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How to respond when biomedical science and global health is under existential threat 当生物医学科学和全球健康面临生存威胁时，如何应对
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-09 DOI: 10.1038/s41577-025-01166-1
Daniel M. Altmann, Angela L. Rasmussen
{"title":"How to respond when biomedical science and global health is under existential threat","authors":"Daniel M. Altmann, Angela L. Rasmussen","doi":"10.1038/s41577-025-01166-1","DOIUrl":"https://doi.org/10.1038/s41577-025-01166-1","url":null,"abstract":"US spending in biomedicine has driven pre-eminence in academia, Nobel prizes, scientific training discovery, translation and healthcare. The associated USAID spend on global health programmes has worldwide impacts, including on the ongoing HIV eradication timeline. Current policy changes place this continued trajectory into doubt, with ramifications for international research collaborations, global health and pandemic preparedness.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"74 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils make matrix to fortify barrier immunity 中性粒细胞制造基质，增强屏障免疫
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-09 DOI: 10.1038/s41577-025-01170-5
Yvonne Bordon
{"title":"Neutrophils make matrix to fortify barrier immunity","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01170-5","DOIUrl":"https://doi.org/10.1038/s41577-025-01170-5","url":null,"abstract":"Neutrophils not only kill invading microorganisms but also help to prevent their entry into tissues in the first place.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"48 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143805685","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Brief blockade of type I IFN increases CD8+ T cell memory I型IFN的短暂阻断增加了CD8+ T细胞的记忆
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-08 DOI: 10.1038/s41577-025-01171-4
Lucy Bird
{"title":"Brief blockade of type I IFN increases CD8+ T cell memory","authors":"Lucy Bird","doi":"10.1038/s41577-025-01171-4","DOIUrl":"https://doi.org/10.1038/s41577-025-01171-4","url":null,"abstract":"A study shows that transient blockade of type I interferon signalling during T cell priming enhances the generation of stem cell-like memory CD8+ T cells after viral infection and mRNA vaccination.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"1 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Lung-resident memory B cells class-switch to IgE 肺驻留记忆B细胞转换为IgE
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-04 DOI: 10.1038/s41577-025-01169-y
Kirsty Minton
{"title":"Lung-resident memory B cells class-switch to IgE","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01169-y","DOIUrl":"https://doi.org/10.1038/s41577-025-01169-y","url":null,"abstract":"Nelson et al. report that lung-resident IgG1+ memory B cells class-switch to IgE to mediate airway hypersensitivity in asthma.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"3 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143775589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CombiCells allow combinatorial display of cell surface ligands CombiCells允许组合显示细胞表面配体
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-01 DOI: 10.1038/s41577-025-01168-z
Sofia Bustamante Eguiguren
{"title":"CombiCells allow combinatorial display of cell surface ligands","authors":"Sofia Bustamante Eguiguren","doi":"10.1038/s41577-025-01168-z","DOIUrl":"https://doi.org/10.1038/s41577-025-01168-z","url":null,"abstract":"In this Tools of the Trade article, Sofia Bustamante Eguiguren (from the Dushek and van der Merwe labs) describes CombiCells, which can be customized to express any combination and concentration of ligands to study receptor–ligands interactions.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"7 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143744681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulatory T cell and endothelial cell crosstalk 调节性T细胞和内皮细胞串扰
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-04-01 DOI: 10.1038/s41577-025-01149-2
Wenji Piao, Zachariah L. Lee, Gregory Zapas, Long Wu, Christopher M. Jewell, Reza Abdi, Jonathan S. Bromberg
