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New insights into the noncanonical inflammasome point to caspase-4 as a druggable target 对非典型炎性体的新见解指出caspase-4是一种可药物靶标
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01142-9
Elad Elkayam, Francois G. Gervais, Hao Wu, Michael A. Crackower, Judy Lieberman
{"title":"New insights into the noncanonical inflammasome point to caspase-4 as a druggable target","authors":"Elad Elkayam, Francois G. Gervais, Hao Wu, Michael A. Crackower, Judy Lieberman","doi":"10.1038/s41577-025-01142-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01142-9","url":null,"abstract":"<p>Recent studies indicate that the human lipopolysaccharide sensor caspase-4, unlike its mouse homologue caspase-11, is constitutively expressed and activates pro-IL-18 as well as gasdermin D-mediated pyroptosis. Activation of human caspase-4 causes vascular leakage systemically and at the blood–brain barrier in mice and is implicated in the pathogenesis of a range of inflammatory diseases for which there are currently no effective therapies. These results suggest the therapeutic potential of modulating caspase-4 activity, and structural studies indicate that the caspase-4 exosite might be a promising inhibitory target.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"1 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PerturbView: scalable image-based perturbation screens in cells and tissues 摄动视图：细胞和组织中可扩展的基于图像的摄动屏幕
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01153-6
Takamasa Kudo
{"title":"PerturbView: scalable image-based perturbation screens in cells and tissues","authors":"Takamasa Kudo","doi":"10.1038/s41577-025-01153-6","DOIUrl":"10.1038/s41577-025-01153-6","url":null,"abstract":"In this Tools of the Trade article, Takamasa Kudo (in the Aviv Regev&nbsp;lab, in collaboration with Eric Lubeck) describes how PerturbView enables robust visualization of many thousands of genetic perturbations.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"232-232"},"PeriodicalIF":67.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T cell exhaustion: early or late in tumour progression? T细胞衰竭：肿瘤进展的早期还是晚期？
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01158-1
Lorenzo Galluzzi
{"title":"T cell exhaustion: early or late in tumour progression?","authors":"Lorenzo Galluzzi","doi":"10.1038/s41577-025-01158-1","DOIUrl":"10.1038/s41577-025-01158-1","url":null,"abstract":"Chronic antigen exposure underlies the stepwise acquisition of a terminally dysfunctional state by CD8+ T cells, commonly known as exhaustion, which is considered a major cause of failed cancer immunosurveillance. Recent data from models of viral infection show that the precursors of terminally exhausted T cells emerge early during disease course, prior to continuous signalling through the T cell receptor. I speculate that these findings might indicate that, at least in some settings, T cell exhaustion may emerge as a late consequence — rather than an early determinant — of cancer progression. Recent studies in mouse models of viral infection showed that precursors of terminally exhausted T cells emerge early during the course of disease. Here, Galluzzi discusses these findings and what they may mean for our understanding of tumour immunology and responses to immunotherapy with immune checkpoint blockade.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"227-228"},"PeriodicalIF":67.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DOTS: DNA origami tension sensors for studying T cell mechanobiology 用于研究T细胞力学生物学的DNA折纸张力传感器
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01152-7
Sarah Al Abdullatif
{"title":"DOTS: DNA origami tension sensors for studying T cell mechanobiology","authors":"Sarah Al Abdullatif","doi":"10.1038/s41577-025-01152-7","DOIUrl":"10.1038/s41577-025-01152-7","url":null,"abstract":"In this Tools of the Trade article, Sarah Al Abdullatif describes a method to measure — in a physiological context — mechanical forces transmitted between a T cell receptor and its ligand.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"231-231"},"PeriodicalIF":67.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 immune response reduces seizure risk after traumatic brain injury 1型免疫反应降低创伤性脑损伤后癫痫发作的风险
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-03 DOI: 10.1038/s41577-025-01154-5
Jennifer S. Y. Ahn, Jennifer L. Gommerman
{"title":"Type 1 immune response reduces seizure risk after traumatic brain injury","authors":"Jennifer S. Y. Ahn,&nbsp;Jennifer L. Gommerman","doi":"10.1038/s41577-025-01154-5","DOIUrl":"10.1038/s41577-025-01154-5","url":null,"abstract":"A preprint by Mroz et al. reports a role for IFNgamma in protecting against seizures after traumatic brain injury.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"234-234"},"PeriodicalIF":67.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils release inflammation-resolving vesicles 中性粒细胞释放消炎囊泡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-25 DOI: 10.1038/s41577-025-01151-8
Kirsty Minton
{"title":"Neutrophils release inflammation-resolving vesicles","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01151-8","DOIUrl":"10.1038/s41577-025-01151-8","url":null,"abstract":"Hsu et al. report in Cell that the release of complement-inhibiting vesicles by neutrophils as they age is a self-resolving, anti-inflammatory mechanism that supports a return to homeostasis.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"229-229"},"PeriodicalIF":67.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trogocytosis of CARs depends on transmembrane domains car细胞的穴居作用依赖于跨膜结构域
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01146-5
Alexandra Flemming
{"title":"Trogocytosis of CARs depends on transmembrane domains","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01146-5","DOIUrl":"10.1038/s41577-025-01146-5","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meningeal Treg cells keep brain in balance 脑膜Treg细胞使大脑保持平衡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01148-3
Alexandra Flemming
{"title":"Meningeal Treg cells keep brain in balance","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01148-3","DOIUrl":"10.1038/s41577-025-01148-3","url":null,"abstract":"A study in Science Immunology shows that meningeal regulatory T (Treg) cells limit the activation, proliferation and parenchymal infiltration of T cells and NK cells, indicating that Treg cells act as gatekeepers of the brain.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced duration of natural protection in the Omicron era 减少了欧米克龙时代的自然保护时间
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01145-6
Alexandra Flemming
{"title":"Reduced duration of natural protection in the Omicron era","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01145-6","DOIUrl":"10.1038/s41577-025-01145-6","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-27 boosts cytotoxic T cells in cancer IL-27促进癌细胞中的细胞毒性T细胞
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01147-4
Alexandra Flemming
{"title":"IL-27 boosts cytotoxic T cells in cancer","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01147-4","DOIUrl":"10.1038/s41577-025-01147-4","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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