Natural Product Communications最新文献

{"title":"Phytochemical Analysis and in vivo Toxicity Study of Extracted Walnut oil in Sprague Dawley Rats","authors":"Talar Hamaali Mohammed, Heshu Sulaiman Rahman, Shirwan Hamasalih Omer","doi":"10.1177/1934578x241271695","DOIUrl":"https://doi.org/10.1177/1934578x241271695","url":null,"abstract":"Background: Medicinal plants have been the focus of scientific research for many decades worldwide, especially those used in traditional medicine. Objective: To perform the phytochemical analysis of extracted walnut oil (EWO) and its subchronic toxicity profile in Sprague Dawley rats. Methods: In this experimental study, the collected Kurdish walnut was authenticated by an authorized taxonomist and the core was obtained. Then, the walnut oil was extracted using the cold press method and sent for phytochemical analysis using GC-MS. Accordingly, the male Sprague Dawley rats were treated with varying doses of the EWO for four consecutive weeks, and animals were checked daily for abnormality and toxicity behaviours while they were weighed each week. At the end of the study, animals were sacrificed under deep anaesthesia, blood samples and organs were collected, and various hematological and biochemical tests were performed together with histopathological analysis. Results: GC-MS analysis showed that EWO contained 49 compounds, some critical in biomedical fields. The body weight of all treated animals was increased significantly. No significant changes were seen for hematological tests except platelets, which decreased in all treated groups (p = 0.015) compared to the control group. At the same time, AST and chloride levels were decreased (p = 0.002 and p = 0.012, respectively), while total protein and calcium were increased (p = 0.004 and p = 0.033, respectively). Simultaneously, histopathological analysis showed no severe lesions in the brain, moderate lesions in the liver and mild, moderate and severe lesions in the kidneys. Conclusions: EWO is rich in various compounds that contain active medicinal components. The EWO can be used at low doses as it does not affect most hematological and biochemical tests and has no significant toxicity in the vital organs of experimental rats.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"11 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactivities and Toxicity of the Golden Camellia Species: A Systematic Review","authors":"Minh-Nhut Truong, The-Long Pham, Tram-Anh Mai Pham, Van-Dat Truong, Linh-Tu Vo, Thao-My Nguyen-Hoang, Lac-Thuy Nguyen-Huu","doi":"10.1177/1934578x241278133","DOIUrl":"https://doi.org/10.1177/1934578x241278133","url":null,"abstract":"Golden camellia, a group of herbal materials belonging to the Theaceae family, was widely distributed in Asian countries, particularly Vietnam and southern China. Numerous pharmacological effects of various golden camellia species have been reported in reputable databases such as PubMed and Google Scholar. These effects included anti-tumor, lipid-lowering, anxiolytic, antidepressant, neuroprotective, antioxidant, antibacterial, and anti-inflammatory properties. Furthermore, toxicity studies on golden camellia species have demonstrated their safety for use. Our systematic review provides a comprehensive understanding of the pharmacological effects and safety of various golden camellia species, aiming to provide reliable evidence for the clinical use of this herbal material.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"60 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study on the Possibility of Developing Functional Source Through Extraction Optimization of Schinus terebinthifolia Bark and Evaluation of Anti-Oxidant, Elastase Inhibitory and Xanthine Oxidase Inhibitory Effect","authors":"Seung-Yub Song, Sung-Ho Lee, Jin-Woo Park, Dae-Hun Park, Seung-Sik Cho","doi":"10.1177/1934578x241275016","DOIUrl":"https://doi.org/10.1177/1934578x241275016","url":null,"abstract":"Introduction: Schinus terebinthifolia (ST) is a plant belonging to the cashew family Anacardiaceae, native to subtropical and tropical South America. ST is commonly called Brazil pepper and aroeira. Several reports have been made on the biological activities of ST, but studies on leaf extracts, especially lectins, have mainly been reported. Objectives: Our study analyzed the active compounds, antioxidant activities, xanthine oxidase inhibitory, elastase inhibitory, and tyrosinase inhibitory activities of S. terebinthifolia (ST) bark extract. Results: Hot water extracts showed the strongest electron donating ability (84.46%) and tyrosinase inhibitory activity (67.1%). Eighty percent ethanol extract showed the highest reducing power, total phenolic, xanthine oxidase (91.7%) and elastase inhibitory ability (85.44%). Catechin, α–amyrin, β–amyrone and 11-Oxo-.