CNS drug delivery improves chemotherapy

IF 28.2 1区医学 Q1 CLINICAL NEUROLOGY

Nature Reviews Neurology Pub Date : 2025-02-17 DOI:10.1038/s41582-025-01070-1

Ian Fyfe

引用次数: 0

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中枢神经系统给药改善化疗

在新的研究中，胶质母细胞瘤相关巨噬细胞（GAMs）已被化疗药物有效靶向，这些化疗药物经过修饰，可以穿过血脑屏障。喜树碱和瑞喹莫特这两种药物被结合到一种串联肽上，该肽与低密度脂蛋白受体相关蛋白1结合，从而促进它们进入大脑的运输。一旦进入中枢神经系统，这些药物将GAMs的表型从支持肿瘤转变为抑制肿瘤，从而提高胶质母细胞瘤对化疗的敏感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Reviews Neurology 医学-临床神经学

CiteScore

29.90

自引率

0.80%

发文量

138

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Neurology aims to be the premier source of reviews and commentaries for the scientific and clinical communities we serve. We want to provide an unparalleled service to authors, referees, and readers, and we work hard to maximize the usefulness and impact of each article. The journal publishes Research Highlights, Comments, News & Views, Reviews, Consensus Statements, and Perspectives relevant to researchers and clinicians working in the field of neurology. Our broad scope ensures that the work we publish reaches the widest possible audience. Our articles are authoritative, accessible, and enhanced with clearly understandable figures, tables, and other display items. This page gives more detail about the aims and scope of the journal.