Nature Reviews Immunology最新文献_第10页

Reduced duration of natural protection in the Omicron era 减少了欧米克龙时代的自然保护时间

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01145-6

Alexandra Flemming

引用次数: 0

IL-27 boosts cytotoxic T cells in cancer IL-27促进癌细胞中的细胞毒性T细胞

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01147-4

Alexandra Flemming

引用次数: 0

Immune-mediated strategies to solving the HIV reservoir problem 解决HIV病毒库问题的免疫介导策略

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-02-13 DOI: 10.1038/s41577-025-01136-7

Deanna A. Kulpa, Mirko Paiardini, Guido Silvestri

{"title":"Immune-mediated strategies to solving the HIV reservoir problem","authors":"Deanna A. Kulpa, Mirko Paiardini, Guido Silvestri","doi":"10.1038/s41577-025-01136-7","DOIUrl":"10.1038/s41577-025-01136-7","url":null,"abstract":"Antiretroviral therapy (ART) has markedly improved the life-expectancy of people living with HIV. However, during both HIV infection of humans and simian immunodeficiency virus infection of macaques, virus replication almost invariably rebounds upon ART interruption, due to the long-term persistency of a pool of latently infected cells harbouring integrated, replication-competent virus (known as the virus reservoir). Solving this ‘HIV reservoir problem’ is the key to achieving a cure (or at least a persistent remission) for HIV infection. Here, we summarize the key scientific evidence supporting the hypothesis that host immune responses, including those mediated by CD8+ T cells, B cells, antibodies and innate immune cells, affect the size, clonality, and cellular, tissue and organ distribution of the HIV reservoir. Importantly, we believe that any solution to the ‘reservoir problem’ must address not only the multifaceted interactions between HIV and the host immune system, but also the complex interplay between the immunobiology of memory CD4+ T helper cells (which form the main virus reservoir) and the molecular mechanisms that regulate HIV latency and reactivation. These concepts provide the rationale to develop new, immune-based approaches to ‘cure’ HIV infection; we review recent efforts to develop such therapies and their efficacy (or lack thereof) in disrupting the establishment and/or persistence of the virus reservoir in preclinical animal models and human clinical trials. HIV infection persists under antiretroviral therapy due to a reservoir of latently infected cells. This Perspective discusses how host immune responses might affect the establishment and persistence of the viral reservoir, an understanding of which supports the development of immune-based approaches to ‘cure’ HIV infection by disrupting the reservoir.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 7","pages":"542-553"},"PeriodicalIF":60.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HDAC9 association with heart disease linked to NLRP3 inflammasome activation HDAC9与NLRP3炎性体激活相关的心脏病

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-02-12 DOI: 10.1038/s41577-025-01144-7

Yvonne Bordon

引用次数: 0

Faulty mitochondria jump between tumours and T cells 有缺陷的线粒体在肿瘤和T细胞之间跳跃

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-02-07 DOI: 10.1038/s41577-025-01143-8

Lucy Bird

引用次数: 0

B cells in non-lymphoid tissues 非淋巴组织中的B细胞

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-02-05 DOI: 10.1038/s41577-025-01137-6

Abrar Samiea, George Celis, Rashi Yadav, Lauren B. Rodda, Joshua M. Moreau

引用次数: 0

Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors 在非典型趋化因子受体的系统命名中包含ACKR5

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-02-03 DOI: 10.1038/s41577-025-01135-8

Martyna Szpakowska, Daniel F. Legler, Stefan Offermanns, Silvano Sozzani, Antal Rot, Marcus Thelen, Andy Chevigné

引用次数: 0

Podoplanin mediates stromal–immune crosstalk in the lymph node Podoplanin介导淋巴结间质免疫串扰

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01140-x

Erika E. McCartney, Matthew B. Buechler

引用次数: 0

Immune control of brain physiology 脑生理学的免疫控制

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01129-6

Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa, Aleksandra Deczkowska

{"title":"Immune control of brain physiology","authors":"Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa, Aleksandra Deczkowska","doi":"10.1038/s41577-025-01129-6","DOIUrl":"10.1038/s41577-025-01129-6","url":null,"abstract":"The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain borders, circumventricular organs and peripheral nerves. These immune–brain communication pathways were classically considered to be dormant under physiological conditions and active only in cases of infection or damage. Yet, peripheral immune cells and signals are key in brain development, function and maintenance. In this Perspective, we propose an alternative framework for understanding the mechanisms of immune–brain communication. During brain development and in homeostasis, these anatomical structures allow selected elements of the peripheral immune system to affect the brain directly or indirectly, within physiological limits. By contrast, in ageing and pathological settings, detrimental peripheral immune signals hijack the existing communication routes or alter their structure. We discuss why a diversity of communication channels is needed and how they work in relation to one another to maintain homeostasis of the brain. The peripheral immune system communicates with the brain through diverse anatomical routes to shape brain physiology. Here we discuss why such diversity is needed and explore how these routes are leveraged during development and hijacked in ageing.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 7","pages":"515-527"},"PeriodicalIF":60.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trained immunity in chronic inflammatory diseases and cancer 慢性炎症性疾病和癌症的训练免疫

IF 60.9 1区医学

Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01132-x

George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis

{"title":"Trained immunity in chronic inflammatory diseases and cancer","authors":"George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis","doi":"10.1038/s41577-025-01132-x","DOIUrl":"10.1038/s41577-025-01132-x","url":null,"abstract":"A decade after the term ‘trained immunity’ (TRIM) was coined to reflect the long-lasting hyper-responsiveness of innate immune cells with an epigenetically imprinted ‘memory’ of earlier stimuli, our understanding has broadened to include the potential implications of TRIM in health and disease. Here, after summarizing the well-documented beneficial effects of TRIM against infections, we discuss emerging evidence that TRIM is also a major underlying mechanism in chronic inflammation-related disorders such as periodontitis, rheumatoid arthritis and cardiovascular disease. Furthermore, mounting evidence indicates that the induction of TRIM by certain agonists confers protective antitumour responses. Although the mechanisms underlying TRIM require further study, the current knowledge enables the experimental development of innovative therapeutic approaches to stimulate or inhibit TRIM in a context-appropriate manner, such as the stimulation of TRIM in cancer or its inhibition in inflammatory disorders. Besides its beneficial effects against infection, trained immunity has recently been implicated in inflammation-related disorders and is being exploited in cancer immunotherapy. These advances may enable the development of therapeutic interventions to modulate trained immunity towards promoting human health.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 7","pages":"497-514"},"PeriodicalIF":60.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0