Neurobiology of Aging最新文献_第2页

Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults 认知正常老年人的 Aβ 和 tau 与执行功能和记忆的纵向关系

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-19 DOI: 10.1016/j.neurobiolaging.2024.10.004

Xi Chen , Alexis Juarez , Suzanne Mason , Sarah Kobayashi , Suzanne L. Baker , Theresa M. Harrison , Susan M. Landau , William J. Jagust

{"title":"Longitudinal relationships between Aβ and tau to executive function and memory in cognitively normal older adults","authors":"Xi Chen , Alexis Juarez , Suzanne Mason , Sarah Kobayashi , Suzanne L. Baker , Theresa M. Harrison , Susan M. Landau , William J. Jagust","doi":"10.1016/j.neurobiolaging.2024.10.004","DOIUrl":"10.1016/j.neurobiolaging.2024.10.004","url":null,"abstract":"<div><div>The early accumulation of AD pathology such as Aβ and tau in cognitively normal older people is predictive of cognitive decline, but it has been difficult to dissociate the cognitive effects of these two proteins. Early Aβ and tau target distinct brain regions that have different functional roles. Here, we assessed specific longitudinal pathology-cognition associations in seventy-six cognitively normal older adults from the Berkeley Aging Cohort Study who underwent longitudinal PiB PET, FTP PET, and cognitive assessments. Using linear mixed-effects models to estimate longitudinal changes and residual approach to characterizing cognitive domain-specific associations, we found that Aβ accumulation, especially in frontal/parietal regions, was associated with faster decline in executive function, not memory, whereas tau accumulation, especially in left entorhinal/parahippocampal regions, was associated with faster decline in memory, not executive function, supporting an “Aβ-executive function, tau-memory” double-dissociation in cognitively normal older people. These specific relationships between accumulating pathology and domain-specific cognitive decline may be due to the particular vulnerabilities of the frontal-parietal executive network to Aβ and temporal memory network to tau.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"145 ","pages":"Pages 32-41"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142528427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Editorial Advisory Board 编辑顾问委员会

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-18 DOI: 10.1016/S0197-4580(24)00176-3

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Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: The Rotterdam Study 听力损失及其与老年人白质微结构纵向变化的关系：鹿特丹研究

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-18 DOI: 10.1016/j.neurobiolaging.2024.10.003

Jordi H.C. Boons , Elisabeth J. Vinke , Gertjan Dingemanse , Bernd Kremer , André Goedegebure , Meike W. Vernooij

{"title":"Hearing loss and its relation to longitudinal changes in white matter microstructure in older adults: The Rotterdam Study","authors":"Jordi H.C. Boons , Elisabeth J. Vinke , Gertjan Dingemanse , Bernd Kremer , André Goedegebure , Meike W. Vernooij","doi":"10.1016/j.neurobiolaging.2024.10.003","DOIUrl":"10.1016/j.neurobiolaging.2024.10.003","url":null,"abstract":"<div><div>Hearing loss is considered a potentially modifiable risk factor for dementia. The sensory deprivation theory postulates that hearing loss adversely affects cognition in older adults through structural brain changes, but longitudinal studies are scarce. To find evidence for a possible detrimental effect of hearing loss on white matter microstructure, we carried out a longitudinal study in the population-based Rotterdam Study. A total of 1877 participants with a median age at baseline of 56.4 years (IQR: [52.2–60.0]) underwent audiometry and had longitudinal diffusion imaging data available with a mean follow-up of 4.0 years. A lower level of hearing acuity was associated with worse white matter microstructure in the left uncinate fasciculus and superior longitudinal fasciculus at baseline. Poorer hearing acuity was also associated with faster microstructural deterioration over time in the left superior longitudinal fasciculus. The strongest effects were observed for low-frequency hearing thresholds, while the high-frequency thresholds showed the weakest associations. These results suggest that hearing loss may contribute to the age-related decline in brain structure, consistent with the sensory deprivation theory.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"145 ","pages":"Pages 24-31"},"PeriodicalIF":3.7,"publicationDate":"2024-10-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142504778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice 饮酒对小鼠衰老大脑前额叶皮质神经元固有兴奋性和自发神经递质信号转导产生持久影响。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-15 DOI: 10.1016/j.neurobiolaging.2024.09.014

Grace C. Smith , Keith R. Griffith , Avery R. Sicher , Dakota F. Brockway , Elizabeth A. Proctor , Nicole A. Crowley

