Natural Product Communications最新文献

{"title":"Absolute Configuration and Cytotoxicity of a New Vouacapane Diterpenoid from Coulteria velutina","authors":"Odessa Magallón-Chávez, Laura Hernández-Padilla, Gabriela Rodríguez-García, Armando Talavera-Alemán, Concepción Armenta-Salinas, Ernestina Gutiérrez-Vázquez, Jesús Campos-García, Rosa E. del Río, Carlos M. Cerda-García-Rojas, Mario A. Gómez-Hurtado","doi":"10.1177/1934578x241252505","DOIUrl":"https://doi.org/10.1177/1934578x241252505","url":null,"abstract":"Objective: Determine the structure, absolute configuration, and antiproliferative activity of a new furan diterpenoid isolated from the leaves of Coulteria velutina (Britton &amp; Rose) Sotuyo &amp; G.P.Lewis (Fabaceae). Methods: The structures of the natural product and those of 2 derivatives were established mainly by nuclear magnetic resonance spectroscopy, while their absolute configurations were established using vibrational circular dichroism involving comparison of the experimental and calculated spectra of a rigid derivative. Results: Isolation of (−)-(4 R,5 R,6 R,8 S,9 S,10 R,14 R)-6-[( E)- p-coumaroyloxy]vouacapan-18-oic acid (1), an undescribed secondary metabolite from the leaves of C velutina, is reported hereafter. Hydrolysis of 1 provided (+)-(4 R,5 R,6 R,8 S,9 S,10 R,14 R)-6-hydroxyvouacapan-18-oic acid (2), identical to a diterpenoid isolated from Caesalpinia echinata, but whose absolute configuration remained undetermined. Subsequent lactonization of 2 yielded (+)-(4 R,5 R,6 R,8 S,9 S,10 R,14 R)-vouacapan-6,18-olide (3). The absolute configurations of compounds 1–3 were established by vibrational circular dichroism studies of 3. In addition, the antiproliferative activity of the natural product 1 against HeLa, MDA-MB-231, Caco-2, and NIH/3T3 cell lines is reported. Conclusions: The leaves of C velutina yielded the new vouacapane 1. It showed weak antiproliferative activity against HeLa and MDA-MB-231 cancer cell lines (IC<jats:sub>50 </jats:sub>= 92.2 and 106.2 μg/mL, respectively), but was also weakly active against the NIH/3T3 healthy cell line (IC<jats:sub>50</jats:sub> value of 127.6 µg/mL). Its absolute configuration was determined by vibrational circular dichroism analysis of the conformationally rigid compound 3. This derivative can be used as a reference for the absolute configuration of related vouacapanes. In addition, this is the first phytochemical investigation of C velutina.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"18 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studies Toward the Total Synthesis of Natalamycin A: Stereoselective Synthesis of the C9–C21 Segment","authors":"Momoko Suzuki, Kazuhiko Takatori, Kenichi Kobayashi","doi":"10.1177/1934578x241250236","DOIUrl":"https://doi.org/10.1177/1934578x241250236","url":null,"abstract":"Toward the total synthesis of natalamycin A, we have synthesized the C9-C21 segment corresponding to the northwestern part of the natural product. Key features of this synthesis were an asymmetric α-chlorination of an aldehyde using MacMillan's catalyst and stereoselective assembly of three contiguous stereocenters via a butenolide intermediate.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"2 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140941944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Enhanced Anti-anxiety Potentiality and Relevant Material Basis for the Extracts of Bile Processed Coptidis Rhizoma","authors":"Long Chen, Ruifeng Wang, Lin Chen, Zhenkai Zhang, Bingxian Zhang, Yongxiang Wang, Weisheng Feng, Xiaoke Zheng, Kai Li, Ning Zhou","doi":"10.1177/1934578x241253444","DOIUrl":"https://doi.org/10.1177/1934578x241253444","url":null,"abstract":"ObjectiveBile-processed Coptidis Rhizoma (CR) exhibits stronger cold properties and central effect. However, the commonly used bile includes pig/cattle/sheep bile. It is currently unclear which kind of bile performs the best synergistic effect, and the enhanced efficacy is mainly contributed by what components. In this work, a comparative study on