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Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors 在非典型趋化因子受体的系统命名中包含ACKR5
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-02-03 DOI: 10.1038/s41577-025-01135-8
Martyna Szpakowska, Daniel F. Legler, Stefan Offermanns, Silvano Sozzani, Antal Rot, Marcus Thelen, Andy Chevigné
{"title":"Inclusion of ACKR5 in the systematic nomenclature of atypical chemokine receptors","authors":"Martyna Szpakowska, Daniel F. Legler, Stefan Offermanns, Silvano Sozzani, Antal Rot, Marcus Thelen, Andy Chevigné","doi":"10.1038/s41577-025-01135-8","DOIUrl":"10.1038/s41577-025-01135-8","url":null,"abstract":"","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"225-226"},"PeriodicalIF":67.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s41577-025-01135-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143077293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Podoplanin mediates stromal–immune crosstalk in the lymph node Podoplanin介导淋巴结间质免疫串扰
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01140-x
Erika E. McCartney, Matthew B. Buechler
{"title":"Podoplanin mediates stromal–immune crosstalk in the lymph node","authors":"Erika E. McCartney, Matthew B. Buechler","doi":"10.1038/s41577-025-01140-x","DOIUrl":"10.1038/s41577-025-01140-x","url":null,"abstract":"A preprint by Makris et al. shows that podoplanin is a key regulator of the functions of fibroblastic reticular cells in lymph nodes, by modulating interactions with immune cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"160-160"},"PeriodicalIF":67.7,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immune control of brain physiology 脑生理学的免疫控制
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01129-6
Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa, Aleksandra Deczkowska
{"title":"Immune control of brain physiology","authors":"Mariángeles Kovacs, Amaia Dominguez-Belloso, Samir Ali-Moussa, Aleksandra Deczkowska","doi":"10.1038/s41577-025-01129-6","DOIUrl":"https://doi.org/10.1038/s41577-025-01129-6","url":null,"abstract":"<p>The peripheral immune system communicates with the brain through complex anatomical routes involving the skull, the brain borders, circumventricular organs and peripheral nerves. These immune–brain communication pathways were classically considered to be dormant under physiological conditions and active only in cases of infection or damage. Yet, peripheral immune cells and signals are key in brain development, function and maintenance. In this Perspective, we propose an alternative framework for understanding the mechanisms of immune–brain communication. During brain development and in homeostasis, these anatomical structures allow selected elements of the peripheral immune system to affect the brain directly or indirectly, within physiological limits. By contrast, in ageing and pathological settings, detrimental peripheral immune signals hijack the existing communication routes or alter their structure. We discuss why a diversity of communication channels is needed and how they work in relation to one another to maintain homeostasis of the brain.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"74 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Trained immunity in chronic inflammatory diseases and cancer 慢性炎症性疾病和癌症的训练免疫
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-31 DOI: 10.1038/s41577-025-01132-x
George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis
{"title":"Trained immunity in chronic inflammatory diseases and cancer","authors":"George Hajishengallis, Mihai G. Netea, Triantafyllos Chavakis","doi":"10.1038/s41577-025-01132-x","DOIUrl":"https://doi.org/10.1038/s41577-025-01132-x","url":null,"abstract":"<p>A decade after the term ‘trained immunity’ (TRIM) was coined to reflect the long-lasting hyper-responsiveness of innate immune cells with an epigenetically imprinted ‘memory’ of earlier stimuli, our understanding has broadened to include the potential implications of TRIM in health and disease. Here, after summarizing the well-documented beneficial effects of TRIM against infections, we discuss emerging evidence that TRIM is also a major underlying mechanism in chronic inflammation-related disorders such as periodontitis, rheumatoid arthritis and cardiovascular disease. Furthermore, mounting evidence indicates that the induction of TRIM by certain agonists confers protective antitumour responses. Although the mechanisms underlying TRIM require further study, the current knowledge enables the experimental development of innovative therapeutic approaches to stimulate or inhibit TRIM in a context-appropriate manner, such as the stimulation of TRIM in cancer or its inhibition in inflammatory disorders.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"122 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143071396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kidney immunology from pathophysiology to clinical translation 肾免疫学从病理生理学到临床的转化
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-30 DOI: 10.1038/s41577-025-01131-y
Christian Kurts, Sibylle von Vietinghoff, Christian F. Krebs, Ulf Panzer
