Neurobiology of Aging最新文献

{"title":"Neural network mechanisms of emotional dysregulation in cerebral small vessel disease","authors":"Olga R. Dobrushina ,&nbsp;Larisa A. Dobrynina ,&nbsp;Galina A. Arina ,&nbsp;Evgenia S. Novikova ,&nbsp;Mariia M. Tsypushtanova ,&nbsp;Angelina G. Makarova ,&nbsp;Mariia V. Gubanova ,&nbsp;Viktoriya V. Trubitsyna ,&nbsp;Vlada V. Kolomoitseva ,&nbsp;Daria A. Kazantseva ,&nbsp;Elena I. Kremneva ,&nbsp;Marina V. Krotenkova","doi":"10.1016/j.neurobiolaging.2025.07.013","DOIUrl":"10.1016/j.neurobiolaging.2025.07.013","url":null,"abstract":"<div><div>Cerebral small vessel disease (CSVD) is a prevalent age-related disorder that leads to progressive white matter damage, resulting in cognitive decline and depression. This study explored the neural network mechanisms of emotional dysregulation in CSVD, focusing on both depression and alexithymia and considering the broader context of studies on emotional cardiovascular risk factors. Study participants (n = 196, age 37–75) were assessed for CSVD, arterial hypertension, depressive symptoms, and alexithymia. Emotional dysregulation, defined by depression and alexithymia, was estimated using a structural equation model accounting for the potential of bidirectional links with CSVD. To investigate the connectivity of networks involved in emotional processing, 167 participants underwent resting-state functional MRI. The study showed that emotional dysregulation was associated with reduced functional connectivity between the salience and language networks and within the language network. Age was associated with reduced functional connectivity within the salience and language networks, suggesting a possibility of synergistic deleterious effects. The revealed alterations in brain connectivity might reflect the dysfunction of the system of allostasis, explaining the observed symptoms of depression and alexithymia, as well as the previous findings on emotional cardiovascular risk factors.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"155 ","pages":"Pages 78-86"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144703719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal non-linear changes in the microstructure of the hippocampal subfields in older adults","authors":"Ghina Zia ,&nbsp;Syed Salman Shahid ,&nbsp;Ho-Ching Yang ,&nbsp;Sujuan Gao ,&nbsp;Shannon L. Risacher ,&nbsp;Andrew J. Saykin ,&nbsp;Yu-Chien Wu","doi":"10.1016/j.neurobiolaging.2025.07.008","DOIUrl":"10.1016/j.neurobiolaging.2025.07.008","url":null,"abstract":"<div><div>Human brains undergo considerable morphologic variation with age, a primary risk factor for neurodegenerative disorders. While aging often causes neurocognitive decline, its governing biological mechanisms remain unclear. These age-related brain microstructural changes may be quantified by advanced diffusion MRI (dMRI) with tissue-specific compartment modeling approach. This longitudinal study investigates age-related differences in hippocampal subfields vulnerable to early stages of Alzheimer’s disease (AD). Thirty-seven cognitively normal (CN) older adults (70.6 ± 6.7 years) from the Indiana Alzheimer's Disease Research Center (IADRC) underwent baseline and follow-up MRI scans, within 24 ± 11.7 months. Grey matter-specific multi-compartment diffusion model, cortical-neurite orientation dispersion, and density imaging (cortical-NODDI) was used to derive diffusion microstructural metrics, namely orientation dispersion index (ODI) and neurite density index (NDI) in hippocampal-subfields (CA1–3, CA4DG, and subiculum). We investigated rate of change in diffusion metrics and its associations with age and baseline diffusion metrics in hippocampal subfields using linear regression analysis, after adjusting for confounding factors (i.e., sex, education, Apolipoprotein E <em>(APOE) ε4</em>, and baseline subfield volumes). CA1–3 and subiculum volumes significantly decreased between baseline and follow-up scans. ODI rate of change was significantly higher than zero in CA4DG, while rate of change in NDI was significantly lower than zero in CA1–3 and CA4DG. ODI rate of change in CA1–3 was significantly associated with baseline age of participants and initial microstructural value of ODI in CA1–3. Results showed that Cornu Ammonis is most sensitive to age-related changes with increased microstructural dispersion and decreased neurite density with age- and initial state-dependent changes.