Nature Reviews Immunology最新文献_第2页

Lessons from neoadjuvant immunotherapy in melanoma: understanding antitumour immunity and tumour escape. 黑色素瘤新辅助免疫治疗的经验教训：了解抗肿瘤免疫和肿瘤逃逸。

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-22 DOI: 10.1038/s41577-025-01222-w

Francesca Fallarino,Christian U Blank

引用次数: 0

Clearing the hurdles for CAR-T cell treatment. 清除CAR-T细胞治疗的障碍。

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-22 DOI: 10.1038/s41577-025-01228-4

Rayne H Rouce

引用次数: 0

Targets of protective immunity and opportunities in hepatitis C virus vaccine development 保护性免疫的目标和丙型肝炎病毒疫苗开发的机遇

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-12 DOI: 10.1038/s41577-025-01215-9

Seung Bum Park, Paul Zimmer-Harwood, T. Jake Liang

引用次数: 0

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-10 DOI: 10.1038/s41577-025-01214-w

Loïc Dupré, Irinka Castanon, Kaan Boztug

{"title":"Immune-related actinopathies at the cross-road of immunodeficiency, autoimmunity and autoinflammation","authors":"Loïc Dupré, Irinka Castanon, Kaan Boztug","doi":"10.1038/s41577-025-01214-w","DOIUrl":"https://doi.org/10.1038/s41577-025-01214-w","url":null,"abstract":"Actin cytoskeleton remodelling drives the migration of immune cells and their engagement in dynamic cell–cell contacts. The importance of actin cytoskeleton dynamics in immune cell function is highlighted by the discovery of inborn errors of immunity (IEIs) that are caused by defects in individual actin-regulatory proteins, resulting in immune-related actinopathies. In addition to susceptibility to infection, these often present with a vast array of autoimmune and autoinflammatory manifestations. Here, we review the role of actin subnetworks in the activation and function of lymphoid and myeloid cells. We focus on the mechanisms by which actin defects result in aberrant lymphocyte function, including dysregulation of T cell- and B cell-mediated tolerance and biased cytokine production, which can result in autoimmunity. We also highlight the relationship between actin defects and inflammasome activation and other pathomechanisms in myeloid cells as the underlying cause of autoinflammation. Finally, we discuss future avenues for research and therapeutic intervention based on a molecular understanding of immune-related actinopathies.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"14 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145031961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic control of innate-like T cells 先天样T细胞的代谢控制

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-08 DOI: 10.1038/s41577-025-01219-5

Thomas Riffelmacher, Mitchell Kronenberg

{"title":"Metabolic control of innate-like T cells","authors":"Thomas Riffelmacher, Mitchell Kronenberg","doi":"10.1038/s41577-025-01219-5","DOIUrl":"https://doi.org/10.1038/s41577-025-01219-5","url":null,"abstract":"Immunometabolism, the intersection of cellular metabolism and immune function, has revolutionized our understanding of T cell biology. Changes in cellular metabolism help guide the development of thymocytes and the transition of T cells from naive to effector, memory and tissue-resident states. Innate-like T cells are a unique group of T cells with special characteristics. They respond rapidly, reside mainly in tissues and express T cell receptors with limited diversity that recognize non-peptide antigens. This group includes invariant natural killer T (iNKT) cells, mucosal-associated invariant T (MAIT) cells and some populations of γδ T cells. Different subsets of innate-like T cells rely on specific metabolic pathways that influence their differentiation and function and distinguish them from conventional CD4+ and CD8+ T cells. Although there are differences between innate-like T cell types, they share metabolic and functional features. In this Review, we highlight recent research in this emerging field. Understanding how metabolic programmes differ between innate-like T cells and other T cells may open opportunities for tailoring innate-like T cell responses and adoptive T cell therapies for use in cancer, metabolic and autoimmune diseases.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"15 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145017916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting MHC-E as a new strategy for vaccines and immunotherapeutics 靶向MHC-E作为疫苗和免疫治疗的新策略