α-amyrin were identified through HPLC and GCMS analysis, while eighty percent extract contained the highest amount of catechin. Catechin, α–amyrin, and β–amyrone are considered to be the main xanthine oxidase inhibitors, while β–amyrone is considered to be the main inhibitor of xanthine oxidase and elastase. Conclusion: Through this study, we reported the basic information that S. terebinthifolia bark extract was used in folk medicine as an anti-inflammatory, anti-gout, and skin disease improvement material. S. terebinthifolia bark extract could be used as an anti-gout natural drug or cosmetic material.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"49 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rigidone or ent-perezone?","authors":"Ma Alvina Bucio-Vásquez, Miguel Ángel Fuentes-Figueroa, Angelina Hernández-Barragan, Luis Gerardo Zepeda-Vallejo, Eleuterio Burgueño-Tapia, Pedro Joseph-Nathan","doi":"10.1177/1934578x241276965","DOIUrl":"https://doi.org/10.1177/1934578x241276965","url":null,"abstract":"IntroductionThe <jats:sup>13</jats:sup>C-NMR data described for perezone (1), a 3-hydroxy p-quinone stated as the first natural product isolated as crystals in the New World, and rigidone (2), a 4-hydroxy o-quinone isolated from a coral species, are essentially the same. Some years ago, we described, using theoretical calculations, that a 4-hydroxy-1,2-quinone is more than 11 kcal/mol less stable than a 3-hydroxy-1,4-quinone making coexistence in nature of this type of quinones. In the present study, we approach the situation by comparing of the experimental <jats:sup>13</jats:sup>C-NMR data for 1 and those described for 2 with the calculated using computational methods. Additional evidence was obtained from a X-ray diffraction analysis for the reaction product of perezone with o-phenylendiamine.MethodsThe <jats:sup>13</jats:sup>C-NMR data for the quinoid rings were calculated using the GIAO and CSGT methods, density functional theory (DFT) and the functional/basis set pairs B3LYP/6-31 g(d,p) and MPW1PW91/6-31 g(d,p); and TPSSTPSS/cc-PVTZ and PBE1PBE/aug-cc-PVDZ. Perezone reaction with o-phenylenediamine was achieved using a described method in MeOH at room temperature. X-Ray diffraction analysis of phenazine from perezone reaction was done using Mo Kα radiation. The data were used to calculate the Flack parameter.ResultsAfter conformational analysis, complete optimization of the geometry of the conformers found and, calculation of the <jats:sup>13</jats:sup>C-NMR chemical shifts for the quinone ring of 1 and 2, in all cases a better agreement was observed between the experimental data for 1 versus 2. Perezone reaction with o-phenylenediamine afforded the corresponding phenazine in its amine-keto tautomeric form as evidenced from a X-ray diffraction study.ConclusionThe better agreement observed between the experimental and calculated data for 1 versus 2, along with the free energy difference of more than 11 kcal/mol in favor of the 3-hydroxy p-quinone versus 4-hydroxy o-quinone, previously established for us, allow to say that the structure described for rigidone corresponds to ent -perezone.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"26 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kaempferol Protects Pulmonary Vascular Endothelial Function in Rats with High Altitude Pulmonary Hypertension by Regulating RAS System and AMPK/Arg2/eNOS Signaling Pathway","authors":"Xin Xie, Huiru Li, Liangqi Wang, Xiaonan Zhang, Dianxiang Lu, Zhanqiang Li","doi":"10.1177/1934578x241274896","DOIUrl":"https://doi.org/10.1177/1934578x241274896","url":null,"abstract":"BackgroundPrevious studies have found that kaempferol can relieve pulmonary hypertension (PH).ObjectiveExplore the protective impact of kaempferol on pulmonary vascular endothelium in rats with high altitude pulmonary hypertension (HAPH).Materials and methodsIn a simulated