Neurobiology of Aging最新文献

{"title":"Predicting brain atrophy and cognitive aging trajectories with baseline subjective cognitive concerns in cognitively normal older adults","authors":"Michelle You ,&nbsp;Cutter A. Lindbergh ,&nbsp;Renaud La Joie ,&nbsp;Emily W. Paolillo ,&nbsp;Rowan Saloner ,&nbsp;Valentina Diaz ,&nbsp;Devyn L. Cotter ,&nbsp;Samantha Walters ,&nbsp;Marie Altendahl ,&nbsp;Adam M. Staffaroni ,&nbsp;Joel H. Kramer ,&nbsp;Leslie S. Gaynor ,&nbsp;Kaitlin B. Casaletto","doi":"10.1016/j.neurobiolaging.2024.08.006","DOIUrl":"10.1016/j.neurobiolaging.2024.08.006","url":null,"abstract":"<div><p>Subjective cognitive concerns (SCC) are common even in cognitively normal older adults who lack objectively-detectable deficits on standard neuropsychological evaluation. The clinical relevance of these concerns, particularly considering the nature of concerns (e.g., memory versus non-memory), remains unclear. Thus, we examined whether baseline memory and non-memory SCC relate to longitudinal change in brain volume and neuropsychological test performance in 476 functionally-intact, objectively unimpaired older adults (<em>M</em>_<em>age</em> = 72y, 56 % female, follow-up time = 1 – 9 years). Mixed-effects models revealed that both higher baseline memory and non-memory SCC predicted greater atrophy in total gray matter and dorsolateral prefrontal cortex atrophy over time, while only memory SCC predicted steeper medial temporal lobe atrophy. Regarding neuropsychological performance, higher non-memory SCC predicted decline in processing speed performance, while memory SCC did not predict neuropsychological trajectories. SCC are a risk factor for more adverse brain and cognitive aging trajectories, even in functionally-intact, seemingly cognitively normal older adults.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma p-tau181 and amyloid markers in Alzheimer’s disease: A comparison between Lumipulse and SIMOA","authors":"Virginia Quaresima ,&nbsp;Andrea Pilotto ,&nbsp;Chiara Trasciatti ,&nbsp;Chiara Tolassi ,&nbsp;Marta Parigi ,&nbsp;Diego Bertoli ,&nbsp;Cristina Mordenti ,&nbsp;Alice Galli ,&nbsp;Andrea Rizzardi ,&nbsp;Salvatore Caratozzolo ,&nbsp;Alberto Benussi ,&nbsp;Nicholas J. Ashton ,&nbsp;Kaj Blennow ,&nbsp;Henrik Zetterberg ,&nbsp;Silvia Giliani ,&nbsp;Duilio Brugnoni ,&nbsp;Alessandro Padovani","doi":"10.1016/j.neurobiolaging.2024.08.007","DOIUrl":"10.1016/j.neurobiolaging.2024.08.007","url":null,"abstract":"<div><p>Aim of the project was to evaluate the technical and clinical validity of plasma Lumipulse p-tau, Aβ42 and Aβ40 species and their correlation with CSF core Alzheimer’s Disease (AD) markers; a method comparison with SIMOA was also performed. One-hundred-thirthy-three participants, namely 55 A+T+N+ AD, 28 Neurodegenerative disorders (NDD) and 50 controls were enrolled for the study. Lumipulse technical validity showed high stability for p-tau181, Aβ42, and Aβ40, with higher stability of p-tau to repeated freezing thaw cycles. p-tau181 levels detected by both techniques were higher in AD compared to both NDD/controls and exhibited a similar correlation with CSF p-tau levels, whereas Aβ42 levels were slightly lower in AD with both methods. In the comparison between SIMOA and Lumipulse plasma markers, both techniques exhibited similar diagnostic accuracy for AD for p-tau181 (0.87; 95 %CI 0.81–0.94, vs 0.85; 95 %CI 0.78–0.93), whereas the best performance was reached by p-tau181/ Aβ42 Lumipulse ratio (ROC AUC 0.915, 95 %CI 0.86–0.97). The study thus confirmed the construct validity of both Lumipulse and SIMOA techniques for the identification of CSF AD pattern in clinical settings.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 30-40"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001374/pdfft?md5=a1f0f456d843a0edb19575e002f8adad&pid=1-s2.0-S0197458024001374-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contrasting association pattern of plasma low-density lipoprotein with white matter integrity in APOE4 carriers versus non-carriers","authors":"Zhenyao Ye ,&nbsp;Yezhi Pan ,&nbsp;Rozalina G. McCoy ,&nbsp;Chuan Bi ,&nbsp;Chen Mo ,&nbsp;Li Feng ,&nbsp;Jiaao Yu ,&nbsp;Tong Lu ,&nbsp;Song Liu ,&nbsp;J. Carson Smith ,&nbsp;Minxi Duan ,&nbsp;Si Gao ,&nbsp;Yizhou Ma ,&nbsp;Chixiang Chen ,&nbsp;Braxton D. Mitchell ,&nbsp;Paul M. Thompson ,&nbsp;L. Elliot Hong ,&nbsp;Peter Kochunov ,&nbsp;Tianzhou Ma ,&nbsp;Shuo Chen","doi":"10.1016/j.neurobiolaging.2024.08.005","DOIUrl":"10.1016/j.neurobiolaging.2024.08.005","url":null,"abstract":"<div><p>Apolipoprotein