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FAS-less allogeneic CAR T cells
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01319-y
Keith P. Eidell, Michael T. Hemann
{"title":"FAS-less allogeneic CAR T cells","authors":"Keith P. Eidell, Michael T. Hemann","doi":"10.1038/s41551-024-01319-y","DOIUrl":"https://doi.org/10.1038/s41551-024-01319-y","url":null,"abstract":"In immunocompetent hosts, the ablation of FAS and CD3 in allogeneic chimeric antigen receptor T cells confers them with partial protection from rejection by T cells and natural killer cells.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"39 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01300-9
Laura Zamfirov, Ngoc-Minh Nguyen, Maria Elena Fernández-Sánchez, Paula Cambronera Ghiglione, Eliott Teston, Alexandre Dizeux, Thomas Tiennot, Emmanuel Farge, Charlie Demené, Mickael Tanter
{"title":"Acoustic-pressure-driven ultrasonic activation of the mechanosensitive receptor RET and of cell proliferation in colonic tissue","authors":"Laura Zamfirov, Ngoc-Minh Nguyen, Maria Elena Fernández-Sánchez, Paula Cambronera Ghiglione, Eliott Teston, Alexandre Dizeux, Thomas Tiennot, Emmanuel Farge, Charlie Demené, Mickael Tanter","doi":"10.1038/s41551-024-01300-9","DOIUrl":"https://doi.org/10.1038/s41551-024-01300-9","url":null,"abstract":"<p>Ultrasound generates both compressive and shear mechanical forces in soft tissues. However, the specific mechanisms by which these forces activate cellular processes remain unclear. Here we show that low-intensity focused ultrasound can activate the mechanosensitive RET signalling pathway. Specifically, in mouse colon tissues ex vivo and in vivo, focused ultrasound induced RET phosphorylation in colonic crypts cells, which correlated with markers of proliferation and stemness when using hours-long insonication. The activation of the RET pathway is non-thermal, is linearly related to acoustic pressure and is independent of radiation-force-induced shear strain in tissue. Our findings suggest that ultrasound could be used to regulate cell proliferation, particularly in the context of regenerative medicine, and highlight the importance of adhering to current ultrasound-safety regulations for medical imaging.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"93 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857804","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancing breast cancer risk stratification using multimodal AI
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01304-5
{"title":"Advancing breast cancer risk stratification using multimodal AI","authors":"","doi":"10.1038/s41551-024-01304-5","DOIUrl":"https://doi.org/10.1038/s41551-024-01304-5","url":null,"abstract":"A modular model integrating clinical metadata and mammography and tri-modal ultrasound images from patients presenting to the clinic with breast cancer symptoms performs similarly or better than experienced human experts at differential diagnosis and tumour classification.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"54 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-20 DOI: 10.1038/s41551-024-01305-4
{"title":"Concurrently depleting regulatory T cells and activating cytotoxic T cells in tumours","authors":"","doi":"10.1038/s41551-024-01305-4","DOIUrl":"https://doi.org/10.1038/s41551-024-01305-4","url":null,"abstract":"An anti-4-1BB antibody fused to interleukin-15 via a peptide that is sensitive to tumour proteases concurrently depletes regulatory T cells and expands cytotoxic T cells in the tumour microenvironment. This fusion protein augments tumour inhibition without increasing systemic toxicity.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"23 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The analgesic potential of heavy water 重水的镇痛潜力
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-19 DOI: 10.1038/s41551-024-01325-0
Michael J. M. Fischer
{"title":"The analgesic potential of heavy water","authors":"Michael J. M. Fischer","doi":"10.1038/s41551-024-01325-0","DOIUrl":"https://doi.org/10.1038/s41551-024-01325-0","url":null,"abstract":"The influx of deuterated water through the TRPV1 channel reduces pain-related behaviour.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"12 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142849034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Stimulating localizable sensations
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-18 DOI: 10.1038/s41551-024-01321-4
Marc H. Schieber
