Nature Reviews Neurology最新文献_第9页

Building an ethnically and racially diverse neurology workforce 建立一支民族和种族多元化的神经病学人才队伍。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-22 DOI: 10.1038/s41582-024-00941-3

Roy H. Hamilton

{"title":"Building an ethnically and racially diverse neurology workforce","authors":"Roy H. Hamilton","doi":"10.1038/s41582-024-00941-3","DOIUrl":"10.1038/s41582-024-00941-3","url":null,"abstract":"As diversity among patient populations continues to grow, racial and ethnic diversity in the neurology workforce is increasingly essential to the delivery of culturally competent care and for enabling inclusive, generalizable clinical research. Unfortunately, diversity in the workforce is an area in which the field of neurology has historically lagged and faces formidable challenges, including an inadequate number of trainees entering the field, bias experienced by trainees and faculty from minoritized racial and ethnic backgrounds, and ‘diversity tax’, the disproportionate burden of service work placed on minoritized people in many professions. Although neurology departments, professional organizations and relevant industry partners have come to realize the importance of diversity to the field and have taken steps to promote careers in neurology for people from minoritized backgrounds, additional steps are needed. Such steps include the continued creation of diversity leadership roles in neurology departments and organizations, the creation of robust pipeline programmes, aggressive recruitment and retention efforts, the elevation of health equity research and engagement with minoritized communities. Overall, what is needed is a shift in culture in which diversity is adopted as a core value in the field. In this Review, Hamilton dissects the importance of racial and ethnic diversity among the neurology workforce for providing inclusive and equitable care to diverse populations. The Review summarizes current barriers to achieving diversity in the field and presents strategic approaches to overcoming these.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41582-024-00941-3.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139932210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Ultrasound and antibodies — a potentially powerful combination for Alzheimer disease therapy 超声波和抗体--阿尔茨海默病治疗的潜在强效组合。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-20 DOI: 10.1038/s41582-024-00943-1

Jürgen Götz, Pranesh Padmanabhan

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Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums 晚期阿尔茨海默病的癫痫和癫痫样活动：临床和病理生理学进展、差距和难题。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-14 DOI: 10.1038/s41582-024-00932-4

Anita Kamondi, Madeleine Grigg-Damberger, Wolfgang Löscher, Heikki Tanila, Andras Attila Horvath

{"title":"Epilepsy and epileptiform activity in late-onset Alzheimer disease: clinical and pathophysiological advances, gaps and conundrums","authors":"Anita Kamondi, Madeleine Grigg-Damberger, Wolfgang Löscher, Heikki Tanila, Andras Attila Horvath","doi":"10.1038/s41582-024-00932-4","DOIUrl":"10.1038/s41582-024-00932-4","url":null,"abstract":"A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in AD by years, and its presence has been shown to predict a faster disease course. In animal models of AD, amyloid and tau pathology are linked to cortical network hyperexcitability that precedes the first signs of memory decline. Thus, detection of epileptiform activity in AD has substantial clinical importance as a potential novel modifiable risk factor for dementia. In this Review, we summarize the epidemiological evidence for the complex bidirectional relationship between AD and epilepsy, examine the effect of epileptiform activity and seizures on cognition in people with AD, and discuss the precision medicine treatment strategies based on the latest research in human and animal models. Finally, we outline some of the unresolved questions of the field that should be addressed by rigorous research, including whether particular clinicopathological subtypes of AD have a stronger association with epilepsy, and the sequence of events between epileptiform activity and amyloid and tau pathology. Growing evidence suggests a bidirectional relationship between Alzheimer disease and epilepsy. This Review summarizes the epidemiological evidence and explores the potential mechanisms that underlie the effects of epileptiform activity on cognition in people with Alzheimer disease.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":null,"pages":null},"PeriodicalIF":38.1,"publicationDate":"2024-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139735696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Questioning the cycad theory of Kii ALS–PDC causation 质疑 Kii ALS-PDC 因果关系的苏铁理论。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-09 DOI: 10.1038/s41582-024-00936-0

Yasumasa Kokubo, Satoru Morimoto, Mari Yoshida

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Reply to: Questioning the cycad theory of Kii ALS–PDC causation 答复质疑 Kii ALS-PDC 因果关系的苏铁理论。

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-09 DOI: 10.1038/s41582-024-00938-y

Katerina Menšíková, Raymond Rosales, Carlo Colosimo, Peter Spencer, Annie Lannuzel, Yoshikazu Ugawa, Ryogen Sasaki, Santiago Giménez-Roldán, Radoslav Matej, Lucie Tuckova, Dominik Hrabos, Kristyna Kolarikova, Radek Vodicka, Radek Vrtel, Miroslav Strnad, Petr Hlustik, Pavel Otruba, Martin Prochazka, Martin Bares, Susana Boluda, Luc Buee, Gerhard Ransmayr, Petr Kaňovský

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T cells implicate Epstein–Barr virus in multiple sclerosis pathogenesis T 细胞表明 Epstein-Barr 病毒与多发性硬化症发病机制有关

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-07 DOI: 10.1038/s41582-024-00939-x

Ian Fyfe

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Mitochondrial DNA instability in Huntington disease 亨廷顿病中线粒体 DNA 的不稳定性

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-07 DOI: 10.1038/s41582-024-00937-z

Lisa Kiani

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Regional vulnerability to Aβ and tau pathology Aβ 和 tau 病理学的区域脆弱性

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-07 DOI: 10.1038/s41582-024-00934-2

Lisa Kiani

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TREM2 mediates phagocytosis in glioblastoma TREM2 在胶质母细胞瘤中介导吞噬作用

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-07 DOI: 10.1038/s41582-024-00935-1

Lisa Kiani

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Neurosteroids alleviate seizures in rats 神经类固醇可减轻大鼠癫痫发作

IF 38.1 1区医学

Nature Reviews Neurology Pub Date : 2024-02-07 DOI: 10.1038/s41582-024-00933-3

Lisa Kiani

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