Nature Cell Biology最新文献_第9页

Publisher Correction: DNA nanodevices detect an acidic nanolayer on the lysosomal surface 出版者更正：DNA纳米装置检测溶酶体表面的酸性纳米层

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-02-04 DOI: 10.1038/s41556-026-01897-w

Yutong Zhang, Meiqin Hu, Yaping Meng, Xin Wang, Fangqian Huang, Ping Li, Yuting Zhuo, Danzhen Chen, Zhimin Wang, Qiang Zhang, Hui Wu, Yao He, Yulin Du, Haoxing Xu, Liping Qiu, Weihong Tan

引用次数: 0

Author Correction: C-to-G editing generates double-strand breaks causing deletion, transversion and translocation 作者更正：C-to-G编辑产生双链断裂，导致缺失、翻转和易位。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-02-03 DOI: 10.1038/s41556-026-01883-2

Min Emma Huang, Yining Qin, Yafang Shang, Qian Hao, Chuanzong Zhan, Chaoyang Lian, Simin Luo, Liu Daisy Liu, Senxin Zhang, Yu Zhang, Yang Wo, Niu Li, Shuheng Wu, Tuantuan Gui, Binbin Wang, Yifeng Luo, Yanni Cai, Xiaojing Liu, Ziye Xu, Pengfei Dai, Simiao Li, Liang Zhang, Junchao Dong, Jian Wang, Xiaoqi Zheng, Yingjie Xu, Yihua Sun, Wei Wu, Leng-Siew Yeap, Fei-Long Meng

引用次数: 0

DOT1L provides transcriptional memory through PRC1.1 antagonism DOT1L通过PRC1.1拮抗提供转录记忆

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-02-03 DOI: 10.1038/s41556-025-01859-8

Daniel Neville, Daniel T. Ferguson, Emily B. Heikamp, Zhihao Lai, Graham W. Magor, Charlene Lam, Olivia G. Dobbs, Vita Levina, Kathy Knezevic, James J. The, Shania Alex, Stephen C. Suits, Bradon Rumler, Michael Uckelmann, Laure Talarmain, Enid Y. N. Lam, Andrew C. Perkins, Scott A. Armstrong, Charles C. Bell, Chen Davidovich, Omer Gilan

{"title":"DOT1L provides transcriptional memory through PRC1.1 antagonism","authors":"Daniel Neville, Daniel T. Ferguson, Emily B. Heikamp, Zhihao Lai, Graham W. Magor, Charlene Lam, Olivia G. Dobbs, Vita Levina, Kathy Knezevic, James J. The, Shania Alex, Stephen C. Suits, Bradon Rumler, Michael Uckelmann, Laure Talarmain, Enid Y. N. Lam, Andrew C. Perkins, Scott A. Armstrong, Charles C. Bell, Chen Davidovich, Omer Gilan","doi":"10.1038/s41556-025-01859-8","DOIUrl":"10.1038/s41556-025-01859-8","url":null,"abstract":"DOT1L and Menin are essential cofactors for the oncogenic activity of MLL fusion proteins (MLL-FPs) in leukaemia. However, the mechanisms underpinning the therapeutic effects of their inhibitors remain unclear. Here we identify a critical role for the non-canonical Polycomb repressive complex 1.1 (PRC1.1) in mediating the cellular responses to DOT1L and Menin inhibitors. Menin inhibition induces PRC1.1-dependent deposition of H2AK119ub to silence a subset of MLL-FP targets, whereas DOT1L inhibition results in a genome-wide increase in H2AK119ub. We show that enhanced PRC1.1 activity arises specifically from the progressive loss of DOT1L-mediated H3K79 methylation, independent of MLL-FP displacement or transcriptional repression. This regulatory crosstalk is conserved across cell types and is driven by direct biochemical antagonism between H3K79 methylation and PRC1 activity. Together, our findings establish DOT1L as a component of transcriptional memory co-opted in leukaemia and suggest it serves as the missing link balancing the opposing forces of the MLL–Polycomb axis. Neville, Ferguson et al. show that non-canonical Polycomb repressive complex 1.1-mediated gene silencing is antagonized by DOT1L and is required for the therapeutic efficacy of Menin and DOT1L inhibitors in mixed-lineage leukaemia.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 2","pages":"307-322"},"PeriodicalIF":19.1,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41556-025-01859-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ER gets out of shape with ageing ER会随着年龄的增长而变形。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-02-02 DOI: 10.1038/s41556-025-01864-x

Kalina Lapenta, Güneş Parlakgül, Ana Paula Arruda

引用次数: 0

ER remodelling is a feature of ageing and depends on ER-phagy 内质网重塑是衰老的一个特征，依赖于内质网吞噬

