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Gasdermin pores on extracellular vesicles spread cell death 细胞外囊泡上的气孔传播细胞死亡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-14 DOI: 10.1038/s41577-025-01133-w
Alexandra Flemming
{"title":"Gasdermin pores on extracellular vesicles spread cell death","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01133-w","DOIUrl":"10.1038/s41577-025-01133-w","url":null,"abstract":"A study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce pyroptotic cell death in bystander cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"75-75"},"PeriodicalIF":67.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity “转录型”解释了先天免疫缺陷的表型变异
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-14 DOI: 10.1038/s41577-025-01134-9
Alexandra Flemming
{"title":"‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01134-9","DOIUrl":"10.1038/s41577-025-01134-9","url":null,"abstract":"A phenomenon called ''autosomal random monoallelic expression'' (aRMAE) may explain phenotypic variability of clinical disease in carriers of mutations that cause inborn errors of immunity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"75-75"},"PeriodicalIF":67.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery 通过多肽- mhc假型逆转录病毒基因传递增强肿瘤特异性T细胞的体内功能
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-08 DOI: 10.1038/s41577-024-01128-z
Hugo Kwong, Persephone Borrow
{"title":"In vivo enhancement of tumour-specific T cells via peptide–MHC-pseudotyped retroviral gene delivery","authors":"Hugo Kwong, Persephone Borrow","doi":"10.1038/s41577-024-01128-z","DOIUrl":"10.1038/s41577-024-01128-z","url":null,"abstract":"A preprint by Xu et al. shows that MHC-pseudotyped retroviruses can reprogramme, activate and expand tumour-specific T cell populations in vivo.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"76-76"},"PeriodicalIF":67.7,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How macrophage heterogeneity affects tuberculosis disease and therapy 巨噬细胞异质性如何影响结核病及其治疗
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-07 DOI: 10.1038/s41577-024-01124-3
David G. Russell, Nelson V. Simwela, Joshua T. Mattila, JoAnne Flynn, Henry C. Mwandumba, Davide Pisu
{"title":"How macrophage heterogeneity affects tuberculosis disease and therapy","authors":"David G. Russell, Nelson V. Simwela, Joshua T. Mattila, JoAnne Flynn, Henry C. Mwandumba, Davide Pisu","doi":"10.1038/s41577-024-01124-3","DOIUrl":"https://doi.org/10.1038/s41577-024-01124-3","url":null,"abstract":"<p>Macrophages are the primary host cell type for infection by <i>Mycobacterium tuberculosis</i> in vivo. Macrophages are also key immune effector cells that mediate the control of bacterial growth. However, the specific macrophage phenotypes that are required for optimal immune control of <i>M. tuberculosis</i> infection in vivo remain poorly defined. There are two distinct macrophage lineages in the lung, comprising embryonically derived, tissue-resident alveolar macrophages and recruited, blood monocyte-derived interstitial macrophages. Recent studies have shown that these lineages respond divergently to similar immune environments within the tuberculosis granuloma. Here, we discuss how the differing responses of macrophage lineages might affect the control or progression of tuberculosis disease. We suggest that the ability to reprogramme macrophage responses appropriately, through immunological or chemotherapeutic routes, could help to optimize vaccines and drug regimens for tuberculosis.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"28 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142934995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of cGAS–STING signalling and its diversity of cellular outcomes cGAS-STING信号的调控及其细胞结局的多样性
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-07 DOI: 10.1038/s41577-024-01112-7
Zhengyin Zhang, Conggang Zhang
{"title":"Regulation of cGAS–STING signalling and its diversity of cellular outcomes","authors":"Zhengyin Zhang, Conggang Zhang","doi":"10.1038/s41577-024-01112-7","DOIUrl":"https://doi.org/10.1038/s41577-024-01112-7","url":null,"abstract":"<p>The cyclic GMP–AMP synthase (cGAS)–stimulator of interferon genes (STING) signalling pathway, which recognizes both pathogen DNA and host-derived DNA, has emerged as a crucial component of the innate immune system, having important roles in antimicrobial defence, inflammatory disease, ageing, autoimmunity and cancer. Recent work suggests that the regulation of cGAS–STING signalling is complex and sophisticated. In this Review, we describe recent insights from structural studies that have helped to elucidate the molecular mechanisms of the cGAS–STING signalling cascade and we discuss how the cGAS–STING pathway is regulated by both activating and inhibitory factors. Furthermore, we summarize the newly emerging understanding of crosstalk between cGAS–STING signalling and other signalling pathways and provide examples to highlight the wide variety of cellular processes in which cGAS–STING signalling is involved, including autophagy, metabolism, ageing, inflammation and tumorigenesis.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"24 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Endogenous thymic regeneration: restoring T cell production following injury 内源性胸腺再生：损伤后恢复T细胞生成
