The links among age, sex, and glutathione: A cross-sectional magnetic resonance spectroscopy study

IF 3.7 3区医学 Q2 GERIATRICS & GERONTOLOGY

Neurobiology of Aging Pub Date : 2024-08-31 DOI:10.1016/j.neurobiolaging.2024.08.010

Lars Michels , Ruth O’Gorman-Tuura , Dario Bachmann , Susanne Müller , Sandro Studer , Antje Saake , Esmeralda Gruber , Katrin Rauen , Andreas Buchmann , Isabelle Zuber , Christoph Hock , Anton Gietl , Valerie Treyer

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引用次数: 0

Abstract

Glutathione (GSH) is a brain marker for oxidative stress and has previously been associated with cerebral amyloid deposition and memory decline. However, to date, no study has examined the links among GSH, sex, age, amyloid, and Apolipoprotein E (APOE) genotype in a large non-clinical cohort of older adults. We performed APOE genotyping, magnetic resonance spectroscopy (MRS) as well as simultaneous positron emission tomography with the radiotracer Flutemetamol (Amyloid-PET), in a group of older adults. The final analysis set comprised 140 healthy older adults (mean age: 64.7 years) and 49 participants with mild cognitive impairment (mean age: 71.4 years). We recorded metabolites in the posterior cingulate cortex (PCC) by a GSH-edited MEGAPRESS sequence. Structural equation modeling revealed that higher GSH levels were associated with female sex, but neither APOE- epsilon 4 carrier status nor age showed significant associations with GSH. Conversely, older age and the presence of an APOE4 allele, but not sex, are linked to higher global amyloid load. Our results suggest that the PCC shows sex-specific GSH alterations in older adults.

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年龄、性别和谷胱甘肽之间的联系：一项横断面磁共振光谱研究

谷胱甘肽（GSH）是大脑氧化应激的标志物，以前曾被认为与脑淀粉样蛋白沉积和记忆力衰退有关。然而，迄今为止，还没有研究在一个大型非临床老年人队列中考察过 GSH、性别、年龄、淀粉样蛋白和载脂蛋白 E（APOE）基因型之间的联系。我们对一组老年人进行了载脂蛋白 E 基因分型、磁共振光谱（MRS）以及使用放射性示踪剂氟替美托（Amyloid-PET）的同步正电子发射断层扫描。最终分析组包括 140 名健康老年人（平均年龄 64.7 岁）和 49 名轻度认知障碍患者（平均年龄 71.4 岁）。我们利用经 GSH 编辑的 MEGAPRESS 序列记录了后扣带回皮层（PCC）中的代谢物。结构方程建模显示，较高的 GSH 水平与女性性别有关，但 APOE- epsilon 4 携带者身份和年龄均与 GSH 无关。相反，年龄较大和存在 APOE4 等位基因（而非性别）与较高的总体淀粉样蛋白负荷有关。我们的研究结果表明，在老年人中，PCC的GSH改变具有性别特异性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Neurobiology of Aging 医学-老年医学

CiteScore

8.40

自引率

2.40%

发文量

225

审稿时长

67 days

期刊介绍： Neurobiology of Aging publishes the results of studies in behavior, biochemistry, cell biology, endocrinology, molecular biology, morphology, neurology, neuropathology, pharmacology, physiology and protein chemistry in which the primary emphasis involves mechanisms of nervous system changes with age or diseases associated with age. Reviews and primary research articles are included, occasionally accompanied by open peer commentary. Letters to the Editor and brief communications are also acceptable. Brief reports of highly time-sensitive material are usually treated as rapid communications in which case editorial review is completed within six weeks and publication scheduled for the next available issue.