{"title":"Alcohol consumption confers lasting impacts on prefrontal cortical neuron intrinsic excitability and spontaneous neurotransmitter signaling in the aging brain in mice","authors":"Grace C. Smith , Keith R. Griffith , Avery R. Sicher , Dakota F. Brockway , Elizabeth A. Proctor , Nicole A. Crowley","doi":"10.1016/j.neurobiolaging.2024.09.014","DOIUrl":"10.1016/j.neurobiolaging.2024.09.014","url":null,"abstract":"<div><div>Both alcohol use disorder (AUD) and cognitive decline include disruption in the balance of excitation and inhibition in the cortex, but the potential role of alcohol use on excitation and inhibition on the aging brain is unclear. We examined the effect of moderate voluntary binge alcohol consumption on the aged, pre-disease neuronal environment by measuring intrinsic excitability and spontaneous neurotransmission on prefrontal cortical pyramidal (excitatory, glutamatergic) and non-pyramidal (inhibitory, GABAergic) neurons following a prolonged period of abstinence from alcohol in mice. Results highlight that binge alcohol consumption has lasting impacts on the electrophysiological properties of prefrontal cortical neurons. A profound increase in excitatory events onto layer 2/3 non-pyramidal neurons following alcohol consumption was seen, along with altered intrinsic excitability of pyramidal neurons, which could have a range of effects on cognitive disorder progression, such as Alzheimer’s Disease, in humans. These results indicate that moderate voluntary alcohol influences the pre-disease environment in aging and highlight the need for further mechanistic investigation into this risk factor.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"145 ","pages":"Pages 42-54"},"PeriodicalIF":3.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142546521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increased inflammation in older high-pressure glaucoma mice 老年高压青光眼小鼠炎症加剧

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-09 DOI: 10.1016/j.neurobiolaging.2024.10.001

Sabrina Reinehr , M. Rahim Pamuk , Rudolf Fuchshofer , H. Burkhard Dick , Stephanie C. Joachim

{"title":"Increased inflammation in older high-pressure glaucoma mice","authors":"Sabrina Reinehr , M. Rahim Pamuk , Rudolf Fuchshofer , H. Burkhard Dick , Stephanie C. Joachim","doi":"10.1016/j.neurobiolaging.2024.10.001","DOIUrl":"10.1016/j.neurobiolaging.2024.10.001","url":null,"abstract":"<div><div>Besides an elevated intraocular pressure (IOP), advanced age is one of the most crucial risk factors for developing glaucoma. βB1-Connective Tissue Growth Factor (βB1-CTGF) high-pressure glaucoma mice were used in this study to assess whether glaucoma mice display more inflammatory and aging processes than age-matched controls. Therefore, 20-month-old βB1-CTGF and corresponding wildtype (WT) controls were examined. After IOP measurements, retinas were processed for (immuno-)histological and quantitative real-time PCR analyses. A significantly higher IOP and diminished retinal ganglion cell numbers were noted in βB1-CTGF mice compared to WT. An enhanced macrogliosis as well as an increased number of microglia/macrophages and microglia was detected in retinas of old glaucoma mice. Interleukin (IL)-1β, IL-6, tumor necrosis factor-α, and transforming growth factor-β2 were upregulated, suggesting an ongoing inflammation. Moreover, βB1-CTGF retinas displayed an increased senescence-associated β-galactosidase staining accompanied by a downregulation of <em>Lmnb1</em> (laminin-B1) mRNA levels. Our results provide a deeper insight into the association between inflammation and high-pressure glaucoma and thus might help to develop new therapy strategies.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"145 ","pages":"Pages 55-64"},"PeriodicalIF":3.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142552646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster 组蛋白酰化阅读器ENL/AF9调控黑腹果蝇的衰老

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-10-09 DOI: 10.1016/j.neurobiolaging.2024.10.002

Ranchana Yeewa , Sureena Pohsa , Titaree Yamsri , Wasinee Wongkummool , Phatcharida Jantaree , Saranyapin Potikanond , Wutigri Nimlamool , Vorasuk Shotelersuk , Luca Lo Piccolo , Salinee Jantrapirom