pig/cattle/sheep bile processed CR (pCR/cCR/sCR) was carried out.Materials and MethodsFirstly, the anxiety model of sthenic heat type was established. Then, pharmacological research involving general state observation, biochemical examination (succinate dehydrogenase, glucokinase, corticosterone, adrenocor ticotropic hormore), pathological evaluation (liver and hippocampus tissue), and behavioral tests (elevated plus maze, open field test) was implemented. Finally, chemical assessment involving high-performance liquid chromatography (HPLC) fingerprints of pCR/cCR/sCR extracts and mass spectrograms of pig/cattle/sheep bile were performed in combination.ResultscCR performed the most prominent enhancement in improving hyperactive energy metabolism in liver and abnormal hyperactivity of hypothalamic–pituitary–adrenal axis axis. As for chemical assessment, HPLC fingerprints of pCR/cCR/sCR extracts indicated that alkaloid components detected in cCR extracts were relatively low, mass spectrograms of pig/cattle/sheep bile suggested that bile acids in cattle bile were relatively abundant, and the contents of taurocholic acid, glycocholic acid, and glycodeoxycholic acid were particularly high.ConclusionCattle bile could be specified as the processing excipient for bile-processed CR, and the high levels of taurocholic acid, glycocholic acid, and glycodeoxycholic acid mainly contributed to the enhanced efficacy of cCR.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"17 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140942016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commiphora gileadenesis Extracts Reduce Blood Glucose Levels, HbA1c, Lipid Profile, and CD4+ and CD8+ Subsets in Type 1 Diabetic Mice","authors":"Ayman Saeed Alhazmi, Abdullah Aldairi, Abdulelah Aljuaid, Ahmad Alghamdi, Mamdouh Allahyani","doi":"10.1177/1934578x241250249","DOIUrl":"https://doi.org/10.1177/1934578x241250249","url":null,"abstract":"Diabetes mellitus is a major health problem that affects the general population. Commiphora gileadensis ( C gileadensis) is a small tree that grows in the Middle East. Objective: This study explored the effect of C gileadensis on blood glucose levels, lipid profile, and T lymphocytes subsets using flow cytometry. Methodology: Forty male mice were classified into four groups: negative control; diabetic nontreated; and two groups of diabetic mice treated with C gileadensis sap and acetone extract. The blood glucose levels, lipid profile, and HbA<jats:sub>1</jats:sub>c were estimated for each mouse in the four groups. Moreover, total lymphocytes, CD3<jats:sup>+</jats:sup>, CD4<jats:sup>+</jats:sup>, CD8<jats:sup>+</jats:sup>, and CD25<jats:sup>+</jats:sup> subsets were estimated for all groups. Results: The blood glucose levels, triglyceride, total cholesterol, and HbA<jats:sub>1</jats:sub>c were significantly reduced in mice treated with C gileadensis sap and acetone extract compared with the diabetic group. Total lymphocyte and CD3<jats:sup>+</jats:sup> were reduced in diabetic mice treated with C gileadensis sap and acetone extract compared with the untreated diabetic group ( P &lt; .05). In addition, CD4<jats:sup>+</jats:sup> and CD8<jats:sup>+</jats:sup> subsets were decreased in the same groups compared with the untreated one ( P &lt; .05). CD4<jats:sup>+</jats:sup> CD25<jats:sup>+</jats:sup> cells were decreased in all diabetic groups compared with the control group ( P &lt; .05). CD8<jats:sup>+</jats:sup> CD25<jats:sup>+</jats:sup> were increased in diabetic groups treated with C gileadensis sap and acetone extract compared with the untreated diabetic group ( P &lt; .05). Conclusion: The present study concludes that C gileadensis sap and acetone extracts reduce the blood glucose, HbA<jats:sub>1</jats:sub>c, and lipid profile in diabetic mice. Moreover, this herb has anti-inflammatory properties that may help in the normalization of glycemic index and prevent T1DM progression.