Nature Reviews Immunology最新文献

Connection and communication between the nervous and immune systems 神经系统和免疫系统之间的联系和交流

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-07-10 DOI: 10.1038/s41577-025-01199-6

Alexander Leunig, Matteo Gianeselli, Scott J. Russo, Filip K. Swirski

{"title":"Connection and communication between the nervous and immune systems","authors":"Alexander Leunig, Matteo Gianeselli, Scott J. Russo, Filip K. Swirski","doi":"10.1038/s41577-025-01199-6","DOIUrl":"https://doi.org/10.1038/s41577-025-01199-6","url":null,"abstract":"<p>Connections between the nervous and immune systems are increasingly recognized as central to brain–body physiology. In this Review, we examine how these systems collaborate to detect and respond to both internal and external stimuli — such as psychological stress, circadian cues, infection, and tissue injury. Rather than operating in isolation, the nervous and immune systems form an integrated network that is more than the sum of its parts. They share a common architecture and vocabulary, enabling bidirectional connection and communication that modulate immune cell characteristics throughout the body. We review immune–nervous interactions within two complementary frameworks: first, a spatial framework that distinguishes communication in the brain, communication within peripheral organs, and communication across distance; and second, a temporal framework that maps nervous system influence across the operational lifespan of the immune system — specifically focusing on how the nervous system impacts immune cell development, distribution, and execution of functions. Finally, we highlight key tools, clinical applications, and questions for future research on how both systems coordinate to respond to somatic and environmental stressors.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"274 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144594069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

BCG plus β-glucan trains neutrophils to beat bladder cancer 卡介苗加β-葡聚糖训练中性粒细胞对抗膀胱癌

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-07-07 DOI: 10.1038/s41577-025-01209-7

Lucy Bird

引用次数: 0

Spatial immunometabolic zonation in tuberculosis granulomas 结核肉芽肿的空间免疫代谢分区

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-07-07 DOI: 10.1038/s41577-025-01210-0

Amitava Sinha, Thomas Weichhart

引用次数: 0

Tumour cells mimic erythroblasts to hijack iron from bone marrow macrophages 肿瘤细胞模仿红母细胞从骨髓巨噬细胞中劫持铁

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-07-01 DOI: 10.1038/s41577-025-01204-y

Mehdi Chaib, James P. Allison

引用次数: 0

Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells 由母体肥胖引起的脂肪肝疾病是由Kupffer细胞的代谢重新布线驱动的

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-30 DOI: 10.1038/s41577-025-01205-x

Yvonne Bordon

引用次数: 0

Tumour-associated vasculature in T cell homing and immunity: opportunities for cancer therapy 肿瘤相关脉管系统在T细胞归巢和免疫：癌症治疗的机会

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-27 DOI: 10.1038/s41577-025-01187-w

Evripidis Lanitis, Melita Irving, George Coukos

{"title":"Tumour-associated vasculature in T cell homing and immunity: opportunities for cancer therapy","authors":"Evripidis Lanitis, Melita Irving, George Coukos","doi":"10.1038/s41577-025-01187-w","DOIUrl":"https://doi.org/10.1038/s41577-025-01187-w","url":null,"abstract":"<p>The formation of new blood vessels — known as angiogenesis — is essential for the growth and spread of solid tumours. It is promoted by the hypoxic conditions that develop in growing tumours and drive the expression of pro-angiogenic growth factors by tumour cells and various stromal cells. However, the tumour-associated vasculature (TAV) generated by angiogenesis is abnormal and is a key barrier to T cell entry into tumours. Moreover, the TAV creates a hostile microenvironment owing to an accumulation of suppressive immune cells, hypoxic and acidic conditions, and high interstitial pressure, which all limit the function and survival of effector T cells. Here, we present the mechanisms of T cell migration into tumours, including via high endothelial venules, and the importance of tertiary lymphoid structures, which function as privileged sites for antigen presentation, activation and co-stimulation of T cells, for mounting effective antitumour immunity. We describe how the tumour vasculature limits antitumour T cell responses and how T cell responses could be improved by therapeutic targeting of the TAV. In particular, the use of combination therapies that aim to normalize tumour blood vessels, favourably reprogramme endogenous immunity, and support T cell trafficking, function and persistence will be key to improving clinical responses.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"245 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144500540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Food allergy: begin at the skin, end at the mast cell? 食物过敏：从皮肤开始，到肥大细胞结束？

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-26 DOI: 10.1038/s41577-025-01185-y

Nicholas W. Lukacs, Simon P. Hogan

引用次数: 0

Insulin neoantigen elicits memory T cell activation in diabetes 胰岛素新抗原在糖尿病中引发记忆T细胞活化

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-25 DOI: 10.1038/s41577-025-01202-0

Boyan K. Tsankov, Dana J. Philpott

引用次数: 0

Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry 肠道微生物群特异性T细胞通过分子模拟诱导神经炎症

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-24 DOI: 10.1038/s41577-025-01201-1

Kirsty Minton

引用次数: 0

Innate immune responses to pathogens at the maternal–fetal interface 母体-胎儿界面对病原体的先天免疫反应

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-06-18 DOI: 10.1038/s41577-025-01191-0

Yael Alippe, Joshua Hatterschide, Carolyn B. Coyne, Michael S. Diamond

引用次数: 0