{"title":"The histone acylation reader ENL/AF9 regulates aging in Drosophila melanogaster","authors":"Ranchana Yeewa , Sureena Pohsa , Titaree Yamsri , Wasinee Wongkummool , Phatcharida Jantaree , Saranyapin Potikanond , Wutigri Nimlamool , Vorasuk Shotelersuk , Luca Lo Piccolo , Salinee Jantrapirom","doi":"10.1016/j.neurobiolaging.2024.10.002","DOIUrl":"10.1016/j.neurobiolaging.2024.10.002","url":null,"abstract":"<div><div>Histone acylation plays a pivotal role in modulating gene expression, ensuring proper neurogenesis and responsiveness to various signals. Recently, the evolutionary conserved YAF9, ENL, AF9, TAF41, SAS5 (YEATS) domain found in four human paralogs, has emerged as a new class of histone acylation reader with a preference for the bulkier crotonyl group lysine over acetylation. Despite advancements, the role of either histone crotonylation or its readers in neurons remains unclear. In this study, we employed <em>Drosophila melanogaster</em> to investigate the role of ENL/AF9 (dENL/AF9) in the nervous system. Pan-neuronal <em>dENL/AF9</em> knockdown not only extended the lifespan of flies but also enhanced their overall fitness during aging, including improved sleep quality and locomotion. Moreover, a decreased activity of dENL/AF9 in neurons led to an up-regulation of <em>catalase</em> gene expression which combined with reduced levels of malondialdehyde (MDA) and an enhanced tolerance to oxidative stress in aging flies. This study unveiled a novel function of histone crotonylation readers in aging with potential implications for understanding age-related conditions in humans.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 153-162"},"PeriodicalIF":3.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142432448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Midlife dynamics of white matter architecture in lexical production 词汇生成中白质结构的中年动态变化

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-28 DOI: 10.1016/j.neurobiolaging.2024.09.013

Clément Guichet , Élise Roger , Arnaud Attyé , Sophie Achard , Martial Mermillod , Monica Baciu

{"title":"Midlife dynamics of white matter architecture in lexical production","authors":"Clément Guichet , Élise Roger , Arnaud Attyé , Sophie Achard , Martial Mermillod , Monica Baciu","doi":"10.1016/j.neurobiolaging.2024.09.013","DOIUrl":"10.1016/j.neurobiolaging.2024.09.013","url":null,"abstract":"<div><div>We aimed to examine the white matter changes associated with lexical production difficulties, beginning in midlife with increased naming latencies. To delay lexical production decline, middle-aged adults may rely on domain-general and language-specific compensatory mechanisms proposed by the LARA model (Lexical Access and Retrieval in Aging). However, the white matter changes supporting these mechanisms remains largely unknown. Using data from the CAMCAN cohort, we employed an unsupervised and data-driven methodology to examine the relationships between diffusion-weighted imaging and lexical production. Our findings indicate that midlife is marked by alterations in brain structure within distributed dorsal, ventral, and anterior cortico-subcortical networks, marking the onset of lexical production decline around ages 53–54. Middle-aged adults may initially adopt a “semantic strategy” to compensate for lexical production challenges, but this strategy seems compromised later (ages 55–60) as semantic control declines. These insights underscore the interplay between domain-general and language-specific processes in the trajectory of lexical production performance in healthy aging and hint at potential biomarkers for language-related neurodegenerative pathologies.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 138-152"},"PeriodicalIF":3.7,"publicationDate":"2024-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142365890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corrigendum to: A clinical, molecular genetics and pathological study of a FTDP-17 family with a heterozygous splicing variant c.823-10 G>T at the intron 9/exon 10 of the MAPT gene. 更正：一个患有 MAPT 基因内含子 9/ 外显子 10 的杂合剪接变异 c.823-10 G>T 的 FTDP-17 家族的临床、分子遗传学和病理学研究。

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-23 DOI: 10.1016/j.neurobiolaging.2024.09.011

Diana A Olszewska, Conor Fearon, Christopher McGuigan, Terri P McVeigh, Henry Houlden, James M Polke, Brian Lawlor, Robert Coen, Michael Hutchinson, Michael Hutton, Alan Beausang, Isabelle Delon, Francesca Brett, Ioanna Sevastou, Nuria Seto-Salvia, Rohan de Silva, Tim Lynch

引用次数: 0

Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging 利用基于 PET 的布拉克分期模拟阿尔茨海默病神经精神症状的发展过程

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-20 DOI: 10.1016/j.neurobiolaging.2024.09.009

