一种用于智能伤口监测和加速愈合的热电电池敷料

IF 26.8 1区 医学 Q1 ENGINEERING, BIOMEDICAL
Jiwu Xin, Liheng Gao, Wenjie Zhang, Xinyu Song, Yuanmeng Yang, Wenrui Li, Xuhui Zhou, Haozhe Zhang, Zhe Wang, Zhixun Wang, Bing He, Yanting Liu, Tianzhu Zhou, Ting Xiong, Shuai Wang, Shixing Yuan, Wulong Li, Say Chye Joahchim Loo, Lu Wang, Lei Wei
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引用次数: 0

摘要

目前具有伤口监测和电刺激功能的智能敷料依赖于由各种传感器和外部电源组成的柔性电子设备。尽管越来越多的努力将所有这些组件集成到柔性,透气和生物相容性的基板上,但在不影响临床适用性的情况下实现零功率电刺激仍然具有挑战性。在这里,我们报告了一种解决方案,利用伤口和敷料之间的温度梯度来产生电刺激,提供主动伤口愈合管理。这是通过由纳米纤维增强的Fe2+/Fe3+交联海藻酸盐水凝胶组成的热原电池(TGC)敷料实现的。TGC敷料具有生物相容性、抗菌性能、易重塑性和透湿性。此外,TGC敷料产生外源电场,促进创面自发加速愈合。我们还集成了一个传感系统,可以监测呼吸速率。在大猪伤口模型中,tgc包扎组在第14天的伤口愈合率较未治疗组提高了约20.6%。我们的无线创面监测系统可以在创面发育的不同阶段对常见的创面模型进行实时监测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

A thermogalvanic cell dressing for smart wound monitoring and accelerated healing

A thermogalvanic cell dressing for smart wound monitoring and accelerated healing

Current smart dressings with wound monitoring and electrical stimulation capabilities rely on flexible electronics comprising various sensors and external power sources. Despite increasing efforts to integrate all these components onto flexible, breathable and biocompatible substrates, realizing a zero-power electrical stimulation without compromising the clinical applicability remains challenging. Here we report a solution that harnesses the temperature gradient between the wound and dressing to generate an electric stimulus that provides active wound healing management. This was achieved by a thermogalvanic cell (TGC) dressing composed of Fe2+/Fe3+ cross-linked alginate hydrogel reinforced by nanofibres. The TGC dressing exhibits biocompatibility, antibacterial performance, easy re-shaping and moisture permeability. Moreover, the TGC dressing generates an exogenous electric field, promoting the spontaneous acceleration of wound healing. We additionally integrate a sensing system that can monitor respiration rate. In the large porcine wound model, the wound healing rate of a TGC-bandaged group is improved by about 20.6% on day 14 compared with an untreated group. Our wireless wound monitoring system may facilitate real-time monitoring of common wound models at different wound development stages.

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来源期刊
Nature Biomedical Engineering
Nature Biomedical Engineering Medicine-Medicine (miscellaneous)
CiteScore
45.30
自引率
1.10%
发文量
138
期刊介绍: Nature Biomedical Engineering is an online-only monthly journal that was launched in January 2017. It aims to publish original research, reviews, and commentary focusing on applied biomedicine and health technology. The journal targets a diverse audience, including life scientists who are involved in developing experimental or computational systems and methods to enhance our understanding of human physiology. It also covers biomedical researchers and engineers who are engaged in designing or optimizing therapies, assays, devices, or procedures for diagnosing or treating diseases. Additionally, clinicians, who make use of research outputs to evaluate patient health or administer therapy in various clinical settings and healthcare contexts, are also part of the target audience.
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