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Publisher Correction: Immune surveillance and immune evasion of senescent cells. 出版者更正：衰老细胞的免疫监视和免疫逃避。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-09-17 DOI: 10.1038/s41577-026-01360-9
Pau Garcia-Baucells, Manuel Serrano, Corina Amor
{"title":"Publisher Correction: Immune surveillance and immune evasion of senescent cells.","authors":"Pau Garcia-Baucells, Manuel Serrano, Corina Amor","doi":"10.1038/s41577-026-01360-9","DOIUrl":"https://doi.org/10.1038/s41577-026-01360-9","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148990793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization. 免疫原性细胞死亡和三级淋巴组织：桥接肿瘤细胞死亡和免疫组织。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-09-16 DOI: 10.1038/s41577-026-01356-5
Rafal Hanc, Robin Demuynck, Dmitri V Krysko
{"title":"Immunogenic cell death and tertiary lymphoid structures: bridging tumour cell death and immune organization.","authors":"Rafal Hanc, Robin Demuynck, Dmitri V Krysko","doi":"10.1038/s41577-026-01356-5","DOIUrl":"https://doi.org/10.1038/s41577-026-01356-5","url":null,"abstract":"<p><p>Recent studies suggest that the formation of tertiary lymphoid structures (TLSs) could be associated with better survival from certain cancers. In this Perspective, we propose that immunogenic cell death (ICD) can act as an upstream organizer of tumour-associated TLSs by coordinating vascular, stromal and immune reprogramming in the tumour microenvironment. ICD leads to the release of tumour antigens and damage-associated molecular patterns that activate innate pathways, such as cGAS-STING signalling, in dendritic cells, myeloid cells, endothelial cells and stromal fibroblasts. These activated cells release type I interferons, TNF and chemokines, such as CCL19, CCL21 and CXCL13, that promote endothelial cell activation and the differentiation of high endothelial venule-like structures. This enables the recruitment of naive and memory lymphocytes and the emergence of perivascular T cell-dendritic cell aggregates, which can form the basis of TLSs. Full structural maturation of TLSs, with segregated B cell and T cell zones, follicular dendritic cell networks and germinal centres, appears to require additional lymphotoxin β receptor (LTβR)-dependent stromal reprogramming. Together, this suggests a two-step model in which ICD first seeds inflammatory vascular niches and then, through LTβR-mediated tissue organization, supports the development of functional TLSs.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148983316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential. 白细胞介素-33及其受体：多方面的作用和新兴的治疗潜力。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-09-02 DOI: 10.1038/s41577-026-01345-8
Sebastian Serve, Max Löhning
{"title":"Interleukin-33 and its receptor: multifaceted roles and emerging therapeutic potential.","authors":"Sebastian Serve, Max Löhning","doi":"10.1038/s41577-026-01345-8","DOIUrl":"10.1038/s41577-026-01345-8","url":null,"abstract":"<p><p>Interleukin-33 (IL-33) is an alarmin and cytokine that has potent biological effects in various tissues. It acts on a broad array of immune cell populations and is involved in many processes associated with health and disease. This Review discusses the biology of IL-33 and its receptor, ST2, and the functional relevance of IL-33-ST2 signalling. It focuses particularly on the differential regulation of IL-33 sensitivity in distinct cell types in diverse tissue settings. Furthermore, we describe the effects of IL-33 in various diseases, including viral infections, cancer, graft-versus-host disease, colitis, autoimmunity, chronic obstructive pulmonary disease, asthma and allergy. We also consider the roles of IL-33 in physiological reactions such as fat tissue biology and tissue regeneration. The Review aims to provide a comprehensive understanding of IL-33 signalling, including its potential as a target for developing new treatments, and to suggest future research directions.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148881155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease. 自身免疫性疾病中B细胞耐受性和功能障碍的表观遗传调控。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-27 DOI: 10.1038/s41577-026-01344-9
Shaocun Zhang, Yu Wang, Wanli Liu
{"title":"Epigenetic regulation of B cell tolerance and dysfunction in autoimmune disease.","authors":"Shaocun Zhang, Yu Wang, Wanli Liu","doi":"10.1038/s41577-026-01344-9","DOIUrl":"https://doi.org/10.1038/s41577-026-01344-9","url":null,"abstract":"<p><p>Epigenetic regulation orchestrates B cell development, lineage commitment, subset differentiation and activation, and is equally central to the maintenance of B cell self-tolerance. Disruption of epigenetic homeostasis at successive tolerance checkpoints - from central tolerance in the bone marrow to peripheral tolerance at germinal centre and extrafollicular stages - can lead to the emergence of autoreactive B cells and the production of autoantibodies in systemic autoimmune diseases. In this Review, we describe the molecular mechanisms by which multiple epigenetic layers - encompassing DNA methylation, histone modification, chromatin remodelling, non-coding RNA regulation and RNA modification - collectively regulate normal B cell function and, when dysregulated, contribute to autoimmune pathogenesis. We examine how specific epigenetic axes, including microRNA-PI3K signalling, DNA demethylation-histone deacetylation balance and chromosome-linked innate immune receptor control, underpin tolerance checkpoint failure and B cell dysfunction in autoimmune disease. Finally, we discuss emerging epigenetic-targeted therapeutic strategies and highlight future research directions aimed at modulating disease-relevant B cell programmes in systemic autoimmunity.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-mediated excitotoxicity in brain disorders. 脑疾病免疫介导的兴奋性毒性。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-27 DOI: 10.1038/s41577-026-01348-5
