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Smartphone calls to detect early Parkinsonism 通过智能手机通话检测早期帕金森病。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01007-0
Lisa Kiani
{"title":"Smartphone calls to detect early Parkinsonism","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01007-0","DOIUrl":"10.1038/s41582-024-01007-0","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"505-505"},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897895","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gaucher disease provides a unique window into Parkinson disease pathogenesis 戈谢病为了解帕金森病的发病机制提供了一个独特的窗口。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-00999-z
Ellen Hertz, Yu Chen, Ellen Sidransky
{"title":"Gaucher disease provides a unique window into Parkinson disease pathogenesis","authors":"Ellen Hertz, Yu Chen, Ellen Sidransky","doi":"10.1038/s41582-024-00999-z","DOIUrl":"10.1038/s41582-024-00999-z","url":null,"abstract":"An exciting development in the field of neurodegeneration is the association between the rare monogenic disorder Gaucher disease and the common complex disorder Parkinson disease (PD). Gaucher disease is a lysosomal storage disorder resulting from an inherited deficiency of the enzyme glucocerebrosidase, encoded by GBA1, which hydrolyses the glycosphingolipids glucosylceramide and glucosylsphingosine. The observation of parkinsonism in a rare subgroup of individuals with Gaucher disease first directed attention to the role of glucocerebrosidase deficiency in the pathogenesis of PD. PD occurs more frequently in people heterozygous for Gaucher GBA1 mutations, and 3–25% of people with Parkinson disease carry a GBA1 variant. However, only a small percentage of individuals with GBA1 variants develop parkinsonism, suggesting that the penetrance is low. Despite over a decade of intense research in this field, including clinical and radiological evaluations, genetic studies and investigations using model systems, the mechanism underlying GBA1-PD is still being pursued. Insights from this association have emphasized the role of lysosomal pathways in parkinsonism. Furthermore, different therapeutic strategies considered or developed for Gaucher disease can now inform drug development for PD. The association between the rare, monogenic lysosomal storage disorder Gaucher disease and Parkinson disease has provided insights into the pathogenesis of this far more common neurodegenerative disease. Here, Sidransky and colleagues review the knowledge gained from decades of Gaucher disease research and explore the relationship between GBA1 and parkinsonism.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"526-540"},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Single-cell atlas of Alzheimer disease vulnerability 阿尔茨海默病易感性单细胞图谱
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01008-z
Lisa Kiani
{"title":"Single-cell atlas of Alzheimer disease vulnerability","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01008-z","DOIUrl":"10.1038/s41582-024-01008-z","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"505-505"},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Rubella virus might increase risk of MS 风疹病毒可能会增加多发性硬化症的风险。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01009-y
Lisa Kiani
{"title":"Rubella virus might increase risk of MS","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01009-y","DOIUrl":"10.1038/s41582-024-01009-y","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"505-505"},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shared glial pathology in HD and schizophrenia HD 和精神分裂症的共同神经胶质病理学。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-06 DOI: 10.1038/s41582-024-01010-5
Lisa Kiani
{"title":"Shared glial pathology in HD and schizophrenia","authors":"Lisa Kiani","doi":"10.1038/s41582-024-01010-5","DOIUrl":"10.1038/s41582-024-01010-5","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 9","pages":"505-505"},"PeriodicalIF":28.2,"publicationDate":"2024-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141897893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Food is brain medicine — relevance and translation to neurology 食物是大脑的良药--与神经学的相关性和转化
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-08-02 DOI: 10.1038/s41582-024-01003-4
Mitchell S. V. Elkind, Kevin G. Volpp
{"title":"Food is brain medicine — relevance and translation to neurology","authors":"Mitchell S. V. Elkind, Kevin G. Volpp","doi":"10.1038/s41582-024-01003-4","DOIUrl":"10.1038/s41582-024-01003-4","url":null,"abstract":"The importance of diet for brain health is increasingly recognized by neurologists, but many neurological disorders impair the ability of individuals to eat healthily. A new initiative known as ‘Food Is Medicine’ has the potential to facilitate healthier eating among people with neurological disorders to improve and maintain brain health.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 11","pages":"639-640"},"PeriodicalIF":28.2,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141877446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Environmental–genetic interactions in ageing and dementia across Latin America 拉丁美洲老龄化和痴呆症的环境-遗传相互作用
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-12 DOI: 10.1038/s41582-024-00998-0
Agustin Ibanez, Andrea Slachevsky
{"title":"Environmental–genetic interactions in ageing and dementia across Latin America","authors":"Agustin Ibanez, Andrea Slachevsky","doi":"10.1038/s41582-024-00998-0","DOIUrl":"10.1038/s41582-024-00998-0","url":null,"abstract":"Current dementia research has developed complex models of environmental–genetic interactions to better address multimodal disease phenotypes. New evidence highlights a stronger effect of social determinants of health than ancestry effects specific to Latin America and the Caribbean, which opens new agendas to address the diversity of these interactions in ageing and dementia. A new study on dementia prevalence in Latin America has found a stronger effect of social determinants of health than ancestry effects specific to this region, highlighting the need for interventions involving lifestyle changes, healthcare access and education.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 10","pages":"571-572"},"PeriodicalIF":28.2,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141597398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Additive effects of EBV and HHV-6A on MS risk EBV 和 HHV-6A 对多发性硬化症风险的叠加效应。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00993-5
Heather Wood
{"title":"Additive effects of EBV and HHV-6A on MS risk","authors":"Heather Wood","doi":"10.1038/s41582-024-00993-5","DOIUrl":"10.1038/s41582-024-00993-5","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"456-456"},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune rejuvenation — a potential AD therapy 免疫返老还童--一种潜在的抗衰老疗法。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00996-2
Heather Wood
{"title":"Immune rejuvenation — a potential AD therapy","authors":"Heather Wood","doi":"10.1038/s41582-024-00996-2","DOIUrl":"10.1038/s41582-024-00996-2","url":null,"abstract":"","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"456-456"},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders 额颞叶痴呆症及相关疾病的血浆细胞外囊泡生物标记物。
IF 28.2 1区 医学
Nature Reviews Neurology Pub Date : 2024-07-09 DOI: 10.1038/s41582-024-00997-1
Lisa Kiani
{"title":"Plasma extracellular vesicle biomarkers for frontotemporal dementia and related disorders","authors":"Lisa Kiani","doi":"10.1038/s41582-024-00997-1","DOIUrl":"10.1038/s41582-024-00997-1","url":null,"abstract":"Concentrations of TDP-43 and tau in extracellular vesicles extracted from blood show potential as biomarkers for frontotemporal dementia, amyotrophic lateral sclerosis and progressive supranuclear palsy.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"20 8","pages":"455-455"},"PeriodicalIF":28.2,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141559325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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