Nature Reviews Immunology最新文献_第5页

New insights into antibody structure with implications for specificity, variable region restriction and isotype choice 抗体结构的新见解与特异性，可变区限制和同型选择的含义

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-03-20 DOI: 10.1038/s41577-025-01150-9

Scott A. McConnell, Arturo Casadevall

{"title":"New insights into antibody structure with implications for specificity, variable region restriction and isotype choice","authors":"Scott A. McConnell, Arturo Casadevall","doi":"10.1038/s41577-025-01150-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01150-9","url":null,"abstract":"The mystery surrounding the mechanisms by which antibody diversity is generated was largely settled in the 1970s by the discoveries of variable gene rearrangements and somatic hypermutation. This led to the paradigm that immunoglobulins are composed of two independent domains — variable and constant — that confer specificity and effector functions, respectively. However, since these early discoveries, there have been a series of observations of communication between the variable and constant domains that affects the overall antibody structure, which suggests that immunoglobulins have a more complex, interconnected functionality than previously thought. Another unresolved issue has been the genesis of ‘restricted’ antibody responses, characterized by the use of only a few variable region gene segments, despite the enormous potential combinatorial diversity. In this Perspective, we place recent findings related to immunoglobulin structure and function in the context of these immunologically important, historically unsolved problems to propose a new model for how antibody specificity is achieved without autoreactivity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"91 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immune regulation by the SUMO family 相扑家族的免疫调节

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41577-025-01155-4

Mohottige D. Neranjan Tharuka, Asimina S. Courelli, Yuan Chen

{"title":"Immune regulation by the SUMO family","authors":"Mohottige D. Neranjan Tharuka, Asimina S. Courelli, Yuan Chen","doi":"10.1038/s41577-025-01155-4","DOIUrl":"https://doi.org/10.1038/s41577-025-01155-4","url":null,"abstract":"Post-translational protein modifications by the small ubiquitin-like modifier (SUMO) family have been shown to regulate immune cells in the context of infection, autoimmunity and, more recently, cancer. Recent clinical trials investigating sumoylation inhibition as a therapeutic approach for cancer have established that sumoylation has important immune modulatory effects. Sumoylation suppresses transcription factors in innate immune cells and in cytotoxic T cells through the direct modification of these factors, which leads to the recruitment of transcriptional repressor complexes containing histone deacetylases. By contrast, in regulatory T cells and T helper 17 cells, sumoylation of transcription factors can enhance transcriptional activity by recruiting transcriptional coactivators. Sumoylation is also involved in the repression of IFNB1 and endogenous retroviruses and is therefore important for regulating interferon expression. A central theme from literature is that the sumoylation of a group of proteins, instead of a single target, collectively contributes to the regulation of various immune processes. In this Review, we consider how these studies provide scientific basis for future exploration of SUMO-mediated immune modulation for the treatment of cancers and autoimmune disorders.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"91 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aspirin helps T cells to stop cancer spread 阿司匹林帮助T细胞阻止癌症扩散

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-17 DOI: 10.1038/s41577-025-01160-7

Yvonne Bordon

引用次数: 0

Defining immune reset: achieving sustained remission in autoimmune diseases 定义免疫重置：实现自身免疫性疾病的持续缓解

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01141-w

Tobias Junt, Thomas Calzascia, Elisabetta Traggiai, André Nogueira da Costa, Peter Gergely, Georg Schett, Thomas Dörner, Richard M. Siegel

{"title":"Defining immune reset: achieving sustained remission in autoimmune diseases","authors":"Tobias Junt, Thomas Calzascia, Elisabetta Traggiai, André Nogueira da Costa, Peter Gergely, Georg Schett, Thomas Dörner, Richard M. Siegel","doi":"10.1038/s41577-025-01141-w","DOIUrl":"https://doi.org/10.1038/s41577-025-01141-w","url":null,"abstract":"Personalized cell therapies for autoimmune diseases — such as autologous haematopoietic stem cell transplantation and chimeric antigen receptor-expressing T cells — have the potential to achieve sustained remission in patients with certain autoimmune diseases. The effective elimination of pathogenic lymphocytes and their subsequent repopulation with naive cells has been termed ‘immune reset’. In this Perspective, we trace the origins of the immune reset concept and its clinical, cellular and molecular definitions, and we review current attempts to identify biomarkers for long-term clinical remission in autoimmune diseases. Emerging data from clinical trials support the concept that higher probabilities of long-term remission can be achieved with therapies that can more deeply and broadly deplete B cells than the anti-CD20 antibody rituximab. A better understanding of the cellular and molecular basis for immune reset and the biomarkers associated with this state should accelerate progress towards the goal of restoring a non-autoimmune state and sustaining remission, while reducing the need for chronic immunosuppression.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"194 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neutrophils are dispensable for Shigella control: macrophages take centre stage 中性粒细胞对于志贺氏菌的控制是必不可少的，巨噬细胞占据中心位置

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01157-2

Didem Ağaç Çobanoğlu, James P. Allison

引用次数: 0

Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells 记忆表型Ly49+CD8+ T细胞的发育轨迹和募集

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01156-3

Guillaume J. Trusz, Verena van der Heide

引用次数: 0

New insights into the noncanonical inflammasome point to caspase-4 as a druggable target 对非典型炎性体的新见解指出caspase-4是一种可药物靶标

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01142-9

Elad Elkayam, Francois G. Gervais, Hao Wu, Michael A. Crackower, Judy Lieberman

引用次数: 0

PerturbView: scalable image-based perturbation screens in cells and tissues 摄动视图：细胞和组织中可扩展的基于图像的摄动屏幕

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01153-6

Takamasa Kudo

引用次数: 0

T cell exhaustion: early or late in tumour progression? T细胞衰竭：肿瘤进展的早期还是晚期？

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01158-1

Lorenzo Galluzzi

引用次数: 0

DOTS: DNA origami tension sensors for studying T cell mechanobiology 用于研究T细胞力学生物学的DNA折纸张力传感器

IF 67.7 1区医学

Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01152-7

Sarah Al Abdullatif

引用次数: 0