发布求助
文献互助 智能选刊 最新文献

Nature Reviews Immunology最新文献

筛选
英文 中文
Why adaptive immunity? 为什么是适应性免疫？
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-18 DOI: 10.1038/s41577-026-01350-x
Caetano Reis e Sousa
{"title":"Why adaptive immunity?","authors":"Caetano Reis e Sousa","doi":"10.1038/s41577-026-01350-x","DOIUrl":"10.1038/s41577-026-01350-x","url":null,"abstract":"Adaptive immunity is indispensable to vertebrates, yet most living organisms defend themselves perfectly well without it. Here, I ask why somatically diversified antigen recognition evolved and whether its original advantage extended beyond host defence.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"714-715"},"PeriodicalIF":47.1,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148795919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune surveillance and immune evasion of senescent cells. 衰老细胞的免疫监视与免疫逃避。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-11 DOI: 10.1038/s41577-026-01335-w
Pau Garcia-Baucells, Manuel Serrano, Corina Amor
{"title":"Immune surveillance and immune evasion of senescent cells.","authors":"Pau Garcia-Baucells, Manuel Serrano, Corina Amor","doi":"10.1038/s41577-026-01335-w","DOIUrl":"10.1038/s41577-026-01335-w","url":null,"abstract":"<p><p>Senescence, which is defined as a state of stable cell cycle arrest, can occur in all tissues of the body. The surveillance and clearance of senescent cells by the immune system is necessary for tissue homeostasis; when this immune surveillance does not occur efficiently, for example, during tumorigenesis and ageing, it has pathological consequences. For example, if the immune clearance of senescent cells is evaded, such as through recruitment of immunosuppressive cells, expression of immune checkpoint molecules by senescent cells or suppression of antigen presentation, senescent cells accumulate and lead to tissue dysfunction. Therefore, therapeutic modulation of the immune surveillance of senescent cells could be effective for the prevention and treatment of age-associated diseases including cancer. In this Review, we discuss our current understanding of the tissue-specific and context-specific processes that influence immune surveillance of senescent cells. We highlight the need for further research examining senescence across additional settings as well as the role of unexplored immune cell populations.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148713323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ferroptosis in T cells: mechanisms, biology and translational opportunities. T细胞中的铁下垂：机制、生物学和转化机会。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-10 DOI: 10.1038/s41577-026-01337-8
Jingshu Song, Qian Wu, Douglas R Green, Fudi Wang, Junxia Min
{"title":"Ferroptosis in T cells: mechanisms, biology and translational opportunities.","authors":"Jingshu Song, Qian Wu, Douglas R Green, Fudi Wang, Junxia Min","doi":"10.1038/s41577-026-01337-8","DOIUrl":"https://doi.org/10.1038/s41577-026-01337-8","url":null,"abstract":"<p><p>Ferroptosis is an iron-dependent form of regulated cell death driven by disrupted iron homeostasis and uncontrolled lipid peroxidation. Various metabolites and enzymes regulate cellular sensitivity to ferroptosis by affecting iron, lipid and redox metabolism. These pathways not only signal ferroptotic cell death but also affect the biology of T cells. The pathways include mechanisms by which iron metabolism regulates T cell activation via transferrin receptor 1-mTOR signalling, mechanisms by which lipid peroxidation drives vulnerability to ferroptosis in tumour-infiltrating CD8<sup>+</sup> T cells, and mechanisms by which redox networks are balanced to maintain T cell survival. Here, we highlight the T cell subset-specific effects of ferroptosis-related pathways and ferroptosis susceptibility, and the implications for immunotherapy. We also discuss the emerging therapeutic strategies, including ferroptosis-resistant adoptive T cell therapy and ferroptosis-inducing approaches, that enhance the efficacy of immune checkpoint blockade for cancer treatment. Finally, we propose a framework for precision T cell-based immunotherapies, positioning ferroptosis as a tunable node linking T cell biology to clinical innovations.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":" ","pages":""},"PeriodicalIF":47.1,"publicationDate":"2026-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148707421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Academic biomedical research is national defence 学术生物医学研究是国防。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-08-06 DOI: 10.1038/s41577-026-01341-y
Miriam Merad
{"title":"Academic biomedical research is national defence","authors":"Miriam Merad","doi":"10.1038/s41577-026-01341-y","DOIUrl":"10.1038/s41577-026-01341-y","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"720-721"},"PeriodicalIF":47.1,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148685384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An ear way to calm the airways 平静呼吸道的好方法。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-30 DOI: 10.1038/s41577-026-01346-7
