Neurobiology of Learning and Memory最新文献_第8页

Engram and behavior: How memory is stored in the brain 印迹与行为：记忆如何在大脑中储存。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1016/j.nlm.2025.108047

Kisang Eom , Donguk Kim , Jung Ho Hyun

引用次数: 0

Developmental changes in brain-wide fear memory networks 全脑恐惧记忆网络的发育变化。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1016/j.nlm.2025.108037

Benita Jin , Michael W. Gongwer , Laura A. DeNardo

{"title":"Developmental changes in brain-wide fear memory networks","authors":"Benita Jin , Michael W. Gongwer , Laura A. DeNardo","doi":"10.1016/j.nlm.2025.108037","DOIUrl":"10.1016/j.nlm.2025.108037","url":null,"abstract":"<div><div>Memory retrieval involves coordinated activity across multiple brain regions. Yet how the organization of memory networks evolves throughout development remains poorly understood. In this study, we compared whole-brain functional networks that are active during contextual fear memory recall in infant, juvenile, and adult mice. Our analyses revealed that long-term memory networks change significantly across postnatal development. Infant fear memory networks are dense and heterogeneous, whereas adult networks are sparse and have a small-world topology. While hippocampal subregions were highly connected nodes at all ages, the cortex gained many functional connections across development. Different functional connections matured at different rates, but their developmental timing fell into three major categories: stepwise change between two ages, linear change across all ages, or inverted-U, with elevated functional connectivity in juveniles. Our work highlights how a subset of brain regions likely maintain important roles in fear memory encoding, but the functional connectivity of fear memory networks undergoes significant reorganization across development. Together, these results provide a blueprint for studying how correlated cellular activity in key areas distinctly regulates memory storage and retrieval across development.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108037"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task 复杂的嗅觉记忆任务需要边缘下皮层，而不是边缘前皮层。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-01 DOI: 10.1016/j.nlm.2025.108038

Dahae J. Jun, Rebecca Shannon, Katherine Tschida, David M. Smith

{"title":"The infralimbic, but not the prelimbic cortex is needed for a complex olfactory memory task","authors":"Dahae J. Jun, Rebecca Shannon, Katherine Tschida, David M. Smith","doi":"10.1016/j.nlm.2025.108038","DOIUrl":"10.1016/j.nlm.2025.108038","url":null,"abstract":"<div><div>The medial prefrontal cortex (mPFC) plays a key role in memory and behavioral flexibility, and a growing body of evidence suggests that the prelimbic (PL) and infralimbic (IL) subregions contribute differently to these processes. Studies of fear conditioning and goal-directed learning suggest that the PL promotes behavioral responses and memory retrieval, while the IL inhibits them. Other studies have shown that the mPFC is engaged under conditions of high interference. This raises the possibility that the PL and IL play differing roles in resolving interference. To examine this, we first used chemogenetics (DREADDs) to suppress mPFC neuronal activity and tested subjects on a conditional discrimination task known to be sensitive to muscimol inactivation. After confirming the effectiveness of the DREADD procedures, we conducted a second experiment to examine the PL and IL roles in a high interference memory task. We trained rats on two consecutive sets of conflicting odor discrimination problems, A and B, followed by test sessions involving a mid-session switch between the problem sets. Controls repeatedly performed worse on Set A, suggesting that learning Set B inhibited the rats’ ability to retrieve Set A memories (i.e. retroactive interference). PL inactivation rats performed similarly to controls. However, IL inactivation rats did not show this effect, suggesting that the IL plays a critical role in suppressing the retrieval of previously acquired memories that may interfere with retrieval of more recent memories. These results suggest that the IL plays a critical role in memory control processes needed for resolving interference.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108038"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143542628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortisol modulates hippocampus activation during semantic substitution in men 皮质醇调节男性语义替代过程中的海马体激活。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1016/j.nlm.2025.108049

Nicole Klein, Carina Zöllner, Tobias Otto, Oliver Tobias Wolf, Christian Josef Merz

