Nature Reviews Immunology最新文献_第9页

Author Correction: Inflammasome components as new therapeutic targets in inflammatory disease 作者更正：炎性体成分是炎症性疾病的新治疗靶点

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-12-05 DOI: 10.1038/s41577-024-01123-4

Rebecca C. Coll, Kate Schroder

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Publisher Correction: Inflammasome components as new therapeutic targets in inflammatory disease 炎性体成分作为炎症性疾病的新治疗靶点

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-12-05 DOI: 10.1038/s41577-024-01122-5

Rebecca C. Coll, Kate Schroder

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Guardians of immune privilege 免疫特权的守护者

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-12-03 DOI: 10.1038/s41577-024-01121-6

Yvonne Bordon

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Sialylated IgG restrains lung inflammation 唾液化IgG抑制肺部炎症

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Nature Reviews Immunology Pub Date : 2024-11-29 DOI: 10.1038/s41577-024-01120-7

Lucy Bird

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Mitochondria in monocyte-derived cells promote tissue damage in multiple sclerosis 单核细胞衍生细胞中的线粒体促进了多发性硬化症的组织损伤

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-11-26 DOI: 10.1038/s41577-024-01116-3

Zi Yan Chen, Arthur Mortha

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Redefining PD1 as a guardian of stem-like T cells 将 PD1 重新定义为干样 T 细胞的守护者

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Nature Reviews Immunology Pub Date : 2024-11-25 DOI: 10.1038/s41577-024-01117-2

Matthew Jackson, Eileen E. Parkes

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Integrating natural commensals and pathogens into preclinical mouse models 将天然共生菌和病原体纳入临床前小鼠模型

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-11-19 DOI: 10.1038/s41577-024-01108-3

Barbara Rehermann, Andrea L. Graham, David Masopust, Sara E. Hamilton

{"title":"Integrating natural commensals and pathogens into preclinical mouse models","authors":"Barbara Rehermann, Andrea L. Graham, David Masopust, Sara E. Hamilton","doi":"10.1038/s41577-024-01108-3","DOIUrl":"10.1038/s41577-024-01108-3","url":null,"abstract":"Fundamental discoveries in many aspects of mammalian physiology have been made using laboratory mice as research models. These studies have been facilitated by the genetic tractability and inbreeding of such mice, the large set of immunological reagents that are available, and the establishment of environmentally controlled, high-throughput facilities. Such facilities typically include barriers to keep the mouse colonies free of pathogens and the frequent re-derivation of the mice severely limits their commensal flora. Because humans have co-evolved with microorganisms and are exposed to a variety of pathogens, a growing community of researchers posits that preclinical disease research can be improved by studying mice in the context of the microbiota and pathogens that they would encounter in the natural world. Here, we provide a perspective of how these different approaches can be combined and integrated to improve existing mouse models to enhance our understanding of disease mechanisms and develop new therapies for humans. We also propose that the term ‘mice with natural microbiota’ is more appropriate for describing these models than existing terms such as ‘dirty mice’. There is emerging evidence that mice with a history of microbial exposures can better model the human immune system than laboratory mice maintained in pathogen-free conditions. In this Perspective, Rehermann and colleagues summarize different approaches that have been used to incorporate microbiota and pathogen exposures into laboratory mouse models. They suggest that the term ‘mice with natural microbiota’ should be used instead of ‘dirty mice’ to describe these systems in the future.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":"1-13"},"PeriodicalIF":67.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142670686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Innate lymphoid cell control of neuronal synapse development 先天性淋巴细胞控制神经元突触的发育

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-11-19 DOI: 10.1038/s41577-024-01113-6

Katherine Whalley

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Viral infection and antiviral immunity in the oral cavity 口腔中的病毒感染和抗病毒免疫力

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-11-12 DOI: 10.1038/s41577-024-01100-x

Heather D. Hickman, Niki M. Moutsopoulos

{"title":"Viral infection and antiviral immunity in the oral cavity","authors":"Heather D. Hickman, Niki M. Moutsopoulos","doi":"10.1038/s41577-024-01100-x","DOIUrl":"10.1038/s41577-024-01100-x","url":null,"abstract":"Individual tissues have distinct antiviral properties garnered through various mechanisms, including physical characteristics, tissue-resident immune cells and commensal organisms. Although the oral mucosa has long been appreciated as a critical barrier tissue that is exposed to a continuous barrage of pathogens, many fundamental aspects of the antiviral immune response in this tissue remain unknown. Several viral pathogens, such as herpesviruses and human papillomaviruses, have been acknowledged both historically and at present for infections in the oral cavity that result in substantial clinical burden. However, recent viral outbreaks, including those with SARS-CoV-2 and mpox, featured oral symptoms even though these viruses are not generally considered oral pathogens. Ensuing studies have shown that the oral cavity is an important locale for viral infection and potential transmission of newly emergent or re-emergent pathogens, highlighting the need for an increased understanding of the mechanisms of antiviral immunity at this site. In this Review, we provide a broad overview of antiviral immune responses in the oral cavity and discuss common viral infections and their manifestations in the oral mucosa. In addition, we present current mouse models for the study of oral viral infections. The oral mucosa is a critical barrier tissue that is continually exposed to pathogens, but antiviral immune responses in this tissue are poorly understood. Moreover, recent viral outbreaks, including SARS-CoV-2 and mpox, feature oral symptoms. This Review discusses antiviral immunity in the oral cavity and presents current mouse models for the study of oral viral infections.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"235-249"},"PeriodicalIF":67.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599167","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Charge-based immunoreceptor signalling in health and disease 健康和疾病中基于电荷的免疫受体信号传递

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2024-11-11 DOI: 10.1038/s41577-024-01105-6

Xiaoshan Shi, Xing He, Chenqi Xu

{"title":"Charge-based immunoreceptor signalling in health and disease","authors":"Xiaoshan Shi, Xing He, Chenqi Xu","doi":"10.1038/s41577-024-01105-6","DOIUrl":"10.1038/s41577-024-01105-6","url":null,"abstract":"Immunoreceptors have crucial roles in sensing environmental signals and initiating immune responses to protect the host. Dysregulation of immunoreceptor signalling can therefore lead to a range of diseases, making immunoreceptor-based therapies a promising frontier in biomedicine. A common feature of various immunoreceptors is the basic-residue-rich sequence (BRS), which is a largely unexplored aspect of immunoreceptor signalling. The BRS is typically located in the cytoplasmic juxtamembrane region of immunoreceptors, where it forms dynamic interactions with neighbouring charged molecules to regulate signalling. Loss or gain of the basic residues in an immunoreceptor BRS has been linked to severe human diseases, such as immunodeficiency and autoimmunity. In this Perspective, we describe the role of BRSs in various immunoreceptors, elucidating their signalling mechanisms and biological functions. Furthermore, we highlight pathogenic mutations in immunoreceptor BRSs and discuss the potential of leveraging BRS signalling in engineered T cell-based therapies. The basic-residue-rich sequence (BRS) is a common motif located in the cytoplasmic tail of most immunoreceptors. This Perspective highlights the mechanisms of BRS signalling, its pathophysiological importance and how to harness BRS signalling to develop next-generation immunotherapy.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"298-311"},"PeriodicalIF":67.7,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142599168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0