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Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry 肠道微生物群特异性T细胞通过分子模拟诱导神经炎症
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-24 DOI: 10.1038/s41577-025-01201-1
Kirsty Minton
{"title":"Gut microbiota-specific T cells induce neuroinflammation through molecular mimicry","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01201-1","DOIUrl":"https://doi.org/10.1038/s41577-025-01201-1","url":null,"abstract":"White et al. show that microbiota-specific T cells are licensed by gut inflammation to infiltrate the central nervous system, where cross-reactivity with self-antigens leads to neuropathology.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"48 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144370466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Innate immune responses to pathogens at the maternal–fetal interface 母体-胎儿界面对病原体的先天免疫反应
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-18 DOI: 10.1038/s41577-025-01191-0
Yael Alippe, Joshua Hatterschide, Carolyn B. Coyne, Michael S. Diamond
{"title":"Innate immune responses to pathogens at the maternal–fetal interface","authors":"Yael Alippe, Joshua Hatterschide, Carolyn B. Coyne, Michael S. Diamond","doi":"10.1038/s41577-025-01191-0","DOIUrl":"https://doi.org/10.1038/s41577-025-01191-0","url":null,"abstract":"<p>During pregnancy, the maternal immune system must navigate a balance between fetal tolerance and a response to acquired microbial infections. Cells at the maternal–fetal interface coordinate this response throughout gestational stages in a dynamic manner, integrating endocrine, developmental, inflammatory and metabolic cues. Although many maternal and fetal cell types activate innate immune signalling pathways in response to infections, excessive inflammation can disrupt tolerance, affect placental function and impair fetal development, leading to congenital disease and other pregnancy complications. In this Review, we discuss the mechanisms of pathogen recognition in the maternal and fetal compartments of the placenta and the consequences of these responses to pregnancy outcomes.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"23 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144311690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron and the immune system 铁和免疫系统
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-16 DOI: 10.1038/s41577-025-01193-y
Joe N. Frost, Hal Drakesmith
{"title":"Iron and the immune system","authors":"Joe N. Frost, Hal Drakesmith","doi":"10.1038/s41577-025-01193-y","DOIUrl":"https://doi.org/10.1038/s41577-025-01193-y","url":null,"abstract":"<p>Iron is a cofactor for hundreds of enzymes and biochemical processes that support cellular metabolism across the kingdoms of life. Because of this, the host and pathogen compete for iron as a vital resource. Moreover, research has shown that iron acquisition and iron trafficking have substantial effects on the immune system. This is especially important because iron-related disorders — both deficiency and overload — are common worldwide. In this Review, we describe how immune cells acquire and use iron, which branches of the immune system are most affected by iron and how changes in iron availability can affect infectious diseases, autoinflammatory disorders and antitumour immunity. We also discuss key unanswered questions and potential therapeutic opportunities to manipulate immunity by controlling iron trafficking.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"14 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144304457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design 发现并填补T细胞介导的结核病免疫机制方面的知识空白，为疫苗设计提供信息
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-13 DOI: 10.1038/s41577-025-01192-z
Emma Lefrançais, Denis Hudrisier, Olivier Neyrolles, Samuel M. Behar, Joel D. Ernst
{"title":"Finding and filling the knowledge gaps in mechanisms of T cell-mediated TB immunity to inform vaccine design","authors":"Emma Lefrançais, Denis Hudrisier, Olivier Neyrolles, Samuel M. Behar, Joel D. Ernst","doi":"10.1038/s41577-025-01192-z","DOIUrl":"https://doi.org/10.1038/s41577-025-01192-z","url":null,"abstract":"<p><i>Mycobacterium tuberculosis</i>, the bacterium that causes tuberculosis (TB), results in more human mortality than any other single pathogen, in part because of the lack of an effective vaccine. Although T cells are essential for immunity to TB, the mechanisms that provide protective immunity are poorly understood. In this Review, we describe current gaps in our knowledge about T cell-mediated immune responses to <i>M. tuberculosis</i> and discuss how recent technologies, including multiphoton intravital microscopy, spatial multiomics and high-resolution in vivo analyses of cell–cell interactions, may be used to gain insights that can inform the design of T cell-targeted TB vaccines.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"10 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144278511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Uncovering the hidden landscape of tumour antigens 揭示肿瘤抗原的隐藏图景
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-12 DOI: 10.1038/s41577-025-01198-7
Benjamin R. Schrank, Betty Y. S. Kim
{"title":"Uncovering the hidden landscape of tumour antigens","authors":"Benjamin R. Schrank, Betty Y. S. Kim","doi":"10.1038/s41577-025-01198-7","DOIUrl":"https://doi.org/10.1038/s41577-025-01198-7","url":null,"abstract":"A preprint by Li et al. presents a comprehensive pan-cancer atlas of tumour-specific peptides that markedly expands the known tumour antigen repertoire.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"44 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gut ILC2s remember IL-25
