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Aspirin helps T cells to stop cancer spread 阿司匹林帮助T细胞阻止癌症扩散
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-17 DOI: 10.1038/s41577-025-01160-7
Yvonne Bordon
{"title":"Aspirin helps T cells to stop cancer spread","authors":"Yvonne Bordon","doi":"10.1038/s41577-025-01160-7","DOIUrl":"10.1038/s41577-025-01160-7","url":null,"abstract":"Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"230-230"},"PeriodicalIF":67.7,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143635108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Defining immune reset: achieving sustained remission in autoimmune diseases 定义免疫重置：实现自身免疫性疾病的持续缓解
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01141-w
Tobias Junt, Thomas Calzascia, Elisabetta Traggiai, André Nogueira da Costa, Peter Gergely, Georg Schett, Thomas Dörner, Richard M. Siegel
{"title":"Defining immune reset: achieving sustained remission in autoimmune diseases","authors":"Tobias Junt, Thomas Calzascia, Elisabetta Traggiai, André Nogueira da Costa, Peter Gergely, Georg Schett, Thomas Dörner, Richard M. Siegel","doi":"10.1038/s41577-025-01141-w","DOIUrl":"https://doi.org/10.1038/s41577-025-01141-w","url":null,"abstract":"<p>Personalized cell therapies for autoimmune diseases — such as autologous haematopoietic stem cell transplantation and chimeric antigen receptor-expressing T cells — have the potential to achieve sustained remission in patients with certain autoimmune diseases. The effective elimination of pathogenic lymphocytes and their subsequent repopulation with naive cells has been termed ‘immune reset’. In this Perspective, we trace the origins of the immune reset concept and its clinical, cellular and molecular definitions, and we review current attempts to identify biomarkers for long-term clinical remission in autoimmune diseases. Emerging data from clinical trials support the concept that higher probabilities of long-term remission can be achieved with therapies that can more deeply and broadly deplete B cells than the anti-CD20 antibody rituximab. A better understanding of the cellular and molecular basis for immune reset and the biomarkers associated with this state should accelerate progress towards the goal of restoring a non-autoimmune state and sustaining remission, while reducing the need for chronic immunosuppression.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"194 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils are dispensable for Shigella control: macrophages take centre stage 中性粒细胞对于志贺氏菌的控制是必不可少的，巨噬细胞占据中心位置
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01157-2
Didem Ağaç Çobanoğlu, James P. Allison
{"title":"Neutrophils are dispensable for Shigella control: macrophages take centre stage","authors":"Didem Ağaç Çobanoğlu,&nbsp;James P. Allison","doi":"10.1038/s41577-025-01157-2","DOIUrl":"10.1038/s41577-025-01157-2","url":null,"abstract":"A preprint by Eislmayr et al. shows that macrophages rather than neutrophils are a key factor in controlling Shigella infection.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"233-233"},"PeriodicalIF":67.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells 记忆表型Ly49+CD8+ T细胞的发育轨迹和募集
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01156-3
Guillaume J. Trusz, Verena van der Heide
{"title":"Mapping the developmental trajectory and recruitment of memory-phenotype Ly49+CD8+ T cells","authors":"Guillaume J. Trusz,&nbsp;Verena van der Heide","doi":"10.1038/s41577-025-01156-3","DOIUrl":"10.1038/s41577-025-01156-3","url":null,"abstract":"A preprint by Laubreton et al. suggests a role for agonist selection and cytokine-driven bystander activation in the differentiation and recruitment of memory-phenotype Ly49+CD8+ T cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"233-233"},"PeriodicalIF":67.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
New insights into the noncanonical inflammasome point to caspase-4 as a druggable target 对非典型炎性体的新见解指出caspase-4是一种可药物靶标
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01142-9
Elad Elkayam, Francois G. Gervais, Hao Wu, Michael A. Crackower, Judy Lieberman
{"title":"New insights into the noncanonical inflammasome point to caspase-4 as a druggable target","authors":"Elad Elkayam, Francois G. Gervais, Hao Wu, Michael A. Crackower, Judy Lieberman","doi":"10.1038/s41577-025-01142-9","DOIUrl":"https://doi.org/10.1038/s41577-025-01142-9","url":null,"abstract":"<p>Recent studies indicate that the human lipopolysaccharide sensor caspase-4, unlike its mouse homologue caspase-11, is constitutively expressed and activates pro-IL-18 as well as gasdermin D-mediated pyroptosis. Activation of human caspase-4 causes vascular leakage systemically and at the blood–brain barrier in mice and is implicated in the pathogenesis of a range of inflammatory diseases for which there are currently no effective therapies. These results suggest the therapeutic potential of modulating caspase-4 activity, and structural studies indicate that the caspase-4 exosite might be a promising inhibitory target.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"1 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
