IL-27促进癌细胞中的细胞毒性T细胞

IF 67.7 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-02-14 DOI:10.1038/s41577-025-01147-4

Alexandra Flemming

引用次数: 0

摘要

肿瘤中的细胞毒性T淋巴细胞（ctl）通常功能失调。bramesart等研究了人类肿瘤细胞因子与CTL的关系，发现il - 27表达与CTL浸润之间存在相关性。在同基因小鼠模型中，用IL-27编码质粒或半衰期增强的IL-27治疗，无论是否有抗pd - l1，都能改善肿瘤排斥反应，且无明显毒性。小鼠CTLs的单细胞RNA测序显示，IL-27诱导细胞毒性基因（如Gzmb）的表达，并下调与衰竭相关的基因（如Tox）。在转移性尿路上皮性膀胱癌或非小细胞肺癌患者中，高IL-27表达与pd - l1靶向治疗的改善相关，并且与人ctl的体外衰竭实验表明，IL-27促进细胞毒性和效应记忆T细胞的分化，同时抑制功能障碍相关标志物。总的来说，IL-27似乎支持CTL适应度和细胞毒性，可能是癌症治疗的一个有吸引力的靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

IL-27 boosts cytotoxic T cells in cancer

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.