Nature Reviews Immunology最新文献_第5页

Neutrophils make matrix to fortify barrier immunity 中性粒细胞制造基质，增强屏障免疫

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Nature Reviews Immunology Pub Date : 2025-04-09 DOI: 10.1038/s41577-025-01170-5

Yvonne Bordon

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Brief blockade of type I IFN increases CD8+ T cell memory I型IFN的短暂阻断增加了CD8+ T细胞的记忆

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Nature Reviews Immunology Pub Date : 2025-04-08 DOI: 10.1038/s41577-025-01171-4

Lucy Bird

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Lung-resident memory B cells class-switch to IgE 肺驻留记忆B细胞转换为IgE

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Nature Reviews Immunology Pub Date : 2025-04-04 DOI: 10.1038/s41577-025-01169-y

Kirsty Minton

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CombiCells allow combinatorial display of cell surface ligands CombiCells允许组合显示细胞表面配体

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Nature Reviews Immunology Pub Date : 2025-04-01 DOI: 10.1038/s41577-025-01168-z

Sofia Bustamante Eguiguren

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Regulatory T cell and endothelial cell crosstalk 调节性T细胞和内皮细胞串扰

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Nature Reviews Immunology Pub Date : 2025-04-01 DOI: 10.1038/s41577-025-01149-2

Wenji Piao, Zachariah L. Lee, Gregory Zapas, Long Wu, Christopher M. Jewell, Reza Abdi, Jonathan S. Bromberg

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Macrophages promote nerve growth in both tumours and spinal cord 巨噬细胞促进肿瘤和脊髓的神经生长

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Nature Reviews Immunology Pub Date : 2025-03-28 DOI: 10.1038/s41577-025-01164-3

Austeja Baleviciute, Sebastien Talbot

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Resident tissue macrophages maintain intraocular pressure by regulating extracellular matrix homeostasis 常驻组织巨噬细胞通过调节细胞外基质稳态维持眼压

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Nature Reviews Immunology Pub Date : 2025-03-28 DOI: 10.1038/s41577-025-01163-4

Alex Lac, Slava Epelman

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Early antiviral type I interferon impairs lung metastasis 早期抗病毒I型干扰素损害肺转移

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Nature Reviews Immunology Pub Date : 2025-03-27 DOI: 10.1038/s41577-025-01165-2

Lisha Jeena, Ester Gea-Mallorquí

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New insights into antibody structure with implications for specificity, variable region restriction and isotype choice 抗体结构的新见解与特异性，可变区限制和同型选择的含义

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Nature Reviews Immunology Pub Date : 2025-03-20 DOI: 10.1038/s41577-025-01150-9

Scott A. McConnell, Arturo Casadevall

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Immune regulation by the SUMO family 相扑家族的免疫调节

IF 100.3 1区医学

Nature Reviews Immunology Pub Date : 2025-03-19 DOI: 10.1038/s41577-025-01155-4

Mohottige D. Neranjan Tharuka, Asimina S. Courelli, Yuan Chen

{"title":"Immune regulation by the SUMO family","authors":"Mohottige D. Neranjan Tharuka, Asimina S. Courelli, Yuan Chen","doi":"10.1038/s41577-025-01155-4","DOIUrl":"https://doi.org/10.1038/s41577-025-01155-4","url":null,"abstract":"Post-translational protein modifications by the small ubiquitin-like modifier (SUMO) family have been shown to regulate immune cells in the context of infection, autoimmunity and, more recently, cancer. Recent clinical trials investigating sumoylation inhibition as a therapeutic approach for cancer have established that sumoylation has important immune modulatory effects. Sumoylation suppresses transcription factors in innate immune cells and in cytotoxic T cells through the direct modification of these factors, which leads to the recruitment of transcriptional repressor complexes containing histone deacetylases. By contrast, in regulatory T cells and T helper 17 cells, sumoylation of transcription factors can enhance transcriptional activity by recruiting transcriptional coactivators. Sumoylation is also involved in the repression of IFNB1 and endogenous retroviruses and is therefore important for regulating interferon expression. A central theme from literature is that the sumoylation of a group of proteins, instead of a single target, collectively contributes to the regulation of various immune processes. In this Review, we consider how these studies provide scientific basis for future exploration of SUMO-mediated immune modulation for the treatment of cancers and autoimmune disorders.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"91 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143653337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0