E ε4 (<em>APOE4</em>) is a strong genetic risk factor of Alzheimer’s disease and metabolic dysfunction. However, whether <em>APOE4</em> and markers of metabolic dysfunction synergistically impact the deterioration of white matter (WM) integrity in older adults remains unknown. In the UK Biobank data, we conducted a multivariate analysis to investigate the interactions between <em>APOE4</em> and 249 plasma metabolites (measured using nuclear magnetic resonance spectroscopy) with whole-brain WM integrity (measured by diffusion-weighted magnetic resonance imaging) in a cohort of 1917 older adults (aged 65.0–81.0 years; 52.4 % female). Although no main association was observed between either <em>APOE4</em> or metabolites with WM integrity (adjusted <em>P</em> &gt; 0.05), significant interactions between <em>APOE4</em> and metabolites with WM integrity were identified. Among the examined metabolites, higher concentrations of low-density lipoprotein and very low-density lipoprotein were associated with a lower level of WM integrity (b=<span><math><mrow><mo>−</mo><mn>0.12</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.14</mn><mo>,</mo><mo>−</mo><mn>0.10</mn></mrow></mfenced></mrow></math></span>) among <em>APOE4</em> carriers. Conversely, among non-carriers, they were associated with a higher level of WM integrity (b=0.05, CI=<span><math><mrow><mfenced><mrow><mn>0.04,0.07</mn></mrow></mfenced></mrow></math></span>), demonstrating a significant moderation role of <em>APOE4</em> (b =<span><math><mrow><mo>−</mo><mn>0.18</mn></mrow></math></span>, CI=<span><math><mrow><mfenced><mrow><mo>−</mo><mn>0.20</mn><mo>,</mo><mo>−</mo><mn>0.15</mn></mrow></mfenced></mrow></math></span>, P&lt;0.00001).</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 41-52"},"PeriodicalIF":3.7,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142099210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between brain structure and dual decline in gait and cognition","authors":"Sadhani Karunarathna ,&nbsp;Monique Breslin ,&nbsp;Jane Alty ,&nbsp;Richard Beare ,&nbsp;Taya A. Collyer ,&nbsp;Velandai K. Srikanth ,&nbsp;James Scott McDonald ,&nbsp;Michele L. Callisaya","doi":"10.1016/j.neurobiolaging.2024.08.004","DOIUrl":"10.1016/j.neurobiolaging.2024.08.004","url":null,"abstract":"<div><p>Dual decline in gait and cognition is associated with an increased risk of dementia, with combined gait and memory decline exhibiting the strongest association. To better understand the underlying pathology, we investigated the associations of baseline brain structure with dual decliners using three serial gait speed and cognitive assessments in memory, processing speed-attention, and verbal fluency. Participants (n=267) were categorized based on annual decline in gait speed and cognitive measures. Lower gray and white matter volume and higher white matter hyperintensity volume increased the risk of being a dual decliner in gait and both the memory and processing speed-attention groups (all p &lt; 0.05). Lower hippocampal volume (p = 0.047) was only associated with dual decline in gait and memory group. No brain structures were correlated with dual decline in gait and verbal fluency. These results suggest that neurodegenerative pathology and white matter hyperintensities are involved in dual decline in gait and both memory and processing speed-attention. Smaller hippocampal volume may only contribute to dual decline in gait and memory.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 10-18"},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001386/pdfft?md5=3f3ee4f11a8de446b5c1252b938496ce&pid=1-s2.0-S0197458024001386-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Older adults do not show enhanced benefits from multisensory information on speeded perceptual discrimination tasks","authors":"Christopher Atkin ,&nbsp;Jemaine E. Stacey ,&nbsp;Harriet A. Allen ,&nbsp;Helen Henshaw ,&nbsp;Katherine L. Roberts ,&nbsp;Stephen P. Badham","doi":"10.1016/j.neurobiolaging.2024.08.003","DOIUrl":"10.1016/j.neurobiolaging.2024.08.003","url":null,"abstract":"<div><p>Some research has shown that older adults benefit more from multisensory information than do young adults. However, more recent evidence has shown that the multisensory age benefit varies considerably across tasks. In the current study, older (65 – 80) and young (18 – 30) adults (<em>N</em> = 191) completed a speeded perceptual discrimination task either online or face-to-face to assess task