祖T细胞耗竭有助于免疫记忆的形成。

IF 60.9 1区医学 Q1 IMMUNOLOGY

Nature Reviews Immunology Pub Date : 2025-05-06 DOI:10.1038/s41577-025-01182-1

Annette Wu, Wen Jiang

引用次数: 0

摘要

Raposo等人的预印本表明，免疫检查点阻断可驱动某些耗尽的T细胞克隆的扩增，这些T细胞在清除慢性病毒感染后可发育为功能性记忆细胞。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Progenitor exhausted T cells contribute to the formation of immunological memory

A preprint by Raposo et al. shows that immune checkpoint blockade drives the expansion of certain clones of exhausted T cells that can develop into functional memory cells after clearance of chronic viral infection.

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来源期刊

Nature Reviews Immunology 医学-免疫学

CiteScore

93.40

自引率

0.40%

发文量

131

审稿时长

6-12 weeks

期刊介绍： Nature Reviews Immunology is a journal that provides comprehensive coverage of all areas of immunology, including fundamental mechanisms and applied aspects. It has two international standard serial numbers (ISSN): 1474-1733 for print and 1474-1741 for online. In addition to review articles, the journal also features recent developments and new primary papers in the field, as well as reflections on influential people, papers, and events in the development of immunology. The subjects covered by Nature Reviews Immunology include allergy and asthma, autoimmunity, antigen processing and presentation, apoptosis and cell death, chemokines and chemokine receptors, cytokines and cytokine receptors, development and function of cells of the immune system, haematopoiesis, infection and immunity, immunotherapy, innate immunity, mucosal immunology and the microbiota, regulation of the immune response, signalling in the immune system, transplantation, tumour immunology and immunotherapy, and vaccine development.