This behavioral pattern was paralleled by an age-related reduction in ipsilateral motor evoked potential presence specific to flexor muscles. Our findings indicate that reduced excitability of the reticulospinal tract, which exhibits strong innervation of flexor muscles, may be a key contributor to upper limb strength decline commonly observed in older adults.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"98-104"},"PeriodicalIF":3.7,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-21 DOI: 10.1016/j.neurobiolaging.2024.12.005

Beatriz Rodrigues, Eduarda Ventura, Patrícia Moreira, Rosa Resende, Joana Bicker, Armanda E Santos, Cláudia Fragão Pereira, Maria Teresa Cruz, Maria Paula Robalo, Ana Silva, Sónia Silva

{"title":"New low-dose curcumin derivative with therapeutic potential in Alzheimer's disease: Results from an in vitro and in vivo study in mice.","authors":"Beatriz Rodrigues, Eduarda Ventura, Patrícia Moreira, Rosa Resende, Joana Bicker, Armanda E Santos, Cláudia Fragão Pereira, Maria Teresa Cruz, Maria Paula Robalo, Ana Silva, Sónia Silva","doi":"10.1016/j.neurobiolaging.2024.12.005","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.005","url":null,"abstract":"Curcumin has been proposed as a potential treatment for Alzheimer's disease (AD) due to its ability to inhibit amyloid-β (Aβ) peptide aggregates and to destabilise pre-formed ones. Derivative 27 was synthesized to improve low-dose efficacy in the context of AD. Its anti-inflammatory, antioxidant and anti-amyloidogenic activities were evaluated in chemico, in vitro using AD and neuroinflammation cell models, and in vivo using the double-transgenic APP/PS1 mice. In vitro, this curcumin derivative significantly reduced nitric oxide (NO) production and levels of pro-inflammatory proteins, inducible NO synthase, pro-interleukin-1β (Pro-IL-1β) and cyclooxygenase-2. Furthermore, Derivative 27 activated nuclear factor erythroid 2-related factor 2 transcription factor (Nrf2) and significantly increased Nrf2 and heme-oxygenase-1 protein levels in the nucleus and in the cytoplasm, respectively. In one-year-old APP/PS1 mice, orally administered-Derivative 27 (50 mg/Kg/day) for 28 days improved spatial short-term memory and significantly decreased hippocampal Pro-IL-1β and amyloid precursor protein levels, as well as Aβ levels in the hippocampus and plasma. This study supports developing new chemical approaches to alter curcumin molecule, enabling lower doses, while increasing the effectiveness in AD treatment.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"105-123"},"PeriodicalIF":3.7,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142903505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-15 DOI: 10.1016/j.neurobiolaging.2024.12.003

Sibah Hasan, Adam Mohammed Khan, Sara Garcia-Ratés, Robin A Murphy, Susan A Greenfield

{"title":"A novel 14mer peptide, T14, is associated with age-dependent behaviour in female mice.","authors":"Sibah Hasan, Adam Mohammed Khan, Sara Garcia-Ratés, Robin A Murphy, Susan A Greenfield","doi":"10.1016/j.neurobiolaging.2024.12.003","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.003","url":null,"abstract":"Age-related cognitive decline presents a healthcare challenge. While age-related mechanisms are mainly studied in humans, animal models provide key insights. Despite evidence of sex-specific differences in aging and cognition, the impact of age on female rodent behaviour is underexplored. This study investigated age-related behavioural changes in female C57BL/6 mice over 8 months, alongside neurochemical markers amyloid, Tau, and T14, a novel peptide from acetylcholinesterase (AChE) that promotes cell growth/renewal. Behavioural assessments showed an age-dependent decline in nest-building ability and familiar odour discrimination from 10 months. Spatial learning declined at 10 and 13 months, while object recognition memory remained intact from 5 to 13 months of age. Neurochemical analyses revealed a decline in T14 and its receptor α7-AChR during postnatal development and adulthood. However, there was a disparity between AChE expression and its enzymatic activity. T14 levels correlated with phosphorylated tau, but not amyloid, and negatively with nest-building scores, suggesting a role of T14 in age-related behavioural changes. This study highlights early behavioural and molecular indicators of cognitive decline in middle-aged female mice.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"88-97"},"PeriodicalIF":3.7,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142877513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modeling functional loss in Alzheimer's Disease through cognitive reserve and cognitive state: A panel data longitudinal study.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-13 DOI: 10.1016/j.neurobiolaging.2024.12.002

