少突胶质祖细胞移植治疗多发性硬化症

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry Biochemistry Pub Date : 2024-11-13 DOI:10.1038/s41582-024-01038-7

Lisa Kiani

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引用次数: 0

摘要

新研究表明，将转基因少突胶质祖细胞（OPC）移植到多发性硬化症小鼠模型中可改善髓鞘再形成。研究人员利用CRISPR技术在人类胚胎干细胞衍生的OPCs中删除了神经蛋白1，这是一种SEMA3A受体，在多发性硬化症患者的脱髓鞘病灶中高度表达，对OPCs有趋化作用。移植经修饰的OPC增强了小鼠的髓鞘再形成，为OPC移植作为多发性硬化症的潜在治疗策略提供了概念证明。

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Oligodendrocyte progenitor cell transplant for MS

Transplantation of genetically modified oligodendrocyte progenitor cells (OPCs) into a mouse model of MS improves remyelination, new research has demonstrated. The researchers used CRISPR in human embryonic stem cell-derived OPCs to delete neuropilin 1, a receptor for SEMA3A that is highly expressed in demyelinated lesions in people with MS and is chemorepulsive to OPCs. Transplantation of the modified OPCs enhanced remyelination in the mice, providing proof of concept for OPC transplantation as a potential therapeutic strategy for MS.

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来源期刊

Biochemistry Biochemistry 生物-生化与分子生物学

CiteScore

5.50

自引率

3.40%

发文量

336

审稿时长

1-2 weeks

期刊介绍： Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.