{"title":"一种用于智能伤口监测和加速愈合的热电电池敷料","authors":"Jiwu Xin, Liheng Gao, Wenjie Zhang, Xinyu Song, Yuanmeng Yang, Wenrui Li, Xuhui Zhou, Haozhe Zhang, Zhe Wang, Zhixun Wang, Bing He, Yanting Liu, Tianzhu Zhou, Ting Xiong, Shuai Wang, Shixing Yuan, Wulong Li, Say Chye Joahchim Loo, Lu Wang, Lei Wei","doi":"10.1038/s41551-025-01440-6","DOIUrl":null,"url":null,"abstract":"<p>Current smart dressings with wound monitoring and electrical stimulation capabilities rely on flexible electronics comprising various sensors and external power sources. Despite increasing efforts to integrate all these components onto flexible, breathable and biocompatible substrates, realizing a zero-power electrical stimulation without compromising the clinical applicability remains challenging. Here we report a solution that harnesses the temperature gradient between the wound and dressing to generate an electric stimulus that provides active wound healing management. This was achieved by a thermogalvanic cell (TGC) dressing composed of Fe<sup>2+</sup>/Fe<sup>3+</sup> cross-linked alginate hydrogel reinforced by nanofibres. The TGC dressing exhibits biocompatibility, antibacterial performance, easy re-shaping and moisture permeability. Moreover, the TGC dressing generates an exogenous electric field, promoting the spontaneous acceleration of wound healing. We additionally integrate a sensing system that can monitor respiration rate. In the large porcine wound model, the wound healing rate of a TGC-bandaged group is improved by about 20.6% on day 14 compared with an untreated group. Our wireless wound monitoring system may facilitate real-time monitoring of common wound models at different wound development stages.</p>","PeriodicalId":19063,"journal":{"name":"Nature Biomedical Engineering","volume":"23 1","pages":""},"PeriodicalIF":26.8000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A thermogalvanic cell dressing for smart wound monitoring and accelerated healing\",\"authors\":\"Jiwu Xin, Liheng Gao, Wenjie Zhang, Xinyu Song, Yuanmeng Yang, Wenrui Li, Xuhui Zhou, Haozhe Zhang, Zhe Wang, Zhixun Wang, Bing He, Yanting Liu, Tianzhu Zhou, Ting Xiong, Shuai Wang, Shixing Yuan, Wulong Li, Say Chye Joahchim Loo, Lu Wang, Lei Wei\",\"doi\":\"10.1038/s41551-025-01440-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>Current smart dressings with wound monitoring and electrical stimulation capabilities rely on flexible electronics comprising various sensors and external power sources. Despite increasing efforts to integrate all these components onto flexible, breathable and biocompatible substrates, realizing a zero-power electrical stimulation without compromising the clinical applicability remains challenging. Here we report a solution that harnesses the temperature gradient between the wound and dressing to generate an electric stimulus that provides active wound healing management. This was achieved by a thermogalvanic cell (TGC) dressing composed of Fe<sup>2+</sup>/Fe<sup>3+</sup> cross-linked alginate hydrogel reinforced by nanofibres. The TGC dressing exhibits biocompatibility, antibacterial performance, easy re-shaping and moisture permeability. Moreover, the TGC dressing generates an exogenous electric field, promoting the spontaneous acceleration of wound healing. We additionally integrate a sensing system that can monitor respiration rate. In the large porcine wound model, the wound healing rate of a TGC-bandaged group is improved by about 20.6% on day 14 compared with an untreated group. Our wireless wound monitoring system may facilitate real-time monitoring of common wound models at different wound development stages.</p>\",\"PeriodicalId\":19063,\"journal\":{\"name\":\"Nature Biomedical Engineering\",\"volume\":\"23 1\",\"pages\":\"\"},\"PeriodicalIF\":26.8000,\"publicationDate\":\"2025-07-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature Biomedical Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://doi.org/10.1038/s41551-025-01440-6\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, BIOMEDICAL\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature Biomedical Engineering","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1038/s41551-025-01440-6","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
A thermogalvanic cell dressing for smart wound monitoring and accelerated healing
Current smart dressings with wound monitoring and electrical stimulation capabilities rely on flexible electronics comprising various sensors and external power sources. Despite increasing efforts to integrate all these components onto flexible, breathable and biocompatible substrates, realizing a zero-power electrical stimulation without compromising the clinical applicability remains challenging. Here we report a solution that harnesses the temperature gradient between the wound and dressing to generate an electric stimulus that provides active wound healing management. This was achieved by a thermogalvanic cell (TGC) dressing composed of Fe2+/Fe3+ cross-linked alginate hydrogel reinforced by nanofibres. The TGC dressing exhibits biocompatibility, antibacterial performance, easy re-shaping and moisture permeability. Moreover, the TGC dressing generates an exogenous electric field, promoting the spontaneous acceleration of wound healing. We additionally integrate a sensing system that can monitor respiration rate. In the large porcine wound model, the wound healing rate of a TGC-bandaged group is improved by about 20.6% on day 14 compared with an untreated group. Our wireless wound monitoring system may facilitate real-time monitoring of common wound models at different wound development stages.
期刊介绍:
Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.