How is self-reported sleep-disordered breathing linked with biomarkers of Alzheimer’s disease?

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2025-06-19 DOI:10.1016/j.neurobiolaging.2025.06.006

Mohammad Akradi , Tara Farzane-Daghigh , Amir Ebneabbasi , Hanwen Bi , Alexander Drzezga , Bryce A. Mander , Simon B. Eickhoff , Masoud Tahmasian , for the Alzheimer’s Disease Neuroimaging Initiative

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Abstract

Sleep-disordered breathing (SDB) is prevalent in Alzheimer’s disease (AD). Here, we assessed how self-reported SDB is linked with AD biomarkers, including amyloid-beta plaque burden (Aβ), regional fluorodeoxyglucose uptake (rFDG-PET), grey matter volume (GMV), cognitive scores, and cerebrospinal fluid (CSF) biomarkers. We selected 757 individuals, including AD, mild cognitive impairment (MCI), and cognitively unimpaired (CU) groups, and divided them according to self-reported SDB condition. Using a stratified subsampling approach, we selected 512 matched subsamples, and effect sizes (ES) of the group-SDB interaction were computed for each biomarker and cognitive score across subsamples. Linear regression assessed associations between the ES of Aβ, rFDG, and GMV with the ES of cognitive scores and CSF biomarkers. The group-SDB interaction had a medium-sized effect on Aβ, rFDG, and GMV biomarkers in several brain areas. Participants with SDB exhibited reduced Aβ burden and increased rFDG uptake in the CU and MCI groups, whereas the AD group showed elevated Aβ burden and decreased rFDG. Additionally, SDB+ individuals demonstrated GMV alterations across all groups. The ES of group-SDB interaction on Aβ in the precuneus, middle temporal gyrus, and fusiform gyrus was associated with the ES of cognitive scores. Taken together, we observed a robust association of SDB with Aβ pathology in PET and CSF relative to rFDG and GMV in the AD group, which was also associated with cognitive decline.

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自我报告的睡眠呼吸障碍与阿尔茨海默病的生物标志物有何联系？

睡眠呼吸障碍（SDB）在阿尔茨海默病（AD）中很普遍。在这里，我们评估了自我报告的SDB与AD生物标志物的联系，包括淀粉样斑块负担（Aβ）、区域氟氧葡萄糖摄取（rFDG-PET）、灰质体积（GMV）、认知评分和脑脊液（CSF）生物标志物。选取757例AD组、轻度认知障碍组（MCI）和认知未受损组（CU），根据自述SDB情况进行分组。采用分层子抽样方法，我们选择了512个匹配的子样本，并计算了每个生物标志物和认知评分的组- sdb相互作用的效应量（ES）。线性回归评估Aβ、rFDG和GMV的ES与认知评分和脑脊液生物标志物的ES之间的相关性。组- sdb相互作用对几个脑区的a β、rFDG和GMV生物标志物有中等程度的影响。患有SDB的参与者在CU和MCI组中表现出减少的Aβ负担和增加的rFDG摄取，而AD组则表现出增加的Aβ负担和减少的rFDG。此外，SDB+ 个体在所有组中都表现出GMV的变化。组- sdb相互作用对楔前叶、颞中回和梭状回Aβ的ES与认知评分的ES相关。综上所述，我们观察到SDB与AD组中PET和CSF中相对于rFDG和GMV的a β病理有很强的相关性，这也与认知能力下降有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.