{"title":"Cortisol modulates hippocampus activation during semantic substitution in men","authors":"Nicole Klein, Carina Zöllner, Tobias Otto, Oliver Tobias Wolf, Christian Josef Merz","doi":"10.1016/j.nlm.2025.108049","DOIUrl":"10.1016/j.nlm.2025.108049","url":null,"abstract":"<div><div>In the case of incomplete episodic memory retrieval, semantic knowledge may play a vital role compared to random memory errors in filling in memory gaps (semantic substitution). Stress impairs (episodic) memory retrieval via stress hormones (mainly cortisol) targeting the hippocampus. This preregistered neuroimaging study aimed to examine the neural mechanisms of the interplay between episodic memories and prior knowledge during the reconstruction of a past scenario under elevated cortisol levels in men. During encoding, sixty men prepared a virtual apartment for having guests over by using button presses to interact with household objects (e.g., toasting a slice of bread) that were placed congruently to semantic knowledge (e.g., a coffee machine in the kitchen) or incongruently (e.g., a toaster in the bathroom). One day later, participants received (order randomized, double-blind) either 20 mg of cortisol (n = 30) or a placebo (n = 30) before a recognition task. After identifying objects as old, we included a room recall using a forced-choice question in which room the objects were remembered. For incongruent objects this allowed us to differentiate the involvement of episodic, semantic, or random memory. Cortisol did not impair general recognition memory. The manipulation of stimuli during encoding, as being congruent and interactable (relevant to the goal) appears to be predictive of later accurate room recall. Semantic substitution in case of episodic memory failure was associated with anterior parahippocampal and gyrus rectus activation. Cortisol administration increased hippocampal activation during semantic substitution, suggesting a compensatory effect. The results characterized the neural correlates of semantic substitution and speak for an intertwined view of episodic memory and semantic knowledge, which is further shaped by the stress hormone cortisol.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108049"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143730626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms 半夜睡眠限制后观察到的记忆损伤不是由工作记忆、注意力或抑制控制机制介导的

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-04-11 DOI: 10.1016/j.nlm.2025.108054

Pim R.A. Heckman , Robbert Havekes , Arjan Blokland

{"title":"Memory impairments observed after a half night sleep restriction are not mediated by working memory, attention, or inhibitory control mechanisms","authors":"Pim R.A. Heckman , Robbert Havekes , Arjan Blokland","doi":"10.1016/j.nlm.2025.108054","DOIUrl":"10.1016/j.nlm.2025.108054","url":null,"abstract":"<div><div>Sleep restriction is a growing issue in our modern society and thus it is crucial to uncover its neurocognitive consequences. Especially declarative memory is negatively affected by sleep loss due to its critical dependence on the hippocampus, a brain area known to be susceptible to sleep loss. Studies have shown that even a half night sleep restriction is sufficient to induce impairments in a range of hippocampus-dependent forms of memory. Nevertheless, memory performance is, at least to some extent, dependent on other cognitive functions. The aim of the current study was to reveal whether memory deficits observed after one night sleep deprivation, as observed in animal studies, translate to man, and whether these effects are mediated by impairments in other cognitive domains. We hypothesized that the memory paradigms would be affected but that, due to the short nature of the sleep restriction, this effect would not be mediated by other cognitive functions. To this end, fifty-five healthy participants conducted a test battery containing paradigms measuring verbal learning, spatial memory, attention, working memory, and response inhibition after a night of regular sleep or acute partial sleep restriction. The results of the study showed an impairment in both hippocampus-dependent memory tests, while no negative consequences of sleep deprivation were revealed on the other cognitive domains. In conclusion, our data indicate that the observed deficit in memory performance after a half night sleep deprivation is not mediated by impairments in attention (alerting, orienting, and executive control), working memory, or motor inhibitory control mechanisms.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108054"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143825785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glutamate receptor expression in the PL-BLA circuit is associated with susceptibility to showing the PTSD-like phenotype PL-BLA回路中的谷氨酸受体表达与ptsd样表型的易感性相关

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-27 DOI: 10.1016/j.nlm.2025.108051