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"155 ","pages":"Pages 113-123"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related increased frontal activation in sentence comprehension reflects inefficiency, not compensation","authors":"Maxime Perron ,&nbsp;Hannah Shatzer ,&nbsp;Michael Zara ,&nbsp;Frank Russo","doi":"10.1016/j.neurobiolaging.2025.07.014","DOIUrl":"10.1016/j.neurobiolaging.2025.07.014","url":null,"abstract":"<div><div>Cognitive aging is associated with increased prefrontal cortex (PFC) activity, often interpreted as either a compensatory mechanism or a sign of neural inefficiency. In the context of speech-in-noise perception, it remains unclear whether this increase supports or impairs performance, as findings across studies are mixed. This study investigated age-related differences in PFC activity during sentence comprehension in noise using functional near-infrared spectroscopy. Fifty-seven participants (22 younger adults, 35 older adults) listened to sentences ending in either a high- or low-predictability word under two signal-to-noise ratio (SNR) conditions. Older adults showed increased PFC activity as SNR decreased, whereas younger adults showed no significant modulation. Among older adults, lower performers exhibited the greatest right-lateralized PFC activity, suggesting the recruitment of suboptimal neural resources. At the trial level, incorrect responses were associated with greater bilateral PFC activity in both age groups. Mediation analyses revealed that the negative effect of age on performance was partially explained by increased bilateral PFC activity, indicating that overactivation contributes to age-related speech-in-noise difficulties. Hearing loss and cognitive ability did not predict overall PFC activity but moderated the effect of SNR on PFC activity. Specifically, older adults with better hearing or higher cognitive scores showed increased PFC activity in the difficult SNR condition compared to the easier one, whereas those with more hearing loss or lower cognition showed similar activity across conditions. No effects of sentence predictability were observed. These findings support a neural inefficiency framework and highlight the importance of addressing PFC overactivation to improve speech-in-noise communication in older adults.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"155 ","pages":"Pages 100-112"},"PeriodicalIF":3.5,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144750225","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated brain MRI utility in identifying neurodegenerative disorders at the pre-dementia stage","authors":"Chiara Carbone ,&nbsp;Chiara Gallingani ,&nbsp;Erica Balboni ,&nbsp;Ludovico Luchetti ,&nbsp;Giordano Gentile ,&nbsp;Riccardo Maramotti ,&nbsp;Daniela Ballotta ,&nbsp;Najara Iacovino ,&nbsp;Silvia Cossutti ,&nbsp;Alessandro Marti ,&nbsp;Manuela Tondelli ,&nbsp;Annalisa Chiari ,&nbsp;Marco Battaglini ,&nbsp;Giovanna Zamboni","doi":"10.1016/j.neurobiolaging.2025.07.012","DOIUrl":"10.1016/j.neurobiolaging.2025.07.012","url":null,"abstract":"<div><div>Despite the increasing availability of biomarkers in clinical settings, diagnosing individuals with subtle cognitive/behavioral symptoms and normal structural brain imaging remains challenging. In real-world settings, it is not feasible to subject all such patients to costly and invasive second-level assessments, and there are no clear guidelines for identifying those who should undergo these procedures beyond clinical follow-up and structural imaging. The present study explores the potential of repeated magnetic resonance imaging (MRI) in this context. We investigated whether detecting pathological brain volume (BV) changes exceeding normal aging could aid in deciding whether advanced biomarker testing is reasonable. Individuals with subtle cognitive/behavioral complaints underwent baseline and 18-month follow-up assessments (neuropsychological evaluation, MRI, and biomarker tests). Annualized percentage of BV change (PBVC/y), adjusted for age, sex, and scanner, was calculated with SIENA, and classified whether exceeding the 80th/95th percentiles of normative data. At follow-up, participants were classified (I) Converters/Non-Converters based on clinical information, (II) Non‐converters+/Non‐Converters‐ based on biomarkers status, and (III) Underlying disease based on both clinical follow-up and biomarkers. Logistic regressions assessed PBVC/y, baseline BV, and Mini-Mental State Examination change as predictors of participants’ classification. Among 110 participants, PBVC/y exceeding both the 80th/95th percentiles increased the probability of being classified Converters or Alzheimer’s disease/Frontotemporal dementia. Exceeding the 80th percentile increased the odds of being classified Non‐Converters+. Our results suggest that the application of SIENA normative data to repeated MRIs may help in deciding whether or not performing more invasive and high-cost second-level procedures in individuals with early-stage and subtle cognitive/behavioural changes.