减少了欧米克龙时代的自然保护时间

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-02-14 DOI:10.1038/s41577-025-01145-6

Alexandra Flemming

引用次数: 0

摘要

2021年底，SARS-CoV-2的欧米克隆变体的到来标志着COVID-19大流行期间的一个重大转变，因为与早期变体相比，该病毒的刺突蛋白发生了数十种突变。现在，《自然》杂志上的一项流行病学研究表明，它也导致了自然感染对再感染的保护作用的转变：在Omicron之前，感染提供了稳定和持久的保护，而在Omicron时代的感染只提供了短时间的保护。作者得出的结论是，这反映了进化压力从内在传播性向免疫逃逸的转变。此外，这一发现强调了定期更新COVID-19疫苗的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Reduced duration of natural protection in the Omicron era

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.