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"1 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical Constituents From the Leaves of Grewia bulot Gagn. and Their Cytotoxic Activity","authors":"Ty Viet Pham, Duc Viet Ho, Y Duy Ngo, Nhan Thanh Thi Dang, Thang Quoc Le, Ninh The Son, Anh Tuan Le, Bao Chi Nguyen","doi":"10.1177/1934578x241250251","DOIUrl":"https://doi.org/10.1177/1934578x241250251","url":null,"abstract":"Objective: The ultimate objective of this study was to isolate bioactive compounds from Grewia bulot Gagn. leaves and evaluate their cytotoxicity against a panel of human cancer cell lines. Methods: Compounds were isolated by column chromatography, whereas their chemical structures were elucidated by NMR spectroscopic data, and literature comparison. The cytotoxic activity of the isolated compounds was assessed using SRB assay against 4 cancer cell lines, including MCF-7 (human breast carcinoma), Hep-G2 (human hepatocellular carcinoma), KB (human carcinoma in the mouth), and SK-LU-1 (human lung carcinoma). Results: From the n-hexane extract, 4 compounds were isolated and identified as taraxerol (1), 3-( E)-coumaroyltaraxerol (2), 3-( Z)-coumaroyltaraxerol (3), and lupeol (4). Additionally, 6 compounds were isolated from the ethyl acetate extract and identified as daucosterol (5), trans-tiliroside (6), inugalactolipid A (7), (3 S,5 R,6 S,7 E,9 R)-7-megastigmene-3,6,9-triol (8), biphenyl-3,3′,4,4′-tetrol (9), and smiglabrone B (10). Among these isolates, only compound 9 exhibited moderate cytotoxic activity against all tested cancer cell lines with the IC<jats:sub>50</jats:sub> values ranging from 31.67 to 63.15 µM. Conclusion: All these compounds have been detected from G bulot for the first time, biphenyl-3,3′,4,4′-tetrol (9) emerged as a promising candidate for cancer drug development. This study contributes to the growing body of knowledge regarding natural compounds with anticancer properties.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"40 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Frying, Freezing, Boiling, and Thawing Processes on Proximate, PH and Energy Values of Fresh (Oncorhynchus mykiss)","authors":"Ali Aberoumand, Kausar Abiyavi, Fatemeh Fardaei, Rania Kouti, Zainab Benafi, Najmeh Ahmadi, Mashhid Hatami, Reza Ahmadi","doi":"10.1177/1934578x241249080","DOIUrl":"https://doi.org/10.1177/1934578x241249080","url":null,"abstract":"Objective/Background: Oncorhynchus mykiss is the most popular type of freshwater fish consumed by Iranians. It has delicious taste and high nutritional value. The purpose of processing and preserving fish is to get it to the end consumer in a good, usable condition. Methods: This study is a descriptive study that compares and determines the analysis results of proximate, protein, and fat between fresh and processed fish using the standard method of AOAC and compares the analysis of this study with that of other studies. The effect of the processing methods’ nutritional composition is determined. In addition to fresh fish, 5 treatments are used for the 5 different methods of fish processing. Results: The fresh fish and the different processed samples were analyzed by standard AOAC methods, and their pH was measured. After analyzing the macronutrient compounds of different samples, the energy values were then calculated in kcal. The moisture content ranged from 72.50% for fresh fish to 19.50% for frozen fish, while the fat content ranged from 8.09% for fresh fish to 64.47% for frozen fish. The ash contents were found to range from 4.82% to 5.82%, while the protein contents were found to range from 10.47% to 13.59%. The results showed that quick freezing of fish preserved nutrients with a high percentage of energy. This sample was recommended for consumption, followed by samples thawed in oven and in hot water. The fried and boiled samples were in the next stages of quality and energy values. Conclusions: Because the fat content of this type of fresh fish is high, and if fish feed and its nutrition are protein materials with high biological value, it will be useful to increase the percentage of meat protein for it to grow.