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"155 ","pages":"Pages 35-43"},"PeriodicalIF":3.7,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144685527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How is self-reported sleep-disordered breathing linked with biomarkers of Alzheimer’s disease?","authors":"Mohammad Akradi ,&nbsp;Tara Farzane-Daghigh ,&nbsp;Amir Ebneabbasi ,&nbsp;Hanwen Bi ,&nbsp;Alexander Drzezga ,&nbsp;Bryce A. Mander ,&nbsp;Simon B. Eickhoff ,&nbsp;Masoud Tahmasian ,&nbsp;for the Alzheimer’s Disease Neuroimaging Initiative","doi":"10.1016/j.neurobiolaging.2025.06.006","DOIUrl":"10.1016/j.neurobiolaging.2025.06.006","url":null,"abstract":"<div><div>Sleep-disordered breathing (SDB) is prevalent in Alzheimer’s disease (AD). Here, we assessed how self-reported SDB is linked with AD biomarkers, including amyloid-beta plaque burden (Aβ), regional fluorodeoxyglucose uptake (rFDG-PET), grey matter volume (GMV), cognitive scores, and cerebrospinal fluid (CSF) biomarkers. We selected 757 individuals, including AD, mild cognitive impairment (MCI), and cognitively unimpaired (CU) groups, and divided them according to self-reported SDB condition. Using a stratified subsampling approach, we selected 512 matched subsamples, and effect sizes (ES) of the group-SDB interaction were computed for each biomarker and cognitive score across subsamples. Linear regression assessed associations between the ES of Aβ, rFDG, and GMV with the ES of cognitive scores and CSF biomarkers. The group-SDB interaction had a medium-sized effect on Aβ, rFDG, and GMV biomarkers in several brain areas. Participants with SDB exhibited reduced Aβ burden and increased rFDG uptake in the CU and MCI groups, whereas the AD group showed elevated Aβ burden and decreased rFDG. Additionally, SDB+ individuals demonstrated GMV alterations across all groups. The ES of group-SDB interaction on Aβ in the precuneus, middle temporal gyrus, and fusiform gyrus was associated with the ES of cognitive scores. Taken together, we observed a robust association of SDB with Aβ pathology in PET and CSF relative to rFDG and GMV in the AD group, which was also associated with cognitive decline.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 16-24"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying lifestyle risk factors that discriminate memory trajectories: Differential findings across racial and ethnic groups in older adults","authors":"Shraddha Sapkota ,&nbsp;Pauline Maillard ,&nbsp;Evan M. Fletcher ,&nbsp;Danielle J. Harvey ,&nbsp;John M. Olichney ,&nbsp;Sarah Tomaszewski Farias ,&nbsp;Paola Gilsanz ,&nbsp;Dan Mungas ,&nbsp;Rachel A. Whitmer ,&nbsp;Charles DeCarli","doi":"10.1016/j.neurobiolaging.2025.07.002","DOIUrl":"10.1016/j.neurobiolaging.2025.07.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Differences in lifestyle factors contribute towards inequalities in dementia incidence and memory trajectories across racial and ethnic groups. We identifieded lifestyle risk factors that best discriminat memory trajectories in older adults without cognitive impairment.</div></div><div><h3>Method</h3><div>The study included 523 older adults from the University of California, Davis–Alzheimer’s disease Research Center and 1097 from the Kaiser Healthy-Aging and Diverse Life-Experiences Study. Age, sex, and 13 lifestyle risk factors were used to discriminate latent class memory trajectories in African Americans, Hispanics, and Whites. Structural equation modeling and machine learning methods were applied.</div></div><div><h3>Results</h3><div>In both cohorts, three patterns of memory trajectories were identified. While there was overlap between risk factors discriminating high and low memory patterns for everyone, we also identified key differences in the top predictors across groups in both cohorts.</div></div><div><h3>Discussion</h3><div>Identifying relative importance of lifestyle risk factors will promote early identification of adults with differential memory performance across and within racial and ethnic groups.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 84-91"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144562926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurobiological effects of exergame interventions in older adults with or without a neurocognitive disorder: A systematic review","authors":"Elpidio Attoh-Mensah ,&nbsp;Jean-François Bel ,&nbsp;Karim El Ayoubi ,&nbsp;Arnaud Boujut ,&nbsp;Stephen Ramanoël ,&nbsp;Anaïck Perrochon","doi":"10.1016/j.neurobiolaging.2025.06.009","DOIUrl":"10.1016/j.neurobiolaging.2025.06.009","url":null,"abstract":"<div><div>Exergames (EG) are interactive video games that require physical activity and use gamification to make exercise more engaging. EG interventions demonstrated various benefits for older adults including improved mental health, quality of life, and a reduced risk of falls. Enhanced cognition is considered one of the principal targets driving these benefits. This systematic review aimed to identify the neurobiological effects of EG interventions in healthy older adults and those with neurocognitive disorders. We systematically searched major databases for studies from inception up until June 2024 and included 12 reports. Findings revealed that EG interventions induced structural and functional brain changes, accompanied by improved cognitive and motor performance, as well as neuroplastic adaptations, such as elevated BDNF levels and enhanced neurovascular coupling, in healthy older adults. Similar findings were reported in older adults with neurocognitive disorders, though only in two studies, one showing increased frontal and temporal activity at rest, and the other reporting an increase in brain volume. Notably, methodological limitations in some studies, particularly those involving neuroimaging, underline the preliminary nature of the findings. Furthermore, the small number of studies included, especially those focusing on older adults with neurocognitive disorders, who often present with diverse clinical profiles, emphasizes the need for further research to validate these encouraging but currently low-evidence findings.