Degeneration decades before disease onset

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-02-17 DOI:10.1038/s41582-025-01069-8

Ian Fyfe

引用次数: 0

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在发病前几十年退行性变

一项新的研究表明，在亨廷顿病（HD）临床发病前几十年，体细胞CAG重复扩增与神经退行性变有关。这项研究涉及57名患有HD基因扩增的患者，他们的临床发病预计在23年后。即使在基线时没有临床损伤，脑脊液和影像学指标显示早期神经变性。随着时间的推移，体细胞CAG重复扩增的增加与更大的萎缩有关，这为早期神经退行性变的机制提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

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