Nature Biomedical Engineering最新文献_第9页

Targeting the PIEZO1 pathway boosts T cell antitumour cytotoxicity 靶向 PIEZO1 通路可增强 T 细胞的抗肿瘤细胞毒性

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-27 DOI: 10.1038/s41551-024-01189-4

引用次数: 0

Methods, techniques, assays and protocols 方法、技术、检测和规程。

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-25 DOI: 10.1038/s41551-024-01199-2

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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes PIEZO1 通过机械方式调节 T 淋巴细胞的抗肿瘤细胞毒性。

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-21 DOI: 10.1038/s41551-024-01188-5

Ruiyang Pang, Weihao Sun, Yingyun Yang, Dahan Wen, Feng Lin, Dingding Wang, Kailong Li, Ning Zhang, Junbo Liang, Chunyang Xiong, Yuying Liu

{"title":"PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes","authors":"Ruiyang Pang, Weihao Sun, Yingyun Yang, Dahan Wen, Feng Lin, Dingding Wang, Kailong Li, Ning Zhang, Junbo Liang, Chunyang Xiong, Yuying Liu","doi":"10.1038/s41551-024-01188-5","DOIUrl":"10.1038/s41551-024-01188-5","url":null,"abstract":"The killing function of cytotoxic T cells can be enhanced biochemically. Here we show that blocking the mechanical sensor PIEZO1 in T cells strengthens their traction forces and augments their cytotoxicity against tumour cells. By leveraging cytotoxic T cells collected from tumour models in mice and from patients with cancers, we show that PIEZO1 upregulates the transcriptional factor GRHL3, which in turn induces the expression of the E3 ubiquitin ligase RNF114. RNF114 binds to filamentous actin, causing its downregulation and rearrangement, which depresses traction forces in the T cells. In mice with tumours, the injection of cytotoxic T cells collected from the animals and treated with a PIEZO1 antagonist promoted their infiltration into the tumour and attenuated tumour growth. As an immunomechanical regulator, PIEZO1 could be targeted to enhance the outcomes of cancer immunotherapies. Blocking the mechanical sensor PIEZO1 in cytotoxic T lymphocytes strengthens their traction forces and augments their cytotoxicity against tumour cells.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":26.8,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Oncolytic mineralized bacteria as potent locally administered immunotherapeutics 作为强效局部免疫疗法的肿瘤溶解矿化细菌。

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-21 DOI: 10.1038/s41551-024-01191-w

Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao, Rui Peng, Zhuang Liu

{"title":"Oncolytic mineralized bacteria as potent locally administered immunotherapeutics","authors":"Chenya Wang, Liping Zhong, Jiachen Xu, Qi Zhuang, Fei Gong, Xiaojing Chen, Huiquan Tao, Cong Hu, Fuquan Huang, Nailin Yang, Junyan Li, Qi Zhao, Xinjun Sun, Yu Huo, Qian Chen, Yongxiang Zhao, Rui Peng, Zhuang Liu","doi":"10.1038/s41551-024-01191-w","DOIUrl":"10.1038/s41551-024-01191-w","url":null,"abstract":"Oncolytic bacteria can trigger innate immune activity. However, the antitumour efficacy of inactivated bacteria is poor, and attenuated live bacteria pose substantial safety risks. Here we show that intratumourally injected paraformaldehyde-fixed bacteria coated with manganese dioxide potently activate innate immune activity, modulate the immunosuppressive tumour microenvironment and trigger tumour-specific immune responses and abscopal antitumour responses. A single intratumoural administration of mineralized Salmonella typhimurium suppressed the growth of multiple types of subcutaneous and orthotopic tumours in mice, rabbits and tree shrews and protected the cured animals against tumour rechallenge. We also show that mineralized bacteria can be administered via arterial embolization to treat orthotopic liver cancer in rabbits. Our findings support the further translational testing of oncolytic mineralized bacteria as potent and safe antitumour immunotherapeutics. Intratumourally administered bacteria coated with manganese dioxide modulate the immunosuppressive tumour microenvironment and potently activate antitumour immune responses, as shown in multiple solid tumours in small animals.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":28.1,"publicationDate":"2024-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140185013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Generation of synthetic whole-slide image tiles of tumours from RNA-sequencing data via cascaded diffusion models. 通过级联扩散模型从 RNA 序列数据生成合成的肿瘤全切片图像。

