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Type 1 immune response reduces seizure risk after traumatic brain injury 1型免疫反应降低创伤性脑损伤后癫痫发作的风险
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-03 DOI: 10.1038/s41577-025-01154-5
Jennifer S. Y. Ahn, Jennifer L. Gommerman
{"title":"Type 1 immune response reduces seizure risk after traumatic brain injury","authors":"Jennifer S. Y. Ahn, Jennifer L. Gommerman","doi":"10.1038/s41577-025-01154-5","DOIUrl":"10.1038/s41577-025-01154-5","url":null,"abstract":"A preprint by Mroz et al. reports a role for IFNgamma in protecting against seizures after traumatic brain injury.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"234-234"},"PeriodicalIF":67.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils release inflammation-resolving vesicles 中性粒细胞释放消炎囊泡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-25 DOI: 10.1038/s41577-025-01151-8
Kirsty Minton
{"title":"Neutrophils release inflammation-resolving vesicles","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01151-8","DOIUrl":"10.1038/s41577-025-01151-8","url":null,"abstract":"Hsu et al. report in Cell that the release of complement-inhibiting vesicles by neutrophils as they age is a self-resolving, anti-inflammatory mechanism that supports a return to homeostasis.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"229-229"},"PeriodicalIF":67.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trogocytosis of CARs depends on transmembrane domains car细胞的穴居作用依赖于跨膜结构域
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01146-5
Alexandra Flemming
{"title":"Trogocytosis of CARs depends on transmembrane domains","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01146-5","DOIUrl":"10.1038/s41577-025-01146-5","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Meningeal Treg cells keep brain in balance 脑膜Treg细胞使大脑保持平衡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01148-3
Alexandra Flemming
{"title":"Meningeal Treg cells keep brain in balance","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01148-3","DOIUrl":"10.1038/s41577-025-01148-3","url":null,"abstract":"A study in Science Immunology shows that meningeal regulatory T (Treg) cells limit the activation, proliferation and parenchymal infiltration of T cells and NK cells, indicating that Treg cells act as gatekeepers of the brain.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Reduced duration of natural protection in the Omicron era 减少了欧米克龙时代的自然保护时间
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01145-6
Alexandra Flemming
{"title":"Reduced duration of natural protection in the Omicron era","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01145-6","DOIUrl":"10.1038/s41577-025-01145-6","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IL-27 boosts cytotoxic T cells in cancer IL-27促进癌细胞中的细胞毒性T细胞
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-14 DOI: 10.1038/s41577-025-01147-4
Alexandra Flemming
{"title":"IL-27 boosts cytotoxic T cells in cancer","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01147-4","DOIUrl":"10.1038/s41577-025-01147-4","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"156-156"},"PeriodicalIF":67.7,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143417696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune-mediated strategies to solving the HIV reservoir problem 解决HIV病毒库问题的免疫介导策略
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-13 DOI: 10.1038/s41577-025-01136-7
Deanna A. Kulpa, Mirko Paiardini, Guido Silvestri
{"title":"Immune-mediated strategies to solving the HIV reservoir problem","authors":"Deanna A. Kulpa, Mirko Paiardini, Guido Silvestri","doi":"10.1038/s41577-025-01136-7","DOIUrl":"https://doi.org/10.1038/s41577-025-01136-7","url":null,"abstract":"<p>Antiretroviral therapy (ART) has markedly improved the life-expectancy of people living with HIV. However, during both HIV infection of humans and simian immunodeficiency virus infection of macaques, virus replication almost invariably rebounds upon ART interruption, due to the long-term persistency of a pool of latently infected cells harbouring integrated, replication-competent virus (known as the virus reservoir). Solving this ‘HIV reservoir problem’ is the key to achieving a cure (or at least a persistent remission) for HIV infection. Here, we summarize the key scientific evidence supporting the hypothesis that host immune responses, including those mediated by CD8<sup>+</sup> T cells, B cells, antibodies and innate immune cells, affect the size, clonality, and cellular, tissue and organ distribution of the HIV reservoir. Importantly, we believe that any solution to the ‘reservoir problem’ must address not only the multifaceted interactions between HIV and the host immune system, but also the complex interplay between the immunobiology of memory CD4<sup>+</sup> T helper cells (which form the main virus reservoir) and the molecular mechanisms that regulate HIV latency and reactivation. These concepts provide the rationale to develop new, immune-based approaches to ‘cure’ HIV infection; we review recent efforts to develop such therapies and their efficacy (or lack thereof) in disrupting the establishment and/or persistence of the virus reservoir in preclinical animal models and human clinical trials.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"8 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143401370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
HDAC9 association with heart disease linked to NLRP3 inflammasome activation HDAC9与NLRP3炎性体激活相关的心脏病
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-12 DOI: 10.1038/s41577-025-01144-7
Yvonne Bordon
{"title":"HDAC9 association with heart disease linked to NLRP3 inflammasome activation","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01144-7","DOIUrl":"10.1038/s41577-025-01144-7","url":null,"abstract":"Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus for cardiovascular disease.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"157-157"},"PeriodicalIF":67.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143393011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Faulty mitochondria jump between tumours and T cells 有缺陷的线粒体在肿瘤和T细胞之间跳跃
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-07 DOI: 10.1038/s41577-025-01143-8
Lucy Bird
{"title":"Faulty mitochondria jump between tumours and T cells","authors":"Lucy Bird","doi":"10.1038/s41577-025-01143-8","DOIUrl":"10.1038/s41577-025-01143-8","url":null,"abstract":"To evade elimination by T cells, tumour cells transfer mutant mitochondria to T cells, which reprogrammes their metabolism and compromises their antitumour activity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"155-155"},"PeriodicalIF":67.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143257886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
B cells in non-lymphoid tissues 非淋巴组织中的B细胞
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-05 DOI: 10.1038/s41577-025-01137-6
Abrar Samiea, George Celis, Rashi Yadav, Lauren B. Rodda, Joshua M. Moreau
{"title":"B cells in non-lymphoid tissues","authors":"Abrar Samiea, George Celis, Rashi Yadav, Lauren B. Rodda, Joshua M. Moreau","doi":"10.1038/s41577-025-01137-6","DOIUrl":"https://doi.org/10.1038/s41577-025-01137-6","url":null,"abstract":"<p>B cells have long been understood to be drivers of both humoral and cellular immunity. Recent advances underscore this importance but also indicate that in infection, inflammatory disease and cancer, B cells function directly at sites of inflammation and form tissue-resident memory populations. The spatial organization and cellular niches of tissue B cells have profound effects on their function and on disease outcome, as well as on patient response to therapy. Here we review the role of B cells in peripheral tissues in homeostasis and disease, and discuss the newly identified cellular and molecular signals that are involved in regulating their activity. We integrate emerging data from multi-omic human studies with experimental models to propose a framework for B cell function in tissue inflammation and homeostasis.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"79 2 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143192154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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