Yvonne Bordon
{"title":"An ear way to calm the airways","authors":"Yvonne Bordon","doi":"10.1038/s41577-026-01346-7","DOIUrl":"10.1038/s41577-026-01346-7","url":null,"abstract":"Stimulating the auricular branch of the vagus nerve can suppress allergic airway inflammation in mice.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 9","pages":"631-631"},"PeriodicalIF":47.1,"publicationDate":"2026-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148631041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How Big Data and AI are revolutionizing human immunology 大数据和人工智能如何彻底改变人类免疫学。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-23 DOI: 10.1038/s41577-026-01340-z
Sarah A. Teichmann
{"title":"How Big Data and AI are revolutionizing human immunology","authors":"Sarah A. Teichmann","doi":"10.1038/s41577-026-01340-z","DOIUrl":"10.1038/s41577-026-01340-z","url":null,"abstract":"Understanding human biology in health and disease has entered a new era, one defined not just by better tools but by a fundamental shift in how biological knowledge is generated.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 10","pages":"709-710"},"PeriodicalIF":47.1,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148579377","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A lymphatic circuit that sustains antitumour immune surveillance 维持抗肿瘤免疫监视的淋巴回路。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-22 DOI: 10.1038/s41577-026-01342-x
Sandhya Yadav, Dmitriy Zamarin
{"title":"A lymphatic circuit that sustains antitumour immune surveillance","authors":"Sandhya Yadav,&nbsp;Dmitriy Zamarin","doi":"10.1038/s41577-026-01342-x","DOIUrl":"10.1038/s41577-026-01342-x","url":null,"abstract":"A preprint by Delclaux et al. reports that dendritic cells recirculate tumour antigen to the draining lymph nodes to re-engage tumour-egressed T cells and sustain the antitumour response.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 9","pages":"632-632"},"PeriodicalIF":47.1,"publicationDate":"2026-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148552526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Drug holidays restore exhausted T cell responses to PD1 blockade 药物假期恢复疲惫的T细胞对PD1阻断的反应。
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-21 DOI: 10.1038/s41577-026-01343-w
Chih-Wei Chu, Kenneth Hu
{"title":"Drug holidays restore exhausted T cell responses to PD1 blockade","authors":"Chih-Wei Chu,&nbsp;Kenneth Hu","doi":"10.1038/s41577-026-01343-w","DOIUrl":"10.1038/s41577-026-01343-w","url":null,"abstract":"A preprint by Ngiow et al. shows that intermittent PD1 blockade incorporating a ‘drug holiday’ preserves the proliferative and differentiation capacity of progenitor exhausted T cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 9","pages":"633-633"},"PeriodicalIF":47.1,"publicationDate":"2026-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148549742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages are constitutive architects of tissue integrity 巨噬细胞是组织完整性的基本建筑师
IF 47.1 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-17 DOI: 10.1038/s41577-026-01334-x
Miriam Merad
{"title":"Macrophages are constitutive architects of tissue integrity","authors":"Miriam Merad","doi":"10.1038/s41577-026-01334-x","DOIUrl":"10.1038/s41577-026-01334-x","url":null,"abstract":"The lineage distinction between inflammatory, defence-oriented, monocyte-derived macrophages and resident macrophages dedicated to tissue maintenance calls into question the primordial function of macrophages and offers untapped therapeutic targets in these cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"26 9","pages":"629-630"},"PeriodicalIF":47.1,"publicationDate":"2026-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interleukin-18 armours antitumour immune effectors 白细胞介素-18装甲抗肿瘤免疫效应器
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2026-07-16 DOI: 10.1038/s41577-026-01330-1
Akshat Sharma, Gina G. Bishara, Scott H. Olejniczak, Joyce E. Ohm, Renier J. Brentjens, Ajay Gupta
{"title":"Interleukin-18 armours antitumour immune effectors","authors":"Akshat Sharma, Gina G. Bishara, Scott H. Olejniczak, Joyce E. Ohm, Renier J. Brentjens, Ajay Gupta","doi":"10.1038/s41577-026-01330-1","DOIUrl":"https://doi.org/10.1038/s41577-026-01330-1","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"38 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148459645","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
首页 上一页 下一页 尾页
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整，为了账户安全，请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们：info@booksci.cn Book学术提供免费学术资源搜索服务，方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号：604180095
Book学术官方微信
小红书