Nature Reviews Neurology最新文献_第7页

Recognition of dementia as a noncommunicable disease is just the start 认识到痴呆症是一种非传染性疾病仅仅是个开始。

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Nature Reviews Neurology Pub Date : 2026-05-18 DOI: 10.1038/s41582-026-01217-8

Paola Barbarino

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Newborn screening for spinal muscular atrophy: time is motor neuron 新生儿脊髓性肌萎缩症筛查：时间为运动神经元。

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Nature Reviews Neurology Pub Date : 2026-05-07 DOI: 10.1038/s41582-026-01216-9

Didu S. Kariyawasam, Giovanni Baranello, Michelle A. Farrar

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CAR T cell therapy shows promise for treatment of stiff person syndrome CAR - T细胞疗法有望治疗僵硬人综合症。

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Nature Reviews Neurology Pub Date : 2026-05-06 DOI: 10.1038/s41582-026-01220-z

Heather Wood

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Satralizumab could reduce relapse risk in people with MOGAD Satralizumab可以降低MOGAD患者的复发风险。

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Nature Reviews Neurology Pub Date : 2026-05-06 DOI: 10.1038/s41582-026-01219-6

Heather Wood

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Plasma biomarkers for Alzheimer disease: the road from laboratory results to clinical practice 阿尔茨海默病的血浆生物标志物：从实验室结果到临床实践的道路

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Nature Reviews Neurology Pub Date : 2026-05-06 DOI: 10.1038/s41582-026-01215-w

Charlotte E. Teunissen, Argonde C. van Harten

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Author Correction: UK Biobank at 20 — a growing, global resource for dementia research 作者更正：20岁的英国生物银行——一个不断增长的全球痴呆症研究资源。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-29 DOI: 10.1038/s41582-026-01213-y

Paul M. Matthews, Naomi E. Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P. Duff, Paul Elliott, Evelynne S. Fulda, Anastasia Ilina, Quentin Le Grand, Adam J. Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K. Rutter, Cynthia Sandor, Rebecca Sims, Stephen M. Smith, Chaoyue Wang

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Nociceptive action of calcitonin gene-related peptide in the trigeminovascular system 降钙素基因相关肽在三叉神经系统中的痛觉作用。

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Nature Reviews Neurology Pub Date : 2026-04-27 DOI: 10.1038/s41582-026-01214-x

Lars Edvinsson, Jacob C. A. Edvinsson

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Extracellular matrix remodelling in neurological diseases 神经系统疾病中的细胞外基质重塑。

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Nature Reviews Neurology Pub Date : 2026-04-22 DOI: 10.1038/s41582-026-01209-8

Jessica Chi Fung Kwok, Alexander Dityatev

{"title":"Extracellular matrix remodelling in neurological diseases","authors":"Jessica Chi Fung Kwok, Alexander Dityatev","doi":"10.1038/s41582-026-01209-8","DOIUrl":"10.1038/s41582-026-01209-8","url":null,"abstract":"The neural extracellular matrix (ECM) in the CNS is a dynamic network of proteins and glycans that exists in multiple forms, including perineuronal nets, perisynaptic ECM and periaxonal coats. Together with the diffuse interstitial ECM, these components regulate synaptic stability, plasticity and network excitability. Behavioural studies highlight the crucial roles of ECM in shaping memory engrams and cognitive flexibility, positioning ECM as a promising therapeutic target for cognitive interventions across neurological diseases. ECM remodelling is a shared hallmark across multiple CNS diseases, yet it manifests in condition-specific patterns, from robust scar formation in trauma and stroke to more subtle and broadly distributed, but functionally substantial, ECM changes in chronic neurological disorders. Mechanistically, ECM remodelling is driven by multiple factors, including neuronal activity, neuromodulation and neuroinflammation. Diverse ECM-targeting treatments have shown efficacy in preclinical models of CNS diseases and provide attractive options for further optimization, repositioning and clinical translation. Furthermore, innovative biochemical and imaging technologies are emerging to provide further insight into ECM composition and dynamics, paving the way for novel ECM-targeting therapeutic strategies and biomarkers for diagnosis and monitoring. This Review outlines how the neural extracellular matrix (ECM) regulates synaptic function, memory and cognitive flexibility, and how its remodelling can contribute to both acute and chronic CNS disorders. The authors highlight emerging ECM-targeted therapies and technologies that could enable new treatments and biomarkers for neurological disorders.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 6","pages":"366-384"},"PeriodicalIF":33.1,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147733756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Alzheimer disease protection from the periphery 从外围保护老年痴呆症。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-14 DOI: 10.1038/s41582-026-01211-0

Kai Wang, Guojun Bu

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UK Biobank at 20 — a growing, global resource for dementia research 20岁的英国生物银行——一个不断增长的全球痴呆症研究资源。

IF 33.1 1区医学

Nature Reviews Neurology Pub Date : 2026-04-14 DOI: 10.1038/s41582-026-01200-3

Paul M. Matthews, Naomi E. Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P. Duff, Paul Elliott, Evelynne S. Fulda, Anastasia Ilina, Quentin Le Grand, Adam J. Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K. Rutter, Cynthia Sandor, Rebecca Sims, Stephen M. Smith, Chaoyue Wang

{"title":"UK Biobank at 20 — a growing, global resource for dementia research","authors":"Paul M. Matthews, Naomi E. Allen, Stephanie Debette, Aiden Doherty, Gwenaëlle Douaud, Eugene P. Duff, Paul Elliott, Evelynne S. Fulda, Anastasia Ilina, Quentin Le Grand, Adam J. Lewandowski, Rebecca Mahoney, Karla Miller, Cecilia Rodriguez, Martin K. Rutter, Cynthia Sandor, Rebecca Sims, Stephen M. Smith, Chaoyue Wang","doi":"10.1038/s41582-026-01200-3","DOIUrl":"10.1038/s41582-026-01200-3","url":null,"abstract":"UK Biobank is the world’s most comprehensive longitudinal population-based data and biosample resource. Twenty years after UK Biobank was first established, the incidence of dementia among participants is rising and is set to increase rapidly over the next 5–10 years, creating a distinct opportunity for studies of dementia risk and onset. In addition to extensive clinical phenotyping of >500,000 volunteers from across the UK at recruitment and at follow-up time points, UK Biobank includes data from serial lifestyle questionnaires, cognitive testing, multimodal imaging, accelerometry, genomics and other omics that are linked to individual health, cancer and death records. In this Perspective, we discuss how the use of UK Biobank data has enabled the discovery of new interactions between systemic and brain health and illustrate how these data can be used to characterize and identify risk factors, support mechanistic hypotheses and identify new biomarkers that predict the onset and course of dementia and related disorders. We also consider future developments of UK Biobank, including the UK Biobank Brain Health Study, which will build on and leverage the increasing incidence of dementias to advance understanding of these conditions. Twenty years after UK Biobank was established, the incidence of dementia among participants is set to rise rapidly. In this Perspective, Matthews et al. highlight how UK Biobank has advanced dementia research in its first 20 years and consider how future developments will leverage increasing incidence to further advance understanding of dementias.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 6","pages":"385-399"},"PeriodicalIF":33.1,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147680712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0