Nature Reviews Neurology最新文献

{"title":"Psychological interventions for migraine","authors":"Licia Grazzi, Paul B. Rizzoli, Danilo Antonio Montisano, Giorgio Lambru, Alberto Raggi","doi":"10.1038/s41582-026-01223-w","DOIUrl":"10.1038/s41582-026-01223-w","url":null,"abstract":"Migraine is a complex condition that imposes substantial epidemiological impact and social burden. In the past decade, innovative and targeted pharmacological preventive therapies have considerably improved the lives of people with migraine. A biopsychosocial model has been proposed to comprehensively explain migraine complexity, shedding light on the interconnections between emotional, psychological, social and biological factors, in contrast to a strict medical model. This modern view recognizes that relying solely on pharmacological treatment might not be sufficient, and that alternative treatment options, in particular, psychological ones, should be considered to help individuals manage the condition and enhance the effectiveness of medications. In this Review, we describe the most relevant psychological interventions for migraine, namely relaxation training, biofeedback, cognitive behavioural therapy, mindfulness, and acceptance and commitment therapy, as well as patient education as a first step of care. We discuss how these interventions can assist individuals throughout their treatment journey and consider possible mechanisms of action and barriers to their implementation. Last, we conclude by presenting the possibilities offered by digital health interventions. Psychological factors influence migraine severity and treatment response, highlighting the value of integrating psychological interventions into care. This Review summarizes the evidence supporting the use of these approaches for migraine therapy, outlines potential mechanisms and discusses barriers to their implementation.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"411-427"},"PeriodicalIF":31.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autophagy protein links ageing and Alzheimer disease","authors":"Ian Fyfe","doi":"10.1038/s41582-026-01235-6","DOIUrl":"10.1038/s41582-026-01235-6","url":null,"abstract":"A key protein in the initiation of autophagy and mitophagy is reduced in Alzheimer disease and could be a novel therapeutic target, new research has shown.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"406-406"},"PeriodicalIF":31.2,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148258907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"APOE ε4 is linked to relapse-associated disability accrual in MS","authors":"Heather Wood","doi":"10.1038/s41582-026-01233-8","DOIUrl":"10.1038/s41582-026-01233-8","url":null,"abstract":"The apolipoprotein E ε4 allele is associated with relapse-associated disability worsening in people with multiple sclerosis, new research reveals.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"407-407"},"PeriodicalIF":31.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing amyotrophic lateral sclerosis research in Egypt","authors":"Heather Wood, Nabila Hamdi","doi":"10.1038/s41582-026-01230-x","DOIUrl":"10.1038/s41582-026-01230-x","url":null,"abstract":"Nature Reviews Neurology is interviewing individuals who are driving efforts to address disparities in neurology through a broad spectrum of diversity, equity and inclusion initiatives. We spoke with Nabila Hamdi from the German University in Cairo about her work to advance amyotrophic lateral sclerosis research in Egypt through international collaboration.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"404-405"},"PeriodicalIF":31.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Standard disability scale could miss symptoms in NMOSD","authors":"Heather Wood","doi":"10.1038/s41582-026-01231-w","DOIUrl":"10.1038/s41582-026-01231-w","url":null,"abstract":"A new study indicates that the Expanded Disability Status Scale, which was originally developed to assess disability in people with multiple sclerosis, fails to capture the full patient experience in neuromyelitis optica spectrum disorder (NMOSD).","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"406-406"},"PeriodicalIF":31.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ZFP384 targeting maintains microglial reparative activity after stroke","authors":"Heather Wood","doi":"10.1038/s41582-026-01234-7","DOIUrl":"10.1038/s41582-026-01234-7","url":null,"abstract":"The transcription factor ZFP384 reduces the reparative capacity of microglia after stroke and could be targeted therapeutically to improve stroke outcomes, according to recent preclinical research.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"407-407"},"PeriodicalIF":31.2,"publicationDate":"2026-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148218835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MRI end-points for clinical trials in ataxias: recommendations from the Ataxia Global Initiative MRI Biomarkers Working Group","authors":"Gülin Öz, Sirio Cocozza, Thiago J. R. Rezende, Pierre-Gilles Henry, Jennifer Faber, Ian H. Harding, on behalf of the Ataxia Global Initiative Working Group on MRI Biomarkers","doi":"10.1038/s41582-026-01218-7","DOIUrl":"10.1038/s41582-026-01218-7","url":null,"abstract":"Disease-modifying therapies for degenerative ataxias, including emerging gene therapies, are in the clinical trial pipeline. Sensitive outcome measures are urgently needed for treatment monitoring and participant selection to improve trial feasibility in these rare diseases. In hereditary ataxias, the ability to identify people who carry disease-causing mutations before symptom onset also raises the possibility of enrolment into trials before symptom manifestation, but biomarker data are key for participant selection and outcome monitoring in such preventive trials. Quantitative neuroimaging readouts have emerged as viable candidate biomarkers of ataxia pathology and progression that could supplement traditional clinical outcome assessments as clinical trial end-points. In this Consensus Statement, the Ataxia Global Initiative MRI Biomarkers Working Group critically reviews candidate MRI end-points for trials in the most common spinocerebellar ataxias (SCA1, SCA2 and SCA3) and Friedreich ataxia and provides evidence-based, disease-specific recommendations for the selection of MRI end-points for trials in these diseases. Recommendations are also provided for further research to address remaining knowledge gaps. Sensitive outcome measures are urgently needed for trials of disease-modifying therapies for degenerative ataxias. In this Consensus Statement, the Ataxia Global Initiative MRI Biomarkers Working Group provides evidence-based, disease-specific recommendations for the selection of MRI end-points for trials, and recommends further research to address knowledge gaps.