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Diabetes could hasten MCI-to-AD conversion 糖尿病会加速 MCI 向AD 的转化。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00994-4
Heather Wood
{"title":"Diabetes could hasten MCI-to-AD conversion","authors":"Heather Wood","doi":"10.1038/s41582-024-00994-4","DOIUrl":"10.1038/s41582-024-00994-4","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"456-456"},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RAB32 variant is associated with PD susceptibility RAB32 变异与帕金森病易感性有关。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00995-3
Heather Wood
{"title":"RAB32 variant is associated with PD susceptibility","authors":"Heather Wood","doi":"10.1038/s41582-024-00995-3","DOIUrl":"10.1038/s41582-024-00995-3","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"456-456"},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis 脑-体机制导致肌萎缩性脊髓侧索硬化症的性双态性
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-04 DOI: 10.1038/s41582-024-00991-7
Sarah M. Jacob, Sukyoung Lee, Seung Hyun Kim, Keith A. Sharkey, Gerald Pfeffer, Minh Dang Nguyen
{"title":"Brain–body mechanisms contribute to sexual dimorphism in amyotrophic lateral sclerosis","authors":"Sarah M. Jacob, Sukyoung Lee, Seung Hyun Kim, Keith A. Sharkey, Gerald Pfeffer, Minh Dang Nguyen","doi":"10.1038/s41582-024-00991-7","DOIUrl":"10.1038/s41582-024-00991-7","url":null,"abstract":"Amyotrophic lateral sclerosis (ALS) is the most common form of human motor neuron disease. It is characterized by the progressive degeneration of upper and lower motor neurons, leading to generalized motor weakness and, ultimately, respiratory paralysis and death within 3–5 years. The disease is shaped by genetics, age, sex and environmental stressors, but no cure or routine biomarkers exist for the disease. Male individuals have a higher propensity to develop ALS, and a different manifestation of the disease phenotype, than female individuals. However, the mechanisms underlying these sex differences remain a mystery. In this Review, we summarize the epidemiology of ALS, examine the sexually dimorphic presentation of the disease and highlight the genetic variants and molecular pathways that might contribute to sex differences in humans and animal models of ALS. We advance the idea that sexual dimorphism in ALS arises from the interactions between the CNS and peripheral organs, involving vascular, metabolic, endocrine, musculoskeletal and immune systems, which are strikingly different between male and female individuals. Finally, we review the response to treatments in ALS and discuss the potential to implement future personalized therapeutic strategies for the disease. Amyotrophic lateral sclerosis (ALS) differs considerably in prevalence and manifestation between sexes. This Review summarizes sexual dimorphism in the epidemiology, clinical presentation and disease mechanisms of ALS and explores the role of brain–body interactions in driving sex-dependent pathogenesis.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"475-494"},"PeriodicalIF":28.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141521513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Precision neuroimmunology in multiple sclerosis — the horizon is near 多发性硬化症的精准神经免疫学--地平线近在眼前
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-04 DOI: 10.1038/s41582-024-00992-6
Jiwon Oh, Amit Bar-Or
{"title":"Precision neuroimmunology in multiple sclerosis — the horizon is near","authors":"Jiwon Oh, Amit Bar-Or","doi":"10.1038/s41582-024-00992-6","DOIUrl":"10.1038/s41582-024-00992-6","url":null,"abstract":"Immunological profiling has revealed biological signatures of multiple sclerosis (MS) that could help with early, accurate diagnosis of the disease and with identifying disease subtypes that could inform treatment decisions. The findings are important steps along the path towards precision medicine for people with MS.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"507-508"},"PeriodicalIF":28.2,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141521512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spinal cord stimulation for the treatment of chronic pain 脊髓刺激治疗慢性疼痛
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-01 DOI: 10.1038/s41582-024-00981-9
Cecile C. de Vos, Kaare Meier
{"title":"Spinal cord stimulation for the treatment of chronic pain","authors":"Cecile C. de Vos, Kaare Meier","doi":"10.1038/s41582-024-00981-9","DOIUrl":"10.1038/s41582-024-00981-9","url":null,"abstract":"Spinal cord stimulation is an invasive therapy for chronic neuropathic pain, usually used as a last-resort treatment when all other treatments have been tried and failed. The clinical value of the therapy has been much debated in recent years; here, we summarize the therapy and discuss the core controversies. Spinal cord stimulation is seen as a last-resort therapy for the treatment of chronic pain. Controversies surrounding the treatment might be addressed through collaborative efforts to conduct innovative clinical trials and reach consensus on treatment guidelines.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"447-448"},"PeriodicalIF":28.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Focused ultrasound brain therapy is a new tool in the box 聚焦超声脑疗法是一种新工具