altitude of 5000 m environment, rats were induced to develop HAPH after continuous intragastric administration of kaempferol (25, 50 and 100 mg·kg<jats:sup>−1</jats:sup>) and Sildenafil (30 mg·kg<jats:sup>−1</jats:sup>) for 28 days. Assessment of isolated pulmonary arterial rings in rats and relevant indicators in lung tissue was performed, with the mechanism of action investigated using Western blotting.ResultsKaempferol effectively dilates rat pulmonary arterial rings, with an EC<jats:sub>50</jats:sub> of 55.75 μmol/L. L-NAME can effectively counteract the vasodilatory effect of kaempferol. Acetylcholine demonstrated better relaxation of pulmonary arterial rings in HAPH rats after kaempferol intervention. Elastic Van Gieson staining (EVG) and immunohistochemistry (CD31) results indicate that kaempferol can partially protect pulmonary vascular endothelial function in HAPH rats. Western blotting reveals that kaempferol has the ability to regulate the Renin-Angiotensin System (RAS). This leads to a compensatory increase in eNOS expression, upregulation of AMPK activity, and downregulation of eNOS monomer/dimer levels.ConclusionsKaempferol can improve pulmonary vascular endothelial dysfunction caused by chronic hypoxia by upregulating the phosphorylation level of AMPK, regulating the RAS system, and inhibiting eNOS uncoupling, thereby achieving vasodilation and endothelial protection.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization and Improvement of Sleep Activity of Ziziphi Spinosae Semen Oil Microcapsules Prepared by Complex Coacervation","authors":"Jiaxin Chen, Xinbo Shi*, Zhishu Tang**, Zhongxing Song, Guolong Li, Hongbo Liu","doi":"10.1177/1934578x241272480","DOIUrl":"https://doi.org/10.1177/1934578x241272480","url":null,"abstract":"Objective: Ziziphi Spinosae Semen oil (ZSSO) is a fatty oil extracted from Ziziphi Spinosae Semen, and its main component is unsaturated fatty acid. It is susceptible to oxidation and deterioration. The aim of this study was to improve the stability of ZSSO and protect its quality. Methods: gelatin-sodium alginate was used as the wall material for the preparation of ZSSO microcapsules by the complex coacervation. The particle size and zeta potential of the microcapsules were determined using a Malvern particle size meter. The microstructure and stability of the microcapsules were determined by SEM, FTIR, TGA and PV. The sleep-improving activity of the microcapsules was also determined by sleep induction assay, Elisa and HE staining. Results: The encapsulation efficiency of microcapsules was 56.08% ± 0.19%, average particle size was 166.17 nm, and zeta potential was 38.2. Morphology of microcapsules was observed by SEM. The FTIR results showed that the fatty oil was successfully embedded, and PV indicated that microcapsules had a slow oxidation rate. A preliminary study on the sleep-improving activity of ZSSO and microcapsules demonstrated that it could shorten sleep latency and prolong sleep time of insomniac mice, and increase the levels of 5-HT and GABA and decrease the level of Glu in the brain of mice. In addition, ZSSO and microcapsules can repair damaged neuronal cells in the hypothalamus of insomniac mice to improve sleep. Conclusion: The quality evaluation of the microcapsules indicates that the prepared ZSSO-MPs have a small particle size and good stability. Moreover, ZSSO and microcapsules can effectively improve the sleep status of insomnia mice.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"9 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Potential Pharmacological Basis and Mechanism of HJT Activity in the Treatment of CHD Based on UPLC-QE-MS and Network Pharmacology","authors":"Wang Qi, Zhong Jianyuan, Zhang Wenxia, Ren Yinghan, Yang Yang","doi":"10.1177/1934578x241275005","DOIUrl":"https://doi.org/10.1177/1934578x241275005","url":null,"abstract":"ObjectiveTo identify the blood-entering components of HanJing Decoction (HJT) after administration based on UPLC-QE-MS/MS, and the key components, therapeutic targets and mechanisms of HJT therapeutic coronary heart disease (CHD) were analyzed using network pharmacology and molecular docking.MethodThe UPLC-QE-MS/MS was used to analyze the blood-entering components of HJT before and after administration. The targets of blood-entering components were predicted by SwissTargetPrediction. Targets