{"title":"Kidney immunology from pathophysiology to clinical translation","authors":"Christian Kurts, Sibylle von Vietinghoff, Christian F. Krebs, Ulf Panzer","doi":"10.1038/s41577-025-01131-y","DOIUrl":"https://doi.org/10.1038/s41577-025-01131-y","url":null,"abstract":"<p>Kidney diseases are widespread and represent a considerable medical, social and economic burden. However, there has been marked progress in understanding the immunological aspects of kidney disease. This includes the identification of distinct intrarenal immunological niches and characterization of kidney disease endotypes according to the underlying molecular immunopathology, as well as a better understanding of the pathological roles for T cells, mononuclear phagocytes and B cells and the renal elements they target. These insights have improved the diagnosis of kidney disease. Here, we discuss new developments in our understanding of kidney immunology, focusing on immune mechanisms of disease and their translational implications for the diagnosis and treatment of kidney disease. We also describe the immune-mediated crosstalk between the kidney and other organs that influences kidney disease and extrarenal inflammation.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"28 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143057117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biomolecular condensates in immune cell fate 免疫细胞命运中的生物分子凝聚
IF 100.3 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-28 DOI: 10.1038/s41577-025-01130-z
Srikanth Kodali, Caroline M. Sands, Lei Guo, Yun Huang, Bruno Di Stefano
{"title":"Biomolecular condensates in immune cell fate","authors":"Srikanth Kodali, Caroline M. Sands, Lei Guo, Yun Huang, Bruno Di Stefano","doi":"10.1038/s41577-025-01130-z","DOIUrl":"https://doi.org/10.1038/s41577-025-01130-z","url":null,"abstract":"<p>Fate decisions during immune cell development require temporally precise changes in gene expression. Evidence suggests that the dynamic modulation of these changes is associated with the formation of diverse, membrane-less nucleoprotein assemblies that are termed biomolecular condensates. These condensates are thought to orchestrate fate-determining transcriptional and post-transcriptional processes by locally and transiently concentrating DNA or RNA molecules alongside their regulatory proteins. Findings have established a link between condensate formation and the gene regulatory networks that ensure the proper development of immune cells. Conversely, condensate dysregulation has been linked to impaired immune cell fates, including ageing and malignant transformation. This Review explores the putative mechanistic links between condensate assembly and the gene regulatory frameworks that govern normal and pathological development in the immune system.</p>","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"67 1","pages":""},"PeriodicalIF":100.3,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond bacteria: Phanta adds flavour to microbiome profiling with a focus on phages 超越细菌：Phanta以噬菌体为重点，为微生物组分析增添了风味
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-28 DOI: 10.1038/s41577-025-01138-5
Yishay Pinto
{"title":"Beyond bacteria: Phanta adds flavour to microbiome profiling with a focus on phages","authors":"Yishay Pinto","doi":"10.1038/s41577-025-01138-5","DOIUrl":"10.1038/s41577-025-01138-5","url":null,"abstract":"In this Tools of the Trade article, Yishay Pinto describes a tool, called Phanta, that profiles phages alongside their bacterial hosts in microbiome analysis.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"159-159"},"PeriodicalIF":67.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049988","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis 用于葡萄糖稳态的器官间神经-免疫-内分泌回路
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-28 DOI: 10.1038/s41577-025-01139-4
Kirsty Minton
{"title":"An inter-organ neuro–immuno–endocrine circuit for glucose homeostasis","authors":"Kirsty Minton","doi":"10.1038/s41577-025-01139-4","DOIUrl":"10.1038/s41577-025-01139-4","url":null,"abstract":"A study in Science reports that intestinal innate lymphoid cells migrate to the pancreas in response to low blood glucose levels to promote glucagon production.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 3","pages":"158-158"},"PeriodicalIF":67.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143049987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gasdermin pores on extracellular vesicles spread cell death 细胞外囊泡上的气孔传播细胞死亡
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-14 DOI: 10.1038/s41577-025-01133-w
Alexandra Flemming
{"title":"Gasdermin pores on extracellular vesicles spread cell death","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01133-w","DOIUrl":"10.1038/s41577-025-01133-w","url":null,"abstract":"A study in Cell shows that gasdermin D pores can be transferred from cell to cell via extracellular vesicles and induce pyroptotic cell death in bystander cells.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"75-75"},"PeriodicalIF":67.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity “转录型”解释了先天免疫缺陷的表型变异
IF 67.7 1区 医学
Nature Reviews Immunology Pub Date : 2025-01-14 DOI: 10.1038/s41577-025-01134-9
Alexandra Flemming
{"title":"‘Transcriptotype’ explains phenotypic variability of inborn errors of immunity","authors":"Alexandra Flemming","doi":"10.1038/s41577-025-01134-9","DOIUrl":"10.1038/s41577-025-01134-9","url":null,"abstract":"A phenomenon called ''autosomal random monoallelic expression'' (aRMAE) may explain phenotypic variability of clinical disease in carriers of mutations that cause inborn errors of immunity.","PeriodicalId":19049,"journal":{"name":"Nature Reviews Immunology","volume":"25 2","pages":"75-75"},"PeriodicalIF":67.7,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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