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-12 DOI: 10.1038/s41577-025-01197-8
Brian Y. Soong, Miriam Merad
{"title":"Gut ILC2s remember IL-25","authors":"Brian Y. Soong, Miriam Merad","doi":"10.1038/s41577-025-01197-8","DOIUrl":"https://doi.org/10.1038/s41577-025-01197-8","url":null,"abstract":"A preprint by Cortez et al. explores how IL-25 produced in response to helminth infection in mice rewires intestinal ILC2s to retain a 'memory' of prior infection.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"5 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A role for microglia in mediating the microbiota–gut–brain axis 小胶质细胞在调节微生物-肠-脑轴中的作用
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-12 DOI: 10.1038/s41577-025-01188-9
Lily Keane, Gerard Clarke, John F. Cryan
{"title":"A role for microglia in mediating the microbiota–gut–brain axis","authors":"Lily Keane, Gerard Clarke, John F. Cryan","doi":"10.1038/s41577-025-01188-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01188-9","url":null,"abstract":"<p>Microglia, the resident immune cells of the brain, are now recognized as being active participants in the onset and progression of many neurological and neuropsychiatric disorders. As a result, substantial effort has been made in finding ways to target, deplete or modulate the aberrant phenotypes of the microglia that are present in these different disease states, albeit with varied levels of success. The gut microbiota has recently emerged as a master regulator of microglia throughout the lifespan; here, we propose that this microbiota–microglia cross-talk may have major implications for our understanding of neurological disorders and neuropsychiatric diseases. We focus on the latest advances in understanding gut–microglia communication in the context of microglial heterogeneity and microglia-related functions, as well as considering the evidence for effects of these pathways on diseases and disorders of the central nervous system. We also address the challenges, opportunities and clinical implications of this emerging area of research.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"47 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144268611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The spatial and temporal activation of macrophages during fibrosis 巨噬细胞在纤维化过程中的时空活化
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-04 DOI: 10.1038/s41577-025-01186-x
Jacques Behmoaras, Kevin Mulder, Florent Ginhoux, Enrico Petretto
{"title":"The spatial and temporal activation of macrophages during fibrosis","authors":"Jacques Behmoaras, Kevin Mulder, Florent Ginhoux, Enrico Petretto","doi":"10.1038/s41577-025-01186-x","DOIUrl":"https://doi.org/10.1038/s41577-025-01186-x","url":null,"abstract":"<p>Macrophages are active participants of tissue repair and when normal repair processes fail, fibrosis can ensue, which leads to major organ dysfunction and affects nearly a billion people worldwide. Here we focus on macrophages in the spatiotemporal control of fibrosis, drawing on our understanding of the roles of these cells in organogenesis, adult organ homeostasis and wound repair. We describe recent insights from single-cell transcriptomics studies of human and mouse tissues that reveal macrophage heterogeneity in healthy and fibrotic niches, as well as the pathways underlying macrophage–fibroblast cooperation during progression from inflammation to fibrosis. Finally, we propose a model to explain how macrophage activity over time and across different tissues controls tissue fibrosis, we discuss therapeutic initiatives based on regulation of macrophage activity and we recommend future research directions.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"9 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144211032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fetal Treg cell reprogramming links maternal immunity to neurodevelopment 胎儿Treg细胞重编程将母体免疫与神经发育联系起来
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-06-02 DOI: 10.1038/s41577-025-01194-x
Mahdieh Golzari-Sorkheh, Juan Carlos Zúñiga-Pflücker
{"title":"Fetal Treg cell reprogramming links maternal immunity to neurodevelopment","authors":"Mahdieh Golzari-Sorkheh, Juan Carlos Zúñiga-Pflücker","doi":"10.1038/s41577-025-01194-x","DOIUrl":"https://doi.org/10.1038/s41577-025-01194-x","url":null,"abstract":"A preprint by Ellul et al. reports that maternal immune activation of mice imprints regulatory T cell dysfunction in offsping that drives autism-like behaviours.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"50 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144192929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Granzyme B from maternal NK cells perturbs fetal brain development 来自母体NK细胞的颗粒酶B干扰胎儿大脑发育
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-05-30 DOI: 10.1038/s41577-025-01196-9
Lucy Bird
{"title":"Granzyme B from maternal NK cells perturbs fetal brain development","authors":"Lucy Bird","doi":"10.1038/s41577-025-01196-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01196-9","url":null,"abstract":"A study describes how maternal immune activation can lead to neurodevelopmental deficits in offspring, through a mechanism involving granzyme B release by decidual natural killer cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"68 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144176660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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