Charlotte S. Rye , Amy L. Milton

{"title":"Glutamate receptor expression in the PL-BLA circuit is associated with susceptibility to showing the PTSD-like phenotype","authors":"Charlotte S. Rye , Amy L. Milton","doi":"10.1016/j.nlm.2025.108051","DOIUrl":"10.1016/j.nlm.2025.108051","url":null,"abstract":"<div><div>While many individuals experience traumatic events during their lifetimes, only some go on to develop post-traumatic stress disorder (PTSD). This susceptibility and resilience to developing PTSD can be modelled in rodents using the stress-enhanced fear learning (SEFL) procedure, in which rats are exposed to a session of massed, unpredictable footshocks and subsequently assessed on tasks of adaptive fear learning. It has previously been observed that subpopulations of rats are susceptible and resilient to showing the PTSD-like phenotype following SEFL, and that these rats show differences in glutamate receptor expression in the basolateral amygdala. However, it is currently unknown whether structural differences are observed in other brain regions implicated in stress responding and memory. Using the refined SEFL procedure, this study aimed to determine whether expression of GluN2B, GluA1 and GluA2 receptor subunits in the prelimbic and infralimbic cortices, and dorsal hippocampus could be correlated to the SEFL-phenotype or shock experience in male rats. Here we show that following SEFL, differences can be observed in receptor subunit expression in the infralimbic cortex and dorsal hippocampus as a function of shock experience, whilst differences in the prelimbic cortex are associated with susceptibility. Importantly, these structural changes can be observed in male rats that are group-housed and exposed to 13-shocks rather than 15-shocks, indicating that the refined SEFL procedure offers a robust animal analogue of the non-associative fear sensitisation that occurs in PTSD. Future studies using this procedure could pave the way to the eventual development of pharmacological treatments to alleviate or prevent stress-induced psychopathology in susceptible individuals.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108051"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143738071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitivity of associative priming to semantic relations: Insights from behavior and event-related potentials 联想启动对语义关系的敏感性：来自行为和事件相关电位的见解

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.1016/j.nlm.2025.108056

Aiqing Nie , Yuanying Wu , Xia Zheng

{"title":"Sensitivity of associative priming to semantic relations: Insights from behavior and event-related potentials","authors":"Aiqing Nie , Yuanying Wu , Xia Zheng","doi":"10.1016/j.nlm.2025.108056","DOIUrl":"10.1016/j.nlm.2025.108056","url":null,"abstract":"<div><div>The priming effects have raised significant concerns. Previous research has solely focused on the priming of individual items, where both the prime and the target are single items. This study innovatively examines the priming effect for pairs and also considers the pair type for the target. In this experiment, the semantic relations of the prime and target pairs were categorized into thematic, taxonomic, and unrelated cases. The prime pairs were considered new, while the target pairs consisted of intact, rearranged, and “old + new” pairs. Behaviorally, we found that the priming effects were more pronounced when considering thematic relations compared to taxonomic relations. This indicates a stronger unitization between the items in taxonomic relations. Neurally, the N300 and N400 amplitudes were significantly larger for thematic relations compared to taxonomic relations. These results suggest that both object identification and semantic processing were more influenced by the semantic relation within the pairs. Moreover, we observed that the pair type exhibited distinct patterns in the ERP priming effect across different semantic relations. This indicates that semantic priming and repetition priming of associative pairs result in different effects.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"219 ","pages":"Article 108056"},"PeriodicalIF":2.2,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143842805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutting-edge RNA technologies to advance the understanding of learning and memory 先进的RNA技术促进对学习和记忆的理解

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-05-01 Epub Date: 2025-03-25 DOI: 10.1016/j.nlm.2025.108050

Joshua William Ashley Davies , Timothy William Bredy , Paul Robert Marshall

引用次数: 0

The effect of fasting on human memory consolidation 禁食对人类记忆巩固的影响。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-01 Epub Date: 2025-02-10 DOI: 10.1016/j.nlm.2025.108034

Xuefeng Yang , Xiu Miao , Franziska Schweiggart , Sophia Großmann , Karsten Rauss , Manfred Hallschmid , Jan Born , Nicolas D. Lutz