response speed. We examined whether presenting stimuli in multiple sensory modalities (audio-visual) instead of one (audio-only or visual-only) benefits older adults more than young adults. Across all three experiments, a consistent speeding of response was found in the multisensory condition compared to the unisensory conditions for both young and older adults. Furthermore, race model analysis showed a significant multisensory benefit across a broad temporal interval. Critically, there were no significant differences between young and older adults. Taken together, these findings provide strong evidence in favour of a multisensory benefit that does not differ across age groups, contrasting with prior research.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 65-72"},"PeriodicalIF":3.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001349/pdfft?md5=562261707f77496910d9ed7e9e43b249&pid=1-s2.0-S0197458024001349-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142020794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in how the shape of alpha and beta oscillations change during reaction time tasks","authors":"George M. Opie ,&nbsp;James M. Hughes ,&nbsp;Rohan Puri","doi":"10.1016/j.neurobiolaging.2024.08.001","DOIUrl":"10.1016/j.neurobiolaging.2024.08.001","url":null,"abstract":"<div><p>While the <em>shape</em> of cortical oscillations is increasingly recognised to be physiologically and functionally informative, its relevance to the aging motor system has not been established. We therefore examined the shape of alpha and beta band oscillations recorded at rest, as well as during performance of simple and go/no-go reaction time tasks, in 33 young (23.3 ± 2.9 years, 27 females) and 27 older (60.0 ± 5.2 years, 23 females) adults. The shape of individual oscillatory cycles was characterised using a recently developed pipeline involving empirical mode decomposition, before being decomposed into waveform motifs using principal component analysis. This revealed four principal components that were uniquely influenced by task and/or age. These described specific dimensions of shape and tended to be modulated during the reaction phase of each task. Our results suggest that although oscillation shape is task-dependent, the nature of this effect is altered by advancing age, possibly reflecting alterations in cortical activity. These outcomes demonstrate the utility of this approach for understanding the neurophysiological effects of ageing.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"142 ","pages":"Pages 52-64"},"PeriodicalIF":3.7,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001325/pdfft?md5=70b87d1e5a245772f9470cc43494761b&pid=1-s2.0-S0197458024001325-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141993355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Explainable artificial intelligence identifies an AQP4 polymorphism-based risk score associated with brain amyloid burden","authors":"Simone Beer ,&nbsp;David Elmenhorst ,&nbsp;Gerard N. Bischof ,&nbsp;Alfredo Ramirez ,&nbsp;Andreas Bauer ,&nbsp;Alexander Drzezga ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2024.08.002","DOIUrl":"10.1016/j.neurobiolaging.2024.08.002","url":null,"abstract":"<div><p>Aquaporin-4 (AQP4) is hypothesized to be a component of the glymphatic system, a pathway for removing brain interstitial solutes like amyloid-β (Aβ). Evidence exists that genetic variation of AQP4 impacts Aβ clearance, clinical outcome in Alzheimer’s disease as well as sleep measures. We examined whether a risk score calculated from several AQP4 single-nucleotide polymorphisms (SNPs) is related to Aβ neuropathology in older cognitively unimpaired white individuals. We used a machine learning approach and explainable artificial intelligence to extract information on synergistic effects of AQP4 SNPs on brain amyloid burden from the ADNI cohort. From this information, we formulated a sex-specific AQP4 SNP-based risk score and evaluated it using data from the screening process of the A4 study. We found in both cohorts significant associations of the risk score with brain amyloid burden. The results support the hypothesis of an involvement of the glymphatic system, and particularly AQP4, in brain amyloid aggregation pathology. They suggest also that different AQP4 SNPs exert a synergistic effect on the build-up of brain amyloid burden.