Josef Shin, Christina Francisca Vogelaar, Stefan Bittner, Frauke Zipp
{"title":"Immune-mediated excitotoxicity in brain disorders.","authors":"Josef Shin, Christina Francisca Vogelaar, Stefan Bittner, Frauke Zipp","doi":"10.1038/s41577-026-01348-5","DOIUrl":"https://doi.org/10.1038/s41577-026-01348-5","url":null,"abstract":"<p><p>Balanced activity of neuronal and immune networks is essential for maintaining central nervous system (CNS) function and mental health, whereas disturbances in network dynamics often lead to excitotoxicity and progressive pathology across brain diseases. Emerging evidence indicates that immune-mediated mechanisms can shape excitotoxic injury at least as profoundly as classical glutamatergic transmission. Here, we extend the concept of excitotoxicity beyond glutamate receptor overactivation to include innate and adaptive immune pathways, introducing the framework of immune-mediated excitotoxicity. We focus on three illustrative settings: epilepsy and ischaemic injury, where reiterative feedback between neuronal excitation and neuroimmune activation promotes acute excitotoxic damage; neurodegenerative disorders, in which misfolded protein aggregates act as immune stressors that amplify local inflammation; and multiple sclerosis, characterized by persistent, compartmentalized inflammation that drives chronic excitotoxic cycles. Across these examples, we define three hallmarks - feedback, stressor and chronicity - as organizing principles of this paradigm and describe the dynamic communication between neuronal and immune networks that underlies immune-mediated excitotoxicity. Recognizing these neuroimmune interactions as central to CNS homeostasis and - when perturbed - to disease opens up new avenues for therapeutic intervention targeting immune-mediated excitotoxicity.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148840665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond the quick win: rebuilding the foundations of cancer immunotherapy 除了速胜之外：重建癌症免疫治疗的基础。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-25 DOI: 10.1038/s41577-026-01352-9
Ira Mellman
{"title":"Beyond the quick win: rebuilding the foundations of cancer immunotherapy","authors":"Ira Mellman","doi":"10.1038/s41577-026-01352-9","DOIUrl":"10.1038/s41577-026-01352-9","url":null,"abstract":"Checkpoint inhibitors, CAR T cells and bispecific T cell engagers have demonstrated the transformative potential of cancer immunotherapy. However, progress has slowed as efforts have focused on replicating PD-(L)1 blockade successes, highlighting the need for deeper understanding of human cancer immunity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"726-727"},"PeriodicalIF":47.1,"publicationDate":"2026-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148818961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Can immunology still surprise itself? 免疫学还能给自己惊喜吗？
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-24 DOI: 10.1038/s41577-026-01351-w
Laura K. Mackay
{"title":"Can immunology still surprise itself?","authors":"Laura K. Mackay","doi":"10.1038/s41577-026-01351-w","DOIUrl":"10.1038/s41577-026-01351-w","url":null,"abstract":"The discoveries that have transformed immunology often seem obvious in retrospect. Yet none began as an inevitable destination. They began with observations that did not fit, assumptions that somebody challenged, or questions that nobody yet realized were important. Discovery was the outcome. Surprise was the process.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"716-717"},"PeriodicalIF":47.1,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148813564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Living in the age of inflammation: the reverse hygiene hypothesis 生活在炎症的时代：反向卫生假说。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-19 DOI: 10.1038/s41577-026-01349-4
Luke A. J. O’Neill
{"title":"Living in the age of inflammation: the reverse hygiene hypothesis","authors":"Luke A. J. O’Neill","doi":"10.1038/s41577-026-01349-4","DOIUrl":"10.1038/s41577-026-01349-4","url":null,"abstract":"Inflammation seems to permeate many aspects of our lives, with the incidence of inflammatory diseases on the rise and ageing being blamed on it. Will the next 25 years see better ways to treat or prevent inflammation and allow us to live longer and healthier lives?","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"722-723"},"PeriodicalIF":47.1,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Building clinical translation on squares of discovery 在发现方阵上构建临床翻译。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-19 DOI: 10.1038/s41577-026-01347-6
Adrian Hayday
{"title":"Building clinical translation on squares of discovery","authors":"Adrian Hayday","doi":"10.1038/s41577-026-01347-6","DOIUrl":"10.1038/s41577-026-01347-6","url":null,"abstract":"Why do so many promising immunotherapies fail to reach their potential? Adrian Hayday argues that transformative clinical advances depend on protecting specialized ‘squares of discovery’ in which deep understanding and unexpected insights emerge, while building stronger pathways to biotechnology, pharmaceutical development and patient care.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"718-719"},"PeriodicalIF":47.1,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Why adaptive immunity? 为什么是适应性免疫？
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-18 DOI: 10.1038/s41577-026-01350-x
Caetano Reis e Sousa
{"title":"Why adaptive immunity?","authors":"Caetano Reis e Sousa","doi":"10.1038/s41577-026-01350-x","DOIUrl":"10.1038/s41577-026-01350-x","url":null,"abstract":"Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen recognition evolved and whether its original advantage extended beyond host defence.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"714-715"},"PeriodicalIF":47.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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