Nature Biomedical Engineering最新文献_第8页

Hormonally mediated mechanical remodelling of human haematopoietic stem cells enhances their bone-marrow engraftment 激素介导的人造血干细胞机械重塑增强其骨髓植入

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2025-01-07 DOI: 10.1038/s41551-024-01310-7

引用次数: 0

Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells 利用肿瘤细胞和诱导多能干细胞共享的表面抗原的强效预防性癌症疫苗

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-27 DOI: 10.1038/s41551-024-01309-0

Nan Li, Hao Qin, Fei Zhu, Hao Ding, Yang Chen, Yixuan Lin, Ronghui Deng, Tianyu Ma, Yuanyuan Lv, Changhao Xiong, Rong Li, Yaohua Wei, Jian Shi, Hanqing Chen, Yuliang Zhao, Guangbiao Zhou, Hua Guo, Mengyao Lv, Yongfang Lin, Bing Han, Guangjun Nie, Ruifang Zhao

{"title":"Potent prophylactic cancer vaccines harnessing surface antigens shared by tumour cells and induced pluripotent stem cells","authors":"Nan Li, Hao Qin, Fei Zhu, Hao Ding, Yang Chen, Yixuan Lin, Ronghui Deng, Tianyu Ma, Yuanyuan Lv, Changhao Xiong, Rong Li, Yaohua Wei, Jian Shi, Hanqing Chen, Yuliang Zhao, Guangbiao Zhou, Hua Guo, Mengyao Lv, Yongfang Lin, Bing Han, Guangjun Nie, Ruifang Zhao","doi":"10.1038/s41551-024-01309-0","DOIUrl":"10.1038/s41551-024-01309-0","url":null,"abstract":"The development of prophylactic cancer vaccines typically involves the selection of combinations of tumour-associated antigens, tumour-specific antigens and neoantigens. Here we show that membranes from induced pluripotent stem cells can serve as a tumour-antigen pool, and that a nanoparticle vaccine consisting of self-assembled commercial adjuvants wrapped by such membranes robustly stimulated innate immunity, evaded antigen-specific tolerance and activated B-cell and T-cell responses, which were mediated by epitopes from the abundant number of antigens shared between the membranes of tumour cells and pluripotent stem cells. In mice, the vaccine elicited systemic antitumour memory T-cell and B-cell responses as well as tumour-specific immune responses after a tumour challenge, and inhibited the progression of melanoma, colon cancer, breast cancer and post-operative lung metastases. Harnessing antigens shared by pluripotent stem cell membranes and tumour membranes may facilitate the development of universal cancer vaccines. A prophylactic cancer vaccine consisting of commercial adjuvants wrapped by membranes from pluripotent stem cells inhibited tumour progression in mice, owing to shared antigens between tumour membranes and the pluripotent stem cell membranes.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"9 2","pages":"215-233"},"PeriodicalIF":26.8,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sharing antigens from stem cell membranes 共享干细胞膜上的抗原

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-27 DOI: 10.1038/s41551-024-01323-2

Yuewen Zhai, Siwen Li

引用次数: 0

Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation 慢性适应性深部脑刺激获取皮层记录的挑战和机遇

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-27 DOI: 10.1038/s41551-024-01314-3

Jeffrey Herron, Aura Kullmann, Timothy Denison, Wayne K. Goodman, Aysegul Gunduz, Wolf-Julian Neumann, Nicole R. Provenza, Maryam M. Shanechi, Sameer A. Sheth, Philip A. Starr, Alik S. Widge

{"title":"Challenges and opportunities of acquiring cortical recordings for chronic adaptive deep brain stimulation","authors":"Jeffrey Herron, Aura Kullmann, Timothy Denison, Wayne K. Goodman, Aysegul Gunduz, Wolf-Julian Neumann, Nicole R. Provenza, Maryam M. Shanechi, Sameer A. Sheth, Philip A. Starr, Alik S. Widge","doi":"10.1038/s41551-024-01314-3","DOIUrl":"https://doi.org/10.1038/s41551-024-01314-3","url":null,"abstract":"<p>Deep brain stimulation (DBS), a proven treatment for movement disorders, also holds promise for the treatment of psychiatric and cognitive conditions. However, for DBS to be clinically effective, it may require DBS technology that can alter or trigger stimulation in response to changes in biomarkers sensed from the patient’s brain. A growing body of evidence suggests that such adaptive DBS is feasible, it might achieve clinical effects that are not possible with standard continuous DBS and that some of the best biomarkers are signals from the cerebral cortex. Yet capturing those markers requires the placement of cortex-optimized electrodes in addition to standard electrodes for DBS. In this Perspective we argue that the need for cortical biomarkers in adaptive DBS and the unfortunate convergence of regulatory and financial factors underpinning the unavailability of cortical electrodes for chronic uses threatens to slow down or stall research on adaptive DBS and propose public–private partnerships as a potential solution to such a critical technological gap.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"65 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An application-based taxonomy for brain–computer interfaces 基于应用程序的脑机接口分类法

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01326-z

Jacob T. Robinson, Sumner L. Norman, Matthew R. Angle, Timothy G. Constandinou, Timothy Denison, John P. Donoghue, Ryan M. Field, Andreas Forsland, Sid Kouider, José del R. Millán, Jonathan A. Michaels, Amy L. Orsborn, Chethan Pandarinath, J. Andrew Pruszynski, Christopher J. Rozell, Nishal P. Shah, Maryam M. Shanechi, Mahsa Shoaran, Sameer A. Sheth, Sergey D. Stavisky, Eric Trautmann, Nicolas Vachicouras, Chong Xie