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"143 ","pages":"Pages 19-29"},"PeriodicalIF":3.7,"publicationDate":"2024-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001337/pdfft?md5=c5699bac2cc221af526e85186f349a58&pid=1-s2.0-S0197458024001337-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142087225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(24)00127-1","DOIUrl":"10.1016/S0197-4580(24)00127-1","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Page IFC"},"PeriodicalIF":3.7,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001271/pdfft?md5=ee9c6407e2fa85942cf08dcabd62ec8c&pid=1-s2.0-S0197458024001271-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141623584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lifespan differences in hippocampal subregion connectivity patterns during movie watching","authors":"Can Fenerci ,&nbsp;Roni Setton ,&nbsp;Giulia Baracchini ,&nbsp;Jamie Snytte ,&nbsp;R. Nathan Spreng ,&nbsp;Cam CAN ,&nbsp;Signy Sheldon","doi":"10.1016/j.neurobiolaging.2024.06.006","DOIUrl":"10.1016/j.neurobiolaging.2024.06.006","url":null,"abstract":"<div><p>Age-related episodic memory decline is attributed to functional alternations in the hippocampus. Less clear is how aging affects the functional connections of the hippocampus to the rest of the brain during episodic memory processing. We examined fMRI data from the CamCAN dataset, in which a large cohort of participants watched a movie (N = 643; 18–88 years), a proxy for naturalistic episodic memory encoding. We examined connectivity profiles across the lifespan both within the hippocampus (anterior, posterior), and between the hippocampal subregions and cortical networks. Aging was associated with reductions in contralateral (left, right) but not ipsilateral (anterior, posterior) hippocampal subregion connectivity. Aging was primarily associated with increased coupling between the anterior hippocampus and regions affiliated with Control, Dorsal Attention and Default Mode networks, yet decreased coupling between the posterior hippocampus and a selection of these regions. Differences in age-related hippocampal-cortical, but not within-hippocampus circuitry selectively predicted worse memory performance. Our findings comprehensively characterize hippocampal functional topography in relation to cognition in older age, suggesting that shifts in cortico-hippocampal connectivity may be sensitive markers of age-related episodic memory decline.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 182-193"},"PeriodicalIF":3.7,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141538212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced PIN1 expression in neocortical and limbic brain regions in female Alzheimer’s patients correlates with cognitive and neuropathological phenotypes","authors":"Camila de Ávila ,&nbsp;Crystal Suazo ,&nbsp;Jennifer Nolz ,&nbsp;J. Nicholas Cochran ,&nbsp;Qi Wang ,&nbsp;Ramon Velazquez ,&nbsp;Eric Dammer ,&nbsp;Benjamin Readhead ,&nbsp;Diego Mastroeni","doi":"10.1016/j.neurobiolaging.2024.06.007","DOIUrl":"10.1016/j.neurobiolaging.2024.06.007","url":null,"abstract":"<div><p>Women have a higher incidence of Alzheimer’s disease (AD), even after adjusting for increased longevity. Thus, there is an urgent need to identify genes that underpin sex-associated risk of AD. PIN1 is a key regulator of the tau phosphorylation signaling pathway; however, potential differences in PIN1 expression, in males and females, are still unknown. We analyzed brain transcriptomic datasets focusing on sex differences in PIN1 mRNA levels in an aging and AD cohort, which revealed reduced PIN1 levels primarily within females. We validated this observation in an independent dataset (ROS/MAP), which also revealed that PIN1 is negatively correlated with multiregional neurofibrillary tangle density and global cognitive function in females only. Additional analysis revealed a decrease in PIN1 in subjects with mild cognitive impairment (MCI) compared with aged individuals, again driven predominantly by female subjects. Histochemical analysis of PIN1 in AD and control male and female neocortex revealed an overall decrease in axonal PIN1 protein levels in females. These findings emphasize the importance of considering sex differences in AD research.</p></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"141 ","pages":"Pages 160-170"},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0197458024001258/pdfft?md5=c32858ca61f61acfd6886574acd18ff8&pid=1-s2.0-S0197458024001258-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141534891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}