Nature Reviews Neurology最新文献_第8页

Granulovacuolar degeneration bodies protect neurons from tau pathology 颗粒空泡变性体保护神经元免受tau病理。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-14 DOI: 10.1038/s41582-026-01210-1

Lisa Kiani

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Understanding the long-term neurological effects of SARS-CoV-2 infection 了解SARS-CoV-2感染的长期神经系统影响。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-13 DOI: 10.1038/s41582-026-01205-y

Rachael Matthews, Ali Alam, Ed Bullmore, Benedict D. Michael

{"title":"Understanding the long-term neurological effects of SARS-CoV-2 infection","authors":"Rachael Matthews, Ali Alam, Ed Bullmore, Benedict D. Michael","doi":"10.1038/s41582-026-01205-y","DOIUrl":"10.1038/s41582-026-01205-y","url":null,"abstract":"Post-COVID-19 condition (PCC), also known as long COVID, is a heterogeneous condition marked by persistent symptoms following acute SARS-CoV-2 infection. As approximately 6% of people who have experienced acute COVID-19 are estimated to develop PCC, the potential population is vast. Many of the key symptoms of PCC reflect involvement of the nervous system, ranging from cognitive impairment (‘brain fog’), headaches and fatigue to anxiety and depression. This Review summarizes the spectrum of neurological and psychological symptoms that occur following acute SARS-CoV-2 infection, with a particular focus on the international consensus-based core outcome set for PCC. We also explore the proposed underlying mechanisms, including evidence for immune system dysregulation, microvascular dysfunction and volumetric changes on neuroimaging. In addition, we review ongoing and completed large-scale treatment trials. Growing evidence suggests a bidirectional interaction between symptoms traditionally considered neurobiological in origin, such as cognitive deficits and headache, and those within the purview of psychiatry, such as anxiety and depression. PCC represents an opportunity to better understand the long-term consequences of acute infection and improve management strategies and outcomes, not only for people with the condition but also for those with other post-viral syndromes that affect brain health. Post-COVID-19 condition (PCC), also known as long COVID, is a heterogeneous condition marked by persistent symptoms following acute SARS-CoV-2 infection. This Review summarizes the spectrum of neurological and psychological symptoms in people with PCC and explores the proposed underlying mechanisms and current and future treatment approaches.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 6","pages":"351-365"},"PeriodicalIF":33.1,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147666581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Qiang Liu: addressing unmet clinical needs through neuroimmune mechanisms 刘强：通过神经免疫机制解决临床未满足的需求。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-10 DOI: 10.1038/s41582-026-01203-0

Ian Fyfe, Qiang Liu

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Lorenzo’s House: shining a light on young-onset dementia 洛伦佐之家：揭示年轻痴呆。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-10 DOI: 10.1038/s41582-026-01206-x

Ian Fyfe, Diana Cose

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Veronique Miron: targeting neuroimmunology to protect myelin Veronique Miron：靶向神经免疫学来保护髓磷脂。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-10 DOI: 10.1038/s41582-026-01201-2

Ian Fyfe, Veronique Miron

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Targeting gut pathology is effective in an Alzheimer disease model 靶向肠道病理在阿尔茨海默病模型中有效。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-10 DOI: 10.1038/s41582-026-01208-9

Ian Fyfe

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Anne-Katrin Pröbstel: B cells, antibodies and microbiota in autoimmune disease Anne-Katrin Pröbstel：自身免疫性疾病中的B细胞、抗体和微生物群。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-10 DOI: 10.1038/s41582-026-01204-z

Ian Fyfe, Anne-Katrin Pröbstel

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Skull bone marrow changes in multiple sclerosis 多发性硬化症颅骨骨髓改变。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-09 DOI: 10.1038/s41582-026-01207-w

Ian Fyfe

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The potential of low-field MRI for global dementia care 低场MRI在全球痴呆症护理中的潜力。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-07 DOI: 10.1038/s41582-026-01199-7