{"title":"Regulatory T cell and endothelial cell crosstalk","authors":"Wenji Piao, Zachariah L. Lee, Gregory Zapas, Long Wu, Christopher M. Jewell, Reza Abdi, Jonathan S. Bromberg","doi":"10.1038/s41577-025-01149-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01149-2","url":null,"abstract":"<p>Regulatory T (T<sub>reg</sub>) cells have a central role in the maintenance of immune surveillance and tolerance. They can migrate from lymphoid organs to blood and then into tissues and egress from tissues into draining lymph nodes. Specialized endothelial cells of blood and lymphatic vessels are the key gatekeepers for these processes. T<sub>reg</sub> cells that transmigrate across single-cell layers of endothelial cells engage in bidirectional crosstalk with these cells and regulate vascular permeability by promoting structural modifications of blood and lymphatic endothelial cells. In turn, blood and lymphatic endothelial cells can modulate T<sub>reg</sub> cell recirculation and residency. Here, we discuss recent insights into the cellular and molecular mechanisms of the crosstalk between T<sub>reg</sub> cells and endothelial cells and explore potential therapeutic strategies to target these interactions in autoimmunity, transplantation and cancer.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"56 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143758181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophages promote nerve growth in both tumours and spinal cord 巨噬细胞促进肿瘤和脊髓的神经生长
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-28 DOI: 10.1038/s41577-025-01164-3
Austeja Baleviciute, Sebastien Talbot
{"title":"Macrophages promote nerve growth in both tumours and spinal cord","authors":"Austeja Baleviciute, Sebastien Talbot","doi":"10.1038/s41577-025-01164-3","DOIUrl":"https://doi.org/10.1038/s41577-025-01164-3","url":null,"abstract":"A preprint by Dolci et al. reports that tumour-associated macrophages secrete SPP1 to drive neurite outgrowth, promoting tumour innervation and spinal cord repair.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"72 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resident tissue macrophages maintain intraocular pressure by regulating extracellular matrix homeostasis 常驻组织巨噬细胞通过调节细胞外基质稳态维持眼压
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-28 DOI: 10.1038/s41577-025-01163-4
Alex Lac, Slava Epelman
{"title":"Resident tissue macrophages maintain intraocular pressure by regulating extracellular matrix homeostasis","authors":"Alex Lac, Slava Epelman","doi":"10.1038/s41577-025-01163-4","DOIUrl":"https://doi.org/10.1038/s41577-025-01163-4","url":null,"abstract":"A preprint by Liu et al. shows that resident tissue macrophages in the conventional outflow tract regulate intraocular pressure in the steady state.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"41 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143723121","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early antiviral type I interferon impairs lung metastasis 早期抗病毒I型干扰素损害肺转移
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-27 DOI: 10.1038/s41577-025-01165-2
Lisha Jeena, Ester Gea-Mallorquí
{"title":"Early antiviral type I interferon impairs lung metastasis","authors":"Lisha Jeena, Ester Gea-Mallorquí","doi":"10.1038/s41577-025-01165-2","DOIUrl":"https://doi.org/10.1038/s41577-025-01165-2","url":null,"abstract":"A preprint by Farias et al. shows that the type I interferon response to respiratory syncytial virus infection reduces lung metastasis of breast cancer in a mouse model.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"118 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143712738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into antibody structure with implications for specificity, variable region restriction and isotype choice 抗体结构的新见解与特异性，可变区限制和同型选择的含义
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-20 DOI: 10.1038/s41577-025-01150-9
Scott A. McConnell, Arturo Casadevall
{"title":"New insights into antibody structure with implications for specificity, variable region restriction and isotype choice","authors":"Scott A. McConnell, Arturo Casadevall","doi":"10.1038/s41577-025-01150-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01150-9","url":null,"abstract":"<p>The mystery surrounding the mechanisms by which antibody diversity is generated was largely settled in the 1970s by the discoveries of variable gene rearrangements and somatic hypermutation. This led to the paradigm that immunoglobulins are composed of two independent domains — variable and constant — that confer specificity and effector functions, respectively. However, since these early discoveries, there have been a series of observations of communication between the variable and constant domains that affects the overall antibody structure, which suggests that immunoglobulins have a more complex, interconnected functionality than previously thought. Another unresolved issue has been the genesis of ‘restricted’ antibody responses, characterized by the use of only a few variable region gene segments, despite the enormous potential combinatorial diversity. In this Perspective, we place recent findings related to immunoglobulin structure and function in the context of these immunologically important, historically unsolved problems to propose a new model for how antibody specificity is achieved without autoreactivity.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"91 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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