High prevalence of hepatitis B in NMOSD

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemistry Biochemistry Pub Date : 2024-11-13 DOI:10.1038/s41582-024-01037-8

Lisa Kiani

引用次数: 0

Abstract

A new study of a Taiwanese cohort found a high prevalence of resolved hepatitis B virus (HBV) infection in people with neuromyelitis optica spectrum disorder (NMOSD). Resolved HBV was found in 63.4% of people with NMOSD, compared with 16.4% in healthy controls, equating to a 5.7-fold increased risk of NMOSD following HBV infection. Furthermore, resolved HBV was associated with later onset of NMOSD and higher disability scores compared with individuals without HBV infection when adjusted for age and sex, suggesting that the immune response to HBV could contribute to NMOSD pathogenesis.

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非传染性疾病中乙型肝炎的高发病率

一项针对台湾队列的新研究发现，神经脊髓炎视网膜频谱紊乱症（NMOSD）患者中乙型肝炎病毒（HBV）感染复发率很高。在 63.4% 的 NMOSD 患者中发现了已解决的 HBV，而在健康对照组中只有 16.4%，相当于 HBV 感染后 NMOSD 风险增加了 5.7 倍。此外，与未感染 HBV 的人相比，经年龄和性别调整后，已解决的 HBV 与 NMOSD 发病时间较晚和残疾评分较高有关，这表明对 HBV 的免疫反应可能是导致 NMOSD 发病的原因之一。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biochemistry Biochemistry 生物-生化与分子生物学

CiteScore

5.50

自引率

3.40%

发文量

336

审稿时长

1-2 weeks

期刊介绍： Biochemistry provides an international forum for publishing exceptional, rigorous, high-impact research across all of biological chemistry. This broad scope includes studies on the chemical, physical, mechanistic, and/or structural basis of biological or cell function, and encompasses the fields of chemical biology, synthetic biology, disease biology, cell biology, nucleic acid biology, neuroscience, structural biology, and biophysics. In addition to traditional Research Articles, Biochemistry also publishes Communications, Viewpoints, and Perspectives, as well as From the Bench articles that report new methods of particular interest to the biological chemistry community.