联系肿瘤血管生成和肿瘤免疫

IF 60.9 1区 医学 Q1 IMMUNOLOGY
Ashraf Ul Kabir, Madhav Subramanian, Yoojung Kwon, Kyunghee Choi
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引用次数: 0

摘要

免疫检查点阻断疗法彻底改变了转移性肿瘤和实体瘤的治疗,在一部分患者中实现了持久的反应。然而,大多数患者对免疫检查点阻断没有反应,这强调了更好地了解治疗效果决定因素的迫切需要。有效抗肿瘤免疫应答的一个关键障碍是肿瘤相关血管的结构和功能异常,这阻碍了免疫细胞的浸润,并促进了免疫抑制肿瘤微环境的发展。目前的研究强调了肿瘤微环境中血管生成和免疫活性之间的负相关关系。在这篇综述中,我们在肿瘤免疫的背景下讨论肿瘤血管生成,研究它如何影响肿瘤进展和免疫治疗结果。我们研究了血管生成和肿瘤免疫之间串扰的分子机制,并讨论了新出现的抗血管生成调节因子,这些调节因子具有联合治疗的潜力。通过整合临床前和临床研究的见解,我们概述了未来的研究方向,以解决当前的挑战,并通过联合抗血管生成和免疫治疗方法优化癌症治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Linking tumour angiogenesis and tumour immunity

Linking tumour angiogenesis and tumour immunity

Immune checkpoint blockade therapy has revolutionized the treatment of metastatic and solid tumours, achieving durable responses in a subset of patients. However, most patients do not respond to immune checkpoint blockade, underscoring the critical need to better understand the determinants of therapeutic efficacy. A key obstacle to effective antitumour immune responses is the abnormal structure and function of tumour-associated blood vessels, which impede immune cell infiltration and contribute to the development of an immunosuppressive tumour microenvironment. Current research highlights the inverse correlation between angiogenesis and immune activity within the tumour microenvironment. In this Review, we discuss tumour angiogenesis in the context of tumour immunity, examining how this affects tumour progression and immunotherapy outcomes. We examine the molecular mechanisms underlying the crosstalk between angiogenesis and tumour immunity and discuss emerging anti-angiogenic regulators that hold potential for combination therapies. By integrating insights from preclinical and clinical studies, we outline future research directions to address current challenges and optimize cancer treatment strategies through combined anti-angiogenic and immunotherapeutic approaches.

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来源期刊
Nature Reviews Immunology
Nature Reviews Immunology 医学-免疫学
CiteScore
93.40
自引率
0.40%
发文量
131
审稿时长
6-12 weeks
期刊介绍: Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.
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