{"title":"A stack of silicon meshes for 3D organoid interfacing","authors":"Yan Huang","doi":"10.1038/s41928-025-01429-8","DOIUrl":"10.1038/s41928-025-01429-8","url":null,"abstract":"","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 7","pages":"556-556"},"PeriodicalIF":40.9,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Aniek Even, Roseanne Minderhoud, Tom Torfs, Francesca Leonardi, Arjan van Heusden, Ria Sijabat, Dimitrios Firfilionis, Ivan Dario Castro Miller, Ramzy Rammouz, Tobias Teichmann, Ruben van Bergen, Günter Vermeeren, Edoardo Capuano, Rachel Armstrong, Klaus Mathwig, Sonja de Vries, Annelies Goris, Nick Van Helleputte, Guido Hooiveld, Chris Van Hoof
{"title":"Measurements of redox balance along the gut using a miniaturized ingestible sensor","authors":"Aniek Even, Roseanne Minderhoud, Tom Torfs, Francesca Leonardi, Arjan van Heusden, Ria Sijabat, Dimitrios Firfilionis, Ivan Dario Castro Miller, Ramzy Rammouz, Tobias Teichmann, Ruben van Bergen, Günter Vermeeren, Edoardo Capuano, Rachel Armstrong, Klaus Mathwig, Sonja de Vries, Annelies Goris, Nick Van Helleputte, Guido Hooiveld, Chris Van Hoof","doi":"10.1038/s41928-025-01411-4","DOIUrl":"10.1038/s41928-025-01411-4","url":null,"abstract":"Redox balance—the equilibrium between oxidants and reductants—is a key modulator of a healthy gut and consequently overall well-being. Excess reactive species, resulting in oxidative stress, are linked to deleterious processes including inflammation and microbiome dysbiosis. However, a lack of suitable in vivo methods has restricted measurements of redox balance in the human gut. Here we report a miniaturized ingestible sensor that is equipped with an oxidation–reduction potential sensor, an electrochemical reference electrode and pH and temperature sensors. We preclinically validate our wireless gastrointestinal (GI) smart module (GISMO) in GI fluids and an animal model and report in-human measurements in 15 healthy individuals. Our high-temporal-resolution data, measured every 20 s, reveal consistent profiles from an oxidative environment in the stomach to a strongly reducing environment in the large intestine. This non-intrusive method has the potential to advance (GI) disease monitoring and offer insights into the gut microbiome. A wireless ingestible sensor that is equipped with an oxidation–reduction potential sensor, electrochemical reference electrode, and pH and temperature sensors can be used to measure redox balance along the human gut.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 9","pages":"856-870"},"PeriodicalIF":40.9,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41928-025-01411-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144639825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Scaling quantum computers with electronic–photonic chips","authors":"Yun Zheng, Xinyu Jia, Jianwei Wang","doi":"10.1038/s41928-025-01416-z","DOIUrl":"10.1038/s41928-025-01416-z","url":null,"abstract":"An electronic–photonic quantum system on a chip could be of use in the scaling of quantum information technologies.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 7","pages":"558-559"},"PeriodicalIF":40.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danielius Kramnik, Imbert Wang, Anirudh Ramesh, Josep M. Fargas Cabanillas, Ðorđe Gluhović, Sidney Buchbinder, Panagiotis Zarkos, Christos Adamopoulos, Prem Kumar, Vladimir M. Stojanović, Miloš A. Popović
{"title":"Scalable feedback stabilization of quantum light sources on a CMOS chip","authors":"Danielius Kramnik, Imbert Wang, Anirudh Ramesh, Josep M. Fargas Cabanillas, Ðorđe Gluhović, Sidney Buchbinder, Panagiotis Zarkos, Christos Adamopoulos, Prem Kumar, Vladimir M. Stojanović, Miloš A. Popović","doi":"10.1038/s41928-025-01410-5","DOIUrl":"10.1038/s41928-025-01410-5","url":null,"abstract":"Silicon photonics could soon be used to create the vast numbers of physical qubits needed to achieve useful quantum information processing by leveraging mature complementary metal–oxide–semiconductor (CMOS) manufacturing to miniaturize optical devices for generating and manipulating quantum states of light. However, the development of practical silicon quantum-photonic integrated circuits faces challenges related to high sensitivity to process and temperature variations, free-carrier and self-heating nonlinearities, and thermal crosstalk. These issues have been partially addressed with bulky off-chip electronics, but this sacrifices many benefits of a chip-scale platform. Here we report an electronic–photonic quantum system-on-chip that consists of quantum-correlated photon-pair sources stabilized via on-chip feedback control circuits and is fabricated in a commercial 45-nm CMOS microelectronics foundry. We use non-invasive photocurrent sensing in a tunable microring cavity photon-pair source to actively lock it to a fixed-wavelength pump laser while operating in the quantum regime, enabling large-scale microring-based quantum systems. We also show that these sources maintain stable quantum properties and operate reliably in a practical setting with many adjacent photon-pair sources creating thermal disturbances on the same chip. Such dense integration of electronics and photonics enables implementation and control of quantum-photonic systems at the scale needed to achieve useful quantum information processing with CMOS-fabricated chips. An electronic–photonic quantum system-on-chip—fabricated in a 45-nm complementary metal–oxide–semiconductor microelectronics foundry—provides scalable control of microring resonator quantum photon-pair sources through the monolithic integration of silicon quantum photonics with complex control electronics on the same die.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 7","pages":"620-630"},"PeriodicalIF":40.9,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144622260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yi Huang, Chaoyi He, Yunzhi Ling, Ning Ge, J. Joshua Yang, Miao Hu, Linda Katehi, Qiangfei Xia
{"title":"Radiofrequency signal processing with a memristive system-on-a-chip","authors":"Yi Huang, Chaoyi He, Yunzhi Ling, Ning Ge, J. Joshua Yang, Miao Hu, Linda Katehi, Qiangfei Xia","doi":"10.1038/s41928-025-01409-y","DOIUrl":"10.1038/s41928-025-01409-y","url":null,"abstract":"The development of wireless communication technology and the Internet of Things requires radiofrequency communication systems with higher frequencies and faster communication speeds. However, traditional digital processing platforms—which involve high-speed analogue-to-digital converters, intensive data movement and complex digital computation in software-defined radio systems—suffer from high energy consumption and latency. Signal processing in the analogue domain using non-volatile memristive devices can reduce data movement and energy consumption, but the development of system-level designs remains limited. Here we report a radiofrequency signal processing system that is based on analogue in-memory computing within a multicore memristive system-on-a-chip. With the approach, we demonstrate an analogue discrete Fourier transform for spectrum analysis, a mixer-free demodulator for in-phase and quadrature demodulation, and analogue neural networks for radiofrequency transmitter identification and anomaly detection. The memristive system-on-a-chip offers an identification accuracy of over 90% and is up to 6.8 times more energy efficient and up to 6.2 times faster than traditional digital processing platforms. A radiofrequency signal processing system that uses a multicore memristive system-on-a-chip can perform analogue discrete Fourier transformation, in-phase and quadrature demodulation and analogue neural network tasks for radiofrequency transmitter identification and anomaly detection.","PeriodicalId":19064,"journal":{"name":"Nature Electronics","volume":"8 7","pages":"587-596"},"PeriodicalIF":40.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144578020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}