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"87 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Toxicity and Hepatoprotective Influence of Hypericum perforatum Against Thioactamid-Induced Liver Fibrosis in Rats","authors":"Ahmed A.J. Jabbar, Zaenah Zuhair Alamri","doi":"10.1177/1934578x241250243","DOIUrl":"https://doi.org/10.1177/1934578x241250243","url":null,"abstract":"Background: Hypericum perforatum (MEHP) is a broadly used therapeutic plant exhibiting numerous bioactivities. The present study evaluates acute toxicity and hepatoprotective effects of MEHP against thioacetamide (TAA)-induced liver injury in rats. Methods: The toxicity trial included a single oral administration of 2000 and 5000 mg/kg to rats. In the hepatoprotective experiment, 30 adult rats were arbitrarily clustered into 5 groups: Normal (A) and TAA control rats (B) treated with daily distilled water; reference rats received 3 oral doses/week of 50 mg/kg silymarin; D and E, rats received daily doses of 250 and 500 mg/kg MEHP, respectively. In addition, group B-E received 3 injections of 200 mg/kg TAA in a week for 60 days. Results: The results have shown a lack of any toxic signs in rats following oral administration of up to 5000 mg/kg. The hepatoprotective evaluations revealed a noticeably lower hepatic injury in MEHP-treated rats shown by reduced liver index and hepatocyte proliferation. Histopathological evaluation (H&amp;E and Masson trichrome stains) showed a significant inhibitory potential of MEHP on the incidence rate of hepatic lesions represented by decreased liver necrosis and lower fibrous connective tissue proliferation initiated by TAA in rats. MEHP treatment meaningfully decreased proliferating cell nuclear antigen and α-SMA (myofibroblasts) in liver parenchymal tissues as well as improved redox (up-regulated SOD, CAT, GPx, and down-regulated MDA) and inflammatory state (decreased serum TNF-α and IL-6 cytokines) compared to fibrosis control rats. In addition, MEHP treatment caused significant restoration of serum liver biomarkers (enzymes and proteins) against TAA-induced hepatotoxicity. Conclusion: The present hepatoprotectives of MEHP could be attributed to its chemical contents (hypericin, hyperforin, quercitrin, and p-coumaric acid) that may validate it as a therapeutic additive for liver fibrosis after some pharmacological evaluations.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"45 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cumulative Data of 1H and 13C NMR Signals and Specific Rotations of Eremophilane Sesquiterpenoids. 4. 10H-3-O-Furanoeremophilanes","authors":"Motoo Tori","doi":"10.1177/1934578x241250240","DOIUrl":"https://doi.org/10.1177/1934578x241250240","url":null,"abstract":"<jats:sup>1</jats:sup>H and <jats:sup>13</jats:sup>C nuclear magnetic resonance (NMR) data and specific rotations of eremophilane sesquiterpenoids are cumulated as a series of review articles. This fourth chapter focuses on furanoeremophilanes bearing 10H with C-3 oxygen functionality, and 175 10H-furanoeremophilanes with 3-O functionality are listed in 38 tables. Those with 15,6-lactones and 6,15-ethers are included in this chapter. Dihydrofurans, lactols, dimers, nor- and seco-compounds, and other related compounds, are not included in this chapter. These data may help chemists working in the area of natural products chemistry and synthetic scientists as well as computational chemists.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"37 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140936415","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Chemical Constituents and Kidney-Yang Tonifying of Traditional Herbs After Processing: A Brief Review","authors":"Minh-Nhut Truong, Hong-Hieu Nguyen Thi, Hoang-Huy Tran, Lan-Phuong Le Thi","doi":"10.1177/1934578x241250237","DOIUrl":"https://doi.org/10.1177/1934578x241250237","url":null,"abstract":"BackgroundKidney-Yang deficiency is one of the common medical syndromes in traditional medicine, characterized by symptoms such as weakness, coldness in the lower back and knees, cold, fatigue, etc. In