引用次数: 0

Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning 通过连续血糖监测和机器学习预测2型糖尿病的代谢亚表型

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01311-6

Ahmed A. Metwally, Dalia Perelman, Heyjun Park, Yue Wu, Alokkumar Jha, Seth Sharp, Alessandra Celli, Ekrem Ayhan, Fahim Abbasi, Anna L. Gloyn, Tracey McLaughlin, Michael P. Snyder

{"title":"Prediction of metabolic subphenotypes of type 2 diabetes via continuous glucose monitoring and machine learning","authors":"Ahmed A. Metwally, Dalia Perelman, Heyjun Park, Yue Wu, Alokkumar Jha, Seth Sharp, Alessandra Celli, Ekrem Ayhan, Fahim Abbasi, Anna L. Gloyn, Tracey McLaughlin, Michael P. Snyder","doi":"10.1038/s41551-024-01311-6","DOIUrl":"https://doi.org/10.1038/s41551-024-01311-6","url":null,"abstract":"<p>The classification of type 2 diabetes and prediabetes does not consider heterogeneity in the pathophysiology of glucose dysregulation. Here we show that prediabetes is characterized by metabolic heterogeneity, and that metabolic subphenotypes can be predicted by the shape of the glucose curve measured via a continuous glucose monitor (CGM) during standardized oral glucose-tolerance tests (OGTTs) performed in at-home settings. Gold-standard metabolic tests in 32 individuals with early glucose dysregulation revealed dominant or co-dominant subphenotypes (muscle or hepatic insulin-resistance phenotypes in 34% of the individuals, and β-cell-dysfunction or impaired-incretin-action phenotypes in 40% of them). Machine-learning models trained with glucose time series from OGTTs from the 32 individuals predicted the subphenotypes with areas under the curve (AUCs) of 95% for muscle insulin resistance, 89% for β-cell deficiency and 88% for impaired incretin action. With CGM-generated glucose curves obtained during at-home OGTTs, the models predicted the muscle-insulin-resistance and β-cell-deficiency subphenotypes of 29 individuals with AUCs of 88% and 84%, respectively. At-home identification of metabolic subphenotypes via a CGM may aid the risk stratification of individuals with early glucose dysregulation.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"39 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors 基于亮氨酸拉链的多受体CAR - T细胞免疫磁纯化

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01287-3

Scott E. James, Sophia Chen, Brandon D. Ng, Jacob S. Fischman, Lorenz Jahn, Alexander P. Boardman, Adhithi Rajagopalan, Harold K. Elias, Alyssa Massa, Dylan Manuele, Katherine B. Nichols, Amina Lazrak, Nicole Lee, Aoife M. Roche, Alexander G. McFarland, Angelina Petrichenko, John K. Everett, Frederic D. Bushman, Teng Fei, Anastasia I. Kousa, Andri L. Lemarquis, Susan DeWolf, Jonathan U. Peled, Santosha A. Vardhana, Christopher A. Klebanoff, Marcel R. M. van den Brink

{"title":"Leucine zipper-based immunomagnetic purification of CAR T cells displaying multiple receptors","authors":"Scott E. James, Sophia Chen, Brandon D. Ng, Jacob S. Fischman, Lorenz Jahn, Alexander P. Boardman, Adhithi Rajagopalan, Harold K. Elias, Alyssa Massa, Dylan Manuele, Katherine B. Nichols, Amina Lazrak, Nicole Lee, Aoife M. Roche, Alexander G. McFarland, Angelina Petrichenko, John K. Everett, Frederic D. Bushman, Teng Fei, Anastasia I. Kousa, Andri L. Lemarquis, Susan DeWolf, Jonathan U. Peled, Santosha A. Vardhana, Christopher A. Klebanoff, Marcel R. M. van den Brink","doi":"10.1038/s41551-024-01287-3","DOIUrl":"10.1038/s41551-024-01287-3","url":null,"abstract":"Resistance to chimaeric antigen receptor (CAR) T cell therapy develops through multiple mechanisms, most notably antigen loss and tumour-induced immune suppression. It has been suggested that T cells expressing multiple CARs may overcome the resistance of tumours and that T cells expressing receptors that switch inhibitory immune-checkpoint signals into costimulatory signals may enhance the activity of the T cells in the tumour microenvironment. However, engineering multiple features into a single T cell product is difficult because of the transgene-packaging constraints of current gene-delivery vectors. Here we describe a cell-sorting method that leverages leucine zippers for the selective single-step immunomagnetic purification of cells co-transduced with two vectors. Such ‘Zip sorting’ facilitated the generation of T cells simultaneously expressing up to four CARs and coexpressing up to three ‘switch’ receptors. In syngeneic mouse models, T cells with multiple CARs and multiple switch receptors eliminated antigenically heterogeneous populations of leukaemia cells coexpressing multiple inhibitory ligands. By combining diverse therapeutic strategies, Zip-sorted multi-CAR multi-switch-receptor T cells can overcome multiple mechanisms of CAR T cell resistance. A cell-sorting method leveraging leucine zippers allows for the generation of T cells displaying multiple chimaeric antigen receptors as well as receptors converting inhibitory signals into stimulatory signals.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"8 12","pages":"1592-1614"},"PeriodicalIF":26.8,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142874558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An antifibrotic therapy for myocardial infarction 一种治疗心肌梗塞的抗纤维化疗法

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01335-y

Valeria Caprettini

引用次数: 0

Making CRISPR more deliverable 让CRISPR更具可交付性

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-12-23 DOI: 10.1038/s41551-024-01332-1

Filipe V. Almeida

引用次数: 0

‘CRISPRing’ with therapeutic cells “crispr”治疗细胞