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-02-02 DOI: 10.1038/s41556-025-01860-1

Eric K. F. Donahue, Nathaniel L. Hepowit, Elizabeth M. Ruark, Alexandra G. Mulligan, Brennen Keuchel, Nicholas D. Urban, Li Peng, Stedman Stephens, Derek J. Johnson, Natalie S. Wallace, Lauren P. Jackson, Mark H. Ellisman, Rafael Arrojo e Drigo, Andrew W. Folkmann, Matthias C. Truttmann, Jason A. MacGurn, Kristopher Burkewitz

{"title":"ER remodelling is a feature of ageing and depends on ER-phagy","authors":"Eric K. F. Donahue, Nathaniel L. Hepowit, Elizabeth M. Ruark, Alexandra G. Mulligan, Brennen Keuchel, Nicholas D. Urban, Li Peng, Stedman Stephens, Derek J. Johnson, Natalie S. Wallace, Lauren P. Jackson, Mark H. Ellisman, Rafael Arrojo e Drigo, Andrew W. Folkmann, Matthias C. Truttmann, Jason A. MacGurn, Kristopher Burkewitz","doi":"10.1038/s41556-025-01860-1","DOIUrl":"10.1038/s41556-025-01860-1","url":null,"abstract":"The endoplasmic reticulum (ER) comprises an array of subdomains, each defined by a characteristic structure and function. Although altered ER processes are linked to age-onset pathogenesis, it is unclear whether shifts in ER structure or dynamics underlie these functional changes. Here we establish ER structural and functional remodelling as a conserved feature of ageing across yeast, Caenorhabditis elegans and mammals. Focusing on C. elegans as the exemplar of metazoan ageing, we reveal striking age-related reductions in ER volume across diverse tissues and a morphological shift from rough sheets to tubular ER. This morphological transition corresponds with large-scale shifts in ER proteome composition from protein synthesis to lipid metabolism, a phenomenon conserved in mammalian tissues. We show that Atg8 and ULK1-dependent ER-phagy drives age-associated ER remodelling through tissue-specific factors, including the previously uncharacterized ER-phagy regulator TMEM-131 and the IRE-1–XBP-1 branch of the unfolded protein response. Providing support for a model where ER remodelling is adaptive, diverse lifespan-extending paradigms downscale and remodel ER morphology throughout life. Furthermore, mTOR-dependent lifespan extension in yeast and worms requires ER-phagy, indicating that ER remodelling is a proactive and protective response during ageing. These results reveal ER-phagy and ER dynamics as pronounced, underappreciated mechanisms of both normal ageing and age-delaying interventions. Donahue et al. show that ageing is associated with changes in ER morphology. ER-phagy drives age-associated ER remodelling through tissue-specific factors.","PeriodicalId":18977,"journal":{"name":"Nature Cell Biology","volume":"28 3","pages":"449-464"},"PeriodicalIF":19.1,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s41556-025-01860-1.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146102116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A p53-controlled lysosomal recycling circuit fuels phospholipid synthesis 由p53控制的溶酶体循环回路为磷脂合成提供燃料。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-01-30 DOI: 10.1038/s41556-025-01868-7

引用次数: 0

Decoding the proton veil around lysosomes 解码溶酶体周围的质子面纱

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-01-26 DOI: 10.1038/s41556-025-01869-6

Massimiliano Stagi

引用次数: 0

Author Correction: Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity 作者更正：通过磷酸化的hTERT维持r环结构可以保持基因组的完整性

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-01-23 DOI: 10.1038/s41556-026-01884-1

Mitsuhiro Machitani, Akira Nomura, Taro Yamashita, Mami Yasukawa, Saori Ueki, Ken-Ichi Fujita, Toshihide Ueno, Akio Yamashita, Yoshikazu Tanzawa, Masahiko Watanabe, Toshiyasu Taniguchi, Noriko Saitoh, Shuichi Kaneko, Yukinari Kato, Hiroyuki Mano, Kenkichi Masutomi

引用次数: 0

Metabolic borders shape immune resistance 代谢边界形成免疫抵抗。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-01-23 DOI: 10.1038/s41556-025-01858-9

Ali Can Savas, Sergei I. Grivennikov

引用次数: 0

Mitochondrial quality control relies on MISO 线粒体质量控制依赖于MISO。

IF 19.1 1区生物学

Nature Cell Biology Pub Date : 2026-01-23 DOI: 10.1038/s41556-025-01866-9

Flavia Fontanesi

引用次数: 0