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-01 DOI: 10.1038/s41582-024-00975-7
Raúl Martínez-Fernández
{"title":"Focused ultrasound brain therapy is a new tool in the box","authors":"Raúl Martínez-Fernández","doi":"10.1038/s41582-024-00975-7","DOIUrl":"10.1038/s41582-024-00975-7","url":null,"abstract":"Similar to any innovation that disrupts the status quo, the advent of magnetic resonance-guided focused ultrasound in neurology was accompanied by controversy and debate. However, evidence suggests that this therapeutic tool, which is already widely used to treat tremor and Parkinson disease, is gaining acceptance and will become a viable therapeutic option for various other neurological conditions in the near future.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"443-444"},"PeriodicalIF":28.2,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141475156","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sensory feedback in upper limb prosthetics: advances and challenges 上肢假肢的感觉反馈：进步与挑战
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-30 DOI: 10.1038/s41582-024-00987-3
Nebojša Malešević, Christian Antfolk
{"title":"Sensory feedback in upper limb prosthetics: advances and challenges","authors":"Nebojša Malešević, Christian Antfolk","doi":"10.1038/s41582-024-00987-3","DOIUrl":"10.1038/s41582-024-00987-3","url":null,"abstract":"Advanced sensory feedback from upper limb prostheses would provide multiple benefits to people with upper limb amputations, but achieving functional and natural-feeling sensation is technologically challenging. Advances are being made with invasive and non-invasive stimulation approaches, but considerable challenges need to be addressed with technological innovation.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"449-450"},"PeriodicalIF":28.2,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141463915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuromodulation for severe brain injury: time for a paradigm shift? 严重脑损伤的神经调控：范式转变的时机已到？
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-30 DOI: 10.1038/s41582-024-00980-w
Aurore Thibaut, Géraldine Martens
{"title":"Neuromodulation for severe brain injury: time for a paradigm shift?","authors":"Aurore Thibaut, Géraldine Martens","doi":"10.1038/s41582-024-00980-w","DOIUrl":"10.1038/s41582-024-00980-w","url":null,"abstract":"Neuromodulation represents a promising approach for promoting neural plasticity following a brain injury, especially for non-communicative patients with prolonged disorders of consciousness. However, so far, the outcomes have been limited and inconsistent, driving researchers to explore alternative strategies to improve the efficacy of brain stimulation techniques.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"441-442"},"PeriodicalIF":28.2,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141463931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders 无创深部脑刺激：针对神经系统疾病的深部脑区进行介入治疗
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-29 DOI: 10.1038/s41582-024-00990-8
Friedhelm C. Hummel, Maximilian J. Wessel
{"title":"Non-invasive deep brain stimulation: interventional targeting of deep brain areas in neurological disorders","authors":"Friedhelm C. Hummel, Maximilian J. Wessel","doi":"10.1038/s41582-024-00990-8","DOIUrl":"10.1038/s41582-024-00990-8","url":null,"abstract":"Recently developed non-invasive deep brain stimulation methods have sufficient focal specificity to target deep brain structures. These techniques show particular promise as treatment strategies for neuropsychiatric disorders in which deep brain structures have critical roles in pathophysiology or in mediating recovery. A non-invasive technique using transcranial electrical stimulation offers an improvement in focality over other non-invasive techniques, presenting an opportunity to target deep brain structures for the treatment of neurological disorders.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"451-452"},"PeriodicalIF":28.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Non-invasive stimulation for treating cognitive impairment in Alzheimer disease 治疗阿尔茨海默病认知障碍的非侵入性刺激疗法
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-06-29 DOI: 10.1038/s41582-024-00976-6
Irena Rektorová
{"title":"Non-invasive stimulation for treating cognitive impairment in Alzheimer disease","authors":"Irena Rektorová","doi":"10.1038/s41582-024-00976-6","DOIUrl":"10.1038/s41582-024-00976-6","url":null,"abstract":"Some device-based non-invasive brain stimulation methods have been recommended as probably effective for cognitive treatment in Alzheimer disease. New targets and novel transcranial electrical stimulation techniques enable physiology-inspired modulation of oscillatory activity and precise targeting of deep brain structures. The use of non-invasive brain stimulation techniques to treat mild cognitive impairment and dementia in Alzheimer disease is expanding. Trials have produced varying results depending on the differing stimulation techniques, targeted brain regions and degrees of cognitive impairment among the treated cohorts.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"445-446"},"PeriodicalIF":28.2,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141462718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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