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 47-61"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144534507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Balance training improves postural control and performance-related prefrontal brain activation in healthy older adults: Results of a six-month randomized controlled training intervention","authors":"Nico Lehmann ,&nbsp;Yves-Alain Kuhn ,&nbsp;Martin Keller ,&nbsp;Norman Aye ,&nbsp;Fabian Herold ,&nbsp;Bogdan Draganski ,&nbsp;Wolfgang Taube ,&nbsp;Marco Taubert","doi":"10.1016/j.neurobiolaging.2025.07.001","DOIUrl":"10.1016/j.neurobiolaging.2025.07.001","url":null,"abstract":"<div><div>Age-related deterioration in postural control is an important factor decreasing quality of life. Functional neuroimaging studies have shown that the activation of the prefrontal cortex (PFC) during balancing is typically higher in older (OA) compared to younger adults (YA), probably reflecting a mechanism contributing to worsened balance control with aging. Here, we hypothesized that balance training (BAL) shifts PFC activation towards a more efficient pattern, enabling improved balance performance. To test this hypothesis, we conducted a randomized controlled trial with healthy older (65–80 y) and young adults (18–35 y) of both sexes (<em>n</em> = 63) comparing the effects of a 6-month BAL intervention (1 h of BAL twice weekly) against age-matched, non-BAL controls (CON). In both age groups, we found that BAL led to a significant reduction in sway in trained and untrained balance tasks compared to CON, which could still be observed 6 months after the end of training (multivariate <em>p</em>’s &lt; .003). In OA, we found a larger reduction in PFC activation assessed with functional near-infrared spectroscopy in BAL compared to CON after training (multivariate <em>p</em> &lt; .02), and a similar yet not significant trend was observed in YA (<em>p</em> &lt; .06). Importantly, in OA, both cross-sectional correlations and longitudinal correlated changes showed that reduced PFC activation was associated with better balance performance. Our results support the idea that BAL may reduce dysfunctional PFC activation in OA, resulting in activation patterns more similar to those of YA, with positive effects on postural control and possibly fall risk.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 71-83"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144563650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Advisory Board","authors":"","doi":"10.1016/S0197-4580(25)00147-2","DOIUrl":"10.1016/S0197-4580(25)00147-2","url":null,"abstract":"","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Page IFC"},"PeriodicalIF":3.5,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144919987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in cerebral morphology and microstructure in rhesus macaques","authors":"Alison R. Weiss ,&nbsp;Anahit Grigorian ,&nbsp;Steven Dash ,&nbsp;Christopher D. Kroenke ,&nbsp;Henryk F. Urbanski ,&nbsp;Steven G. Kohama","doi":"10.1016/j.neurobiolaging.2025.06.004","DOIUrl":"10.1016/j.neurobiolaging.2025.06.004","url":null,"abstract":"<div><div>The rhesus macaque presents a promising model for translational research into human brain aging due to this species’ long lifespan and close phylogenic relationship. We conducted a cross-sectional study identifying microstructural and morphological biomarkers of aging in a cohort of 37 healthy animals (18F/19M, aged 5–28 years), using high-resolution T2-weighted (T2w) and diffusion-weighted (DW) images. Using Tensor Based Morphometry, significant age-associated regional brain atrophy was observed in some areas of the frontal and parietal cortex, as well as the striatum. Additionally, age-associated differences in white matter diffusion were observed in several brain regions, including frontal and temporal white matter areas, and regions of the internal capsule and corpus callosum. Taken together, the results demonstrate that morphological and microstructural age-related differences can be disclosed in cortical, striatal, and thalamic regions, as well as in the white matter fiber pathways connecting these areas, using high-resolution DTI and MRI.</div></div>","PeriodicalId":19110,"journal":{"name":"Neurobiology of Aging","volume":"154 ","pages":"Pages 37-46"},"PeriodicalIF":3.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144502414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}