{"title":"Stimulating localizable sensations","authors":"Marc H. Schieber","doi":"10.1038/s41551-024-01321-4","DOIUrl":"https://doi.org/10.1038/s41551-024-01321-4","url":null,"abstract":"Overlapping projected fields from multiple intracortical electrodes produce sensations on the hand that are more easily localizable, as shown in three participants with cervical spinal cord injury.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"259 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142840880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep profiling of gene expression across 18 human cancers 对 18 种人类癌症的基因表达进行深度剖析
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-17 DOI: 10.1038/s41551-024-01290-8
Wei Qiu, Ayse B. Dincer, Joseph D. Janizek, Safiye Celik, Mikael J. Pittet, Kamila Naxerova, Su-In Lee
{"title":"Deep profiling of gene expression across 18 human cancers","authors":"Wei Qiu, Ayse B. Dincer, Joseph D. Janizek, Safiye Celik, Mikael J. Pittet, Kamila Naxerova, Su-In Lee","doi":"10.1038/s41551-024-01290-8","DOIUrl":"https://doi.org/10.1038/s41551-024-01290-8","url":null,"abstract":"<p>Clinical and biological information in large datasets of gene expression across cancers could be tapped with unsupervised deep learning. However, difficulties associated with biological interpretability and methodological robustness have made this impractical. Here we describe an unsupervised deep-learning framework for the generation of low-dimensional latent spaces for gene-expression data from 50,211 transcriptomes across 18 human cancers. The framework, which we named DeepProfile, outperformed dimensionality-reduction methods with respect to biological interpretability and allowed us to unveil that genes that are universally important in defining latent spaces across cancer types control immune cell activation, whereas cancer-type-specific genes and pathways define molecular disease subtypes. By linking latent variables in DeepProfile to secondary characteristics of tumours, we discovered that mutation burden is closely associated with the expression of cell-cycle-related genes, and that the activity of biological pathways for DNA-mismatch repair and MHC class II antigen presentation are consistently associated with patient survival. We also found that tumour-associated macrophages are a source of survival-correlated MHC class II transcripts. Unsupervised learning can facilitate the discovery of biological insight from gene-expression data.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"10 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Efficient production of non-immunogenic, long circular RNAs for high protein yield 高效生产非免疫原性长环状 RNA，提高蛋白质产量
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-17 DOI: 10.1038/s41551-024-01307-2
{"title":"Efficient production of non-immunogenic, long circular RNAs for high protein yield","authors":"","doi":"10.1038/s41551-024-01307-2","DOIUrl":"https://doi.org/10.1038/s41551-024-01307-2","url":null,"abstract":"Using trans-ribozyme-mediated circularization, we have produced circular RNAs that are not limited by RNA sequence or length and that allow for modifications. The synthesized RNAs increase protein expression more than 7,000-fold.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"4 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Latent spaces for tumour transcriptomes 肿瘤转录组的潜伏空间
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-17 DOI: 10.1038/s41551-024-01322-3
Adriana Ivich, Casey S. Greene
{"title":"Latent spaces for tumour transcriptomes","authors":"Adriana Ivich, Casey S. Greene","doi":"10.1038/s41551-024-01322-3","DOIUrl":"https://doi.org/10.1038/s41551-024-01322-3","url":null,"abstract":"Generating low-dimensional latent spaces for gene-expression data via unsupervised deep learning can unveil biological insight across cancers.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"254 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142832160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolving virus-like particles
IF 28.1 1区 医学
Nature Biomedical Engineering Pub Date : 2024-12-16 DOI: 10.1038/s41551-024-01330-3
Alessandra Griffo
{"title":"Evolving virus-like particles","authors":"Alessandra Griffo","doi":"10.1038/s41551-024-01330-3","DOIUrl":"https://doi.org/10.1038/s41551-024-01330-3","url":null,"abstract":"Virus-like particles can be evolved to enhance the delivery of ribonucleoproteins and to increase particle production.","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"29 1","pages":""},"PeriodicalIF":28.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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