clinical practice, Yang tonifying medicines are often used to treat patients with Kidney-Yang deficiency. Moreover, the medicinal processing method according to the principles of traditional medicine can enhance the effects on the Kidney of these herbs. This brief overview aims to gather and assess the post-processing modifications to the chemical composition and the kidney-Yang tonifying effects of specific traditional herbal remedies.MethodologyFirstly, all kidney-Yang tonifying herbs were collected. Next, the selection was made based on the herbs with processing procedures specified in Circular 30/2017/TT-BYT issued by the Vietnamese Ministry of Health. All studies on the chemical composition and/or effects of processed drugs were searched in the PubMed and Google Scholar databases using the search formula: processed + scientific name of herbal medicine. Finally, among the studies on the changes in effects after processing, only studies on the tonifying Yang effect were included in this review.ResultsThe kidney Yang-nourishing effects of the five traditional herbal medicines prescribed in Circular 30/2017/TT-BYT by the Ministry of Health of Vietnam (Radix Morindae officinalis, Cortex Eucommiae, Herba Cistanches, Semen Cuscutae, and Radix Dipsaci) have been demonstrated through several studies and summarized. From the PubMed and Google Scholar databases, 25 studies were collected for the review. Additionally, the changes in composition and content of certain active compounds in these herbal medicines have also been searched and reported.ConclusionThis report provides a brief overview of the differences between chemical constituents and kidney-Yang tonifying of some traditional herbs after processing to partially contribute scientific evidence for standardizing the preparation processes and serve as an important reference for clinical practitioners of traditional medicine.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"90 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140882540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatic Analysis of Ping-Wei-San Decoction for Pulmonary Malignancy Based on UPLC-QE-Orbitrap-MS Detection","authors":"Ding Li, Xiao-Qing Ma, Xue Yang, Xiao-yuan Li, Ru-yong Yao","doi":"10.1177/1934578x241249089","DOIUrl":"https://doi.org/10.1177/1934578x241249089","url":null,"abstract":"BackgroundThe traditional Chinese medicine prescription Ping-Wei-San decoction (PWS) has been used historically in East Asian countries. This study aimed to investigate the ingredients of the decoction and explore its potential role in the adjuvant treatment of pulmonary malignancies.ObjectivesThe primary objective was to analyze the ingredients of PWS and understand its potential in the treatment of pulmonary malignancy.MethodsMedical records of 143 394 patients using PWS over a decade were collected from the Affiliated Hospital of Qingdao University. UPLC-QE-Orbitrap-MS detected 13 chemical components, including 12 known components. Lung adenocarcinoma data were obtained from the TCGA-LUAD dataset, and differential genes were screened using R studio. The EVENN website and the STRING database were used to identify drug action and disease targets.SettingThe study was conducted at the Affiliated Hospital of Qingdao University.ParticipantsThe study included 3147 patients with “pulmonary malignancies.”InterventionPWS was used as an adjuvant treatment.ResultsNetwork analysis revealed 10 core targets (CCNA2, CHEK1, TOP2A, CDK1, CCNB1, CCNB2, AURKA, AURKB, KIF11, and MELK) for the treatment of lung adenocarcinoma and associated pathways.ConclusionPWS may offer multifunctional efficacy in the treatment of pulmonary malignancies based on constituent analysis. Further research and clinical trials are needed to explore its potential.","PeriodicalId":19019,"journal":{"name":"Natural Product Communications","volume":"20 1","pages":""},"PeriodicalIF":1.8,"publicationDate":"2024-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140882400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}