Arthur C. Macedo , Joseph Therriault , Cécile Tissot , Étienne Aumont , Stijn Servaes , Nesrine Rahmouni , Jaime Fernandez-Arias , Firoza Z. Lussier , Yi-Ting Wang , Kok Pin Ng , Marie Vermeiren , Gleb Bezgin , Kely Quispialaya Socualaya , Jenna Stevenson , Seyyed Ali Hosseini , Mira Chamoun , João Pedro Ferrari-Souza , Pâmela C.L. Ferreira , Bruna Bellaver , Douglas Teixeira Leffa , Pedro Rosa-Neto

{"title":"Modeling the progression of neuropsychiatric symptoms in Alzheimer’s disease with PET-based Braak staging","authors":"Arthur C. Macedo , Joseph Therriault , Cécile Tissot , Étienne Aumont , Stijn Servaes , Nesrine Rahmouni , Jaime Fernandez-Arias , Firoza Z. Lussier , Yi-Ting Wang , Kok Pin Ng , Marie Vermeiren , Gleb Bezgin , Kely Quispialaya Socualaya , Jenna Stevenson , Seyyed Ali Hosseini , Mira Chamoun , João Pedro Ferrari-Souza , Pâmela C.L. Ferreira , Bruna Bellaver , Douglas Teixeira Leffa , Pedro Rosa-Neto","doi":"10.1016/j.neurobiolaging.2024.09.009","DOIUrl":"10.1016/j.neurobiolaging.2024.09.009","url":null,"abstract":"<div><div>In Alzheimer’s disease (AD), neuropsychiatric symptoms (NPS) correlate with tau deposition in the brain. Here, we investigated the association of PET-based Braak stages with NPS and assessed whether they predict annual changes in NPS. We evaluated 231 individuals in the aging and AD continuum. Participants were assigned a Braak stage at baseline and followed for 1.97 (s.d. 0.62) years. NPS were investigated using the Mild Behavioral Impairment Checklist (MBI-C) and the Neuropsychiatric Inventory Questionnaire severity (NPI-Q-S) and distress (NPI-Q-D) scales. Multiple linear regressions (MLR) assessed the association of Braak stages with baseline NPS and the annual change in NPS scores. At baseline, stages I-II, III-IV, and V-VI were associated with higher MBI-C, NPI-Q-S, and NPI-Q-D scores. Stages V-VI were associated with a significant annual increase in MBI-C scores. These findings suggest that tau accumulation may manifest clinically with an increase in NPS, which seems to be an early event in AD pathophysiology. Moreover, PET-based Braak staging appears to be a good predictor of NPS severity progression.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 127-137"},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142320423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study 听觉分心、时间感知和年龄的作用：来自大型队列研究的 ERP 证据

IF 3.7 3区医学

Neurobiology of Aging Pub Date : 2024-09-20 DOI: 10.1016/j.neurobiolaging.2024.09.012

Stephan Getzmann , Stefan Arnau , Patrick D. Gajewski , Edmund Wascher

{"title":"Auditory distraction, time perception, and the role of age: ERP evidence from a large cohort study","authors":"Stephan Getzmann , Stefan Arnau , Patrick D. Gajewski , Edmund Wascher","doi":"10.1016/j.neurobiolaging.2024.09.012","DOIUrl":"10.1016/j.neurobiolaging.2024.09.012","url":null,"abstract":"<div><div>Cognitive aging is typically associated with a higher susceptibility to distraction by concurrent, but task-irrelevant stimuli. Here, we studied the cognitive sub-processes involved in a sample of 484 healthy adults aged 20–70 years from the Dortmund Vital Study (Clinicaltrials.gov NCT05155397). Participants judged the duration of tone stimuli of a random sequence of long and short tones, having either a regular (standard) pitch or rare (deviant) pitch. Deviance-related ERPs were explored, reflecting neuro-cognitive correlates of pre-attentive deviance detection (MMN), attention allocation toward (P3a) and processing of (P3b) the deviance, and re-orienting toward the task-relevant stimulus feature (RON). Accuracy was reduced for deviant long tones, possibly due to withdrawing attention from processing the time information, making long stimuli appear shorter. This effect increased with age, and cluster-based permutation tests on the correlation of ERPs and age as well as linear mixed modeling indicated a decrease in MMN, an increase in P3a with long tones, and decreases in P3b and RON. This suggests a greater attentional orienting to the deviant stimulus feature and a reduced re-orienting to the task-relevant feature with increasing age.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"144 ","pages":"Pages 114-126"},"PeriodicalIF":3.7,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001684/pdfft?md5=9e201cba5e1f630157f34d81aa6fade5&pid=1-s2.0-S0197458024001684-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142312402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0