Laura Veronelli, Giorgia Tosi, Daniele Romano

{"title":"Modeling functional loss in Alzheimer's Disease through cognitive reserve and cognitive state: A panel data longitudinal study.","authors":"Laura Veronelli, Giorgia Tosi, Daniele Romano","doi":"10.1016/j.neurobiolaging.2024.12.002","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.002","url":null,"abstract":"Cognitive Reserve (CR) refers to the brain's ability, supported by active and modifiable forms of lifestyle compensation, to cope with neural changes due to age or disease, delaying the onset of cognitive deficits. In CR studies, neuropsychological performances and functional autonomy are considered alternative outcomes. While decreased functional independence gains importance in dementia diagnosis and monitoring, cognitive functioning may play a role in staging its severity. The main aim of the present study was to test a longitudinal model of Alzheimer's Disease (AD), in which CR (years of education) and current cognitive status (Mini-Mental State Examination, MMSE, score) would predict clinical progression in terms of loss of functional independence at a later time. From the ADNI database, we considered 308 AD participants, and for 180 of them, we could extract CSF Aβ1-42 baseline levels as an index of amyloid burden. Functional decline (one-year delta score at the Functional Activities of Daily Living Questionnaire) was explained by the CR and MMSE score interaction net of age; a trend was found also when controlling for amyloid burden. Functional decline at one year was increased for patients with high CR levels and low MMSE and with low CR and high cognitive state, compared to the opposite. The present investigation demonstrated the mutual role of past acquired CR and current cognitive status in predicting functional progression in AD. The study suggests a way to predictively interpret available demographic and clinical data, defining differential longitudinal trajectories that might be useful for clinical management.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"60-67"},"PeriodicalIF":3.7,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142872701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer's disease pathology.

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-12-10 DOI: 10.1016/j.neurobiolaging.2024.12.001

Ashley M Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal P Pandey, James M Cook, Etienne L Sibille, Thomas D Prevot

{"title":"Procognitive and neurotrophic benefits of α5-GABA-A receptor positive allosteric modulation in a β-amyloid deposition mouse model of Alzheimer's disease pathology.","authors":"Ashley M Bernardo, Michael Marcotte, Kayla Wong, Dishary Sharmin, Kamal P Pandey, James M Cook, Etienne L Sibille, Thomas D Prevot","doi":"10.1016/j.neurobiolaging.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.neurobiolaging.2024.12.001","url":null,"abstract":"Reduced somatostatin (SST) and SST-expressing GABAergic neurons are well-replicated findings in Alzheimer's disease (AD) and are associated with cognitive deficits. SST cells inhibit pyramidal cell dendrites through α5-GABA-A receptors (α5-GABAA-R). α5-GABAAR positive allosteric modulation (α5-PAM) has procognitive and neurotrophic effects in stress and aging models. We tested whether α5-PAM (GL-II-73) could prevent cognitive deficits and neuronal spine loss in early stages, and reverse them in late stages of β-amyloid deposition in the 5xFAD model (N = 48/study; 50 % female). Acute administration of GL-II-73 prevented spatial working memory deficits in 5xFAD mice at 2 months of age, while chronic administration reversed the deficits at 5 months of age. Chronic GL-II-73 treatment prevented 5xFAD-induced loss of spine density, spine count and dendritic length at both time points, despite β-amyloid accumulation. These results demonstrate procognitive and neurotrophic effects of GL-II-73 in early and late stages of Alzheimer-related β-amyloid deposition. This suggests α5-PAM as a novel β-amyloid-independent symptomatic therapeutic approach.","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"147 ","pages":"49-59"},"PeriodicalIF":3.7,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0