PerturbView: scalable image-based perturbation screens in cells and tissues 摄动视图：细胞和组织中可扩展的基于图像的摄动屏幕
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-05 DOI: 10.1038/s41577-025-01153-6
Takamasa Kudo
{"title":"PerturbView: scalable image-based perturbation screens in cells and tissues","authors":"Takamasa Kudo","doi":"10.1038/s41577-025-01153-6","DOIUrl":"10.1038/s41577-025-01153-6","url":null,"abstract":"In this Tools of the Trade article, Takamasa Kudo (in the Aviv Regev&nbsp;lab, in collaboration with Eric Lubeck) describes how PerturbView enables robust visualization of many thousands of genetic perturbations.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"232-232"},"PeriodicalIF":67.7,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143546073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
T cell exhaustion: early or late in tumour progression? T细胞衰竭：肿瘤进展的早期还是晚期？
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01158-1
Lorenzo Galluzzi
{"title":"T cell exhaustion: early or late in tumour progression?","authors":"Lorenzo Galluzzi","doi":"10.1038/s41577-025-01158-1","DOIUrl":"10.1038/s41577-025-01158-1","url":null,"abstract":"Chronic antigen exposure underlies the stepwise acquisition of a terminally dysfunctional state by CD8+ T cells, commonly known as exhaustion, which is considered a major cause of failed cancer immunosurveillance. Recent data from models of viral infection show that the precursors of terminally exhausted T cells emerge early during disease course, prior to continuous signalling through the T cell receptor. I speculate that these findings might indicate that, at least in some settings, T cell exhaustion may emerge as a late consequence — rather than an early determinant — of cancer progression. Recent studies in mouse models of viral infection showed that precursors of terminally exhausted T cells emerge early during the course of disease. Here, Galluzzi discusses these findings and what they may mean for our understanding of tumour immunology and responses to immunotherapy with immune checkpoint blockade.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"227-228"},"PeriodicalIF":67.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DOTS: DNA origami tension sensors for studying T cell mechanobiology 用于研究T细胞力学生物学的DNA折纸张力传感器
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-04 DOI: 10.1038/s41577-025-01152-7
Sarah Al Abdullatif
{"title":"DOTS: DNA origami tension sensors for studying T cell mechanobiology","authors":"Sarah Al Abdullatif","doi":"10.1038/s41577-025-01152-7","DOIUrl":"10.1038/s41577-025-01152-7","url":null,"abstract":"In this Tools of the Trade article, Sarah Al Abdullatif describes a method to measure — in a physiological context — mechanical forces transmitted between a T cell receptor and its ligand.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"231-231"},"PeriodicalIF":67.7,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143538302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Type 1 immune response reduces seizure risk after traumatic brain injury 1型免疫反应降低创伤性脑损伤后癫痫发作的风险
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-03-03 DOI: 10.1038/s41577-025-01154-5
Jennifer S. Y. Ahn, Jennifer L. Gommerman
{"title":"Type 1 immune response reduces seizure risk after traumatic brain injury","authors":"Jennifer S. Y. Ahn,&nbsp;Jennifer L. Gommerman","doi":"10.1038/s41577-025-01154-5","DOIUrl":"10.1038/s41577-025-01154-5","url":null,"abstract":"A preprint by Mroz et al. reports a role for IFNgamma in protecting against seizures after traumatic brain injury.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"234-234"},"PeriodicalIF":67.7,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143532421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophils release inflammation-resolving vesicles 中性粒细胞释放消炎囊泡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-25 DOI: 10.1038/s41577-025-01151-8
Kirsty Minton
{"title":"Neutrophils release inflammation-resolving vesicles","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01151-8","DOIUrl":"10.1038/s41577-025-01151-8","url":null,"abstract":"Hsu et al. report in Cell that the release of complement-inhibiting vesicles by neutrophils as they age is a self-resolving, anti-inflammatory mechanism that supports a return to homeostasis.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 4","pages":"229-229"},"PeriodicalIF":67.7,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143485663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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