related to CHD were collected using multiple databases. The GO and KEGG enrichment analyses were used to predict the mechanisms of HJT therapeutic CHD, and PPI and “Components-Targets-Pathways” network were used to identify and elucidate the core targets. The key blood-entering components aimed at the core target are screened by molecular docking and QSAR analysis.ResultsA total of 14 blood-entering components were detected in serum samples of rat after administration, and the 32 potential targets of HJT therapeutic CHD were screened out. The result of PPI network showed that the core targets of HJT for the treatment of CHD include MMP1, GSK3B, EGFR and PTGS2, and the 5 key components with high degree were screened out. The GO and KEGG enrichment analyses indicate that HJT therapy for CHD is associated with the IL-17 and cGMP-PKG signaling pathways. The result of molecular docking indicate that the binding energy of coroglaucigenin to PTGS2 is the largest and it may be the key pharmacological component of HJT, and the QSAR analysis showed that Boldine and Coroglaucigenin had excellent activity in inhibiting PTGS2.ConclusionsIn this study, the blood-entering components of HJT were preliminarily identified, Combined network pharmacology and molecular docking analyses revealed that the PTGS2 may be a core target, and the IL-17 and cGMP-PKG signaling pathways may be the key pathways. Moreover, the coroglaucigenin and boldine may be the key pharmacological components of HJT.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"59 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Bioactivity of Siddhalepa Asamodagam Spirit from Seeds of Trachyspermum roxburghianum (DC.) H. Wolff","authors":"Dilan Jayawantha, Lankani Hettigoda, Tharindya Dinethri Mudalige, Priyani Ashoka Paranagama","doi":"10.1177/1934578x241271629","DOIUrl":"https://doi.org/10.1177/1934578x241271629","url":null,"abstract":"ObjectivesThe water distillate derived from Trachyspermum roxburghianum seeds has been traditionally employed in medicine for treating stomach infections and gastric ulcers. However, no systematic study has been conducted to evaluate its efficacy. Therefore, the present study focused on evaluating the potential health benefits, including the chemical constituents of the distillate. This distillate was prepared and identified as Siddhalepa Asamodagam Spirit (Sid.AS).MethodsThe chemical constituents of Sid.AS were identified and quantified using Gas Chromatography-Mass Spectrometry (GC-MS) method. The antioxidant potential of Sid.AS samples was assessed in vitro using DPPH and ABTS assays. Various concentrations of Sid.AS were subjected to antimicrobial, anti-obesity, anti-diabetic, anti-inflammatory, and urease inhibition assays according to the standard methods specified by the Ayurvedic Department in Sri Lanka.ResultsThymol was identified as the major compound in Sid.AS through GC-MS analysis. Sid.AS demonstrated significant anti-urease, anti-inflammatory, anti-lipase, and antioxidant activities, as evidenced by low IC<jats:sub>50</jats:sub> values compared to the positive controls. This suggests its potential in controlling gastric-related disorders, scavenging free radicals, and managing obesity by inhibiting the breakdown and absorption of fats. Additionally, Sid.AS exhibited inhibitory effects against alpha-amylase and alpha-glucosidase enzymes, indicating potential anti-diabetic activity by regulating blood sugar levels. Sid.AS displayed strong antimicrobial activity against tested microorganisms, with higher zones of inhibition and lower MIC and MLC values, indicating its effectiveness in combating microbial infections. Findings from the anti-lipase assay demonstrated activity comparable to that of the positive control, Orlistat.ConclusionThe findings of Sid.AS suggest its potential as a multi-functional bioactive herbal distillate with various pharmacological activities. Our results highlight that Sid.AS is a promising natural herbal extract with diverse pharmacological properties, including anti-urease, antioxidant, anti-inflammatory, anti-diabetic, anti-obesity, and antimicrobial activities. Further research and development could explore its potential applications in various therapeutic areas.