Tavia E. Evans, Joshua Harper, Aram Salehi, Andrew G. Webb, James H. Cole, Ana Correa, Hieab H. H. Adams, David M. Cash, Derek K. Jones

{"title":"The potential of low-field MRI for global dementia care","authors":"Tavia E. Evans, Joshua Harper, Aram Salehi, Andrew G. Webb, James H. Cole, Ana Correa, Hieab H. H. Adams, David M. Cash, Derek K. Jones","doi":"10.1038/s41582-026-01199-7","DOIUrl":"10.1038/s41582-026-01199-7","url":null,"abstract":"With elderly populations increasing in many countries, rates of Alzheimer disease and related dementias (ADRD) are expected to rise worldwide in the coming years. Low-income and middle-income countries, where barriers to health care are most pronounced and research representation is limited, are predicted to experience the greatest increases in ADRD prevalence. Access to advanced diagnostic and research tools, such as neuroimaging, is severely restricted in these regions, but low-field MRI is emerging as a promising, accessible alternative to conventional imaging. By reducing infrastructure, cost and siting requirements, low-field MRI offers a potential pathway to expand access to dementia-relevant imaging beyond specialized centres. In this article, we summarize key structural imaging biomarkers in ADRD and review the current literature supporting the use of low-field MRI in the ADRD field. We highlight the utility of low-field MRI for the assessment of regional atrophy and cerebrovascular lesion burden and discuss emerging diffusion-based markers. We also consider challenges and future directions, offering insights to advance equitable access to diagnostic imaging, guide research priorities and support global implementation of low-field MRI in ADRD care and investigation. The prevalence of dementia is rising in low-income and middle-income countries, but access to advanced diagnostic and research tools such as neuroimaging remains severely restricted in these regions. This Review highlights the potential of low-field MRI as an accessible alternative to conventional imaging in resource-limited settings.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 6","pages":"337-350"},"PeriodicalIF":33.1,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147630247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bidirectional brain–heart interactions in health and disease 健康和疾病中的双向脑-心相互作用

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-02 DOI: 10.1038/s41582-025-01180-w

Jan F. Scheitz, Arno Villringer, Nidaa Mikail, Catherine Gebhard, Matthias Endres

{"title":"Bidirectional brain–heart interactions in health and disease","authors":"Jan F. Scheitz, Arno Villringer, Nidaa Mikail, Catherine Gebhard, Matthias Endres","doi":"10.1038/s41582-025-01180-w","DOIUrl":"10.1038/s41582-025-01180-w","url":null,"abstract":"The brain and heart constantly communicate with each other to adapt to changes in the environment. In recent years, we have seen increasing recognition that brain–heart interactions influence many cognitive and behavioural functions, and that disturbances in this bidirectional relationship can have detrimental effects on both organs. Clinically, such disturbances can manifest as cardiac dysfunction following acute psychological stress or a brain injury such as acute ischaemic stroke, or as cognitive disorders in patients with acute or chronic heart disease. In this Review, we provide an overview of the physiological interaction between the heart and the brain and show how injury or dysfunction in one of these organs can lead to dysfunction in the other. We describe the current state of knowledge on neuronal correlates and humoral mediators of brain–heart interactions, as well as state-of-the-art methods for studying these interactions. We highlight the clinical implications of disturbances in physiological brain–heart communication for various clinical conditions, including Takotsubo syndrome resulting from emotional stress or from brain disorders, cardiac complications after stroke (so-called stroke–heart syndrome), and cognitive dysfunction in patients with cardiac diseases such as heart failure and atrial fibrillation. In addition, we address sex and gender differences in this bidirectional relationship. This Review explores how reciprocal brain–heart interactions can cause dysfunction in one of these organs to adversely affect the other. The authors discuss clinical conditions, such as Takotsubo syndrome and stroke–heart syndrome, in which these interactions are particularly prominent and address sex and gender differences in brain–heart interactions.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 4","pages":"209-225"},"PeriodicalIF":33.1,"publicationDate":"2026-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147585369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0