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-09-03 DOI: 10.1038/s41577-025-01218-6

Klaus Früh, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael, Louis J. Picker

{"title":"Targeting MHC-E as a new strategy for vaccines and immunotherapeutics","authors":"Klaus Früh, Persephone Borrow, Geraldine M. Gillespie, Andrew J. McMichael, Louis J. Picker","doi":"10.1038/s41577-025-01218-6","DOIUrl":"https://doi.org/10.1038/s41577-025-01218-6","url":null,"abstract":"MHC-E is a highly conserved, non-polymorphic MHC protein that engages inhibitory and activating receptors on natural killer (NK) cells and T cells and can also present antigens to T cell receptors. NK cell responses driven by activating receptor interactions with MHC-E are implicated in controlling chronic viral infections and cancer. Immunotherapeutic targeting of interactions between MHC-E and inhibitory receptors to increase the activation of NK cells and T cells shows promise in improving antitumour immune responses. Furthermore, MHC-E-restricted CD8+ T cells elicited by cytomegalovirus-based vaccines might, for certain infections and cancers, be more effective than CD8+ T cells restricted by classical MHC class I or class II molecules. The ability of MHC-E to regulate or mediate both innate and adaptive immune responses independently of the MHC haplotype of an individual raises the possibility of new, universally effective vaccines and immunotherapies for infectious disease and cancer. Although the therapeutic exploitation of MHC-E is still in its infancy, recent advances in the understanding of MHC-E biology show enormous potential, as described in this Review.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"32 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144930867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

B cell trailblazers connect EBV to MS B细胞开拓者将EBV与MS联系起来

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-09-01 DOI: 10.1038/s41577-025-01224-8

Lucy Bird

引用次数: 0

Regulatory KIR+CD8+ T cells in pregnancy 妊娠期KIR+CD8+ T细胞的调节性

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-09-01 DOI: 10.1038/s41577-025-01225-7

Yvonne Bordon

引用次数: 0

Clock genes keep intestinal ILC3s ticking 时钟基因保持肠道ILC3s的运转

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-08-29 DOI: 10.1038/s41577-025-01220-y

Kirsty Minton

引用次数: 0

Linking tumour angiogenesis and tumour immunity 联系肿瘤血管生成和肿瘤免疫

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-08-14 DOI: 10.1038/s41577-025-01211-z

Ashraf Ul Kabir, Madhav Subramanian, Yoojung Kwon, Kyunghee Choi

{"title":"Linking tumour angiogenesis and tumour immunity","authors":"Ashraf Ul Kabir, Madhav Subramanian, Yoojung Kwon, Kyunghee Choi","doi":"10.1038/s41577-025-01211-z","DOIUrl":"https://doi.org/10.1038/s41577-025-01211-z","url":null,"abstract":"Immune checkpoint blockade therapy has revolutionized the treatment of metastatic and solid tumours, achieving durable responses in a subset of patients. However, most patients do not respond to immune checkpoint blockade, underscoring the critical need to better understand the determinants of therapeutic efficacy. A key obstacle to effective antitumour immune responses is the abnormal structure and function of tumour-associated blood vessels, which impede immune cell infiltration and contribute to the development of an immunosuppressive tumour microenvironment. Current research highlights the inverse correlation between angiogenesis and immune activity within the tumour microenvironment. In this Review, we discuss tumour angiogenesis in the context of tumour immunity, examining how this affects tumour progression and immunotherapy outcomes. We examine the molecular mechanisms underlying the crosstalk between angiogenesis and tumour immunity and discuss emerging anti-angiogenic regulators that hold potential for combination therapies. By integrating insights from preclinical and clinical studies, we outline future research directions to address current challenges and optimize cancer treatment strategies through combined anti-angiogenic and immunotherapeutic approaches.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"16 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144840128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0