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"439-456"},"PeriodicalIF":31.2,"publicationDate":"2026-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41582-026-01218-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148157570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting toxic HTT1a could be the key to treating Huntington disease","authors":"Freja Sadler, Sarah J. Tabrizi","doi":"10.1038/s41582-026-01222-x","DOIUrl":"10.1038/s41582-026-01222-x","url":null,"abstract":"Huntington disease is a neurodegenerative disorder caused by pathological expansion of the huntingtin (HTT) gene, and no disease-modifying therapies are currently available. Two new studies demonstrate different genetic approaches to targeting the toxic Htt transcript Htt1a in knockin mouse models of Huntington disease, which might inform future strategies to lower mutant HTT in humans.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 9","pages":"547-548"},"PeriodicalIF":31.2,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Motor neuron disease in Africa: a critical appraisal of the literature","authors":"Jeannine M. Heckmann, Niki Floudiotis, Akintomiwa Makanjuola, Adesola Ogunniyi, Andre Mochan, Rhanda R. Mongwe, Dilraj S. Sokhi, Melissa Nel","doi":"10.1038/s41582-026-01221-y","DOIUrl":"10.1038/s41582-026-01221-y","url":null,"abstract":"Motor neuron disease (MND) refers to a group of neurodegenerative diseases that cause motor neuron degeneration and death. The most common subtype, amyotrophic lateral sclerosis (ALS), is characterized by both upper and lower motor neuron impairment, which can manifest clinically in the bulbar region or asymmetrically in a limb. Typically, the disease progresses over several months, and death from respiratory failure occurs within 2–5 years of onset. As we highlight in this Review, data on MND in Africa are sparse, although common observations in this region — and in other populations with relatively low life expectancy — include apparent earlier disease onset and lower disease incidence compared with the rest of the world. In view of the HIV epidemic in Africa, we critically examine the evidence for an association between ALS and HIV infection. We briefly discuss conditions that might be regarded as ALS mimics and summarize the limited data on MND genetics in this region. Other issues pertinent to people living with MND in Africa include the absence of cognitive and behavioural data and the limited access to multidisciplinary clinics, therapies and palliative care. We share our perspective on how the ALS Africa Network is coordinating a shift in the African MND landscape to improve patient care. Heckmann and colleagues critically appraise the literature on amyotrophic lateral sclerosis (ALS) and other motor neuron diseases in Africa, highlighting knowledge gaps and barriers to patient care. They also consider potential ALS mimics that are prevalent in this region and assess the evidence for a link between HIV infection and ALS.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"428-438"},"PeriodicalIF":31.2,"publicationDate":"2026-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148033525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking prognosis in multiple sclerosis: a multiaxial perspective","authors":"Luca Prosperini, Carla Tortorella, Frederik Barkhof, Luca Battistini, Benedetta Bodini, Massimiliano Calabrese, Declan Chard, Olga Ciccarelli, Nicola De Stefano, Christian Enzinger, Massimo Filippi, Ludwig Kappos, Jens Kuhle, Roberta Magliozzi, Maria Assunta Rocca, Alex Rovira, Serena Ruggieri, Jaume Sastre-Garriga, Menno M. Schoonheim, Maria Pia Sormani, Bruno Stankoff, Mar Tintoré, Tarek Yousry, Xavier Montalban, Claudio Gasperini, on behalf of the MAGNIMS network","doi":"10.1038/s41582-026-01212-z","DOIUrl":"10.1038/s41582-026-01212-z","url":null,"abstract":"Multiple sclerosis (MS) is a condition marked by considerable prognostic uncertainty, despite advances in therapeutic strategies and biomarker development. Current approaches to prognosis are largely focused on disease burden, failing to consider the influence of compensatory mechanisms, which complicate the evaluation of long-term outcomes. No unified framework currently exists to guide the integration of diverse prognostic factors, ranging from lesion burden and location to neuroaxonal injury, structural and cognitive reserve, lifestyle and digital biomarkers. To address this gap, a consortium from the Magnetic Resonance Imaging in MS (MAGNIMS) network has reviewed the latest research on MS prognosis and, in this Expert Recommendation, proposes a multiaxial conceptual model that incorporates the overall burden of damage, the topography of injury and the capacity for compensation. These three axes can be explored with different tools, such as clinical history and neurological examination, MRI-based tools, biofluid markers and additional techniques, including multimodal evoked potentials, optical coherence tomography and technology-based passive monitoring systems. The MAGNIMS consortium evaluated the existing tools, their limitations and potential future directions across each axis, proposing an integrated, non-prescriptive framework for individualized risk prediction. This work is intended not as a clinical guideline but as a conceptual roadmap to inform future research and refinement of prognostic models in MS. Multiple sclerosis is marked by considerable prognostic uncertainty, and no unified framework currently exists to guide the integration of diverse prognostic factors. To address this gap, a MAGNIMS consortium proposes a multiaxial model, incorporating the overall burden of damage, the topography of injury and the capacity for compensation.","PeriodicalId":19085,"journal":{"name":"Nature Reviews Neurology","volume":"22 7","pages":"457-471"},"PeriodicalIF":31.2,"publicationDate":"2026-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147974317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}