Nature Reviews Immunology最新文献_第10页

Author Correction: Using BCG vaccination to protect against COVID-19: when reality fails to meet expectation 作者更正：使用卡介苗预防 COVID-19：当现实与期望不符时。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-13 DOI: 10.1038/s41577-024-01023-7

Laure F. Pittet, Christie C. A. Noble, Nicole L. Messina, Nigel Curtis

引用次数: 0

Breaking tolerance: the autoimmune aspect of atherosclerosis 打破耐受：动脉粥样硬化的自身免疫方面。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-12 DOI: 10.1038/s41577-024-01010-y

Amir Khan, Payel Roy, Klaus Ley

{"title":"Breaking tolerance: the autoimmune aspect of atherosclerosis","authors":"Amir Khan, Payel Roy, Klaus Ley","doi":"10.1038/s41577-024-01010-y","DOIUrl":"10.1038/s41577-024-01010-y","url":null,"abstract":"Atherosclerotic cardiovascular disease (ASCVD) is a chronic inflammatory disease of the arterial walls and is characterized by the accumulation of lipoproteins that are insufficiently cleared by phagocytes. Following the initiation of atherosclerosis, the pathological progression is accelerated by engagement of the adaptive immune system. Atherosclerosis triggers the breakdown of tolerance to self-components. This loss of tolerance is reflected in defective expression of immune checkpoint molecules, dysfunctional antigen presentation, and aberrations in T cell populations — most notably in regulatory T (Treg) cells — and in the production of autoantibodies. The breakdown of tolerance to self-proteins that is observed in ASCVD may be linked to the conversion of Treg cells to ‘exTreg’ cells because many Treg cells in ASCVD express T cell receptors that are specific for self-epitopes. Alternatively, or in addition, breakdown of tolerance may trigger the activation of naive T cells, resulting in the clonal expansion of T cell populations with pro-inflammatory and cytotoxic effector phenotypes. In this Perspective, we review the evidence that atherosclerosis is associated with a breakdown of tolerance to self-antigens, discuss possible immunological mechanisms and identify knowledge gaps to map out future research. Rational approaches aimed at re-establishing immune tolerance may become game changers in treating ASCVD and in preventing its downstream sequelae, which include heart attacks and strokes. In this Perspective article, Ley and colleagues explain the association between atherosclerosis and the loss of tolerance to self-proteins. They discuss why re-establishing immune tolerance could improve outcomes for patients with atherosclerotic cardiovascular disease.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":null,"pages":null},"PeriodicalIF":67.7,"publicationDate":"2024-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140110746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulation of innate-like activities of neonatal CD8+ T cells 新生儿 CD8+ T 细胞先天样活动的调控。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-11 DOI: 10.1038/s41577-024-01020-w

Alexandra Flemming

引用次数: 0

Made to order: emergency myelopoiesis and demand-adapted innate immune cell production 按需定制：紧急骨髓造血和适应需求的先天性免疫细胞生成

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-11 DOI: 10.1038/s41577-024-00998-7

James W. Swann, Oakley C. Olson, Emmanuelle Passegué

{"title":"Made to order: emergency myelopoiesis and demand-adapted innate immune cell production","authors":"James W. Swann, Oakley C. Olson, Emmanuelle Passegué","doi":"10.1038/s41577-024-00998-7","DOIUrl":"10.1038/s41577-024-00998-7","url":null,"abstract":"Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly regulated to maintain a stable output of blood cells in health, the haematopoietic system is capable of extensive remodelling in response to external challenges, prioritizing the production of certain cell types at the expense of others. In this Review, we consider how acute insults, such as infections and cytotoxic drug-induced myeloablation, cause molecular, cellular and metabolic changes in haematopoietic stem and progenitor cells at multiple levels of the haematopoietic hierarchy to drive accelerated production of the mature myeloid cells needed to resolve the initiating insult. Moreover, we discuss how dysregulation or subversion of these emergency myelopoiesis mechanisms contributes to the progression of chronic inflammatory diseases and cancer. Acute infection and other insults cause extensive remodelling in the bone marrow to drive the production of new blood cells, often prioritizing the production of mature myeloid cells at the expense of other blood cell types. Here, the authors describe how haematopoiesis is affected by acute demand and how this can contribute to inflammatory disease and cancer when dysregulated.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":null,"pages":null},"PeriodicalIF":67.7,"publicationDate":"2024-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140096958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CARD8 kills CD4+ T cells in response to HIV entry CARD8 能杀死进入人体的 CD4+ T 细胞。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-11 DOI: 10.1038/s41577-024-01021-9

Alexandra Flemming

引用次数: 0

The eye provides an immunological gateway to the brain 眼睛是通往大脑的免疫通道。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-11 DOI: 10.1038/s41577-024-01019-3

Alexandra Flemming

引用次数: 0

A Treg cell duo for VAT control 用于控制增值性血管炎的 Treg 细胞二重奏。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-08 DOI: 10.1038/s41577-024-01018-4

Maria Papatriantafyllou

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Lymph node resection does not impair cancer immunotherapy responses 淋巴结切除术不会损害癌症免疫疗法反应。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-06 DOI: 10.1038/s41577-024-01013-9

Lucas Baldran-Groves, Jeroen Melief

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Author Correction: Clonal haematopoiesis-associated, age-related motor deficits caused by monocyte-derived microglia 作者更正：单核细胞衍生的小胶质细胞导致的克隆性血液病相关的、与年龄有关的运动障碍。

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-06 DOI: 10.1038/s41577-024-01017-5

Austeja Baleviciute, Lily Keane

引用次数: 0

Pre-existing antibody allows for maturation of new B cells in ‘recall’ germinal centres 预先存在的抗体允许新的 B 细胞在 "召回 "生殖中心成熟

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-03-01 DOI: 10.1038/s41577-024-01012-w

Jake Herb, Maria Curotto de Lafaille

引用次数: 0