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-21 DOI: 10.1038/s41551-024-01193-8

Francisco Carrillo-Perez, Marija Pizurica, Yuanning Zheng, Tarak Nath Nandi, Ravi Madduri, Jeanne Shen, Olivier Gevaert

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Affinity maturation of CRISPR-engineered B cell receptors in vivo CRISPR 工程 B 细胞受体在体内的亲和成熟

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-20 DOI: 10.1038/s41551-024-01184-9

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Towards on-skin analysis of sweat for managing disorders of substance abuse 对汗液进行皮肤分析，以控制药物滥用失调症

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-18 DOI: 10.1038/s41551-024-01187-6

Noe Brasier, Juliane R. Sempionatto, Steven Bourke, George Havenith, Dietmar Schaffarczyk, Jörg Goldhahn, Christian Lüscher, Wei Gao

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Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation 用于长期监测慢性肠道炎症的微型植入式温度传感器

IF 26.8 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-18 DOI: 10.1038/s41551-024-01183-w

Surabhi R. Madhvapathy, Matthew I. Bury, Larry W. Wang, Joanna L. Ciatti, Raudel Avila, Yonggang Huang, Arun K. Sharma, John A. Rogers

{"title":"Miniaturized implantable temperature sensors for the long-term monitoring of chronic intestinal inflammation","authors":"Surabhi R. Madhvapathy, Matthew I. Bury, Larry W. Wang, Joanna L. Ciatti, Raudel Avila, Yonggang Huang, Arun K. Sharma, John A. Rogers","doi":"10.1038/s41551-024-01183-w","DOIUrl":"10.1038/s41551-024-01183-w","url":null,"abstract":"Diagnosing and monitoring inflammatory bowel diseases, such as Crohn’s disease, involves the use of endoscopic imaging, biopsies and serology. These infrequent tests cannot, however, identify sudden onsets and severe flare-ups to facilitate early intervention. Hence, about 70% of patients with Crohn’s disease require surgical intestinal resections in their lifetime. Here we report wireless, miniaturized and implantable temperature sensors for the real-time chronic monitoring of disease progression, which we tested for nearly 4 months in a mouse model of Crohn’s-disease-like ileitis. Local measurements of intestinal temperature via intraperitoneally implanted sensors held in place against abdominal muscular tissue via two sutures showed the development of ultradian rhythms at approximately 5 weeks before the visual emergence of inflammatory skip lesions. The ultradian rhythms showed correlations with variations in the concentrations of stress hormones and inflammatory cytokines in blood. Decreasing average temperatures over the span of approximately 23 weeks were accompanied by an increasing percentage of inflammatory species in ileal lesions. These miniaturized temperature sensors may aid the early treatment of inflammatory bowel diseases upon the detection of episodic flare-ups. Wireless miniaturized implantable temperature sensors enable real-time monitoring of the progression of inflammatory bowel diseases, as shown in a mouse model of Crohn’s-disease-like ileitis.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":null,"pages":null},"PeriodicalIF":26.8,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140145981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Techniques for supercharging academic writing with generative AI. 利用生成式人工智能提高学术写作水平的技术。

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-18 DOI: 10.1038/s41551-024-01185-8

Zhicheng Lin

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Author Correction: Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager 作者更正：小分子介导的超分子双特异性 T 细胞吸引剂抗肿瘤活性和瘤外毒性控制。

IF 28.1 1区医学

Nature Biomedical Engineering Pub Date : 2024-03-15 DOI: 10.1038/s41551-024-01198-3

Ningqiang Gong, Xuexiang Han, Lulu Xue, Margaret M. Billingsley, Xisha Huang, Rakan El-Mayta, Jingya Qin, Neil C. Sheppard, Carl H. June, Michael J. Mitchell

引用次数: 0