{"title":"The effect of fasting on human memory consolidation","authors":"Xuefeng Yang , Xiu Miao , Franziska Schweiggart , Sophia Großmann , Karsten Rauss , Manfred Hallschmid , Jan Born , Nicolas D. Lutz","doi":"10.1016/j.nlm.2025.108034","DOIUrl":"10.1016/j.nlm.2025.108034","url":null,"abstract":"<div><div>The consolidation of long-term memory is thought to critically rely on sleep. However, first evidence from a study in <em>Drosophila</em> suggests that hunger, as another brain state, can benefit memory consolidation as well. Here, we report two human (within-subjects crossover) experiments examining the effects of fasting (versus satiated conditions) during a 10-hour post-encoding consolidation period on subsequent recall of declarative and procedural memories in healthy men. In Experiment 1, participants (n = 16), after an 18.5-hour fasting period, encoded 3 memory tasks (word paired associates, a visual version of the Deese-Roediger-McDermott task, finger tapping) and subsequently either continued to fast or received standardized meals. Recall was tested 48 h later in a satiated state. Experiment 2 (n = 16 participants) differed from Experiment 1 in that a What-Where-When episodic memory task replaced the Deese-Roediger-McDermott task and recall was tested only 24 h later in a fasted state. Compared with the satiated state, fasting enhanced cued recall of word paired associates (more correct and faster responses) and item recognition in the What-Where-When task. By contrast, fasting impaired recall of episodic context memory, i.e., spatial context in the Deese-Roediger-McDermott task, and temporal-spatial context in the What-Where-When task. Procedural memory (finger tapping) remained unaffected. This pattern suggests a differential effect of fasting selectively promoting consolidation of semantic-like representations in cortical networks whereas hippocampal representations of episodic context are weakened. We speculate that hunger strengthens cortical representations by suppressing hippocampal interference during wake consolidation. Yet, the underlying mechanism remains to be clarified.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108034"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143409360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GluA1-containing AMPA receptors are necessary for sparse memory engram formation 含有glua1的AMPA受体是稀疏记忆印迹形成所必需的。

IF 2.2 4区心理学

Neurobiology of Learning and Memory Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1016/j.nlm.2025.108031

Thije S. Willems , Hui Xiong , Helmut W. Kessels , Sylvie L. Lesuis

{"title":"GluA1-containing AMPA receptors are necessary for sparse memory engram formation","authors":"Thije S. Willems , Hui Xiong , Helmut W. Kessels , Sylvie L. Lesuis","doi":"10.1016/j.nlm.2025.108031","DOIUrl":"10.1016/j.nlm.2025.108031","url":null,"abstract":"<div><div>Memory formation depends on the selective recruitment of neuronal ensembles into circuits known as engrams, which represent the physical substrate of memory. Sparse encoding of these ensembles is essential for memory specificity and efficiency. AMPA receptor (AMPAR) subunits, particularly GluA1, play a central role in synaptic plasticity, which underpins memory encoding. This study investigates how GluA1 expression influences the recruitment of neurons into memory engrams. Using global GluA1 knockout (GluA1<sup>KO</sup>) mice, localized knockout models, and contextual fear-conditioning paradigms, we evaluated the role of GluA1 in memory formation and engram sparsity.</div><div>GluA1<sup>KO</sup> mice exhibited impaired short-term memory retention but preserved 24-hour contextual memory. Despite this, these mice displayed increased expression of the immediate early gene Arc in hippocampal neurons, indicative of a denser engram network. Electrophysiological analyses revealed reduced synaptic strength in GluA1-deficient neurons, irrespective of Arc expression. Localized GluA1 knockout in the hippocampus confirmed that GluA1 deficiency increases neuronal recruitment into engrams, disrupting the sparse encoding typically observed in wild-type mice.</div><div>These findings demonstrate that GluA1-containing AMPARs constrain engram size, ensuring selective recruitment of neurons for efficient memory encoding. By regulating synaptic plasticity, GluA1 facilitates both the encoding and size of memory circuits. This study highlights the critical role of GluA1 in maintaining sparse engram formation and provides insight into mechanisms underlying memory deficits in conditions where synaptic composition is altered.</div></div>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":"218 ","pages":"Article 108031"},"PeriodicalIF":2.2,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143374482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0