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-06 DOI: 10.1038/s41577-024-01119-0
David Granadier, Dante Acenas, Jarrod A. Dudakov
{"title":"Endogenous thymic regeneration: restoring T cell production following injury","authors":"David Granadier, Dante Acenas, Jarrod A. Dudakov","doi":"10.1038/s41577-024-01119-0","DOIUrl":"https://doi.org/10.1038/s41577-024-01119-0","url":null,"abstract":"<p>Despite its importance for generating and maintaining a healthy and broad T cell repertoire, the thymus is exquisitely sensitive to acute damage. Marked thymic involution occurs in response to stimuli as diverse as infection, stress, pregnancy, malnutrition, drug use and cytoreductive chemotherapy. However, the thymus also has a remarkable capacity for repair, although this regenerative capacity declines with age. Endogenous thymic regeneration is a crucial process that allows for the recovery of immune competence after acute damage and delay to this recovery can have important clinical effects. Until recently, the mechanisms that drive endogenous thymic regeneration were not well understood, but recent work in mice has revealed multiple distinct pathways of regeneration and the molecular mechanisms that trigger these pathways after damage. In this Review, we discuss the effects of different types of damage to the thymus, with a focus on an emerging body of work in mice that provides insight into the cellular and molecular mechanisms that regulate endogenous tissue regeneration in the thymus. We also highlight some of the clinical challenges that are presented by dysregulated thymic regeneration.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"36 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142929718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancer immune evasion, immunoediting and intratumour heterogeneity 癌症免疫逃避、免疫编辑和肿瘤内异质性
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41577-024-01111-8
Malte Roerden, Stefani Spranger
{"title":"Cancer immune evasion, immunoediting and intratumour heterogeneity","authors":"Malte Roerden, Stefani Spranger","doi":"10.1038/s41577-024-01111-8","DOIUrl":"https://doi.org/10.1038/s41577-024-01111-8","url":null,"abstract":"<p>Cancers can avoid immune-mediated elimination by acquiring traits that disrupt antitumour immunity. These mechanisms of immune evasion are selected and reinforced during tumour evolution under immune pressure. Some immunogenic subclones are effectively eliminated by antitumour T cell responses (a process known as immunoediting), which results in a clonally selected tumour. Other cancer cells arise to resist immunoediting, which leads to a tumour that includes several distinct cancer cell populations (referred to as intratumour heterogeneity (ITH)). Tumours with high ITH are associated with poor patient outcomes and a lack of responsiveness to immune checkpoint blockade therapy. In this Review, we discuss the different ways that cancer cells evade the immune system and how these mechanisms impact immunoediting and tumour evolution. We also describe how subclonal antigen presentation in tumours with high ITH can result in immune evasion.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"6 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-22 protects against stress-induced anxiety IL-22可以防止压力引起的焦虑
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-02 DOI: 10.1038/s41577-024-01127-0
Lucy Bird
{"title":"IL-22 protects against stress-induced anxiety","authors":"Lucy Bird","doi":"10.1038/s41577-024-01127-0","DOIUrl":"10.1038/s41577-024-01127-0","url":null,"abstract":"Stress-induced gut leakage and immune activation lead to the release of IL-22, which acts directly on septal neurons in the brain to dampen their activation and protect against anxiety behaviour.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"75-75"},"PeriodicalIF":67.7,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142911456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transposon-derived decoy fine-tunes IFN responses 转座子衍生的诱饵微调IFN响应
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2024-12-19 DOI: 10.1038/s41577-024-01126-1
Yvonne Bordon
{"title":"Transposon-derived decoy fine-tunes IFN responses","authors":"Yvonne Bordon","doi":"10.1038/s41577-024-01126-1","DOIUrl":"10.1038/s41577-024-01126-1","url":null,"abstract":"A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN signalling.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"74-74"},"PeriodicalIF":67.7,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142857808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle spindle macrophages regulate motor coordination 肌肉纺锤体巨噬细胞调节运动协调
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2024-12-16 DOI: 10.1038/s41577-024-01125-2
Kirsty Minton
{"title":"Muscle spindle macrophages regulate motor coordination","authors":"Kirsty Minton","doi":"10.1038/s41577-024-01125-2","DOIUrl":"10.1038/s41577-024-01125-2","url":null,"abstract":"Yan et al. report the identification of a population of muscle spindle macrophages, which regulate the muscle stretch reflex through glutamate production.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"73-73"},"PeriodicalIF":67.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142825555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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