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"88 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Jiangzhi Paizhuo Decoction Combined with Silibinin Capsules Improve the Outcomes of Metabolic Associated Fatty Liver Disease","authors":"Jianmei Hao, Yuanjing Xie, Zhiping Yang, Jianwei Dou, Minghua Mao, Xiaofang Li","doi":"10.1177/1934578x241274900","DOIUrl":"https://doi.org/10.1177/1934578x241274900","url":null,"abstract":"The study aimed to evaluate the impact of combining silibinin capsules with Jiangzhi Paizhuo Decoction (JZPZ) versus silibinin capsules alone in patients with MAFLD. The research was carried out at the Xi'an Hospital of Traditional Chinese Medicine using a case-control design following to STROBE guideline. Eligible participants meeting the inclusion criteria were randomly allocated into two groups. The participants in control group and intervention group were assigned to receive oral administration of 70 mg (3 times daily) silibinin capsules or 70 mg silibinin capsules (3 times daily) plus colon dialysis with 150 ml JZPZ decoction for 8 weeks. The primary outcome and secondary outcome on the effects of JZPZ decoction in MAFLD were detected. We found that liver function significantly improved in both groups after treatment (p &lt; 0.05) compared with the baseline. Importantly, JZPZ decoction was associated with significant decrease in hepatic steatosis (CAP changes: −18.91 ± 11.50 vs −26.86 ± 16.62, P = 0.0305). The JZPZ decoction reduced significantly the TCM syndromes score compared to control (−5.74 ± 0.95 versus −7.17 ± 1.23, P &lt; 0.0001). Meanwhile, the weight and BMI in JZPZ group increased significantly more than control group (P = 0.0003, P &lt; 0.0001). In conclusion, the JZPZ decoction combined with silibinin capsules in the treatment of MAFLD patients with liver depression and heat syndrome has more advantages in decreasing hepatic steatosis and TCM syndromes scores. It is worthy of clinical recommendation.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"9 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Encapsulation of Pomelo Peel Essential oil (Citrus maxima) Using the Alginate/Chitosan complex","authors":"Cam Ngan Thi Nguyen, Thuong Nhan Phu Nguyen, Chi Khang Van, Huynh Cang Mai","doi":"10.1177/1934578x241275015","DOIUrl":"https://doi.org/10.1177/1934578x241275015","url":null,"abstract":"Objective: This study aimed to determine appropriate parameters for encapsulating pomelo peel essential oil (Citrus maxima) using the alginate/chitosan complex. Methods: The investigated parameters included the concentration of sodium alginate solution (2 ‒ 3.5% w/v based on the volume of mixture), the concentration of pomelo essential oil (20 ‒ 40% w/w based on dry matter of wall marerials), the concentration of Tween 80 (0 ‒ 20% w/w based on dry matter of wall marerials), the concentration of CaCl<jats:sub>2</jats:sub> solution (0.5 ‒ 3.5% w/v based on the volume of mixture), time (10 min – 20 min) and speed of emulsion homogenization (489-4402 × g), the concentration of chitosan solution (0.5 ‒ 2% w/v based on the volume of mixture), and pH of chitosan solution (4 ‒ 6). Results: The results showed encapsulation yield (EY%) and encapsulation efficiency (EE%) of 91.64% and 85.18%, respectively, when using the concentration of sodium alginate solution as 3% (w/v based on the volume of mixture), the concentration of essential oil as 30% (w/w based on dry matter of wall marerials), the concentration of Tween 80 as 15% (w/w based on dry matter of wall marerials), the concentration of CaCl<jats:sub>2</jats:sub> solution as 1.5% (w/v based on the volume of mixture), homogenization time as 10 min and homogenization speed as 4402 × g, the concentration of chitosan as 2% (w/v based on the volume of mixture) and pH of Chitosan solution as 5. Conclusion: The alginate/chitosan complex was proven effective in encapsulating pomelo essential oil (Citrus maxima) on a laboratory scale. The resulting encapsulated particles had a relatively uniform size and a high ability to retain essential oils in the core of the particles. Further studies should be conducted to elucidate the mechanism of the encapsulation process and to additionally evaluate the physical and chemical properties of the encapsulated particles.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"47 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142177341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}