Brain stimulation aids walking after spinal injury

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-01-17 DOI:10.1038/s41582-025-01057-y

Ian Fyfe

引用次数: 0

Abstract

In a new study, deep brain stimulation (DBS) of the lateral hypothalamus facilitated recovery after spinal cord injury (SCI) in rodents and humans. The researchers identified glutamatergic neurons in the lateral hypothalamus as a therapeutic target from a brain atlas of neurons involved in recovery of walking. Stimulation of these neurons in mice and rats with SCI improved walking and led to a durable improvement in recovery. Application of the same approach in two people with incomplete SCI also improved walking and supported longer-term recovery when combined with rehabilitation. Further trials are now needed to establish the safety and efficacy of the approach.

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脑刺激有助于脊髓损伤后的行走

在一项新研究中，对外侧下丘脑进行深部脑刺激（DBS）有助于啮齿动物和人类脊髓损伤（SCI）后的恢复。研究人员从参与行走恢复的神经元脑图谱中确定了下丘脑外侧的谷氨酸能神经元为治疗靶点。对患有脊髓损伤的小鼠和大鼠的这些神经元进行刺激后，行走能力得到改善，恢复情况也得到持久改善。在两个患有不完全性脊髓损伤的人身上应用同样的方法，也能改善行走能力，并在结合康复治疗的情况下支持更长期的恢复。现在还需要进一步的试验来确定这种方法的安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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